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Chinese Chemical Letters 2020年第2期31卷 501-504页

作者： Lin Liu Liying Yin hang bian Ning Zhang Department of Chemistry Northeast Normal UniversityChangchun 130024China School of Material Science and Engineering Jilin Jianzhu UniversityChangchun 130118China

A straightforward coassembly strategy was developed for the preparation of polymeric nanoparticles driving by the intermolecular hydrogen bond between neutral poly(2-methyl-2-oxaozline)(PMeOx),tannic acid(TA) and doxorubicin hydrochloride(Dox).The occurrence of the hydrogen-bonding amongst the different functionalities within the formed nanoparticles was verified by infrared(IR) *** electron microscopy(SEM),dynamic light scattering(DLS),UV-vis absorption and photoluminescent measurements indicated the rapid formation of uniform and water dispersible/stable *** relative poor stability of PMeOx-TA-Dox in fetal bovine serum(FBS) solution enabled the rapid separation of Dox and PMeOx-TA,facilitating the release of Dox and its entrance into cellular nuclei as revealed by confocal laser scanning microscopy(CLSM).The presented strategy may provide an efficient alternative for the construction of multifunctional nanomedicines.

关键词： Polymeric nanoparticle Poly(2-oxazoline) Drug delivery Self-assembly Doxorubicin

Selective modification of two-dimensional MoS_2 nanosheets by polymer grafting

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Chinese Chemical Letters 2019年第2期30卷 311-313页

作者： hang bian Xuejian Zhang Dexin Huang Ning Zhang School of Material Science and Engineering Jilin Jianzhu University Key Laboratory of Synthetic Rubber Changchun Institute of Applied ChemistryChinese Academy of Sciences

As an emerging two-dimensional (2D) nanomaterial, single layer ora few layers of molybdenum disulfide (MoS_2) has drawn significant attention in the past decade. In the present work, we report a strategy in direct creating polymer brushes on MoS_2 surfaces via S—C bond in the presence of UV light. The modification of MoS_2 nanosheets can be achieved bilaterally or homolaterally by performing the UVgrafting polymerization on exfoliated MoS_2 nanosheets or a single layer of MoS_2 deposited on a silicon substrate. A series of vinyl monomers including methyl methacrylate (MMA), styrene (St) and 2-isopropenyl-2-oxazoline (IPOx) could be applied to this approach, leading to the formation of poly (methyl methacrylate) (PMMA), polystyrene (PS) and poly (2-isopropenyl-2-oxazoline) (PIPOx) ***, IR, and XPS characterizations indicate the successful formation of homogeneous brush layers on MoS_2 surfaces. The polymer brushes modified MoS_2 may found potential applications in photo dynamic therapy and sensing technologies.

关键词： Molybdenum disulfide Polymer brushes SIPGP Surface modification S-C bond

Controlled synthesis of silver nanoparticles from polyoxometalates-immobilized poly(4-vinylpyridine) brushes

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Chinese Chemical Letters 2019年第5期30卷 1097-1099页

作者： hang bian Xuejian Zhang Hongkai Zhao Ning Zhang School of Material Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Department of Chemistry Northeast Normal UniversityChangchun 130024China

This contribution reports the immobilization of polyoxometalate(POM)into poly(4-vinyl pyridine)(P4 VP)brushes and the controlled reduction of silver ions,in-situ generating metal nanoparticles in the brushes.P4 VP brushes were straightforwardly created by UV-assisted photopolymerization of 4-vinyl pyridine(4VP)on silicon or glass *** acid(H3 PW12 O40),one of the most widely used Keggin-type POM was anchored onto these pyridine moieties through electrostatic interaction,leading to the P4 VP/POM hybrid *** immobilized POM was further reduced to heteropolyblue,which could be used to generate silver nanoparticles in a controlled ***,UV-vis and IR characterization indicate that P4 VP brushes not only provide an efficient platform in the controlled preparation of Ag nanoparticles,but also efficiently disperse and stabilize POM,thus preventing the aggregation of the generated Ag nanoparticles.

