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Journal of Materiomics 2024年第1期10卷 145-153页

作者： bi Hui Zhang Diming Xu Rui Ze Guo Lu Liu Xiao Qiang Liu Xiang Ming chen Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310058China Key Laboratory of Multifunctional Materials and Structures Ministry of EducationSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an710049China

Hybrid improper ferroelectricity has been extensively reported through theoretical prediction and experimental investigation in the oxides with Ruddlesden-Popper(R-P)***,the experimentally reported ferroelectric materials based on triple-layer R-P structures are rare,and the weak ferroelectricity impedes its practical *** the present work,the single-phase Li_(2)Nd_(2)Ti_(3)O_(10)ceramics with A-site cation ordered triple-layer R-P structure was obtained by spark plasma sintering technique,and the crystal structure of P2_(1)ab symmetry was revealed by neutron powder diffraction and transmission electron microscope ***,the switchable ferroelectricity in Li_(2)Nd_(2)Ti_(3)O_(10)ceramics has been observed at room temperature,and the saturated polarization-electric field hysteresis loop was obtained with P_(r)=0.4μC/cm^(2)under the electric field of 250 kV/*** phase transition behavior of Li_(2)Nd_(2)Ti_(3)O_(10)oxides was revealed by the temperature-dependence Raman and dielectric spectra combined with the piezoelectric property.

关键词： Hybrid improper ferroelectricity A-site ordered Ruddlesden-Popper structure Phase transition behavior

A compact X-band backward traveling-wave accelerating structure

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Nuclear Science and Techniques 2024年第5期35卷 13-29页

作者： Xian-Cai Lin Hao Zha Jia-Ru Shi Qiang Gao Fang-Jun Hu Qing-Zhu Li Huai-bi chen department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Very high-energy electrons(VHEEs)are potential candidates for FLASH radiotherapy for deep-seated *** proposed a compact VHEE facility based on an X-band high-gradient high-power *** this study,we investigated and realized the first X-band backward traveling-wave(BTW)accelerating structure as the buncher for a VHEE facility.A method for calculating the parameters of single cell from the field distribution was introduced to simplify the design of the BTW ***-domain circuit equations were applied to calculate the transient beam parameters of the buncher in the unsteady state.A prototype of the BTW structure with a thermionic cathode-diode electron gun was designed,fabricated,and tested at high power at the Tsinghua X-band high-power test *** structure successfully operated with 5-MW microwave pulses from the pulse compressor and outputted electron bunches with an energy of 8 MeV and a pulsed current of 108 mA.

关键词： Backward traveling-wave accelerating structure Equivalent circuit model High-power test Very high-energy electron radiotherapy

Effect of distribution of fines on evolution of cooperation in spatial public goods game

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Chinese Physics B 2024年第9期33卷 239-245页

作者： Xing-Ping Sun Yan-Zheng bi Hong-Wei Kang Yong Shen Qing-Yi chen School of Software Yunnan UniversityKunming 650000China

In the realm of public goods game,punishment,as a potent tool,stands out for fostering *** it effectively addresses the first-order free-rider problem,the associated costs can be *** incur expenses in imposing sanctions,while defectors face ***,these monetary elements seemingly vanish into thin air,representing a loss to the system ***,by virtue of the redistribution of fines to cooperators and punishers,not only can we mitigate this loss,but the rewards for these cooperative individuals can be *** upon this premise,this paper introduces a fine distribution mechanism to the traditional pool punishment *** identical parameter settings,by conducting a comparative experiment with the conventional punishment model,the paper aims to investigate the impact of fine distribution on the evolution of cooperation in spatial public goods *** experimental results clearly demonstrate that,in instances where the punishment cost is prohibitively high,the cooperative strategies of the traditional pool punishment model may completely ***,the model enriched with fine distribution manages to sustain a considerable number of cooperative strategies,thus highlighting its effectiveness in promoting and preserving cooperation,even in the face of substantial punishment cost.

