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Metabolic reprogramming in cancer: the bridge that connects intracellular stresses and cancer behaviors

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National Science Review 2020年第8期7卷 1270-1273页

作者： Yi Zhou Huiyan sun ying Xu Cancer Systems biology Center The China-Japan Union Hospital Department of biochemistry and Molecular biology University of Georgia School of Artificial Intelligence Jilin University

Extensive changes in cellular metabolisms have been observed in cancer. They are probably induced by the same intracellular stressor, persistent off-balance in intracellular p H across possibly all adult cancers. It is these altered metabolisms that gives rise to a variety of cancerous behaviors such as continuous cell division, metastasis and drug resistance.

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Changes in extreme high temperature warning indicators over China under different global warming levels

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Science China Earth Sciences 2024年第6期67卷 1895-1909页

作者： Yuxia ZHANG ying sun Ting HU Chinese Academy of Meteorological Sciences Beijing 100081China National Climate Center Laboratory for Climate StudiesChina Meteorological AdministrationBeijing 100081China

High temperature warning indicators play a pivotal role in meteorological departments,serving as crucial criteria for issuing warnings that guide both social production and daily *** their importance,limited studies have explored the relationship between different global warming levels and changes in high temperature warning *** this study,we analyze data from 2,419 meteorological stations over China and utilize the Coupled Model Intercomparison Project Phase 6(CMIP6)models to examine historical changes in high temperature warning indicators used by the China Meteorological *** evaluate model performance and estimate future changes in these indicators using an annual cycle bias correction *** results indicate that since 1961,the number of high temperature days(TX35d and TX40d)and length of season(TX40d and TX40l)with daily maximum temperature reaching or exceeding 35℃ and 40℃ have increased over *** intensity of high temperatures(TXx)has strengthened and the geographical extent affected by high temperatures has *** 2022,the occurrence of 40℃ high temperatures surges,with Eastern China experiencing a two-day increase in TX40d and an extended seasonal length in TX40l by over five *** CMIP6 models have underestimated the high temperature indictors associated with 35℃ during historical periods,notable difference is not observed between the models and observations for TX40d and TX40l,given their rare ***,future projections,after bias correction,indicate that the increasing trends for 35℃ and 40℃ high temperature days and length of season become more pronounced than the raw projection,suggesting a more severe increase than that anticipated *** global warming intensifies,the high temperature days and length of season are projected to increase non-linearly,while the intensity of high temperatures is expected to increase *** every 1℃ increase in global temperature,the intensity is

关键词： Extreme high temperatures Meteorological warning CMIP6 Global warming levels Future projection

Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： Shuo Chen Shengpeng Su Yanfang Huang bingbing Liu Hu sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

Method of accurate grinding for single enveloping TI worm

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Science China(Technological Sciences) 2005年第4期48卷 430-440页

作者： sun Yuehai ZHENG Huijiang bi Qingzhen WANG Shuren School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China

TI worm drive consists of involute helical gear and its enveloping Hourglass worm. Accurate grinding for TI worm is the key manufacture technology for TI worm gearing being popularized and *** to the theory of gear mesh, the equations of tooth surface of worm drive are gained, and the equation of the axial section profile of grinding wheel that can accurately grind TI worm is extracted. Simultaneously, the relation of position and motion between TI worm and grinding wheel are expounded. The method for precisely grinding single enveloping TI worm is obtained.

关键词： worm gears, helical gear, hourglass worm, grinding, grinding wheel.

Rapid repair techniques for severely earthquake-damaged circular bridge piers with flexural failure mode

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Earthquake Engineering and Engineering Vibration 2017年第2期16卷 415-433页

作者： sun Zhiguo Li Hongnan bi Kaiming Si bingjun Wang Dongsheng Department of Disaster Prevention Engineering Institute of Disaster Prevention Faculty of Infrastructure Engineering Dalian University of Technology Centre for Infrastructural Monitoring and Protection School of Civil and Mechanical EngineeringCurtin University Institute of Road and Bridge Engineering Dalian Maritime University

In this study, three rapid repair techniques are proposed to retrofit circular bridge piers that are severely damaged by the flexural failure mode in major earthquakes. The quasi-static tests on three 1：2.5 scaled circular pier specimens are conducted to evaluate the efficiency of the proposed repair techniques. For the purpose of rapid repair, the repair procedure for all the specimens is conducted within four days, and the behavior of the repaired specimens is evaluated and compared with the original ones. A finite element model is developed to predict the cyclic behavior of the repaired specimens and the numerical results are compared with the test data. It is found that all the repaired specimens exhibit similar or larger lateral strength and deformation capacity than the original ones. The initial lateral stiffness of all the repaired specimens is lower than that of the original ones, while they show a higher lateral stiffness at the later stage of the test. No noticeable difference is observed for the energy dissipation capacity between the original and repaired pier specimens. It is suggested that the repair technique using the early-strength concrete jacket confined by carbon fiber reinforced polymer （CFRP） sheets can be an optimal method for the rapid repair of severely earthquake-damaged circular bridge piers with flexural failure mode.

