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Myc inhibition tips the immune balance to promote antitumor immunity

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Cellular & Molecular Immunology 2022年第9期19卷 1030-1041页

作者： Chao Yang Yun Liu Yudi hu liang fang Zhe huang huanhuan Cui Jun xie Yazhen Hong Wei Chen Nengming Xiao Qiyuan Li Wen-Hsien Liu Changchun Xiao State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102FujianChina Institute of Hematology School of MedicineXiamen UniversityXiamen361102FujianChina Shenzhen Key Laboratory of Gene Regulation and Systems Biology School of Life Sciences and Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen518005GuangdongChina Sanofi Institute for Biomedical Research Suzhou215123JiangsuChina Department of Immunology and Microbiology The Scripps Research InstituteLa JollaCA92037USA

Aberrant expression of Myc is one of the most common oncogenic events in human *** of Myc inhibitors are currently under development for treating Myc-driven *** addition to directly targeting tumor cells,Myc inhibition has been shown to modulate the tumor microenvironment to promote tumor ***,the effect of Myc inhibition on immune cells in the tumor microenvironment remains poorly ***,we show that the adaptive immune system plays a vital role in the antitumor effect of pharmacologic inhibition of *** genetic and pharmacologic approaches,we found that Myc inhibition enhanced CD8 T cell function by suppressing the homeostasis of regulatory T(Treg)cells and the differentiation of resting Treg(rTreg)cells to activated Treg(aTreg)cells in ***,we demonstrated that different Myc expression levels confer differential sensitivity of T cell subsets to pharmacologic inhibition of *** ablation of the Myc gene has been shown to suppress CD8 T cell function,Treg cells,which express much less Myc protein than CD8 T cells,are more sensitive to Myc *** differential sensitivity of CD8 T and Treg cells to Myc inhibitors resulted in enhanced CD8 T cell function upon Myc *** findings revealed that Myc inhibitors can induce an antitumor immune response during tumor progression.

关键词： Myc inhibition Regulatory T cells Differential sensitivity Antitumor immunity Cancer immunotherapy

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山西晋祠公园藻类植物的初步研究

晋中学院学报 2009年第3期26卷 51-54,85页

作者：罗爱国胡变芳谢树莲山西大学生命科学与技术学院山西太原030006 晋中学院生命科学与技术学院山西晋中030600

对山西晋祠公园的藻类植物进行初步研究,经鉴定,共有藻类植物47种,隶属于6门,17科,24属.其中,硅藻门种类最多,共计30种,隶属5科10属;其次是绿藻门,有8种,隶属7科7属;再次为蓝藻门,有3种,隶属2科3属;黄藻门3种,隶属1科1属;轮藻门2种,隶属... 详细信息

对山西晋祠公园的藻类植物进行初步研究,经鉴定,共有藻类植物47种,隶属于6门,17科,24属.其中,硅藻门种类最多,共计30种,隶属5科10属;其次是绿藻门,有8种,隶属7科7属;再次为蓝藻门,有3种,隶属2科3属;黄藻门3种,隶属1科1属;轮藻门2种,隶属1科2属;最后为红藻门有1种,隶属1科,1属.

关键词：藻类植物晋祠公园山西

BLIND SYMBOL RATE ESTIMATION OF SATELLITE COMMUNICATION SIGNAL BY HAAR WAVELET TRANSFORM

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Journal of Electronics(China) 2011年第2期28卷 198-203页

作者： Wang Long Zhang Gengxin bian Dongming xie Zhidong hu Jing Institute of Communication Engineering PLA UST Nanjing 210007 China

As the raised cosine shaping filter is often employed in practical satellite communication system,the envelope fluctuation at the symbol transition point is decreased which leads to the failure of the common wavelet algorithm under low ***,a method of blind symbol rate estimation using signal preprocessing and Haar wavelet is proposed in this ***,the effect of filter shaping can be reduced by the signal ***,the optimal scale factor is searched and the signal is processed and analyzed by the Haar wavelet ***,the symbol rate line is extracted and a nonlinear filter method is inducted for improving the estimation *** analysis and computer simulation show the efficiency of the proposed algorithm under low SNR and small roll-off factor.

