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Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps to Maintain Respiratory Frequency Under Sevoflurane Anesthesia

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Neuroscience Bulletin 2024年第8期40卷 1127-1140页

作者： Lin wu Donghang Zhang Yujie wu Jin Liu Jingyao Jiang cheng Zhou Department of Anesthesiology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengdu 610041China

The lateral parabrachial nucleus(PBL)is implicated in the regulation of respiratory *** leak channel(NALCN)mutations disrupt the respiratory rhythm and influence anesthetic sensitivity in both rodents and ***,we investigated whether the NALCN in PBL glutamatergic neurons maintains respiratory function under general *** results showed that chemogenetic activation of PBL glutamatergic neurons increased the respiratory frequency(RF)in mice;whereas chemogenetic inhibition suppressed *** knockdown in PBL glutamatergic neurons but not GABAergic neurons significantly reduced RF under physiological conditions and caused more respiratory suppression under sevoflurane *** knockdown in PBL glutamatergic neurons did not further exacerbate the respiratory suppression induced by propofol or *** sevoflurane anesthesia,painful stimuli rapidly increased the RF,which was not affected by NALCN knockdown in PBL glutamatergic *** study suggested that the NALCN is a key ion channel in PBL glutamatergic neurons that maintains respiratory frequency under volatile anesthetic sevoflurane but not intravenous anesthetic propofol.

关键词： Glutamatergic neurons Lateral parabrachial nucleus NALCN Respiration General anesthesia

Preparation of Flower-like Copper Foam Supported Co_(3)O_(4) Electrocatalyst and Its Hydrogen Evolution Performance

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Journal of wuhan University of Technology(Materials Science) 2024年第2期39卷 327-331页

作者：李兆 cheng Julong WANG Yanan wu Kunyao CAO Jing School of Materials Engineering Xi’an Aeronautical InstituteXian 710077China

Flower-like copper foam Co_(3)O_(4) catalysts(Co_(3)O_(4)/CF) were prepared by hydrothermal *** crystalline structure and microscopic morphology of the prepared samples were characterized by using X-ray diffractometer(XRD) and scanning electron microscope(SEM),and the electrochemical properties were investigated by an electrochemical *** experimental results show that the Co_(3)O_(4) catalysts are successfully prepared on the foamed copper support by hydrothermal method,and the material’s morphology is mainly flower *** the current density is 10 mA·cm^(-2),the overpotential value of the Co_(3)O_(4)/CF catalyst is 141 mV,lower than that of blank *** electrochemical impedance(EIS) spectrum shows that the R_(ct )value of the Co_(3)O_(4)/CF catalyst decreases,and the Coulomb curves of double-layer show that the electrochemically active area of the Co_(3)O_(4)/CF catalyst efficiently increases compared with that of the blank ***,the as-obtained Co_(3)O_(4)/CF catalyst exhibits a good hydrogen evolution rate,showing great applicability potential in the catalytic electrolysis of water for hydrogen production.

关键词： Co_(3)O_(4)/CF composite structure electrocatalysis hydrogen evolution reaction

bioinspired integrated triboelectric electronic tongue

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Microsystems & Nanoengineering 2024年第3期10卷 97-108页

作者： Jiaming Liu Jingui Qian Murtazt Adil Yali bi Haoyi wu Xuefeng Hu Zuankai Wang Wei Zhang Anhui Province Key Laboratory of Measuring Theory and Precision Instruments School of Instrumental Science and Optoelectronics EngineeringHefei University of Technology230009 HefeiAnhuiChina School of Physics and Optoelectronic Engineering Guangdong University of Technology510006 GuangzhouGuangdongChina Department of Mechanical Engineering The Hong Kong Polytechnical UniversityHong Kong SARChina

An electronic tongue(E-tongue)comprises a series of sensors that simulate human perception of taste and embedded artificial intelligence(AI)for data analysis and *** E-tongues based on electrochemical methods suffer from a bulky size and require larger sample volumes and extra power sources,limiting their applications in in vivo medical diagnosis and analytical *** by the mechanics of the human tongue,triboelectric components have been incorporated into E-tongue platforms to overcome these *** this study,an integrated multichannel triboelectric bioinspired E-tongue(TbiET)device was developed on a single glass slide chip to improve the device’s taste classification accuracy by utilizing numerous sensory *** detection capability of the TbiET was further validated using various test samples,including representative human body,environmental,and beverage *** TbiET achieved a remarkably high classification *** instance,chemical solutions showed 100%identification accuracy,environmental samples reached 98.3%accuracy,and four typical teas demonstrated 97.0%***,the classification accuracy of NaCl solutions with five different concentrations reached 96.9%.The innovative TbiET exhibits a remarkable capacity to detect and analyze droplets with ultrahigh sensitivity to their electrical ***,it offers a high degree of reliability in accurately detecting and analyzing various liquid samples within a short *** development of a self-powered portable triboelectric E-tongue prototype is a notable advancement in the field and is one that can greatly enhance the feasibility of rapid on-site detection of liquid samples in various settings.

