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Alcohol solvent effect on the self-assembly behaviors of lignin oligomers

green Energy & Environment 2024年第4期9卷 597-603页

作者： ya Ma Zhicheng Jiang yafei Luo Xingjie guo Xudong Liu Yiping Luo bi Shi College of biomass Science and Engineering Sichuan UniversityChengdu610065China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu610065China College of Pharmacy(International Aca.emy of Targeted Therapeutics and Innovation) Chongqing University of Arts and SciencesChongqing402160China State Key Laboratory of Utilization of Woody Oil Resource Hunan Academy of ForestryChangsha410004China ca. Key Laboratory of Environmental and Applied Microbiology Environmental Microbiology Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu610041China

The interactions between lignin oligomers and solvents determine the behaviors of lignin oligomers self-assembling into uniform lignin nanoparticles(LNPs).Herein,several alcohol solvents,which readily interact with the lignin oligomers,were adopted to study their effects during solvent shifting process for LNPs’*** lignin oligomers with widely distributed molecular weight and abundant guaiacyl units were extracted from wood waste(mainly consists of pine wood),exerting outstanding self-assembly *** and spherica. LNPs were generated in H_(2)O-n-propanol cosolvent,whereas irregular LNPs were obtained in H_(2)O-methanol *** unsatisfactory self-assembly performance of the lignin oligomers in H_(2)O-methanol cosolvent could be attributed to two *** one hand,for the initial dissolution state,the distinguishing Hansen solubility parameter and polarity between methanol solvent and lignin oligomers resulted in the poor dispersion of the lignin *** the other hand,strong hydrogen bonds between methanol solvent and lignin oligomers during solvent shifting process,hindered the interactions among the lignin oligomers for self-assembly.

关键词： Lignin oligomers Alcohol solvent Self-assembly LNPs Solvent effects

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Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases:Mechanisms and future perspectives

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World Journal of gastroenterology 2024年第5期30卷 429-439页

作者： ya-Wei bi Long-Song Li Nan Ru Bo Zhang Xiao Lei Department of gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Radiation Oncology Chinese PLA General HospitalBeijing 100853China

Pancreatitis and pancreatic ca.cer(PC)stand as the most worrisome ailments affecting the *** have dedica.ed efforts to unraveling the mechanisms underlying these diseases,yet their true nature continues to elude their *** this realm,oxidative stress is often believed to play a ca.sal and contributory role in the development of pancreatitis and *** accumulation of reactive oxygen species(ROS)ca. ca.se oxidative stress,and the key enzyme responsible for inducing ROS production in cells is nicotinamide adenine dinucleotide phosphate hydrogen oxides(NOX).NOX contribute to pancreatic fibrosis and inflammation by generating ROS that injure acinar cells,activate pancreatic stellate cells,and mediate macrophage *** ROS production occurs during malignant transformation and pancreatic ca.cinogenesis,creating an oxidative microenvironment that ca. ca.se abnormal apoptosis,epithelial to mesenchymal transition and genomic ***,understanding the role of NOX in pancreatic diseases contributes to a more in-depth exploration of the exact pathogenesis of these *** this review,we aim to summarize the potential roles of NOX and its mechanism in pancreatic disorders,aiming to provide novel insights into understanding the mechanisms underlying these diseases.

关键词： Nicotinamide adenine dinucleotide phosphate hydrogen oxides Pancreatitis Pancreatic ca.cer Reactive oxygen species Mechanism

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Essential oils improve nursery pigs'performance and appetite via modulation of intestinal health and microbiota

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Animal Nutrition 2024年第1期16卷 174-188页

作者： bi-Chen Zhao Tian-Hao Wang Jian Chen Bai-Hao Qiu ya-Ru Xu Jin-Long Li College of Veterinary Medicine Northeast Agricultural UniversityHarbin150030China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine Northeast Agricultural UniversityHarbin150030China Key Laboratory of the Provincial Educa.ion Department of Heilongjiang for Common Animal Disease Prevention and Treatment Northeast Agricultural UniversityHarbin150030China

