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Is repeat wide excision plus radiotherapy of localized rectal melanoma another choice before abdominoperineal resection?A case report

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World Journal of Clinical cases 2022年第15期10卷 5057-5063页

作者： Hao-Tse Chiu ta-Wei pu Hao Yen Tung Liu Chia-Cheng Wen Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgerySongshan BranchTri-Service General HospitalNational Defense Medical CenterTaipei 10581Taiwan Department of pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Rectal melanoma is an uncommon neoplasm that accounts for approximately 1 percent of rectal cancer *** resection was regarded as the radical procedure for disease ***,it led to more postoperative complications than sphincter-sparing wide local excision(WLE)and reduced the patient’s quality of life(QOL)owing to creation of ***,in this study,WLE,radiotherapy(RT),and a second WLE were conducted on a patient who had been diagnosed with localized rectal *** SUMMARY The patient was a 79-year-old woman who had been experiencing anal pain and bloody stool for 1 ***,magnetic resonance imaging,positron emission tomography–computed tomography,and histological analysis of tissue biopsy using the histological markers Melan-A(+),S-100(+),and Ki-67(+,50%)lead to the diagnosis of localized rectal *** patient had initially undergone WLE to resolve problem of anal bleeding,followed by RT to treat the residual lesion with partial ***,the residual lesion was removed with margin-free resection by the second *** patient’s postoperative course was smooth and *** the 2-year follow-up,no local recurrence was ***,a good functional outcome and improved QOL were *** Combining WLE,RT,and repeat WLE is proposed as a viable alternative for treating rectal melanoma accompanied by bleeding symptoms that cannot be completely resected at the beginning.

关键词： Sphincter-sparing local wide excision Radiotherapy Rectal melanoma case report

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A pRELIMINARY AppROACH TO THE GEOTECTONIC EVOLUTION HISTORY AND MINERLIZATION IN VICTORIA, AUSTRALIA

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Geotectonica et Metallogenia 2001年第1期25卷 37-44页

作者： daI ta-gen and CHEN Gua da (Dept. of Geology, Central South Univ., Changsha 410083, China) Dept.of Geology Central South Univ.Changsha410083China

According to the available data and field research, based on the diwa theory, the authors have studied the geotectonic evolution history and the associated minerlization in the Victoria area. It has been shown that this area is in fact a part of the Lachlan diwa region. The Victoria area can be divided into geodome fault fold zone and subsidence zone. The former can be subdivided into three zones, from west to east, which are western uplift zone, central depression zone and eastern uplift zone. The evolution history of the Victoria area can be divided into four stages——pregeosyncline, geosyncline, plateform and diwa. Each stage has distinct sedimentary, magmatic and structural features. Of the four stages, diwa stage is the most important for minerlization. Diwa stage started in the Devonian. During the development of diwa, a number of granites, which are characterized by high SiO 2 and Na 2O+K 2O, were formed. The granites were abundance with mineral forming material. On the other hand, diwa geotectonism reformed and enriched the geosynclinal or platform ore deposits. Therefore, most of the ore deposits that occurred in the Victoria area are, more or less, related with diwa tectonism.

关键词： Diwa theory minerlization geotectonics Victoria

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Discrepancy among microsatellite instability detection methodologies in non-colorectal cancer:Report of 3 cases

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World Journal of Clinical cases 2023年第13期11卷 3105-3113页

作者： ElifŞenocak taşçı İbrahim Yıldız Sibel Erdamar LeylaÖzer Department of Medical Oncology Acıbadem MAA UniversityIstanbul 12345Turkey Department of pathology Acıbadem MAA UniversityIstanbul 12345Turkey

BACKGROUND Microsatellite instability(MSI)is a predictive biomarker for cancer *** tumor-agnostic nature of MSI makes it a denominator for immunotherapy in several solid *** can be assessed using next-generation sequencing(NGS),fluorescent multiplex pCR,and immunohistochemistry(IHC).caSE SUMMARY Here,we report 3 cases with discordant MSI results detected using different methods.A cholangiocellular carcinoma case revealed proficient mismatch repair(MMR)by IHC but high MSI(MSI-H)by liquid NGS.A cervical cancer case revealed deficient MMR by IHC,microsatellite stable by pCR,and MSI-H by ***,an endometrial cancer case revealed proficient MMR by IHC but MSI-H by *** IHC for MMR status is the first choice due to several ***,in cases of indeterminate IHC results,molecular testing by MSI-pCR is ***,NGS-based MSI assays are being widely used to detect MSI-H *** three methods have high accuracy;however,the inconsistencies between them may lead to misdiagnosis.