关键词： electronic utilizing overcome

A Novel Disturbance Observer Based Fixed-Time Sliding Mode Control for Robotic Manipulators With Global Fast Convergence

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 661-672页

作者： Dan Zhang Jiabin Hu Jun cheng Zheng-Guang wu Huaicheng Yan IEEE Zhejiang University of Technology Guangxi Normal University Zhejiang University the East China University of Science and Technology

This paper proposes a new global fixed-time sliding mode control strategy for the trajectory tracking control of uncertain robotic ***,a fixed-time disturbance observer(FTDO) is designed to deal with the adverse effects of model uncertainties and external disturbances in the manipulator *** an adaptive scheme is used and the adaptive FTDO(AFTDO) is developed,so that the priori knowledge of the lumped disturbance is not ***,a new non-singular fast terminal sliding mode(NFTSM) surface is designed by using an arctan function,which helps to overcome the singularity problem and enhance the robustness of the *** on the estimation of the lumped disturbance by the AFTDO,a fixed-time non-singular fast terminal sliding mode controller(FTNFTSMC)is developed to guarantee the trajectory tracking errors converge to zero within a fixed *** settling time is independent of the initial state of the *** addition,the stability of the AFTDO and FTNFTSMC is strictly proved by using Lyapunov ***,the fixed-time NFESM(FTNFTSM) algorithm is validated on a 2-link manipulator and comparisons with other existing sliding mode controllers(SMCs) are *** comparative results confirm that the FTNFTSMC has superior control performance.

关键词： Disturbance observer(DO) fixed-time non-singular sliding mode control robotic manipulator trajectory tracking

Numerical investigation on ball-sealers transport and diversion performance in shale gas horizontal well based on semi-resolved CFD-DEM

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Particuology 2024年第10期93卷 137-153页

作者： Yinjian Huang Jinzhou Zhao Lan Ren Ran Lin Jianfa wu cheng Shen Jianjun wu bing Li National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Tianfu Yongxing Laboratory Chengdu610213China Shale Gas Research Institute PetroChina Southwest Oil&Gasfield CompanyChengdu610056China PetroChina Coalbed Methane Company Limited Xi’an710082China

In the staged multi-cluster fracturing of shale gas horizontal wells, ball sealers are used to ensure uniform fluid distribution among clusters, a strategy that is both cost-effective and operationally beneficial. Despite these advantages, comprehending the ball sealers' dynamics within the wellbore and their plugging behavior at perforations is still challenging. This complexity results in prediction difficulties regarding their diversion efficiency. To address this, our study utilized a semi-resolved CFD-DEM model based on kernel approximation to simulate the behavior of medium-sized ball sealers in single and multiple cluster scenarios. Our findings from a single cluster scenario reveal that the plugging probability is co-determined by velocity gradients in the fluid ingestion area near the perforation, backflow region, and inertial forces of the ball sealers. As the critical flow rate is achieved, the plugging probability negatively correlated with fluid viscosity and displacement, and positively correlated with the perforation flow ratio (PFR), the difference in particle-fluid density, ball sealer’s diameter, and the ball sealer’s offset from the pipeline center. Temporary plugging control efficiency was used to evaluate the flow balance effect among multiple clusters. The results indicate that an increased number of ball sealers enhances the fault tolerance during the temporary plugging process. Nevertheless, excessive ball sealers might undermine the temporary plugging control efficiency, as perforations with lower fluid inflow rates are unexpectedly plugging. Higher differences in fluid injection rates between clusters led to increased efficiency in temporary plugging control. Premature deployment of ball sealers cannot effectively plug perforations with marginally higher fluid inflow rates, but instead accidently plug intermediate clusters with lower fluid inflow rates. These findings offer a theoretical basis for optimizing the design of ball sealers.

