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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 255-259页

作者： Jing-Yi Tan Xue-Qin Chen bi-jun kang Zi-Xi Qin Jia-Hong Chen Ren-Dong Hu Liang-Cai Wu Pharmacology Department of Basic Medical Sciences School of Medicine Jinan University The 6th Affiliated Hospital.Sun Yat-sen University

Objective: To explore the therapeutic effect and mechanism of myricctin on disseminated intravascular coagulation(DIC). Methods: The DIC model was established by injection of60 mg/kg LPS in KM mice, and the treatment groups were injected myricetin with different concentrations(25 or 50 mg/kg) 30 min before the model was established. Both coagulation indicators and organ function were tested, including PT, APTT, fibrinogen. AST, ALT. BUN and tissue section. In vitro, the inflammatory model of RAW 264.7 macrophage cells were established by 10 μg/mL LPS. The treatment group was treated with 50 μmol/mL myricetin for 30 min before LPS, and the expression of TNF-a and p-NF-KB was detected, further to explore the therapeutic mechanism. Results: LPS-induced DIC led to a reduction of fibrinogen and a rise of PT, APTT,AST, ALT, BUN levels, but the treatment of myricctin significantly inhibited these abnormalities. Histopathology analysis also revealed that myricetin remarkably protected the liver and renal damage. In vitro, the expression of TNF-α and p-NF-κB induced by LPS was repressed by myricetin. Conclusions: This study provides new insights into the protective effects of myricetin in LPS-induced DIC by anticoagulant and anti-inflammatory via suppressing the activation of p-NF-κB which decreased TNF-α level.

关键词： Myricetin Lipopolysaccharide Disseminated intravascular coagulation Anti-inflammatory Macrophages

Experimental Study on Conversion Efficiency of A Floating OWC Pentagonal Backward Bent Duct Buoy Wave Energy Converter

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China Ocean Engineering 2019年第3期33卷 297-308页

作者： LI Meng WU Ru-kang WU bi-jun ZHANG Yun-qiu Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China Key Laboratory of Renewable Energy Chinese Academy of Sciences Guangzhou 510640 China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640 China University of Chinese Academy of Sciences Beijing 100049 China

Wave tank tests were carried out to evaluate the total efficiency of a floating OWC Pentagonal Backward Bent Duct Buoy (PBBDB). Two kinds of turbine generators were used in tests. The incident wave power, pneumatic power and electricity were measured. The test results show that the primary efficiency can reach up to 185.98% in regular waves and 85.86% in irregular waves. The total efficiency from wave to wire with Wells turbine-generator set is 33.43% in regular waves and 15.82% in irregular waves. The peak total efficiency of the PBBDB with check valves equipped with the impulse turbine-generator set is 41.68% in regular waves and 27.10% in irregular waves. The efficiency of the turbine-generator set is about 30% in the tests. Obviously, the total efficiency can be further improved with the increasing of turbine efficiency.

关键词： wave energy Oscillating Water Column (OWC) PBBDB Capture Width Ratio (CWR) total efficiency

RP-HPLC Determination and Pharmacokinetic Comparison of Cinnamic Acid in Rat Plasma After Administration of Di-Gu-Pi Decoction and Pure Cinnamic Acid

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Chemical Research in Chinese Universities 2006年第1期22卷 56-60页

作者： LI kang bi Kai-shun Department of Pharmacy Shenzhen Hospital Beijing University Shenzhen 518036 P.R. China College of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 P.R. China

A sensitive, simple, and accurate method was developed for the determination and pharmacokinetic comparison of cinnamic acid in rat plasma after the administration of a Traditional Chinese Medicinal preparation, Di-Gu-Pi decoction, and pure cinnamic acid using RP-HPLC. Di-Gu-Pi was extracted with 5% aqueous sodium bicarbonate, which was followed by purification with ion exchange column chromatography. The plasma samples taken from rats were deproteinized with methanol. The reversed-phase （HPLC） system with a Diamonsil C18 column and methanol-acetonitfile-water （8： 32： 60, volume ratio）（adjusted to pH = 3.0 with glacial acetic acid） as the mobile phase was employed for the separation of cinnamic acid in the plasma samples. The detection was set at 272 nm and 3-（p-fluoro-phenyl）-2-propenoic acid was chosen as the internal standard. The calibration curve was linear in a range from 0. 10 to 25.0μg/mL （R2 = 0. 9988, n = 9）. The precision was 3.42%-10. 10%; the between-day precision was 2. 84%-8.91% ; the accuracy was - 1.51%-1.26% ; the mean recovery was 99. 9%. The method was found to be sensitive, simple, accurate and appropriate for the determination of cinnamic acid.

关键词： Di-Gu-Pi decoction Cinnamic Acid Pharmacokinetics RP-HPLC

定向电场下W_(6)C_(6)团簇的超卤素调制及非线性光学特性

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原子与分子物理学报 2025年第3期42卷 72-76页

作者：蔡璧钧段宇静魏强重庆理工大学理学院重庆400050

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且... 详细信息

本文采用密度泛函(DFT)方法研究了定向外电场(OEEF)对W_(6)C_(6)团簇几何结构、电子性质以及非线性光学响应(NLO)的影响.计算结果表明W_(6)C_(6)的结构在一定OEEF强度下可以保持稳定.OEEF可以增大W_(6)C_(6)团簇的电子亲和能(EA值),且在特定强度下,OEEF可以将W_(6)C_(6)团簇转变为超卤素.通过对EA值的非线性拟合可以实现对W_(6)C_(6)团簇的连续调制.进一步对不同外电场下W_(6)C_(6)团簇的最高占据分子轨道(HOMO)和最低未占据分子轨道(LUMO)能级进行分析,发现OEEF降低了W_(6)C_(6)团簇LUMO能级是其EA值增大的主因.此外,OEEF可以显著增大W_(6)C_(6)团簇的平均极化率和第一超极化率,尤其是第一超极化率,改变其非线性光学性质.