关键词： Discordance Immunohistochemistry Microsatellite instability Nextgeneration sequencing case report

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Analysis and calculation of thermal conductivity of rock in deep strata

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Journal of Central South University of Technology 2005年第Z1期12卷 114-119页

作者： LIU Dun-wen GU De-sheng daI ta-gen Herbert Henkel School of Resources and Safety Engineering Central South University Changsha 410083 China School of Resources and Safety Engineering Central South University Changsha 410083 China School of Geoscience and Environmental Engineering Central South University Changsha 410083 China Department of Land and Water Resources Engineering Royal Institute of Technology (KTH) Stockholm S10044 Sweden

The thermal conductivity of rock is an important parameter for the deep mine and the geothermal development. It is often not possible to measure the thermal conductivity of the rocks present in the deep strata, and the usual approach is to calculate thermal conductivity including mineralogy and porosity. The compositions of core samples from the MID01 borehole in the Bjorko area were determined, and the mineral composition was classified. The calculation of the thermal conductivity of rock in the borehole was carried out, and the main factors for the thermal conductivity of rock were analyzed. The results show that the calculated thermal conductivity of rock is reliable and useful for the design and calculation of geothermal development in the Bjorko area.

关键词： thermal conductivity of rock thermal conductivity calculation mineral composition rock porosity

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Cloning, physical Mapping and Expression Analysis of a Wheat Mlo-like Gene

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Journal of Integrative plant Biology 2005年第2期47卷 214-222页

作者： LingYU Ji-ShanNIU pei-DuCHEN Zheng-QiangMA da-JunLIU StateKeyLaboratoryofCropGeneticsandGermplasmEnhancement NanjingAgriculturalUniversityNanjing210095China NorthwestNormalUniversity Lanzhou730070China Currentaddress：NationalEngineeringandResearchCenterforWheat HenanAgriculturalUniversityZhengzhou450002China

Reverse transcription-polymerase chain reaction (RT-pCR) was performed to isolate a cDNA clone using specific primers designed based on the barley (Hordeum vulgare L.) Mlo gene cDNA sequence.A full-length cDNA encoding an Mlo-like protein was isolated and characterized in a Triticum aestivum L.-Haynaldia villosa L. 6VS/6AL translocation line. The putative protein consists of 534 amino acid residues,which contain a nuclear localization motif (NLS), nine casein kinase Ⅱ motifs (S/T-X-X-D/E) and seven protein kinase C motifs (S/T-X-R/K). It is highly homologous to other plant Mlo proteins. Thus, this clone was designated as ta-Mlo (GenBank accession No. AF384144). Northern blotting analysis showed that the transcription of ta-Mlo was enhanced slightly by Blumeria graminis (DC) EO Speer f. sp. tritici. Western blotting analysis showed that the protein expression product of the ta-Mlo gene in wheat seedling leaves is a membrane-bound protein. The protein could be induced by B. graminis. Southern blotting analysis indicated that there is one copy of the ta-Mlo gene in each wheat genome. ta-Mlo was localized on specific chromosomal regions of 2AL, 2BL, and 2DL in wheat.

