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Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong Li Xuanwei zh.ng Shaolong xue Yu Cao Gabriele Niedermann You Lu Jianxin xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and B7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

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Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1109-1120页

作者： Tian-Xiang Dong Dong Wang Qun zh.o zh.-Dong zh.ng xue-Feng zh.o bi-Bo Tan Yu Liu Qing-Wei Liu Pei-Gang Yang Ping-An Ding Tao zh.ng Yong Li Zi-Jing Liu Third Department of Surgery of the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric CancerShijiazhuang 050011Hebei ProvinceChina

BACKGROUND The incidence of gastric cancer has significantly increased in recent *** resection is the main treatment,but the method of digestive tract reconstruction after gastric cancer surgery remains *** the current study,we sought to explore a reasonable method of digestive tract reconstruction and improve the quality of life and nutritional status of patients after *** this end,we statistically analyzed the clinical results of patients with gastric cancer who underwent jejunal interposition double-tract reconstruction(DTR)and esophageal jejunum Roux-en-Y reconstruction(RY).AIM To explore the application effect of DTR in total laparoscopic radical total gastrectomy(TLTG)and evaluate its safety and *** We collected the relevant data of 77 patients who underwent TLTG at the Fourth Hospital of Hebei Medical University from October 2021 to January *** them,35 cases were treated with DTR,and the remaining 42 cases were treated with traditional *** 1:1 propensity score matching,the cases were grouped into 31 cases per group,with evenly distributed *** clinical characteristics and short-and long-term clinical outcomes of the two groups were statistically *** The two groups showed no significant differences in basic data,intraoperative blood loss,number of lymph node dissections,first defecation time after operation,postoperative hospital stay,postoperative complications,and laboratory examination results on the 1st,3rd,and 5th days after *** operation time of the DTR group was longer than that of the RY group[(307.58±65.14)min vs(272.45±62.09)min,P=0.016],but the first intake of liquid food in the DTR group was shorter than that in the RY group[(4.45±1.18)d vs(6.0±5.18)d,P=0.028].The incidence of reflux heartburn(Visick grade)and postoperative gallbladder disease in the DTR group was lower than that in the RY group(P=0.033 and P=0.038).Although there was no significant difference in bod

关键词： Gastric cancer Jejunal interposition double-tract reconstruction Roux-en-Y reconstruction Laparoscope

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父母过度保护与大学生困难解释风格:真实性和抑郁的链式中介作用

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中国临床心理学杂志 2024年第1期32卷 160-164,170页

作者：李永雪毕重增西南大学心理学与社会发展研究中心西南大学心理学部重庆400715

目的:考察大学生的父母过度保护、真实性、抑郁与两种不同类型的困难解释风格(不可能性解释风格、进取性解释风格)之间的关系。方法:采用简式父母教养方式问卷、真实性问卷、抑郁-焦虑-压力量表、困难解释风格量表对706名大学生进行调... 详细信息

目的:考察大学生的父母过度保护、真实性、抑郁与两种不同类型的困难解释风格(不可能性解释风格、进取性解释风格)之间的关系。方法:采用简式父母教养方式问卷、真实性问卷、抑郁-焦虑-压力量表、困难解释风格量表对706名大学生进行调查。结果:(1)大学生的父母过度保护、真实性、抑郁、不可能性解释风格以及进取性解释风格两两之间均显著相关;(2)父母过度保护对大学生面对困难的不可能性解释风格和进取性解释风格的直接效应显著,也分别通过真实性和抑郁的中介以及二者的链式中介产生间接效应。结论:父母过度保护水平越高,大学生面对困难时越会采取不可能性解释风格,越少采取进取性解释风格,真实性和抑郁在这一关系中发挥了链式中介效应。

关键词：父母过度保护真实性抑郁困难解释风格进取性解释风格不可能性解释风格

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High-resolution remote thermometry based on bi^(3+)-doped 0D zinc halide hybrids

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Science China Chemistry 2024年第8期67卷 2599-2605页

作者： Cui-Mi Shi Shu-Hua xue Jin-Yun Wang Liang-Jin Xu zh.ng-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science Technology Innovation Laboratory for Optoelectronic Information of ChinaFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China

Developing highly sensitive optical thermometers is of great significance due to their capability to enable remote and non-contact temperature measurements, rendering them highly applicable in diverse and harsh environments. Herein we report a temperature-dependent phosphor of 0D metal halide hybrid by incorporating bi^(3+)into the(MePPh_(3))_(2)ZnCl_(4) matrix. Through bi^(3+)doping,the initially non-luminescent(MePPh_(3))_(2) ZnCl_(4) matrix exhibits a deep-blue emission centered at 453 nm, with a photoluminescence quantum yield(PLQY) of 5.71% and a Stokes shift of 75 nm at room temperature. Experimental characterization demonstrates that exciton-like luminescence of bi^(3+)is mainly responsible for the blue emission. Single crystals of bi^(3+)-doped(MePPh_(3))_(2)ZnCl_(4) show an unusual correlation between photoluminescence(PL) lifetime and temperature. Particularly, the dependence of luminescence lifetime on temperature is most remarkable in the temperature range of 80 to 100 K with an exceptional sensitivity up to 0.09 K^(-1), representing one of the best levels for thermometry based on PL decay lifetime. Our work not only provides a viable strategy for designing a novel, environmentally friendly, and stable blue emitter, but also paves the way for precise thermometric application at low temperature.