关键词： Haar wavelet Symbol rate Preprocessing Blind estimation

Early hepatitis B viral DNA clearance predicts treatment response at week 96

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World Journal of Gastroenterology 2017年第16期23卷 2978-2986页

作者： Xiao-Yu Fu De-Ming Tan Cui-Mei Liu Bin Gu Li-hua hu Zhong-Tian Peng Bin Chen Yuan-Lin xie huan-Yu Gong Xiao-Xuan hu lian-hui Yao Xiao-Ping Xu Zheng-Yuan Fu Lang-Qiu He Si-Hai Li Yun-Zhu Long De-hui Li Ji-Long Gu Shi-fang Peng Key Laboratory of Viral Hepatitis Department of Infectious DiseasesXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina The Second People’s Hospital of Chenzhou Chenzhou 423000Hunan ProvinceChina The Third People’s Hospital of Hengyang Hengyang 421005Hunan ProvinceChina The First Affiliated Hospital of Nanhua University Hengyang 421001Hunan ProvinceChina The First Affiliated Hospital of hunan Traditional Chinese Medicine University Changsha 430100Hunan ProvinceChina The First Hospital of Changsha Changsha 430100Hunan ProvinceChina The Third Xiangya Hospital Changsha 410008Hunan ProvinceChina The People’s Hospital of hunan Province Changsha 410005Hunan ProvinceChina Wangwang Hospital of Changsha Changsha 410005Hunan ProvinceChina The People’s Hospital of Xiangxi Jishou 416000Hunan ProvinceChina The First People’s Hospital of huaihua Huaihua 418000Hunan ProvinceChina The Central Hospital of Xiangtan Xiangtan 411100Hunan ProvinceChina The First People’s Hospital of Yueyang Yueyang 414000Hunan ProvinceChina The Central Hospital of Zhuzhou Zhuzhou 412007Hunan ProvinceChina The First People’s Hospital of Changde Changde 415003Hunan ProvinceChina The Central Hospital of Shaoyang Shaoyang 422000Hunan ProvinceChina

AIM To investigate whether hepatitis viral DNA load at 24 wk of treatment predicts response at 96 wk in patients with chronic hepatitis *** A total of 172 hepatitis B envelope antigen(HBe Ag)-positive chronic hepatitis B patients who received initial treatment at 16 tertiary hospitals in hunan Province, China were enrolled in this study. All patients received conventional doses of lamivudine and adefovir dipivoxil, telbivudine, entecavir dispersible tablets, or entecavir tablets for 96 wk. Patients who used other antiviral drugs or antitumor and immune regulation therapy were excluded. Patients were stratified into three groups according to their viral DNA load at 24 wk: 103 IU/m L(group 3). Correlations of 24-wk DNA load with HBe Ag negative status and HBe Ag seroconversion at 96 wk were analyzed. Receiver operating characteristic curve analysis was used to test the predictive value of the HBV DNA load at 24 wk for long-term *** The rates of conversion to HBe Ag negative status and HBe Ag seroconversion rates were 53.7% and 51.9%, respectively, in group 1; 35.21% and 32.39% in group 2; and 6.38% and 6.38% in group 3. The receiver operating characteristic curves for the three subgroups revealed that the lowest DNA load( 200 IU/m L at 96 wk; resistance mutations involving different loci were present in 26 patients, and three of these patients had a viral DNA load 10-103 IU/m L at 96 wk. CONCLUSION Hepatitis B viral DNA load at 24 wk of antiviral treatment in patients with chronic hepatitis B is a predictor of the viral load and response rate at 96 wk.