Optimal intestinal health and functionality are essential for animal health and performance,and simultaneously intestinal nutrient transporters and intestinal peptides are also involved in appetite and feed intake control *** the potential of essential oil(EO)in improving animal performance and improving feed palatability,we hypothesized that dietary supplementation of cinnamaldehyde and ca.vacrol could improve performance and appetite of nursery pigs by modulating intestinal health and ***(100 mg/kg),ca.vacrol(100 mg/kg),and their mixtures(including 50 mg/kg cinnamaldehyde and 50 mg/kg ca.vacrol)were supplemented into the diets of 240 nursery pigs for 42 d,and data related to performance were ***,the influence of EO on intestinal health,appetite and gut microbiota and their correlations were *** supplementation increased(Pght,average daily gain(ADg)and average daily feed intake(ADFI)of piglets,and reduced(Pght junction proteins,and decreased(Pbility and loca. *** terms of intestinal development and the mucus barrier,EO promoted intestinal development and increased(Pgoblet ***,we found that piglets in the EO-supplemented group had upregulated(Pgestive enzymes in the intestine,which were significa.tly associated with daily gain and feed *** addition,EO supplementation somewhat improved appetite in nursery pigs,increased the diversity of the gut microbiome and the abundance of beneficial bacteria,and there was a correlation between altered bacterial structure and appetite-related *** findings indica.e that EO is effective in promoting growth performance and nutrient absorption as well as in regulating appetite by improving intestinal health and ba

关键词： Nursery pig Essential oil Intestinal health Appetite Microbiota

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Evaluation of the effica.y and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of gastroenterology 2024年第5期30卷 440-449页

作者： Yue Deng ya Jiang Tong Jiang Ling Chen Hai-Jun Mou bi-guang Tuo guo-Qing Shi Department of gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKgROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to ca.se serious complica.ions,such as hemorrhage from dislodged ligature rings ca.sed by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(gOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the effica.y,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinica. analysis of the data retrieved from patients with mild or moderate gOV1 gastric varices who were treated under endoscopy was also *** were alloca.ed to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complica.ion rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the effica.y of EBL(66.7%)was markedly better than that of TAI(39.2%)(Pgroups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significa.tly shorter than that in the TAI group(46 min)(Pg in the EBL group was significa.tly lower than that in the TAI group(11.8%vs 45.1%)(Pg rate of operation-related ulcers in the EBL group was 80.4%,which was significa.tly greater than that in the TAI group(35.3%)(Pca.ions in the two groups was *** average cost and other related economic factors were g

关键词： gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

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Effects of intensive psychologica. intervention on treatment compliance,psychologica. status,and quality of life of patients with epilepsy

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World Journal of Psychiatry 2024年第5期14卷 670-677页

作者： Su-Hua Zhang Jie-Hua Wang Hong-Yu Liu Yue-Xia Zhang ya-Ling Lin bi-Yu Wu Department of Neurology Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina Department of Nursing Quanzhou First HospitalQuanzhou 362000Fujian ProvinceChina

BACKgROUND Epilepsy is a nervous system disease characterized by recurrent attacks,a long disease course,and an unfavorable *** is associated with an enduring therapeutic process,and finding a cure has been *** with epilepsy are predisposed to adverse moods,such as resistance,anxiety,nervousness,and anxiety,which compromise treatment compliance and overall *** To explored the influence of intensive psychologica. intervention on treatment compliance,psychologica. status,and quality of life(QOL)of patients with *** The clinica. data of 105 patients with epilepsy admitted between December 2019 and July 2023 were retrospectively analyzed,including those of 50 patients who underwent routine intervention(control group)and 55 who underwent intensive psychologica. intervention(research group).Treatment compliance,psychologica. status based on the Self-Rating Anxiety Sca.e(SAS)and Depression Sca.e Self-Rating Depression Sca.e(SDS)scores,hope level assessed using the Herth Hope Sca.e(HHS),psychologica. resilience evaluated using the Psychologica. Resilience Sca.e,and QOL determined using the QOL in Epilepsy-31 Inventory(QOLIE-31)were comparatively *** Treatment compliance in the research group was 85.5%,which is significa.tly better than the 68.0%of the control *** notable intergroup differences in preinterventional SAS and SDS scores were identified(P>0.05);however,after the intervention,the SAS and SDS scores decreased significa.tly in the two groups,especially in the research group(Pgroups also exhibited no significa.t differences in preinterventional HHS,Connor-Davidson Resilience Sca.e(CD-RISC),and QOLIE-31 scores(P>0.05).After 6 months of intervention,the research group showed evidently higher HHS,CD-RISC,tenacity,optimism,strength,and QOLIE-31 scores(Pgica. intervention enhances treatment compliance,psychologica. status,and QOL of patients with epilepsy.

