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Role of ferroptosis in fibrosis:From mechanism to potential therapy

Chinese Medical Journal 2024年第7期137卷 806-817页

作者： Xuemeng qiu Qing bi Jiyue Wu Zejia Sun Wei Wang Department of Urology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Surgery Third Clinical Medical CollegeCapital Medical UniversityBeijing 100020China Urinary and Nephropathy Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Institute of Urology Capital Medical UniversityBeijing 100020China

Fibrosis,which is a manifestation of the physiological response to injury characterized by excessive accumulation of extracellular matrix components,is a ubiquitous outcome of the repair ***,in cases of repetitive or severe injury,fibrosis may become dysregulated,leading to a pathological state and organ *** recent years,a novel form of regulated cell death,referred to as ferroptosis,has been identified as a possible contributor to fibrosis;it is characterized by iron-mediated lipid *** has garnered attention due to the growing body of evidence linking ferroptosis and fibrogenesis,which is believed to be driven by underlying inflammation and immune *** the increasing interest in the relationship between ferroptosis and fibrosis,a comprehensive understanding of the precise role that ferroptosis plays in the formation of fibrotic tissue remains *** review seeks to synthesize previous research related to the *** categorized the different direct and indirect mechanisms by which ferroptosis may contribute to fibrosis into three categories:(1)iron overload toxicity;(2)ferroptosis-evoked necroinflammation,with a focus on ferroptosis and macrophage interplay;and(3)ferroptosis-associated pro-fibrotic factors and ***,the review considers the potential implications of these findings and highlights the utilization of ferroptosis-targeted therapies as a promising strategy for mitigating the progression of *** conclusion,novel anti-fibrotic treatments targeting ferroptosis could be an effective treatment for fibrosis.

关键词： Ferroptosis Fibrosis Anti-fibrotic Iron metabolism Necroinflammation Epithelial-mesenchymal transition

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Insights into the role of oxygen-containing functional groups on carbon surface in water–electricity generation

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Nano Research 2024年第7期17卷 6645-6653页

作者： Wan Xue Zongbin Zhao Honghui bi Bolun Zhang Xuzhen Wang Jieshan qiu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Energy Materials and Chemical EngineeringSchool of ChemistryDalian University of TechnologyDalian 116024China State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

A deep understanding of the electricity generation mechanism from the interaction between water molecules and carbon material surfaces is attractive for next-generation water-based energy conversion and storage ***,an asymmetric generator was assembled based on functionalized carbon nanotubes films to investigate the relative contribution from various oxygen functional groups on carbon surface to the water-electrical *** and calculations demonstrate that the electricity mainly originates from the water molecule adsorption by carboxyl groups and dissociation of functional groups on carbon surface,which leads to the formation of electrical double layers at *** device allows the electricity generation with a variety of water sources,such as deionized water,tap water,as well as *** particular,the generator based on carboxyl carbon nanotubes can induce a voltage of over 200 mV spontaneously in natural seawater with the power density of about 0.11 mW·g^(−1).High voltages can be achieved easily through the series-connection strategy to power electronic products such as a liquid crystal *** work reveals the dominant role of carboxyl groups in carbon-based water–electricity conversion and is expected to offer inspiration for the preparation of carbon materials with high electrical performance.

关键词： electricity generation water adsorption dissociation carboxyl groups carbon nanotubes

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Formation mechanism of Fe-based amorphous powders produced by spark erosion

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Journal of Materials Science & Technology 2024年第3期170卷 33-46页

作者： Chekai Liu Ran Li Jiazi bi Ding Ma Xiaobin Liu tao Zhang School of Materials Science and Engineering Key Laboratory of Aerospace Materials and Performance(Ministry of Education)Beihang UniversityBeijing 100191China

Spark erosion is a convenient,flexible,and low-cost method to quickly produce fine powders of metals,alloys,and semiconductors in size ranging from nearly a hundred micrometers to submicrometer by repetitive spark *** to the complexity of the powder-forming journey,normally accompanied by high temperature,high pressure,decomposition,diffusion and rapid quenching caused by discharge plasma,the mechanisms of powder formation and possible contaminant infiltration are still controversial,posing a significant challenge to control particle size and chemical composition of the powder produced by this *** this study,Fe-based amorphous powders in different particle-size distributions with high sphericity were fabricated by spark erosion under different discharge-energy *** max-imum particle size of the resultant powders can be correlated with discharge parameters,crater depth,and crater radius,respectively.A multi-ring-breakup model is proposed to reveal the particle-size distribution of the powder formed from the electrode melt under a single-pulse ***,a dielectric-element infiltration model is provided to quantitatively evaluate the infiltration mass ratio of the contaminant elements,stemming from the decomposed products of dielectric liquid,in the resultant powder with different particle *** models verified through the experimental data are significant for the development of high-performance fine Fe-based amorphous powder with controlled particle size and chemical composition.