关键词： Chronic hepatitis B Nucleoside analogue Viral DNA load Hepatitis B antigens Hepatitis B antibodies Hepatitis B virus DNA Hepatitis B virus

A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis

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Horticulture Research 2021年第1期8卷 2260-2274页

作者： Jian-ye Chen fang-fang xie Yan-ze Cui Can-bin Chen Wang-jin Lu Xiao-di hu Qing-zhu hua Jing Zhao Zhi-jiang Wu Dan Gao Zhi-ke Zhang Wen-kai Jiang Qing-ming Sun Gui-bing hu Yong-hua Qin State Key Laboratory for Conservation and Utilization of Subtropical Agrobioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China) Ministry of Agriculture and Rural Affairs/Lingnan Guangdong Laboratory of Modern AgricultureCollege of HorticultureSouth China Agricultural University510642 GuangzhouGuangdongChina Novogene Bioinformatics Institute 100083 BeijingChina Horticulture Research Institute Guangxi Academy of Agricultural Sciences530007 NanningGuangxiChina Institute of Fruit Tree Research Guangdong Academy of Agricultural Sciences/Key Laboratory of South Subtropical Fruit Biology and Genetic Resource Utilization(MOA)/Guangdong Province Key Laboratory of Tropical and Subtropical Fruit Tree Research510640 GuangzhouChina

Pitaya(Hylocereus)is the most economically important fleshy-fruited tree of the Cactaceae family that is grown worldwide,and it has attracted significant attention because of its betalain-abundant ***,the lack of a pitaya reference genome significantly hinders studies focused on its evolution,as well as the potential for genetic improvement of this ***,we employed various sequencing approaches,namely,PacBio-SMRT,Illumina HiSeq paired-end,10×Genomics,and Hi-C(high-throughput chromosome conformation capture)to provide a chromosome-level genomic assembly of‘GHB’pitaya(***,2n=2x=22 chromosomes).The size of the assembled pitaya genome was 1.41 Gb,with a scaffold N50 of~127.15 *** total,27,753 protein-coding genes and 896.31Mb of repetitive sequences in the *** genome were *** has undergone a WGT(whole-genome triplication),and a recent WGD(whole-genome duplication)occurred after the gamma event,which is common to the other species in Cactaceae.A total of 29,328 intact LTR-RTs(~696.45Mb)were obtained in ***,of which two significantly expanded lineages,Ty1/copia and Ty3/gypsy,were the main drivers of the expanded genome.A high-density genetic map of F1 hybrid populations of‘GHB’×‘Dahong’pitayas(***)and their parents were constructed,and a total of 20,872 bin markers were identified(56,380 SNPs)for 11 linkage *** importantly,through transcriptomic and WGCNA(weighted gene coexpression network analysis),a global view of the gene regulatory network,including structural genes and the transcription factors involved in pitaya fruit betalain biosynthesis,was *** data present a valuable resource for facilitating molecular breeding programs of pitaya and shed novel light on its genomic evolution,as well as the modulation of betalain biosynthesis in edible fruits.

关键词： evolution expanded linkage

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我国被害人刑事法治程序研究现状及其评价

武汉理工大学学报（社会科学版） 2014年第4期27卷 631-636页

作者：解源源胡莲芳中国人民公安大学警务实战训练部北京100038 中国政法大学刑事司法学院北京100088

我国首部刑事诉讼法颁布实施以来,理论界对被害人刑事法治程序问题展开了研究,并取得了一些学术成果。基于中国学术期刊网1980-2013年相关论文,对过往的研究成果进行了整理,对未曾涉猎的研究领域进行了探讨,这有利于我们发现和纠正这一... 详细信息

我国首部刑事诉讼法颁布实施以来,理论界对被害人刑事法治程序问题展开了研究,并取得了一些学术成果。基于中国学术期刊网1980-2013年相关论文,对过往的研究成果进行了整理,对未曾涉猎的研究领域进行了探讨,这有利于我们发现和纠正这一问题在研究视角、研究方法上的偏差,为今后被害人刑事法治程序研究提供了素材和经验。