关键词： rapid repair severely earthquake-damaged circular bridge piers flexural failure mode CFRP early-strengthconcrete

Multilayer polyethylene separator with enhanced thermal properties for safe lithium-ion batteries Author links open overlay panel

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Particuology 2024年第8期91卷 29-37页

作者： ying Jiang Chen sun Feilong Dong Haiming Xie Liqun sun National&Local United Engineering Laboratory for Power Battery Department of ChemistryNortheast Normal UniversityChangchun130024China

The separator plays an important part in battery safety and *** separators are widely used in commercial Lithium-ion batteries(LIBs),owing to their excellent properties,but they suffer from serious thermal shrinkage and poor electrolyte ***,a multilayer separator(ASPESA)is developed by coating two thin layers of low-density polyethylene(LDPE)and Al_(2)O_(3)on both sides of a polyethylene membrane using a facile and environmentally friendly casting *** ASPESA separator demonstrates a shutdown function at 120℃and shows enhanced thermal stability under 185℃,with a small thermal shrinkage of 1%.Meanwhile,the LDPE and Al_(2)O_(3)layers can improve the electrolyte wettability and electrolyte uptake(407.23%).The multilayer ASPESA separator delivers an excellent cycle performance in LiFePO_(4)||Li cells with a discharge capacity of 144.5 mAh g^(-1)after 900 cycles,with a high-capacity retention of 98.9%(compared to the 5th cycle).Therefore,the multilayer ASPESA separator has great utilization potential as a high-safety separator in LIBs.

关键词： Low-density polyethylene microspheres Al_(2)O_(3)particles Thermal shutdown High safety Lithium-ionbatteries

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi Li Li sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

Novel Annulus-shaped Flexure Pivot in Rotation Application and Dimensionless Design

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Chinese Journal of Mechanical Engineering 2009年第6期22卷 800-809页

作者： bi Shusheng ZHAO Shanshan sun Minglei YU Jingjun ZONG Guanghua School of Mechanical Engineering and Automation Beijing University of Aeronautics and Astronautics Beijing 100191 China

Large-deflection flexure pivot is widely used in high precision rotation application, but there are less flexure configurations and simple and convenient design methods, This paper presents a novel large-deflection curved-compliant annulus-shaped flexure pivot composed of six curved beam flexure elements. It can offer more than lO^angular stroke theoretically. Firstly, main-motion pseudo-rigid-body method is introduced to establish the flexure pivot model. Although pseudo-rigid-body method can be used to analyze the large-deformation flexure pivot performance, the method is definitely a laborious and difficult task for designing this novel flexure pivot. In order to simply the designing process, dimension-design graphs based on the parametric models and finite element analysis is presented. Using the dimension-design method as a tool, the designers can determine the optimal geometry rapidly, based on the stiffness and rotation demands of an annulus-shaped flexure pivot. Finally, dimension-design graph examples are given whose primary design aims to achieve a rotation stroke of annulus-shaped flexure pivot. The finite element analysis results show that the relative designing error between anticipative rotation stroke and graph design result is less than 4%. The dimensionless method used in designing annulus-shaped flexure pivot can reduce design process in both time and complexity. The novel annulus-shaped flexure pivot and dimension-design method are helpful supplement to configuration and design method of large-deflection flexure pivot.

关键词： annulus-shaped flexure pivot dimensionless design pseudo-rigid-body model

Progress on Regulation of NLRP3 Inflammasome by Chinese Medicine in Treatment of Ulcerative Colitis

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Chinese Journal of Integrative Medicine 2023年第8期29卷 750-760页

作者： sun Hao-xian ZHU ying Department of Gastroenterology the First Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410007)China Hunan University of Chinese Medicine Changsha(410208)China

Ulcerative colitis(UC)is a chronic,non-specific intestinal disease that not only affects the quality of life of patients and their families but also increases the risk of colorectal *** nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome is an important component of inflammatory response system,and its activation induces an inflammatory cascade response that is involved in the development and progression of UC by releasing inflammatory cytokines,damaging intestinal epithelial cells,and disrupting the intestinal mucosal *** medicine(CM)plays a vital role in the prevention and treatment of UC and is able to regulate NLRP3 *** experimental studies on the regulation of NLRP3 inflammasome mediated by CM have been carried out,demonstrating that CM formulae with main effects of clearing heat,detoxifying toxicity,drying dampness,and activating blood *** and phenylpropanoids can effectively regulate NLRP3 *** active components of CM can interfere with the process of NLRP3 inflammasome assembly and activation,leading to a reduction in inflammation and UC ***,the reports are relatively scattered and lack systematic *** paper reviews the latest findings regarding the NLRP3 inflammasome activation-related pathways associated with UC and the potential of CM in treating UC through modulation of NLRP3 *** purpose of this review is to explore the possible pathological mechanisms of UC and suggest new directions for development of therapeutic tools.

关键词： NLRP3 inflammasome ulcerative colitis Chinese medicine mechanism of action review