关键词： Amorphous alloy Particle Spark erosion Infiltration Modeling

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Interpretable data-driven fault diagnosis method for data centers with composite air conditioning system

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Building Simulation 2024年第6期17卷 965-981页

作者： Yiqi Zhang Fumin tao Baoqi qiu Xiuming Li Yixing Chen Zongwei Han SEP Key Laboratory of Eco-Industry School of MetallurgyNortheastern UniversityShenyang110819China Energy Saving and Low-carbon Technology of Process Industry Engineering Research Center of Liaoning Province Northeastern UniversityShenyang110819China College of Civil Engineering Hunan UniversityChangsha410082China

Fault detection and diagnosis are essential to the air conditioning system of the data center for elevating reliability and reducing energy *** study proposed a convolutional neural network(CNN)based data-driven fault detection and diagnosis model considering temporal dependency for composite air conditioning system that is capable of cooling the high heat flux in data *** input of fault detection and diagnosis model was an unsteady dataset generated by the experimentally validated transient mathematical *** dataset concerned three typical faults,including refrigerant leakage,evaporator fan breakdown,and condenser ***,the CNN model was trained to construct a map between the input and system operating ***,the performance of the CNN model was validated by comparing it with the support vector machine and the neural ***,the score-weighted class mapping activation method was utilized to interpret model diagnosis mechanisms and to identify key input features in various operating *** results demonstrated in the pump-driven heat pipe mode,the accuracy of the CNN model was 99.14%,increasing by around 8.5%compared with the other two *** the vapor compression mode,the accuracy of the CNN model achieved 99.9%and declined the miss rate of refrigerant leakage by at least 61%*** score-weighted class mapping activation results indicated the ambient temperature and the actuator-related parameters,such as compressor frequency in vapor compression mode and condenser fan frequency in pump-driven heat pipe mode,were essential features in system fault detection and diagnosis.

关键词： data center composite air conditioning system fault detection and diagnosis interpretable artificial intelligence

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High-yield production of porous carbon spheres derived from enzymatic hydrolysis lignin for zinc ion hybrid capacitors

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 127-136页

作者： tao Huang Xihong Zu Jianhui Ma Wenbin Jian Xueqing qiu Wenli Zhang Guangdong Provincial Key Laboratory of Plant Resources biorefinery School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006China School of Advanced Manufacturing Guangdong University of TechnologyJieyang 522000China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

The widespread implementation of supercapacitors is hindered by the limited energy density and the pricey porous carbon electrode *** cost of porous carbon is a significant factor in the overall cost of supercapacitors,therefore a high carbon yield could effectively mitigate the production cost of porous *** study proposes a method to produce porous carbon spheres through a spray drying technique combined with a carbonization process,utilizing renewable enzymatic hydrolysis lignin as the carbon source and KOH as the activation *** purpose of this study is to examine the relationship between the quantity of activation agent and the development of morphology,pore structure,and specific surface area of the obtained porous carbon *** demonstrate that this approach significantly enhances the carbon yield of porous carbon,achieving a yield of 22%in contrast to the conventional carbonization-activation method(9%).The samples acquired through this method were found to contain a substantial amount of mesopores,with an average pore size of 1.59 to 1.85 nm and a mesopore ratio of 25.6%.Additionally,these samples showed high specific surface areas,ranging from 1051 to 1831 m2·g^(−1).Zinc ion hybrid capacitors with lignin-derived porous carbon cathode exhibited a high capacitance of 279 F·g^(−1) at 0.1 A·g^(−1) and an energy density of 99.1 Wh·kg^(−1) when the power density was 80 kW·kg^(−1).This research presents a novel approach for producing porous carbons with high yield through the utilization of a spray drying approach.

关键词： enzymatic hydrolysis lignin porous carbon spheres spray drying zinc ion hybrid capacitors

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Anti-OX40 Antibody Combined with HBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

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biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU Jia Jia SU qiu Dong YI Yao SHEN Li Ping bi Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer *** Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc *** Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody Hepatitis B core virus-like particles Tumor Combination therapy

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Clustering for bivariate Functional Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 613-629页

作者： Shi-yun CAO Yan-qiu ZHOU Yan-ling WAN tao ZHANG School of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Marxism Guangxi University of Science and TechnologyLiuzhou 545006China Key Laboratory of Intelligent Information Processing and Graph Processing Guangxi University of Science and TechnologyLiuzhou 545006China

In this paper,we consider the clustering of bivariate functional data where each random surface consists of a set of curves recorded repeatedly for each *** k-centres surface clustering method based on marginal functional principal component analysis is proposed for the bivariate functional data,and a novel clustering criterion is presented where both the random surface and its partial derivative function in two directions are *** addition,we also consider two other clustering methods,k-centres surface clustering methods based on product functional principal component analysis or double functional principal component *** results indicate that the proposed methods have a nice performance in terms of both the correct classification rate and the adjusted rand *** approaches are further illustrated through empirical analysis of human mortality data.