关键词： public goods game fine distribution cooperation

Preparation and Performance of Organically Modified Montmorillonite Composite Separation Membrane

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1100-1107页

作者： LIU Peng bi Yuanyuan chen Shaowei WAN Ye YU Yunwu FANG Yanfeng GU Yaxin LI Feihong TANG Ning LI Xiangyu School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new composite separation membrane was developed by using organically modified montmorillonite(OMMT)as an *** effects of OMMT on the modification and properties of PVDF composite membranes were *** is found that different kinds and amounts of OMMT into the casting solution can obviously change the pure water flux,separation performance and hydrophilicity of composite membrane in varying *** the TA/PDA-MMT was 0.5 wt%,the pure water flux of the membrane reached the maximum,which was 584.7 L/(m^(2)·h),about 6 times that of the original *** OMMT/PVDF composite membrane had good hydrophilicity and stability in the treatment of oily *** development of novel OMMT/PVDF composite membrane will provide a new idea for solving the problem of oily wastewater treatment.

关键词： membrane montmorillonite composite wastewater

The acceptance of traditional Chinese medicine among patients with Parkinson's disease:A hospital survey

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Journal of Integrative Medicine 2024年第2期22卷 180-187页

作者： Peng Wang Jing Hong Zhu-qian Tang bi-zhen Gong Xiao-rong Qi Han Jiang Bo Pan Qi chen Postgraduate School Medical School of Chinese People’s Liberation ArmyBeijing 100853China Senior department of Traditional Chinese Medicine the Sixth Medical Center of PLA General HospitalBeijing 100853China department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking UniversityBeijing 100191China department of Integrative Oncology the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina department of dermatology the First Clinical Medical CollegeAnhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

Objective:The efficacy of medications for Parkinson’s disease(PD)tend to decline over time,which has a serious impact on patients’health and quality of *** some extent,traditional Chinese medicine(TCM)can resolve the distressing problem of ineffective dopaminergic medication in PD *** purpose of this study was to investigate the attitude,acceptance,and independent predictors of TCM in PD patients admitted to the outpatient department of a tertiary ***:A cross-sectional study of PD patients was conducted in the outpatient department of a large tertiary hospital in Beijing from March 2022 to June 2023.A self-report questionnaire was developed to investigate PD patients’attitudes and acceptance of TCM based on the *** logistic regression analyses were also performed to further clarify the independent predictors influencing patients’adoption of TCM ***:A total of 397 patients completed the questionnaire,of which 78.09%were willing to be treated with TCM and 21.91%indicated that they were not willing to use *** logistic regression analysis showed that several parameters were correlated with a patient’s willingness to include TCM in their therapeutic *** included education level of a bachelor’s degree(odds ratio[OR)=8.554;95%confidence interval[CI]:4.112–17.794;Pderlying diseases(OR=5.126;95%CI:3.078–8.537;Pderstood),and being willing to discuss ongoing TCM therapy with an attending physician(OR=62.468;95%CI:30.350–128.574;P<0.001,vs not informed).Conclusion:This study initially investigated the acceptance

关键词： Parkinson's disease Traditional Chinese medicine Cross-sectional study

demethylase-assisted site-specific detection of N^(1)-methyladenosine in RNA

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Chinese Chemical Letters 2024年第5期35卷 397-401页

作者： Jun Xiong Ke-Ke chen Neng-bin Xie Wei chen Wen-Xuan Shao Tong-Tong Ji Si-Yu Yu Yu-Qi Feng bi-Feng Yuan College of Chemistry and Molecular Sciences Research Center of Public HealthRenmin Hospital of Wuhan UniversitySchool of Public HealthWuhan UniversityWuhan 430071China department of Laboratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China