关键词： cloning expression Mlo-like gene RT-pCR Triticum aestivum-Haynaldia villosa 6VS/6AL translocation line

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Investigation of the hydro-mechanical behaviour of compacted expansive clay

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Frontiers of Structural and Civil Engineering 2010年第2期4卷 154-164页

作者： Yujun CUI An Ninh ta Anh Minh taNG Yingfa LU Ecole des ponts parisTech UR Navier-CERMESParis 77455France The China Three Gorges University Yichang 443002China

The hydro-mechanical behaviour of compacted expansive Romainville clay was *** soil was air-dried,crushed,and passed through a 2 mm sieve before being statically compacted to a dry density of 1.35 Mg/*** mechanical behaviour was investigated by tests in oedometer with controlled suction using the vapor equilibrium technique(suction s=0,9,39,and 110 Mpa).The vertical stress was applied in the range of 0-800 *** experimental results are shown as follows:1)wetting-induced swelling was higher at lower vertical stresses;2)the vertical stress under which no swelling occurred during water flooding was estimated at 60 kpa,which can be considered as the swelling pressure of the soil tested;3)the soil compressibility(changes of volume upon stress increases)was strongly influenced by the soil suction:the lower the suction,the higher the *** hydraulic behaviour was investigated using a large-scale infiltration chamber(800mm×1000 mm in section and 1000mm high).The large size of the soil column allowed bttrying the volumetric water content sensors(Thetaprobe)without significantly affecting the water transfer and the soil swelling during *** soil suction was monitored along the soil height(every 100 mm)using various relative humidity sensors and *** the infiltration test,water was kept on the soil surface and changes in suction and volumetric water content were monitored for 338 *** wetting front has reached the bottom of the soil column at the end of the *** data from the simultaneous monitoring of suction and water content were used to determine the water retention curve and the unsaturated hydraulic conductivity using the instantaneous profile *** has been observed that the soil water retention curve depends on the soil depth;that is to be related to the soil depthdependent *** unsaturated hydraulic conductiv-ity was found to be quite low,comprised between 3×10-11m/s(at saturated state)and 10-14

关键词： Romainville clay suction control oedometer test large infiltration task hydro-mechanical behaviour

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preparation and Compaction Behaviour of poly(methyl methacrylate) Coated Iron Microparticles

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Journal of Materials Science & Technology 2010年第5期26卷 454-460页

作者： daniela Kladeková Renáta Orináková Annamária Krajníková Miriam Kupková Margita Kabátová Kveta Markuová Institute of Chemistry Faculty of ScienceP.J.afárik University in Koice Institute of Materials Research of the Slovak Academy of Sciences in Koice

The poly（methyl methacrylate）（pMMA） coatings onto surface of iron particles were electrochemically prepared and the effect on both surface structure and internal structure of the resulted material after compaction was carried *** electrochemical polymerization treatment was performed in a fluidized bed electrolyzer using sulphuric acid solution containing potassium persulphate and methyl methacrylate（MMA）.The surface topography and the microstructure of the samples were observed by scanning electron microscopy（SEM） and optical microscopy（OM）.It was found that the pMMA layer coated onto iron particles results in improvement of their compressibility compared with uncoated powders,and classical lubricants are not necessary for compacting particles coated.

关键词： cathodic electropolymerization poly(methyl methacrylate) coating Surface appearance Microstructure Compaction process

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Ag-GST/HfO_(x)-based unidirectional threshold switching selector with low leakage current and threshold voltage distribution for high-density cross-point arrays

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Rare Metals 2024年第1期43卷 280-288页

作者： Kyoung-Joung Yoo dae-Yun Kang Nahyun Kim Ho-Jin Lee ta-Hyeong Kim taeho Kim tae Geun Kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea

The use of electrochemical-metallization-based volatile threshold switching selectors in cross-point arrays has been widely explored owing to their high on-off ratios and simple ***,these devices are unsuitable for cross-point architectures because of the difficulty in controlling the random filament formation that results in large fluctuations in the threshold voltage during *** this study,we investigated the unidirectional threshold transition characteristics associated with an Ag/GST/HfO_(x)/pt-based bilayer selector and demonstrated the occurrence of a low leakage current(tage(Δ0.11 V).The bilayer structure could control the filament formation in the intermediate state through the insertion of an HfO_(x) tunneling *** stacking a bilayer selector with NiO_(x)based resistive random-access memory,the leakage and programming currents of the device could be significantly *** the crossbar array configuration,we performed equivalent circuit analysis of a one-selector oneresistor(1S1R) devices and estimated the optimal array size to demonstrate the applicability of the proposed *** maximum acceptable crossbar array size of the 1S1R device with the Ag/GST/HfO_(x)/pt/Ti/NiO_(x)/pt structure was 5.29×10^(14)(N^(2),N=2.3×10^(7)).