关键词： Gas shale Horizontal wells Ball sealer Semi-resolved CFD-DEM Diversion

Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-Long Chen Chun-Yan wu Dong-Sheng Yang Bo-cheng Tang Huai-Yu Wang Zhi-cheng Yu Anling Li Yan-Dong wu An-Xin wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling

Infiltration,runoff,and slope stability behaviors of infinite slope with macropores based on an improved Green–Ampt model

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Journal of Mountain Science 2024年第7期21卷 2220-2235页

作者： LI Shanghui wu Guoxiong QUE Yun JIANG Zhenliang cheng Gaoyun College of Intelligent Construction Fuzhou University of International Studies and TradeFuzhou 350202China College of Civil Engineering Chongqing Jiao Tong UniversityChongqing 400074China Chongqing Vocational College of Architectural Engineering Chongqing 400072China College of Civil Engineering Fuzhou UniversityFuzhou 350000China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHong Kong 999077China T.Y.Lin International Engineering Consulting(China)Co.Ltd Chongqing 401120China

Infiltration–runoff–slope instability mechanism of macropore slope under heavy rainfall is *** paper studied its instability mechanism with an improved Green–Ampt(GA)model considering the dual-porosity(i.e.,matrix and macropore)and ponding condition,and proposed the infiltration equations,infiltration–runoff coupled model,and safety factor calculation *** show that the infiltration processes of macropore slope can be divided into three stages,and the proposed model is rational by a comparative *** wetting front depth of the traditional unsaturated slope is 17.2%larger than that of the macropore slope in the early rainfall stage and 27%smaller than that of the macropore slope in the late rainfall ***,macropores benefit the slope stability in the early rainfall but not in the *** flow does not occur initially but becomes pronounced with increasing rainfall *** equal depth of the wetting front in the two domains is regarded as the onset criteria of macropore *** analysis shows that macropore flow is delayed by increasing proportion of macropore domain(ω_(f)),whereas promoted by increasing ratio of saturated permeability coefficients between the two domains(μ).The increasing trend of ponding depth is sharp at first and then grows ***,when rainfall duration is less than 3 h,ωf andμhave no significant effect on the safety factor,whereas it decreases with increasingωf and increases with increasingμunder longer duration(≥3 h).With the increase ofω_(f),the slope maximum instability time advances by 10.5 h,and with the increase ofμ,the slope maximum instability time delays by 3.1 h.

关键词： Macropore slope Green–Ampt infiltration model Equivalent wetting front Ponding response time Slope stability

Activatable photoacoustic bioprobe for visual detection of aging in vivo

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Chinese Chemical Letters 2024年第4期35卷 324-329页

作者： Zihong Li Jie cheng Ping Huang Guoliang wu Weiying Lin Institute of Optical Materials and Chemical biology Guangxi Key Laboratory of Electrochemical Energy MaterialsSchool of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Aging is a natural physiological process with various challenges, related to the loss of homeostasis within the organism, which is not a disease, but a significantly strong risk factor for multiple diseases, including myocardial infarction, stroke, some age-related cancers, macular degeneration, osteoarthritis, neurodegeneration, and many others. In the body, the main manifestation of aging is cellular aging, which exists within tissues and has a local or global impact on tissue function. However, the lack of effective aging detection tools has always been an issue that cannot be ignored in the field of aging research. Therefore,it is necessary to construct a non-invasive tool for in vivo detection of aging. Here, we show that the photoacoustic probe(LGAL), which has peak excitation and emission wavelengths in the near-infrared optical window, binds in vivo and at high contrast to the hallmark of aging, and allows for the microscopic imaging of aging through the intact mice. Firstly, this tool LGAL has been successfully applied to detect senescence in cells, displaying stronger photoacoustic signals than normal cells. Then, by using the photoacoustic probe, the blood vessels and tissues inside the mice can be visualized. Young and elderly mice exhibit varying intensities of photoacoustic signals, marking the first time a probe has been used to explore the aging of blood vessels and tissues inside the mice. Finally, we monitored the changes in the degree of aging during tumor treatment under photoacoustic(PA) imaging for the first time. As the treatment time increased, the degree of aging of the tumor gradually deepened. We expect the powerful tool could be a noninvasive and powerful tool for the study of aging biology.

关键词： Near-infrared Photoacoustic Aging Senescence Tumor Sa-β-gal

Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

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Food Science and Human Wellness 2024年第2期13卷 1065-1078页

作者： Dai cheng Qianqian Yu Kexin Zhu Dingdong Bu Zijian wu State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of biotechnology and Food Science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress