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Cardiac arrest, stony heart, and cardiopulmonary resuscitation: An updated revisit

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World Journal of Cardiology 2024年第3期16卷 126-136页

作者： Ayman El-menyar bianca m Wahlen Department of Trauma and Vascular Surgery Clinical ResearchHamad Medical CorporationDoha 3050Qatar Department of Clinical medicine Weill Cornell Medical CollegeDoha 24144Qatar Department of Anesthesiology Hamad Medical CorporationDoha 3050Qatar

The post-resuscitation period is recognized as the main predictor of cardiopul-monary resuscitation(CPR)*** first description of post-resuscitation syndrome and stony heart was published over 50 years *** manifestations may include but are not limited to,persistent precipitating pathology,systemic ischemia/reperfusion response,post-cardiac arrest brain injury,and finally,post-cardiac arrest myocardial dysfunction(PAmD)after successful *** do some patients initially survive successful resuscitation,and others do not?Also,why does the myocardium response vary after resuscitation?These ques-tions have kept scientists busy for several decades since the first successful resuscitation was *** modifying the conventional modalities of resu-scitation together with new promising agents,rescuers will be able to salvage the jeopardized post-resuscitation myocardium and prevent its progression to a dismal,stony *** awareness and staff education are crucial for shortening the resuscitation time and improving short-and long-term *** of these components before and early after the restoration of circulation will enhance the resuscitation *** review extensively addresses the underlying pathophysiology,management,and outcomes of post-resuscitation *** pattern,management,and outcome of PAmD and post-cardiac arrest shock are different based on many factors,including in-hospital cardiac arrest vs out-of-hospital cardiac arrest(OHCA),witnessed vs unwitnessed cardiac arrest,the underlying cause of arrest,the duration,and protocol used for *** restoring spontaneous circulation is a vital sign,it should not be the end of the game or lone primary outcome;it calls for better understanding and aggressive multi-disciplinary interventions and *** development of stony heart post-CPR and OHCA remain the main challenges in emergency and critical care medicine.

关键词： Cardiac arrest Out-of-hospital cardiac arrest In-hospital cardiac arrest Post-resuscitation myocardial dysfunction Cardiopulmonary resuscitation Stony heart

The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela m.Josepetti bianca P.Sousa Simone A.J.Rodrigues Renato G.Freitas Gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

A novel paradigm for feedback control in LPBF:layer-wise correction for overhang structures

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Advances in manufacturing 2022年第2期10卷 326-344页

作者： Ema Vasileska Ali Gokhan Demir bianca maria colosimo Barbara Previtali Department of mechanical Engineering Polytechnic University of MilanVia La Masa 120156 MilanItaly

In laser powder bed fusion(LPBF),it is common practice to select process parameters to achieve high density parts starting from simple geometries such as cubes or ***,additive manufacturing is usually adopted to producevery complex geometries,where parameters should be tuned locally,depending on the local features to be *** fact,geometrical features,such as overhangs,acute corners,and thin walls may lead to over-or under-heating conditions,which may result in geometrical inaccuracy,high roughness,volumetric errors(i.e.,porosity)oreven job failure due to *** work proposes a layer-wise control strategy to improve the geometrical precision of overhanging regions using a coaxial melt pool monitoring *** meltpool images acquired at each layer are used in a controlloop toadapt theprocess parameters locally at the next layer in order to minimize surface *** particular,the laser duty cycle is used as a controllable parameterto correct the energy *** work presents the main architecture of the proposed approach,the control strategy and the experimental procedure that need to be applied to design the control *** layer-wise control strategy was tested on AISI 316L stainless steel using an open LPFB *** results showed that the proposed layer-wise control solution results in a constant melt pool observed via the laser heated area size starting from the second layer onward,leading to a significant improvement in the geometrical accuracy of 5 mm-long bridge geometries.

关键词： Closed-loop control melt pool monitoring:Defect correction Pulsed-wave emission

Evidence-Based Complementary and Alternative medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 mice

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Journal of Biosciences and medicines 2024年第5期12卷 213-232页

作者： Rafael m. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa bianca T. Ciambarella Rodrigo N. Ferreira Jorge José de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity metabolic Syndrome

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase mETTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： bianca Cesaro Alessia Iaiza Fabio Piscopo marco Tarullo Eleonora Cesari Dante Rotili Antonello mai Alberto Diana michela Londero Luca Del Giacco Riccardo masetti Alba Di Leone Chiara Naro Silvia masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(mETTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

Overweight and obesity in young adults with patellofemoral pain:Impact on functional capacity and strength

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Journal of Sport and Health Science 2023年第2期12卷 202-211页

作者： Amanda Schenatto Ferreira Benjamin Fmentiplay bianca Taborda marcella Ferraz Pazzinatto Fábio mícolis de Azevedo Danilo de Oliveira Silva Department of Physiotherapy School of Science and TechnologySao Paulo State University(UNESP)Presidente Prudente19060-900Brazil La Trobe Sport and Exercise medicine Research Centre School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVIC 3086Australia