关键词： Polymer brushes Polyoxometalate Ag nanoparticles Grafting polymerization

Polymer brushes on hydrogen-terminated silicon substrates via stable Si--C bond

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Chinese Chemical Letters 2018年第1期29卷 171-174页

作者： hang bian Xiaozhe Dong Shanshan Chen Dewen Dong Ning Zhang School of Material Science and Engineering Jilin jianzhu University Changchun 130118 China Key Laboratory of Synthetic Rubber Changchun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022. China

We demonstrate a straightforward and efficient method for the creation of polymer brushes on hydrogen-terminated silicon substrates through the UV-induced photopoiymerization. The surface grafting polymerization is applicable to a series of monomers, allowing the direct formation of homogeneous polymer coatings ranging from hydrophilic poly（2-isopropenyl-2-oxazoline）（PIPOx）, amphiphilic poly（N-isopropyl acrylamide）（PNIPAM）, to hydrophobic polystyrene （PS） and poly（4- （1H,1H,2H,2H-perfiuorohexyl）oxymethylstyrene）（PPHMS） on Si（100） and Si（lll） surfaces via stable Si--C bonds. Polymerization kinetic investigation indicates a linear increase of polymer layer thickness with the polymerization time. Moreover, the as-prepared polymer brushes exhibit superior stability against basic conditions in contrast to those that were formed on silicon substrates via conventional Si--O--C bond.

关键词： Polymer brushesSilicon substratesSIPGPSurface wettabilitySurface functionalization

Synthesis, supramolecular structures and luminescent properties of quinacridone derivatives bearing carbazole groups

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Chinese Science Bulletin 2009年第10期54卷 1677-1684页

作者： ZHAO GuoLi FAN Yan HUO Cheng bian hang SONG WeiFeng Zhang JingYing WANG Yue State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China

The syntheses of three carbazyl-containing quinacridone derivatives, N,N’-di((N-carbazyl)-n-butyl) quinacridone (DCBQA), N,N’-di((N-carbazyl)-n-hexyl)quinacridone (DCHQA) and N,N’-di((N-carbazyl)-n-octyl)quinacridone (DCOQA), are reported, and the photoluminescent (PL) characteristics are pre- sented. The single crystal X-ray structures of DCBQA, DCHQA and DCOQA are investigated. The crystal of DCBQA is characterized by intermolecular π…π interactions between quinacridone cores and carbazole moieties resulting in the formation of DCBQA molecule layer, in which every quinacridone core is surrounded by four carbazole groups. In DCHQA crystal, molecules assemble into two kinds of oriented columns based on intermolecular π…π interactions between quinacridone cores. The DCOQA crystal displays intermolecular CH…π and hydrogen bonding interactions feature. In DCOQA solid, every quinacridone core is sandwiched by two alkyl chains from two adjacent DCOQA molecules and simultaneously linked together with two other quinacridone cores by hydrogen bonding interactions. The PL spectra of the three compounds in solution exhibit concentration-dependent properties and their PL quantum causes decrease with the increasing concentration.

关键词：吖啶酮衍生物超分子结构发光性能合成咔唑氢键相互作用喹吖啶酮浓度依赖性

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河西务油田务45断块稳产对策研究

茜草素对APP/PS1双转基因小鼠肠道菌群的干预作用及机制研究

中国科技纵横 2024年第11期 9-11页

作者：王新亚李亚博林小宁边航付国艳柏龙华北油田第四采油厂河北廊坊 065600

务45断块构造复杂,注水见效较差,历年来针对断块措施工作量少,使油藏长期处于低产状态生产,需加大断块综合治理工作,改善开发效果.本文通过区块研究准确认识油藏的开发生产规律,针对存在的问题和潜力进行分类梳理,并制定出相应的开发技... 详细信息

务45断块构造复杂,注水见效较差,历年来针对断块措施工作量少,使油藏长期处于低产状态生产,需加大断块综合治理工作,改善开发效果.本文通过区块研究准确认识油藏的开发生产规律,针对存在的问题和潜力进行分类梳理,并制定出相应的开发技术对策,以期为夯实老油田稳产基础提供参考.

