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基于轻量化YOLOv8的安全帽检测

电脑与电信 2024年第1期 35-39页

作者：张碧川刘卫东米浩景亚宁山西师范大学物理与信息工程学院山西太原030092

安全帽检测是一项具有重要应用价值的计算机视觉任务,涉及建筑工地、矿山、电力等多个领域的安全管理。然而,安全帽检测也面临着诸多挑战,如目标尺寸和长宽比的巨大变化、目标速度的快速变化、目标遮挡和背景干扰等。为了解决这些问题,... 详细信息

安全帽检测是一项具有重要应用价值的计算机视觉任务,涉及建筑工地、矿山、电力等多个领域的安全管理。然而,安全帽检测也面临着诸多挑战,如目标尺寸和长宽比的巨大变化、目标速度的快速变化、目标遮挡和背景干扰等。为了解决这些问题,提出了一种基于轻量化YOLOv8算法的安全帽检测方法,利用YOLOv8的高速和高精度特点,结合安全帽的特征,实现了对安全帽的有效检测。

关键词：轻量化 YOLOv8算法 python 目标检测图像分割计算机视觉

褪黑素通过改善胆汁酸代谢减轻胆汁淤积肝损伤

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陆军军医大学学报 2024年第11期46卷 1187-1193页

作者：张弘佳谭雅赵楠柴进陆军军医大学(第三军医大学)第一附属医院消化内科全军消化病研究所胆汁淤积肝病中心代谢相关脂肪性肝病中心重庆400038

目的初步探究褪黑素(melatonin,Mel)减轻胆酸(cholic acid,ca.诱导的胆汁淤积肝损伤的机制。方法将15只8周龄雄性C57BL/6J小鼠按随机数字表法分为3组(n=5):对照组、1%ca.和1%ca.Mel组,对照组喂养正常饮食,1%ca.和1%ca.Mel组喂养1%ca.... 详细信息

目的初步探究褪黑素(melatonin,Mel)减轻胆酸(cholic acid,ca.诱导的胆汁淤积肝损伤的机制。方法将15只8周龄雄性C57BL/6J小鼠按随机数字表法分为3组(n=5):对照组、1%ca.和1%ca.Mel组,对照组喂养正常饮食,1%ca.和1%ca.Mel组喂养1%ca.食14 d构建胆汁淤积小鼠模型,1%ca.Mel组同时腹腔注射褪黑素(100 mg/kg)。对1%ca.和1%ca.Mel组小鼠的肝组织进行α-SMA免疫组化染色,采用RT-qPCR检测小鼠肝纤维化相关指标的mRNA表达水平。采用液相色谱-串联质谱联用技术检测肝脏总胆汁酸,自动生化分析仪检测血清总胆汁酸。为了进一步了解胆汁酸代谢的机制,采用RT-qPCR检测小鼠胆汁酸合成和肝脏解毒酶相关指标的mRNA表达水平,Western blot检测胆汁酸合成和肝脏解毒酶相关指标的蛋白表达水平。结果与1%ca.相比,1%ca.Mel组的小鼠肝纤维化相关指标Tgfβ1、ColⅠa1、ColⅡa1和α-SMA的mRNA表达水平明显降低(Pca.相比,1%ca.Mel组小鼠血清与肝脏中胆汁酸含量显著减少,其中Tca.量显著降低,胆汁酸合成酶胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,Cyp7a1)和Cyp8b1的mRNA水平均显著降低,肝脏解毒酶Cyp2b10和尿苷二磷酸葡萄糖醛基酶1A1(udp-glucuronosyltransferase,Ugt1a1)的mRNA水平明显升高,Cyp2b10和胆盐磺基转移酶(sulfotransferase family 2A member 1,Sult2a1/2)的蛋白水平明显升高(P<0.05)。结论褪黑素通过减少胆汁酸合成和增加肝脏解毒酶的方式改善胆汁淤积。

关键词：肝损伤胆汁淤积褪黑素胆汁酸代谢

多发性骨髓瘤患者胸部CT第4胸椎平面人体成分与预后的关联性分析

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吉林大学学报（医学版） 2024年第4期50卷 1098-1108页