关键词：被害人刑事法治程序诉讼权利研究

A NOVEL MODULATION FOR MOBILE SATELLITE COMMUNICATIONS

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Journal of Electronics(China) 2011年第2期28卷 174-180页

作者： xie Zhidong bian Dongming hu Jing Sun Qian Institute of Communication Engineering PLA University of Science and Technology Nanjing 210007 China

It is a challenging problem to design a high performance modulation for mobile satellite communications due to the limited power and bandwidth *** paper improves Feher patented Quadrature Phase Shift Keying(FQPSK) by redefining the *** novel FQPSK,with con-stant envelope,can be used to improve the power efficiency and frequency efficiency of mobile satellite *** study shows that the improved FQPSK outperforms conventional FQPSK over AWGN and is immune to the non-linearity of high power *** last,the impact of flat fading and multi-path fading of channel on the BER performance of improved modulation is analyzed.

关键词： Mobile satellite communication Modulation Feher Quadrature Phase Shift Keying(FQPSK) Fading

Theoretical Models on Interfacial Thermal Conductance of Nanoscale Solid Interfaces in Chips:A Mini Review

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Chinese Physics Letters 2024年第10期41卷 70-77页

作者： Zhicheng Zong Xiandong Chen Bin Yan Yelei xie Jian Pang Guangyao Li Jiqiang hu Zhipeng Wu Bo Li Haisheng fang Nuo Yang School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Packaging and Testing Institution Sanechips Technology Co.Ltd.Shenzhen 518055China State Key Laboratory of Mobile Network and Mobile Multimedia Technology ZTE CorporationShenzhen 518055China

With the rapid increase in power density of electronic devices,thermal management has become urgent for the electronics *** temperature in the back-end-of-line is crucial for maintaining the reliability of integrated circuits,where many atomic-scale interfaces *** theoretical models of interface thermal conductance not only accurately predict the values but also help to analyze the underlying *** review picks up and introduces some representative theoretical models considering interfacial roughness,elastic and inelastic processes,and electron–phonon couplings,***,the limitations and problems of these models are also discussed.

关键词： mechanism. roughness limitations

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麻痹性痴呆二例的临床特征与诊断

中华神经科杂志 2005年第2期38卷 74-77页

作者：彭福华邱伟边连防胡学强中山大学附属第三医院神经科广州510630

目的分析麻痹性痴呆(GPI)的临床特征及提供早期诊断依据。方法回顾性分析经临床和实验室检查确诊的2例麻痹性痴呆患者的有关临床资料。结果GPI的临床特征(1) 2例患者慢性起病,进行性发展; (2)痴呆是核心症状, 2例患者入院时长谷川痴呆... 详细信息

目的分析麻痹性痴呆(GPI)的临床特征及提供早期诊断依据。方法回顾性分析经临床和实验室检查确诊的2例麻痹性痴呆患者的有关临床资料。结果GPI的临床特征(1) 2例患者慢性起病,进行性发展; (2)痴呆是核心症状, 2例患者入院时长谷川痴呆量表评分为4分和17分,均伴夸大妄想、病理性欣快等精神症状; (3) 1例患者的瞳孔左右不等大,光反射迟钝或消失但辐辏反射保持, 2例患者均有构音障碍、肌张力增高及反射异常等; (4) 2例患者血清、脑脊液梅毒抗体反应均为阳性,脑脊液蛋白含量增加、细胞数增多(以淋巴细胞为主); (5)头颅MRI示2例患者均有脑萎缩, 1例患者有脑实质异常信号影,为多发、散在病灶,广泛脑白质纤维变性。结论GPI误诊率高,临床表现、实验室及影像学检查是诊断的重要依据。

关键词：麻痹性痴呆临床特征诊断长谷川痴呆量表病理性欣快夸大妄想