关键词： lead-free hybrids bi^(3+)doping blue emission temperature sensing

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Tunable quantum anomalous Hall effects in ferromagnetic van der Waals heterostructures

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National Science Review 2024年第3期11卷 100-107页

作者： Feng xue Yusheng Hou zh. Wang zh.ming Xu Ke He Ruqian Wu Yong Xu Wenhui Duan Beijing Academy of Quantum Information Sciences State Key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Center for Neutron Science and Technology School of Physics Sun Yat-sen University State Key Laboratory of Surface Physics Key Laboratory of Computational Physical Sciences and Department of PhysicsFudan University Frontier Science Center for Quantum Information Department of Physics and Astronomy University of California-Irvine Tencent Quantum Laboratory Tencent Technology(Shenzhen)Co.Ltd RIKEN Center for Emergent Matter Science(CEMS) Institute for Advanced Study Tsinghua University

The quantum anomalous Hall effect（QAHE） has unique advantages in topotronic applications, but it is still challenging to realize the QAHE with tunable magnetic and topological properties for building functional devices. Through systematic first-principles calculations, we predict that the in-plane magnetization induced QAHE with Chern numbers C = ±1 and the out-of-plane magnetization induced QAHE with high Chern numbers C = ±3 can be realized in a single material candidate, which is composed of van der Waals（vdW）coupled bi and Mnbi2Te4monolayers. The switching between different phases of QAHE can be controlled in multiple ways, such as applying strain or（weak） magnetic field or twisting the vdW materials. The prediction of an experimentally available material system hosting robust, highly tunable QAHE will stimulate great research interest in the field. Our work opens a new avenue for the realization of tunable QAHE and provides a practical material platform for the development of topological electronics.

关键词： quantum anomalous Hall effect topological quantum phase transition van der Waals heterostructures tunable Chern number high Chern number

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钢脚裂纹原因分析

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金属热处理 2024年第6期49卷 305-307页

作者：毕廉刘冬杰薛峰鞍钢集团北京研究院有限公司北京102209

通过金相显微镜、布氏硬度计和电感耦合等离子体发射光谱仪对钢脚裂纹进行分析。结果表明,钢脚非金属夹杂物较少,显微组织为调质态索氏体,与热处理工艺相符,化学成分满足GB/T 3077—2015要求。断口形貌呈细瓷状,未见疲劳开裂特点。整个... 详细信息

通过金相显微镜、布氏硬度计和电感耦合等离子体发射光谱仪对钢脚裂纹进行分析。结果表明,钢脚非金属夹杂物较少,显微组织为调质态索氏体,与热处理工艺相符,化学成分满足GB/T 3077—2015要求。断口形貌呈细瓷状,未见疲劳开裂特点。整个裂纹两侧均未见脱碳、氧化、折叠形貌,为典型淬火裂纹形貌。开裂原因为大小工件同炉处理,造成小工件冷速过快,应力过大,进而形成开裂。

关键词：钢脚淬火裂纹原因分析

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Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

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Cancer Advances 2024年第7期7卷 1-9页

作者： Wen-Kai Wang Yuan-Yuan Feng Yi-Yang zh.o Zi-Wei Wang Chao-Wei Wang xue-Qing Hu Ling bi Yan Wang Department of Medical Oncology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer ***:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index *** CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research ***:This investigation yielded a total of 336 relevant *** is the most productive *** University of Traditional Chinese Medicine is the leading *** journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative *** author with the most citations and centrality is Lin *** terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness ***:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment *** recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and ***,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

关键词： colorectal cancer Traditional Chinese Medicine bibliometrics study visualization analysis CiteSpace

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融合跨平台用户偏好与异质信息网络的推荐算法研究

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现代情报 2024年第9期44卷 31-41页

作者：张雪毕达天陈功坤杜小民吉林大学商学与管理学院吉林长春130012 海南大学国际商学院海南海口570228

[目的/意义]本文基于跨平台用户的异构大数据,提出一种融合跨平台用户偏好与异质信息网络的推荐算法(CPHAR),对于缓解个性化推荐的稀疏性和冷启动问题具有重要意义。[方法/过程]首先,根据跨平台用户信息构建核心兴趣朋友圈,使用卷积神... 详细信息