Purpose:This study aimed to(a)investigate the proportion of overweight/obesity in a cohort of young adults with patellofemoral pain(PFP)and(b)explore the association of body mass index(BmI),body fat,and lean mass with functional capacity and hip and knee strength in people with ***:We included a mixed-sex sample of young adults(18-35 years old)with PFP(n=100).measurements for BmI,percentage of body fat,and lean mass(assessed by bioelectrical impedance)were *** capacity was assessed by the Anterior Knee Pain Scale,plank test,and single-leg hop *** of the knee extensors,knee flexors,and hip abductors was evaluated isometrically using an isokinetic *** proportion of overweight/obesity was calculated based on *** association between BmI,body fat,and lean mass and functional capacity and strength was investigated using partial correlations,followed by hierarchical regression analysis,adjusted for covariates(sex,bilateral pain,and current pain level).Results:A total of 38%of our cohort had their BmI categorized as overweight/*** BmI was associated with poor functional capacity(ΔR^(2)=0.06-0.12,pmass was associated with poor functional capacity(ΔR^(2)=0.04-0.13,p≤0.032)and reduced strength(ΔR^(2)=0.29-0.31,pmI,body fat,and lean mass should be considered in the assessment and management of young people with PFP because it may be detrimental to function and strength.

关键词： Body fat distribution Body mass index Patellofemoral pain syndrome Torque

Epidemiology and Clinical Features of mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma bianca miranda Gouveia Ismari Perini Furlaneto Victória menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of mycobacterium avium complex pulmonary disease (mACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The m. avium group represented 58.9% of cases, followed by m. intracellulare (35.7%), m. colombiense (3.6%), and m. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for mAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of mAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of mAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： mACDP Nontuberculous mycobacteria mycobacterium avium Lung Disease

Exploring overweight and obesity beyond body mass index:A body composition analysis in people with and without patellofemoral pain

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Journal of Sport and Health Science 2023年第5期12卷 630-638,F0003页

作者： Amanda Schenatto Ferreira Benjamin F mentiplay bianca Taborda marcella Ferraz Pazzinatto Fabio mıcolis de Azevedo Danilo De Oliveira Silva Department of Physiotherapy School of Science and TechnologySao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil La Trobe Sport and Exercise medicine Research Centre School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVIC 3086Australia

Background:We compared body mass index(BmI),body fat,and skeletal muscle mass between(1) a mixed-sex nonathletic cohort of people with patellofemoral pain(PFP) and pain-free people,and(2) a nonathletic cohort of people with PFP and pain-free people subgrouped by sex(i.e.,men and women with PFP ***-free men and women).methods:This cross-sectional study included 114 people with PFP(71 women,43 men) and 54 pain-free controls(32 women,22 men).All participants attended a single testing session to assess body composition measures,which included BmI,percentage of body fat(%BFBioimpedance),and skeletal muscle mass(both assessed by bioelectrical impedance analysis),and percentage of body fat(%BFskinfoid)(assessed by skinfold caliper analysis).A one-way univariate analysis of covariance(age and physical activity levels as covariates) was used to compare body composition measures between groups(i.e.,PFP ***-free group;women with PFP ***-free women;men with PFP ***-free men).Results:Women with PFP presented significantly higher BmI,%BFBiompedance,and %BFSkinfold,and lower skeletal muscle mass compared to pain-free women(p≤0.04;effect size:-0.47 to 0.85).men with PFP and men and women combined had no differences in BmI,%BFBioimpedance,%BFSkinfold,and skeletal muscle mass compared to their respective pain-free groups(p> 0.05).Conclusion:Our findings indicate that BmI and body composition measures should be considered as part of the evaluation and management of people with PFP,especially in women,who have demonstrated higher BmI and body fat and lower skeletal muscle mass compared to pain-free *** studies should not assess body composition measures in a mixed-sex population without distinguishing men participants from women participants.

关键词： Body composition Body mass index Patellofemoral pain syndrome Skinfold thicknessTagedEnd

Calcitriol induces post-thawed bovine sperm capacitation

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BIOCELL 2023年第5期47卷 1135-1143页

作者： ANA CECILIA LIAUDAT FRANCISCA EBEL bianca ANA OPIZZO mARINA AURORA GONZALEZ DAmIÁN BLOIS PABLO BOSCH NANCY RODRIGUEZ Departamento de Biología molecular Instituto de Biotecnología Ambiental y Salud(INBIAS)Río Cuarto5800Argentina

Background:Capacitation is a set of physiological changes sperms undergo to acquire fertilizing *** vivo,this process is directly associated with high calcium levels in sperm ***,the vitamin D hypercalcemic metabolite,is related to human sperm motility,capacitation,and acrosome *** work aimed to study the effect of calcitriol on bull sperm quality parameters and ***:One million freezethawed spermatozoa were obtained from different bulls and treated with 20 nm of calcitriol for 30 *** cells(negative control)and treated ones with calcitriol or heparin(100μg/mL,positive capacitation control)were evaluated for motility,viability,and functional ***(70μm,30 min)treatment was included as a reactive oxygen species(ROS)positive sperm ***:The results elucidated that sperm exposed to 20 nm calcitriol showed higher viability,vigor,and capacitation than their positive and negative *** percentage of sperm with intact plasma and acrosome membranes,mitochondrial membrane potential(ΔΨm),and phosphatidylserine externalization was similar in all the conditions evaluated,while ROS production was higher with heparin and menadione-treated groups than the calcitriol group or negative ***:Our results indicate that calcitriol induces the capacitation of thawed bull spermatozoa and maintains acceptable values of progressive motility,viability,and vigor without altering key biological parameters such as redox status,ΔΨm,and cell death.

关键词： Bovine Sperm capacitation Calcitriol Cell viability Plasma membrane integrity Reactive oxygen species