The dynamic RNA modifications have been viewed as new posttranscriptional regulator in modulating gene expression as well as in a broad range of physiological processes.N^(1)-methyladenosine(m^(1)A)is one of the most prevalent modifications existing in multiple types of ***-depth investigation of the functions of m^(1)A requires the site-specific assessment of m^(1)A stoichiometry in ***,we established a demethylase-assisted method(DA-m^(1)A)for the site-specific detection and quantification of m^(1)A in RNA.N^(1)-methyl group in m^(1)A could result in the stalling of reverse transcription at m^(1)A site,thus producing the truncated *** AlkB is a demethylase that can demethylate m^(1)A to produce adenine in RNA,thus generating full-length cDNA from AlkB-treated *** of the produced amounts of full-length cDNA by quantitative real-time PCR can achieve the site-specific detection and quantification of m^(1)A in *** the DA-m^(1)A method,we examined and successfully confirmed the previously well-characterized m^(1)A sites in various types of RNAs with low false positive *** addition,we found that the level of m^(1)A was significantly decreased at the bromodomain containing 2(BRD2)mRNA position 1674 and CST telomere replication complex component 1(CTC1)mRNA position 5643 in human hepatocellular carcinoma *** results suggest that these two m^(1)A sites in mRNA may be involved in liver *** together,the DA-m^(1)A method is simple and enables the rapid,cost-effective,and site-specific detection and quantification of m^(1)A in RNA,which provides a valuable tool to decipher the functions of m^(1)A in human diseases.

关键词： N^(1)-methyladenosine RNA modification AlkB demethylase RNA epigenetics Quantitative real-time PCR Hepatocellular carcinoma

Effect of quantitative consciousness index on seizure parameters during electroconvulsive therapy in patients with major depressive disorder

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World Journal of Psychiatry 2024年第9期14卷 1375-1385页

作者： Bang-Shu Zhao bi deng Qi-bin chen Xiao Li You Yang Su Min department of Anesthesiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Anesthesiology The First Clinical College of Chongqing Medical UniversityChongqing 400016China department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Electroconvulsive therapy(ECT)is both an effective treatment for patients with major depressive disorder(MDD)and a noxious *** some studies have explored the effect of sedation depth on seizure parameters in ECT,there is little research on the noxious stimulation response to *** this study,we used two electroencephalography(EEG)-derived indices,the quantitative consci-ousness(qCON)index and quantitative nociceptive(qNOX)index,to monitor sedation,hypnosis,and noxious stimulation response in patients with MDD undergoing acute *** Patients with MDD(n=24)underwent acute bilateral temporal ECT under propofol *** ECT,the patients were randomly divided into three groups according to qCON scores(qCON60-70,qCON50-60,and qCON40-50).Continuous qCON monitoring was performed 3 minutes before and during ECT,and the qCON,qNOX,vital signs,EEG seizure parameters,and complications during the recovery period were *** 24-item Hamilton Rating Scale for depression,Zung’s Self-rating depression Scale,and Montreal Cognitive Asse-ssment scores were evaluated before the first ECT session,after the fourth ECT session,and after the full course of *** A total of 193 ECT sessions were performed on 24 *** qCON index significantly affected the EEG seizure duration,peak mid-ictal amplitude,and maximum heart rate during ECT(Pdex significantly affected the post-ictal suppression index(Pdepression scores,Zung’s Self-rating depression Scale scores,or Montreal Cognitive Assessment scores among the three groups(P>0.05).CONCLUSION Electrical stimulation at a qCON index of 60-70 resulted in better EEG seizure parameters without increasing complications in patients with MDD undergoing b

关键词： Electroconvulsive therapy Propofol Nociception depression Electroencephalogram

detection and analysis of landslide geomorphology based on UAV vertical photogrammetry

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Journal of Mountain Science 2024年第4期21卷 1190-1214页