[目的/意义]本文基于跨平台用户的异构大数据,提出一种融合跨平台用户偏好与异质信息网络的推荐算法(CPHAR),对于缓解个性化推荐的稀疏性和冷启动问题具有重要意义。[方法/过程]首先,根据跨平台用户信息构建核心兴趣朋友圈,使用卷积神经网络和自注意力机制捕捉用户在源平台和目标平台中的信息偏好特征;其次,根据核心兴趣网络以及推荐项目之间的关系构建异质信息网络,使用异质图注意力网络模型进行特征聚合;最后,将以上特征嵌入改进后的矩阵分解模型,计算推荐得分。[结果/结论]模型在自主构建的4个跨平台数据集中均表现出优越的性能,本文不仅弥补了推荐领域中跨平台多属性和细粒度数据集的空缺,而且通过引入跨平台特征进一步完善了推荐系统相关的理论与方法体系。

关键词：推荐算法跨平台异质信息网络用户偏好深度学习

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基于16S rRNA测序技术研究尘肺病患者肠道菌群特征

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中国微生态学杂志 2024年第4期36卷 414-419,430页

作者：吴昊寇佳祥毕磊薛原天津大学生命科学学院天津300350 天津大学浙江研究院(绍兴) 绍兴312300 国家卫生健康委职业安全卫生研究中心北京102300

目的基于16S rRNA测序技术,研究尘肺病患者与健康人群的肠道菌群差异,为肠道菌群与尘肺病相关联系提供参考。方法以20名尘肺病患者为研究对象,以20名健康志愿者为对照组。采用16S r RNA测序技术对两组人群的肠道菌群分布情况进行统计... 详细信息

目的基于16S rRNA测序技术,研究尘肺病患者与健康人群的肠道菌群差异,为肠道菌群与尘肺病相关联系提供参考。方法以20名尘肺病患者为研究对象,以20名健康志愿者为对照组。采用16S r RNA测序技术对两组人群的肠道菌群分布情况进行统计及差异分析,结合KEGG数据库和COG数据库等进行综合生物信息学分析。结果尘肺组肠道菌群的丰富度较低,厚壁菌门与拟杆菌门比例较对照组显著降低(P<0.05),变形菌门相对丰度增加,放线菌门相对丰度明显下降(P<0.05)。在属水平上,埃希氏菌属相对丰度增加,双歧杆菌属和罗氏菌属相对丰度显著降低(P<0.05)。戈登杆菌属、艾森伯格菌属、Negativibacillus和Tyzzerella可能为尘肺患者肠道的特异菌群。COG功能基因分析发现,两组在L2层级的4个代谢通路上差异存在统计学意义(P<0.05)。结论尘肺患者肠道菌群和代谢通路与健康人群存在显著差异,戈登杆菌属、艾森伯格菌属、Negativibacillus和Tyzzerella可能是尘肺患者肠道菌群生物标志物。

关键词：尘肺病肠道菌群代谢通路

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Heterogeneous body compositions and all-cause mortality in acute coronary syndrome patients:a ten-year retrospective cohort study

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Journal of Geriatric Cardiology 2024年第5期21卷 534-541页

作者： Guang-zh. LIAO Lin BAI Yu-Yang YE xue-Feng CHEN Xin-Ru HU Yong PENG Department of Cardiology West China HospitalSichuan UniversityChengduSichuanChina

BACKGROUND The association of different body components,including lean mass and body fat,with the risk of death in acute coronary syndrome(ACS)patients are *** We enrolled adults diagnosed with ACS at our center between January 2011 and December 2012 and obtained fol-low-up outcomes via telephone *** used restricted cubic splines(RCS)with the Cox proportional hazards model to analyze the associations between body mass index(BMI),predicted lean mass index(LMI),predicted body fat percentage(BF),and the value of LMI/BF with 10-year *** also examined the secondary outcome of death during *** During the maximum 10-year follow-up of 1398 patients,331 deaths(23.6%)occurred,and a U-shaped relationship was found between BMI and death risk(P_(nonlinearity)=0.03).After adjusting for age and history of diabetes,the overweight group(24≤BMI<28 kg/m^(2))had the lowest mortality(HR=0.53,95%CI:0.29-0.99).Predicted LMI and LMI/BF had an inverse linear relationship with a 10-year death risk(P_(nonlinearity)=0.24 and P_(nonlinearity)=0.38,respectively),while an increase in BF was associ-ated with increased mortality(P_(nonlinearity)=0.64).During hospitalization,31 deaths(2.2%)were recorded,and the associations of the indicators with in-hospital mortality were consistent with the long-term outcome *** Our study provides new insight into the“obesity paradox”in ACS patients,highlighting the importance of considering body composition *** LMI and BF may serve as useful tools for assessing nutritional status and predicting the prognosis of ACS,based on their linear associations with all-cause mortality.

关键词： patients mortality coronary

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