关键词： Selector device Tunneling barrier Threshold switching Sputtering 1S1R Cross-point array

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Regulating Ecosystem Service (Filtering/ Immobilization of Inorganic pollutants) Supplied by Soil in Model Regions of Slovakia

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Journal of Geoscience and Environment protection 2021年第11期9卷 61-72页

作者： Jarmila Makovníková Boris pálka Miloš Širáň Stanislav Kološta National Agricultural and Food Centre/Soil Science and Conservation Research Institute Bratislava Regional Station Banská Bystica Slovakia Faculty of Economics Matej Bel University in Banská Bystrica Banská Bystrica Slovakia

The immobilization of soil contaminants (as one of the regulating ecosystem services) plays very important role in environment. This regulatory service prevents groundwater contamination and the entry of contaminants ... 详细信息

The immobilization of soil contaminants (as one of the regulating ecosystem services) playpan>s very important role in environment. This regulatory service prevents groundwater contamination and the entry of contaminants into the food chain. The evaluation as well as the spatial distribution of this regulatory service is important for optimal land management in a specific region. Mapping system combining input layers—slope topography, soil texture, climate region and land use (arable land, grassland)—were created for the analysis and the evaluation of potential of agroecosystem services. Filtering potential was calculated as accumulative function of soil sorption potential and potential of total content of inorganic pollutants evaluated according to The Slovak Soil Law. Calculated potential was categorised into five categories: very low, low, medium, high and very high. Four model areas were selected for the analysis of pollutant filtration, as one of the regulatory agroecosystem services, which are located in different climatic areas and different soil-ecological conditions of Slovakia. The greatest differences among model regions can be found in relation to climatic conditions, land use and diversity of soil types. The warm, dry, and lowland region has a higher potential for pollutant filtration than the moderately warm or cold region. These results are consistent with the location of the soil, its properties, processes and functions within the concept of agro-ecosystem services.pan> pan style="font-family:"">Based on the results, we can state that the high risk of inorganic contaminants is i

关键词： Filtering Ecosystem Service Inorganic Contaminants Soil Sorbents

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Human dendritic cell-specific IcaM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis

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Cellular & Molecular Immunology 2019年第3期16卷 288-301页

作者： Wen-Yu Chen Sheng-Yang Wu ta-Chun Lin Shuei-Liong Lin Betty A.Wu-Hsieh Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Graduate Institute of physiology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina

We generated a human dendritic cell-specific IcaM-3-grabbing non-integrin(DC-SIGN)transgenic mouse in which renal tubular epithelial cells expressed *** transgenic mice were infected with candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic *** discovered that,while *** infection induced renal fibrosis in both transgenic and littermate control mice,the transgenic mice had significantly lower levels of Acta2,Col1a2,Col3a1,and Col4a1 mRNA transcripts compared to the ***-1,an emerging biomarker for kidney injury,along with Tnf,Il6,and Tgfb1 transcripts,were lower in infected transgenic mice,and yet,the levels of Il10 remained comparable to the *** renal CD45+infiltrating cells were the source of Tnf,Il6,and Il10,LTL+renal proximal tubular epithelial cells were TGF-β1 producers in both infected transgenic and littermate ***-SIGN-expressing tubular epithelial cells produced less TGF-β1 in response to *** *** vivo experiments demonstrated that renal proximal tubular epithelial cell production of TGF-β1 was key to ***-induced renal fibrosis and *** of transgenic mice induced a marked increase of phosphorylated Raf-1 and p38 in the ***,ERK1/2 and JNK phosphorylation was more pronounced in the infected-littermate ***,treating the infected transgenic mice with a Raf-1 inhibitor increased the levels of the Tgfb1,Kim1,and Acta2 *** results indicate that DC-SIGN signaling,through activation of Raf-1 and p38 and suppression of JNK and ERK1/2 phosphorylation,reduces TGF-β1 production and ***-induced renal *** study reveals for the first time the effect of DC-SIGN expression on ***-induced renal fibrosis.

关键词： DC-SIGN candida albicans Renal fibrosis TGF-β1 Raf-1

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