作者： bi Rui GAN Shu YUAN Xiping LI Kun LI Raobo LUO Weidong chen cheng GAO Sha HU Lin ZHU Zhifu School of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China Plication Engineering Research Center of Spatial Information Surveying and Mapping Technology in Plateau and Mountainous Areas Set by Universities in Yunnan Province Kunming 650093China West Yunnan University of Applied Sciences Key Laboratory of Mountain Real Scene Point Cloud Data Processing and Application for Universities in Yunnan ProvinceDali 671006China

High-resolution landslide images are required for detailed geomorphological analysis in complex topographic environment with steep and vertical landslide *** study proposed a vertical route planning method for unmanned aerial vehicles(UAVs),which could achieve rapid image collection based on strictly calculated route *** effectiveness of this method was verified using a DJI Mavic 2 Pro,obtaining high-resolution landslide images within the Dongchuan debris flow gully,in the Xiaojiang River Basin,Dongchuan District,Yunnan,China.A three-dimensional(3D)model was constructed by the structure-from-motion and multi-view stereo(SfM-MVS).Micro-geomorphic features were analyzed through visual interpretation,geographic information system(GIS),spatial analysis,and mathematical statistics *** results demonstrated that the proposed method could obtain comprehensive vertical information on landslides while improving measurement *** 3D model was constructed using the vertically oriented flight route to achieve centimeter-level accuracy(horizontal accuracy better than 6 cm,elevation accuracy better than 3 cm,and relative accuracy better than 3.5 cm).The UAV technology could further help understand the micro internal spatial and structural characteristics of landslides,facilitating intuitive acquisition of surface *** slope of landslide clusters ranged from 36°to 72°,with the majority of the slope facing east and *** elevation levels were relatively consistent while middle to lower elevation levels gradually decreased from left to right with significant variations in lower elevation *** the rainy season,surface runoff was abundant,and steep topography exacerbated changes in surface *** route method is suitable for unmanned aerial vehicle(UAV)landslide surveys in complex mountainous *** geomorphological analysis methods used will provide references for identifying and describing topographic

关键词： UAV Landslide Vertical route SfM-MVS Topographic features

Structure-regulated fluorine-containing additives to improve the performance of perovskite solar cells

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Nano Research 2024年第7期17卷 6080-6086页

作者： Peiya chen Xiaoman bi Hao Yan Yingjie Zhao Yihao Liu Zhuo Huang Qian Xiao Yongpeng Yang Shasha Zhang Yiqiang Zhang Yanlin Song Henan Institute of Advanced Technology College of ChemistrySchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

Perovskite solar cells(PSCs)have seen remarkable progress in recent years,largely attributed to various additives that enhance both efficiency and *** these,fluorine-containing additives have garnered significant interest because of their unique hydrophobic properties,effective defect passivation,and regulation capability on the crystallization ***,a targeted structural approach to design such additives is necessary to further enhance the performance of ***,fluoroalkyl ethylene with different fluoroalkyl chain lengths(CH_(2)CH(CF_(2))nCF_(3),n=3,5,and 7)as liquid additives is used to investigate influences of fluoroalkyl chain lengths on crystallization regulation and defect *** findings indicate that optimizing the quantity of F groups plays a crucial role in regulating the electron cloud distribution within the additive *** optimization fosters strong hydrogen bonds and coordination effects with FA+and uncoordinated Pb^(2+),ultimately enhancing crystal quality and device ***,1H,1H,2H-perfluoro-1-hexene(PF_(3))with the optimal number of F presents the most effective modulation effect.A PSC utilizing PF_(3)achieves an efficiency of 24.05%,and exhibits exceptional stability against humidity and thermal *** work sheds light on the importance of tailored structure designs in additives for achieving high-performance PSCs.

关键词： perovskite solar cells fluorine number additive structure crystallization regulation defect passivation

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong Xu Benyan Lu chengpeng Tao Weiming chen Wen Hou Kui cheng Huichang bi Wanyi Pan Jianjun chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic degrader PROTAC Molecularglue Hydrophobic tagging