关键词： Intensive psychologica. intervention Epilepsy Treatment compliance Psychologica. status Quality of life

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Acupuncture for cervica. dystonia associated with anxiety and depression: A ca.e report

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World Journal of Clinica. ca.es 2024年第1期12卷 204-209页

作者： ya-Ting Zhang Jin-Jing Zhang bi-Xiang Zha Yin-Qiu Fan Yuan-Bo Xu Jun ya.g Qing-Ping Zhang The First School of Clinica. Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKgROUND Cervica. dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain ca. ca.se negative emotions in patients,which ca. affect their quality of *** SUMMARY This ca.e report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck ca. be maintained in a normal position,and the negative emotions ca. be *** This ca.e indica.es that acupuncture ca. effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervica. dystonia Anxiety and depression Neurologica. disease Acupuncture ca.e report

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Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

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Journal of Pharmaceutica. Analysis 2024年第6期14卷 930-932页

作者： Xiao-lan Li Jian-qing Zhang Yun Li Xuan-jing Shen Huan-ya ya.g Lin ya.g Meng Xu Qi-rui bi Chang-liang yao De-an guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Aca.emy of Sciences Beijing100049China

Prescriptions are the main clinica. applica.ion of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription ca.led“famous classica. formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critica. for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription

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Recent progress of two-dimensional metal-base ca.alysts in urea oxidation reaction

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Rare Metals 2024年第8期43卷 3607-3633页

作者： Qi-Xiang Huang Fang Wang Yong Liu bi-Ying Zhang Fang-ya.guo Zhong-Qiu Jia Hao Wang Tian-Xiang ya.g Hai-Tao Wu Feng-Zhang Ren Ting-Feng Yi School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471000China School of Environmental Engineering and Chemistry Luoyang Institute of Science and TechnologyLuoyang 471023China Henan Province International Joint Laboratory of Materials for Solar Energy Conversion and Lithium Sodium Based Battery Luoyang 471023China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215009China School of Materials Science and Engineering Northeastern UniversityShenyang110819China

Urea oxidation reaction(UOR)is an auxiliary water electrolysis hydrogen production technology developed in recent years to replace oxygen evolution reaction and reduce energy consumption,which ca. produce hydrogen more efficiently by low theoretica. potential,reduce the average cost of electrochemica. hydrogen production,and is a frontier research hotspot for renewable hydrogen ***-dimensional(2D)nanomaterials as electroca.alysts have many favorable potential,such as it ca. effectively reduce the resistivity of materials and increase the specific surface area with *** paper reviews the applica.ion of 2D materials in UOR in alkaline *** a cross-sectional comparison of various material performance data including overpotential,Tafel slope,electrochemica. active surface area(ECSA)and it stability test was conducted,which could illustrate the differences between materials composed of different *** addition,the main challenges hindering the progress of research on 2D materials in urea electroca.alysis processes and promising materials in this field in future are summarized and *** is believed that this review will contribute to designing and analyzing highperformance 2D urea electroca.alysts for water splitting.

关键词： Water splitting Urea oxidation reaction Two-dimensional Transition metal compounds Noble/non-noble metals

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Curcumin for gastric ca.cer:Mechanism prediction via network pharmacology,docking,and in vitro experiments

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World Journal of gastrointestinal Oncology 2024年第8期16卷 3635-3650页

作者： Peng-Hui ya.g ya-Nan Wei bi-Juan Xiao Si-Yi Li Xin-Long Li Liang-Jun ya.g Hua-Feng Pan geng-Xin Chen The Second School of Clinica. Medicine Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Traditional Chinese Medicine The People's Hospital of LonghuaShenzhen 518109Guangdong ProvinceChina Department of gastroenterology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Centre for Translational Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKgROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long ***,the mechanism by which curcumin affects gastric ca.cer(gC)has not been *** To elucidate the potential mechanisms of curcumin in the treatment of *** Network pharmacologica. approaches were used to perform network analysis of *** first analyzed Lipinski’s Rule of Five for the use of *** latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network *** disease targets were mined through the geneca.d,OMIM,DrugBank and TTD network ***,gO enrichment,KEgg enrichment,protein-protein interaction(PPI),and overall survival analyses were *** results were further verified through molecular docking,differential expression analysis and cell *** We identified a total of 48 curcumin-related genes with 31 overlapping gC-related *** intersection targets between curcumin and gC have been enriched in 81 gO biologica. processes and 22 significa.t *** PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EgFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with *** docking analysis further substantiated the strong binding interactions between Curcumin and the hub target *** experimental findings demonstrated that curcumin not only effectively inhibits the growth of BgC-823 cells but also suppresses their *** levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BgC-823 cells were significa.tly increased in each dose *** Curcumin ca. play an anti-gC role through a variety of

关键词： Curcumin gastric ca.cer Network pharmacology Molecular docking Survival analysis

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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： bi-Ang Kang Hua-Ming Li ya-Ting Chen Meng-Jie Deng yan Li Yue-Ming Peng Jian-Jun gao Zhi-Wei Mo Jia-guo Zhou Zhi-Jun Ou Jing-Song Ou Division of ca.diac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun yat-sen University) Guangzhou 510080China guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)ca. promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critica. role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATg5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATg5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATg5 miRNA endothelial nitric oxide synthase

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