作者：白雪王晨晨石张镇毕林涛吉林大学中日联谊医院肿瘤血液科吉林长春130033

目的:利用深度学习模型自动分割初诊多发性骨髓瘤(MM)患者胸部CT第4胸椎平面4种人体成分,探讨4种人体成分与MM患者预后的相关性。方法:对2017年1月-2021年12月于本院确诊的MM患者的临床资料进行回顾性分析,收集患者的年龄、性别、体质... 详细信息

目的:利用深度学习模型自动分割初诊多发性骨髓瘤(MM)患者胸部CT第4胸椎平面4种人体成分,探讨4种人体成分与MM患者预后的相关性。方法:对2017年1月-2021年12月于本院确诊的MM患者的临床资料进行回顾性分析,收集患者的年龄、性别、体质量、身高和体质量指数(BMI)等临床信息,收集患者血清中乳酸脱氢酶(LDH)、血钙(ca.、血肌酐(Scr)、白蛋白(Alb)、血红蛋白(Hb)、β2-微球蛋白(β2-Mg)和血清游离轻链水平等实验室数据,利用深度学习模型分别将79例规律进行疗效评价MM患者的胸部CT影像结果分割为胸大肌、胸小肌、皮下脂肪和纵隔脂肪4种人体成分,采用Image J软件分别测量第4胸椎平面4种人体成分面积,分析其与MM患者预后的相关性,并进行Kaplan-Meier生存分析。结果:单因素分析,皮下脂肪面积、血ca.平、Scr水平和国际分期系统(ISS)分期与MM患者总生存期(OS)有关(HR=2.260,95%CI:1.116~4.578,P=0.024;HR=2.088,95%CI:1.007~4.327,P=0.048;HR=2.209,95%CI:1.105~4.414,P=0.025;HR=1.730,95%CI:1.040~2.879,P=0.035)。多因素分析,4种人体成分中皮下脂肪面积是影响MM患者预后的独立危险因素(95%CI:1.228~5.782,P=0.013)。Log-Rank检验,在所有患者中,与皮下脂肪面积高值组比较,皮下脂肪面积低值组MM患者OS缩短(P=0.018);在不同性别患者中,皮下脂肪面积高值组与皮下脂肪面积低值组MM患者OS比较差异无统计学意义(P>0.05);在未行造血干细胞移植的患者中,与皮下脂肪面积高值组比较,皮下脂肪面积低值组患者OS缩短(P=0.037)。结论:第4胸椎平面4种人体成分中,皮下脂肪组织面积与MM患者OS有关,是MM患者预后的独立危险因素,而纵隔脂肪组织、胸大肌和胸小肌面积对MM患者的预后无预测作用。

关键词：多发性骨髓瘤计算机断层扫描人体成分深度学习模型

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紫外-可见吸收光谱结合化学计量学算法的水体总有机碳浓度快速检测

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光谱学与光谱分析 2024年第3期44卷 722-730页

作者：李煜毕卫红孙建成贾亚杰付广伟王思远王兵燕山大学信息科学与工程学院河北省特种光纤与光纤传感重点实验室河北秦皇岛066004 长春理工大学中山研究院广东中山528437 秦皇岛红燕光电科技有限公司河北秦皇岛066004

总有机碳(TOC)指悬浮或溶解于水中有机物的含碳总量,是以单位体积水体中含碳的质量来表示水中有机物的浓度,通过总有机碳可以更全面反映水中有机污染物的总量。总有机碳的监测能够推动我国实现“碳达峰”和“碳中和”的目标,也对我国海... 详细信息

总有机碳(TOC)指悬浮或溶解于水中有机物的含碳总量,是以单位体积水体中含碳的质量来表示水中有机物的浓度,通过总有机碳可以更全面反映水中有机污染物的总量。总有机碳的监测能够推动我国实现“碳达峰”和“碳中和”的目标,也对我国海洋地球碳循环的研究具有重要的意义。目前,国标法测量水质TOC主要采用高温催化氧化法和湿法氧化法,这两种方法虽测量准确、可解释性强,但都具有测试方法复杂、测量时间长、易产生二次污染、人力物力消耗巨大等缺点,且仅能在实验室内完成,无法进行TOC的原位在线测量。因此发展水质TOC快速、实时、在线监测技术具有重要意义。为此,建立了TOC标准溶液浓度基于紫外吸收光谱的单波长检测模型,针对物质种类更为复杂的真实水样分别使用ACO-PLS和SPA算法筛选特征波长,对比S-g平滑处理、最小最大归一化、标准正态变换(SNV)、消除常数偏移量、导数校正等多种光谱预处理方法的效果,经过粒子群算法优化的最小二乘支持向量机算法(PSO-LSSVM)建立快速检测模型。结果表明,选取不同数量特征波长,经SNV算法预处理后的建模效果普遍优于其他预处理方法;选用不同预处理算法,最佳特征波长数量普遍为50个,过多或过少的波长数量会使建模精度降低;最佳建模参数为选用SNV预处理方法,经ACO-PLS算法筛选50个特征波长组合并利用PSO-LSSVM算法建模,最优模型结果训练集Rc达到0.984 3, RMSEC为0.457 4,验证集Rp为0.974 5, RMSEP为0.481 1。将最优光谱检测模型应用于新采集水样,预测结果较为准确,具有一定鲁棒性。表明ACO-PLS算法可以有效选取特征波长,结合PSO-LSSVM算法可以实现利用紫外-可见吸收光谱对水体中TOC的测量,为水体TOC含量快速检测提供一种快速、无污染的测量方案,给相应传感器的研发提供了科学支持。

关键词：总有机碳紫外-可见吸收光谱蚁群-偏最小二乘算法粒子群-最小二乘支持向量机

Characteristics of immune and inflammatory responses among different age groups of pediatric patients with COVID-19 in China

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World Journal of Pediatrics 2021年第4期17卷 375-384页

作者： Su-Qiong Ji Min Zhang Yong Zhang Kun Xia Yuan Chen Qian Chu Yong-Chang Wei Fu-Ling Zhou bi-Tao Bu Hong-Lei Tu ya-Yun ca. Li-ya Hu Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of ca.diovascular Medicine Wuhan Children’HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Radiation and Medica. Oncology Hubei Key Laboratory of Tumor Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhanChina Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhanChina

Background Severe ca.es of coronavirus disease 2019(COVID-19)among pediatric patients are more common in children less than 1 year of *** aim is to address the underlying role of immunity and inflammation conditions among different age groups of pediatric *** We recruited pediatric patients confirmed of moderate COVID-19 symptoms,admitted to Wuhan Children's Hospital from January 28th to April 1st in *** were divided into four age groups(≤1,1–6,7–10,and 11–15 years).Demographic information,clinica. characteristics,laboratory results of lymphocyte subsets test,immune and inflammation related markers were all *** Analysis included 217/241(90.0%)of patients with moderate clinica. stage *** recovery time of children more than 6 years old was significa.tly shorter than of children younger than 6 years(P=0.001).Reduced neutrophils and increased lymphocytes were significa.tly most observed among patients under 1 year old(Pgnifica.tly elevated immune cells,especially among patients under 1 year old(cell proportion:n=12,30.0%,Pglobulin(Ig)g(PgA(PgM(Pg patients under 1 year old,together with elevated levels of inflammation related markers,such as tumor necrosis factor γ (P=0.007),interleukin(IL)-10(P=0.011),IL-6(P=0.008),lactate dehydrogenase(Pca.citonin(P=0.007).Conclusion The higher rate of severe ca.es and long course of COVID-19 among children under 1 year old may be due to the lower production of antibodies and serum complements of in this age group.

关键词： Age difference China Coronavirus disease 2019 Immune Inflammation Pediatric

Diagnosing the environmental impacts of typica. fatliquors in leather manufacture from life cycle assessment perspective

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Journal of Leather Science and Engineering 2022年第2期4卷 76-89页

作者： Yue Yu Qingyong Sun Yunhang Zeng Yirui Lin ya-nan Wang bi Shi National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065China Key Laboratory of Leather Chemistry and Engineering(Sichuan University) Ministry of EducationChengdu 610065China Sichuan Decision New Material Technology Co. Ltd.Deyang 618000China.