关键词：开发效果评价综合治理老油田稳产

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中国预防兽医学报 2024年第6期46卷 584-592页

作者：边宇航宁天一王震红张凌崔子寅吴运谱张泽辉王春田梁喜才辽宁中医药大学辽宁沈阳110847 辽宁省药品检验检测院辽宁沈阳110032

为研究茜草素(AZ)对APP/PS1双转基因小鼠(APP/PS1小鼠)肠道菌群、学习与记忆能力的影响,本实验将APP/PS1小鼠分为模型组(APP/PS1组)、AZ组[低剂量(Low)、中等剂量(Middle)、高剂量(High)]、阳性对照组[盐酸多奈哌齐(Donepezil组)],以APP... 详细信息

为研究茜草素(AZ)对APP/PS1双转基因小鼠(APP/PS1小鼠)肠道菌群、学习与记忆能力的影响,本实验将APP/PS1小鼠分为模型组(APP/PS1组)、AZ组[低剂量(Low)、中等剂量(Middle)、高剂量(High)]、阳性对照组[盐酸多奈哌齐(Donepezil组)],以APP/PS1阴性小鼠为空白对照组(Control组)。AZ组小鼠连续给药AZ 4周后,利用Morris水迷宫检测各组小鼠的学习与记忆能力;利用16S rRNA基因测序检测各组小鼠粪便肠样品中道菌群的变化。结果显示,与Control组小鼠相比,APP/PS1组小鼠逃避潜伏期显著延长(P<0.05)、穿越平台次数和象限停留时间极显著或显著减少(P<0.01、P<0.05),本实验选择AZ中剂量组(20 mg/kg AZ)进行后续试验;模型组小鼠肠道菌群多样性明显改变、菌落组成差异明显。给予AZ干预后,小鼠逃避潜伏期显著缩短(P<0.05)、穿越平台次数和象限停留时间均显著增加(P<0.05);AZ能有效提高APP/PS1小鼠肠道菌群多样性及改变肠道微生物结构,在门水平上,AZ能提高小鼠肠道厚壁菌门丰度,降低拟杆菌门相对丰度;在科水平上,AZ增加了小鼠肠道Muribaculaceae和Lachnospiraceae细菌的相对丰度,降低了Prevotellaceae、norank_o__Clostridia_UCG-014、Ruminococcaceae等菌群丰度;在属水平上,AZ明显提高了小鼠肠道Lactobacillus的相对丰度,进一步筛选出AZ组小鼠肠道优势菌种为o__Lactobacillales、f__Lactobacillaceae、g__Lactobacillus。通过PICRUSt2功能预测分析发现,AZ调节小鼠肠道菌群功能与炎症相关信号通路有关。本研究首次证实AZ可通过调节肠道菌群改善APP/PS1小鼠的学习及记忆能力,其机制与炎症信号通路有关,为AZ的临床应用奠定基础。

关键词：茜草素 APP/PS1双转基因小鼠肠道菌群学习与记忆能力

Synthesis and Characterization of Neodymium and Ytterbium-doped Yttrium Aluminum Garnet Nano-powder

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Synthesis and Characterization of Neodymium and Ytterbium-do...