关键词： bivariate functional data -centres surface clustering functional principal component analysis partial derivative function

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Recent progress of two-dimensional metal-base catalysts in urea oxidation reaction

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Rare Metals 2024年第8期43卷 3607-3633页

作者： Qi-Xiang Huang Fang Wang Yong Liu bi-Ying Zhang Fang-Ya Guo Zhong-qiu Jia Hao Wang Tian-Xiang Yang Hai-tao Wu Feng-Zhang Ren Ting-Feng Yi School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Henan Province International Joint Laboratory of Materials for Solar Energy Conversion and Lithium Sodium Based Battery Luoyang 471023China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Materials Science and Engineering Northeastern UniversityShenyang110819China

Urea oxidation reaction(UOR)is an auxiliary water electrolysis hydrogen production technology developed in recent years to replace oxygen evolution reaction and reduce energy consumption,which can produce hydrogen more efficiently by low theoretical potential,reduce the average cost of electrochemical hydrogen production,and is a frontier research hotspot for renewable hydrogen ***-dimensional(2D)nanomaterials as electrocatalysts have many favorable potential,such as it can effectively reduce the resistivity of materials and increase the specific surface area with *** paper reviews the application of 2D materials in UOR in alkaline *** a cross-sectional comparison of various material performance data including overpotential,Tafel slope,electrochemical active surface area(ECSA)and it stability test was conducted,which could illustrate the differences between materials composed of different *** addition,the main challenges hindering the progress of research on 2D materials in urea electrocatalysis processes and promising materials in this field in future are summarized and *** is believed that this review will contribute to designing and analyzing highperformance 2D urea electrocatalysts for water splitting.

关键词： Water splitting Urea oxidation reaction Two-dimensional Transition metal compounds Noble/non-noble metals

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Numerical investigation on compressible flow around a cylinder in proximity to the heated wall

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Journal of Hydrodynamics 2024年第3期36卷 519-533页

作者： Yu-lu Liu Jun-wang Qu Yi-zhou tao Yong-guang Lyu Xiang qiu Shanghai Institute of Technology School of ScienceShanghai201418China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China

In this study,direct numerical simulations were conducted to investigate the compressible flow around a circular cylinder near a heated wall at a Reynolds number(Re)of 500 and a Mach number(Ma)of *** heating ratio T^(*)ranging from 1.0 to 1.6 represents the different situations of a heated wall,whereas the gap ratio ranges from 0.3 to *** study analyzed the impact of heating effect and wall proximity on flow characteristics and aerodynamic *** results indicated that the stability of the flow was enhanced as the gap ratio decreased or the heating ratio *** the calculation of enstrophy,it was found that the strength of shedding vortices weakens with a decrease in gap ratio or an increase in heating ***,the mean drag coefficient decreases as the heating ratio increases or the gap ratio *** contrast,the mean lift coefficient initially decreases and then increases as the gap ratio ***,the drag reduction mechanism was analyzed by examining the pressure distribution on the surface of the cylinder.

关键词： Compressible flow wall proximity heating effect stability enstrophy

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SemID: Blind Image Inpainting with Semantic Inconsistency Detection

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Tsinghua Science and Technology 2024年第4期29卷 1053-1068页

作者： Xin Li Zhikuan Wang Chenglizhao Chen Chunfeng tao Yuanbo qiu Junde Liu Baile Sun College of Computer Science and Technology China University of Petroleum(East China)Qingdao 266580China CNPC Oriental Geophysical Exploration Co.Ltd. Baoding 072751China

Most existing image inpainting methods aim to fill in the missing content in the inside-hole region of the target image. However, the areas to be restored in realistically degraded images are unspecified. Previous studies have failed to recover the degradations due to the absence of the explicit mask indication. Meanwhile, inconsistent patterns are blended complexly with the image content. Therefore, estimating whether certain pixels are out of distribution and considering whether the object is consistent with the context is necessary. Motivated by these observations, a two-stage blind image inpainting network, which utilizes global semantic features of the image to locate semantically inconsistent regions and then generates reasonable content in the areas, is proposed. Specifically, the representation differences between inconsistent and available content are first amplified, iteratively predicting the region to be restored from coarse to fine. A confidence-driven inpainting network based on prediction masks is then used to estimate the information regarding missing regions. Furthermore, a multiscale contextual aggregation module is introduced for spatial feature transfer to refine the generated contents. Extensive experiments over multiple datasets demonstrate that the proposed method can generate visually plausible and structurally complete results that are particularly effective in recovering diverse degraded images.

关键词： blind image inpainting inconsistent pattern representation difference contextual aggregation

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