The environmental impacts of typica. fatliquors were diagnosed by the life cycle assessment of industrial production and use(post-tanning)*** cycle impact assessment and sensitivity analysis showed that fatliquor and fatliquoring operation were the major contributors to the environmental impacts of post-tanning beca.se a large amount of fatliquors was consumed during fatliquoring *** environmental impacts of fatliquors decreased in the following order:chlorinated paraffin(CP)>sulfonated rape oil(SNR)>sulfated rape oil(SR)>phosphated rape oil(PR)>oxidized-sulfited rape oil(OSR).Sulfuric acid,fuming sulfuric acid,and chlorine used for fatliquor modifica.ion gave the main contribution to most impact ca.egories for SR,SNR,and CP production,whereas rape oil contributed the most for PR and OSR *** use process reduced the primary energy demand,abiotic depletion potential,and global warming potential by 38.5%,56.0%,and 48.5%,respectively,compared with CP use *** results suggested that biomass-derived fatliquors,especially oxidized-sulfited and phosphate modified fatiliquors,helped reduce the environmental burdens in leather manufacturing.

关键词： Fatliquor Life cycle assessment Natural fatliquor Synthetic fatliquor Modifica.ion Environmental impact

Concurrence of Sarcoidosis and Takayasu Aortitis

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Chinese Medica. Journal 2015年第6期128卷 851-852页

作者： Yuan Liu Shan Li Jian ca. yan-Xun Wang ya-Lan bi Zuo-Jun Xu Hui Huang Department of Internal Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China DePartment of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

To the Editor： Sarcoidosis is a systemic granulomatous disorder that most commonly affects young or middle-aged women. Sarcoidosis ca. coexist with a wide range of autoimmune disorders and other granulomatous diseases. Here, we describe a rare ca.e of sarcoidosis coexisting with another granulomatous autoimmune disease, Takayasu arteritis （TA）.

关键词： Concurrence Sarcoidosis Takayasu Aortitis

Artificial ca.ernosa-like tissue based on multibubble Matrigel and a human corpus ca.ernous fibroblast sca.fold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo yan Ming Xiao biao Liu Ying-Hao Yin Xiao-Li Tan Yong-Quan Huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-Ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medica. Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus ca.ernosum(cc)ca. be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed sca.folds are used to solve the sca.city of primary penis tissue ***,inconvenience and high costs limit the wide applica.ion of such ***,we describe a simple,fast,and economica. method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were loca.ed inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus ca.ernosum ex vivo fibroblasts

Effects of reaction parameters on preparation of Cu nanoparticles via aqueous solution reduction method with NaBH_4

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Transactions of Nonferrous Metals Society of China 2012年第12期22卷 2991-2996页

作者：刘清明周德璧 Yu-ya yaMAMOTO Kensuke KURUDA Masazumi OKIDO 中南大学化学化工学院长沙410083 Department of Materials Science Graduate School of Engineering Nagoya University

The preparation of Cu nanoparticles by the aqueous solution reduction method was investigated. The effects of different reaction parameters on the preparation of Cu nanoparticles were studied. The optimum conditions for preparing well-dispersed nanoparticles were found as follows: 0.4 mol/L NaBH4 was added into solution containing 0.2 mol/L Cu2+, 1.0% gelatin dispersant in mass fraction, and 1.2 mol/L NH3?H2O at pH 12 and 313 K. In addition, a series of experiments were performed to discover the reaction process. NH3?H2O was found to be able to modulate the reaction process. At pH=10, Cu2+ was transformed to Cu(NH3)42+ as precursor after the addition of NH3?H2O, and then Cu(NH3)42+ was reduced by NaBH4 solution. At pH=12, Cu2+ was transformed to Cu(OH)2 as precursor after the addition of NH3?H2O, and Cu(OH)2 was then reduced by NaBH4 solution.

关键词： Cu nanoparticles NaBH4 Cu(OH)2 Cu(NH3)42+ aqueous solution reduction method precursor reaction process