Retinal layer segmentation using gradient feature calculation in OCT

第十七届全国晶体生长与材料学术会议(CCCG-17)

作者： Xuejian Zhang Chun Li DeXin Huang bian hang HongLiang Hu Jinghe Liu Jilin JianZhu University Changchun Structural and Functional material Engineering Research Center Changchun University of Science and Technology

Nd /Yb-co-doped YAG transparent ceramic nano-powder was prepared by sol-gel combustion *** structure,morphology and properties were characterized by thermogravimetric-differential thermal analysis,X-ray diffraction,transmission electron microscopy,infrared spectrum,absorption and fluorescence *** results showed that the mass loss of the powder calcinated at 900℃ for 3h was about 49.56%.Well-crystallized Nd /Yb:YAG nano-powder was obtained with excellent sintering performance and high purity,and the particle shapes were regular with the average diameter in the range of 60-100 *** nano-powder samples exhibited strong absorption at 808 nm,corresponding to the 4I9/2-4F7/2transition of Nd ions,which is suitable to absorb the wavelength of 808 nm from laser diode *** emission peak at 1046 nm of the Nd/Yb:YAG sample was stronger than that of Nd:*** results indicated that the energy absorbed by Yb ions from the laser diode source can be transmitted to Nd ions based on the cross relaxation process of[(4F3/2)Nd,(2F7/2)Yb]-+[(4I9/2)Nd,(2F5/2)Yb].

关键词： sol-gel combustion method neodymium and ytterbium-doped yttrium aluminum garnet transparent ceramics nano-powder properties characterization

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 137-147页

作者： Lei Liu Yeman Liu Xiaoteng Yan Haiyi bian hang Xu Chunzhong Li Hongnan Duan Faculty of Electronic Information Engineering Huaiyin Institute of Technology Huai'an Jiangsu 223003P.R.China Department of Ophthalmology A±liated Huai'an Hospital of Xuzhou Medical University Huai'an Jiangsu 223003P.R.China

Retinal diseases pose significant challenges to global healthcare systems,necessitating accurate and e±cient diagnostic *** Coherence Tomography(OCT)has emerged as a valuable tool for diagnosing and monitoring retinal conditions due to its noncontact and noninvasive *** paper presents a novel retinal layering method based on OCT images,aimed at enhancing the accuracy of retinal lesion *** method utilizes gradient analysis to effectively identify and segment retinal *** selecting a column of pixels as a segmentation line and utilizing gradient information from adjacent pixels,the method initiates and proceeds with the layering *** approach addresses potential issues arising from partial layer overlapping,minimizing deviations in layer *** results demonstrate the e±cacy of the proposed method in accurately segmenting eight retinal boundaries,with an average absolute position deviation of 1.75 *** providing accurate segmentation of retinal layers,this approach contributes to the early detection and management of ocular conditions,ultimately improving patient outcomes and reducing the global burden of vision-related ailments.

关键词： Retinal diseases optical coherence tomography retinal layer segmentation.

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聚合离子液体对二甲基二硫醚的吸附研究

化学工程 2019年第9期47卷 29-33页

作者：孙爽张娟卞宇航河北科技大学化学与制药工程学院

二甲基二硫醚作为MTBE中的主要硫化物之一,其不但含量高而且很难去除,成为一些MTBE生产厂家的难题。文中研究合成了嫁接硅胶的金属酞菁功能化聚合离子液体。对研究合成的6种金属酞菁功能化聚合离子液体,考察了其对二甲基二硫醚的吸附性... 详细信息

二甲基二硫醚作为MTBE中的主要硫化物之一,其不但含量高而且很难去除,成为一些MTBE生产厂家的难题。文中研究合成了嫁接硅胶的金属酞菁功能化聚合离子液体。对研究合成的6种金属酞菁功能化聚合离子液体,考察了其对二甲基二硫醚的吸附性能。并详细考察了金属酞菁单体、载体、单体用量和吸附剂用量等影响因素对吸附效果的影响。结果表明硅胶负载金属酞菁铁功能化的聚合离子液体吸附剂吸附效果最佳。最优工艺条件为:金属酞菁用量为载体的25%,吸附剂用量为150g/L,吸附时间为15min,吸附去除率高达83.6%。吸附剂重复使用5次后,吸附去除率仍能达到80%以上。

关键词：合成聚合离子液体二甲基二硫醚吸附剂金属酞菁环境条件