关键词：定向外电场超原子密度泛函理论 NLO W_(6)C_(6)团簇

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Generalization of the mixed-space cluster expansion method for arbitrary lattices

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npj Computational Materials 2023年第1期9卷 1598-1608页

作者： kang Wang Du Cheng bi-Cheng Zhou Department of Materials Science and Engineering University of VirginiaCharlottesvilleVA 22904USA

Mixed-space cluster expansion(MSCE),a first-principles method to simultaneously model the configuration-dependent short-ranged chemical and long-ranged strain interactions in alloy thermodynamics,has been successfully applied to binary FCC and BCC ***,the previously reported MSCE method is limited to binary alloys with cubic crystal symmetry on a single *** the current work,MSCE is generalized to systems with multiple sublattices by formulating compatible reciprocal space interactions and combined with a crystal-symmetry-agnostic algorithm for the calculation of constituent strain *** generalized approach is then demonstrated in a hypothetical HCP system and Mg-Zn *** current MSCE can significantly improve the accuracy of the energy parameterization and account for all the fully relaxed structures regardless of lattice *** generalized MSCE method makes it possible to simultaneously analyze the short-and long-ranged configuration-dependent interactions in crystalline materials with arbitrary lattices with the accuracy of typical first-principles methods.

关键词： alloy cluster expansion

Distributed interference suppression scheme for multi-cell uplink OFDMA system based on non-cooperative game

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The Journal of China Universities of Posts and Telecommunications 2011年第2期18卷 65-71页

作者： CHANG Ling-jun TANG bi-hua XIE Gang ZENG Ling-kang LIU Kai-ming School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing 100876 China School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

In this paper,a distributed interference suppression scheme is proposed for multi-cell uplink orthogonal frequency division multiple access（OFDMA） ***,we model resource allocation process as a non-cooperative *** we show the concept of Nash equilibrium（NE） and investigate its existence and uniqueness in *** enhance the performance of multi-cell OFDMA system,the further improvement process based on NE is *** adjustable parameters are set to make the system achieve different tradeoffs between the total capacity and *** results show that the proposed scheme can greatly improve the system performance comparing with conventional scheme.

关键词： multi-cell non-cooperative game OFDMA uplink ICI

Nanocarbon-based electrode materials applied for supercapacitors

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Rare Metals 2022年第12期41卷 3957-3975页

作者： Yu-Xiang Yang kang-kang Ge Sajid ur Rehman Hong bi School of Chemistry and Chemical Engineering School of Materials Science and EngineeringAnhui UniversityHefei 230601China CIRIMAT UMR CNRS 5085UniversitéPaul Sabatier ToulouseⅢToulouse 31062France CAS Key Laboratory of High Magnetic Field and Ion Beam Physical biology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

As one of the promising energy storage and conversion systems,supercapacitors(SCs)are highly favored owing to their high power density and good service *** all the key components of supercapacitor devices,the design and investigation of electrode materials play an essential role in determining the whole electrochemical charge storage ***,nanocarbon-based materials(e.g.,graphene,carbon dots,graphene quantum dots,etc.)have been widely used as SC electrode materials because of their good physical structure and chemical properties,providing a new route to further improve the energy density and life span of ***,we review the latest progress of nanocarbon-based materials(including nanocarbon and nanocarbon-based composite materials)as electrode materials in SCs *** recent progress of carbon dots,graphene,carbon nanotubes,and other nanocarbon materials electrodes is summarized,while the capacitance and energy density of the above nanocarbon electrodes still need to be ***,the preparation and performance of nanocarbonbased composite electrodes comprising transition metal oxides,conductive polymer,and metal-organic framework derived porous carbon are ***,we outline major challenges and propose some ideas on building better nanocarbon-based SC electrodes.

关键词： Supercapacitor(SC) Nanocarbon Electrode materials Carbon dots Nanocarbon-based composite

IS: Interest Set to Enhance Flow Transmission in Named-Data Networking

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China Communications 2016年第S1期13卷 65-71页

作者： JIANG Xiaoke bi jun Institute for Network Sciences and Cyberspace Tsinghua University Department of Computer Science and Technology Tsinghua University Tsinghua National Laboratory for Information Science and Technology

Named-data Networking(NDN) is a promising future Internet architecture, which introduces some evolutionary elements into layer-3, e.g., consumer-driven communication, soft state on data forwarding plane and hop-byhop traffic control. And those elements ensure data holders to solely return the requested data within the lifetime of the request, instead of pushing data whenever needed and whatever it is. Despite the dispute on the advantages and their prices, this pattern requires data consumers to keep sending requests at the right moments for continuous data transmission, resulting in significant forwarding cost and sophisticated application design. In this paper, we propose Interest Set(IS) mechanism, which compresses a set of similar Interests into one request, and maintains a relative long-term data returning path with soft state and continuous feedback from upstream. In this way, IS relaxes the above requirement, and scales NDN data forwarding by reducing forwarded requests and soft states that are needed to retrieve a given set of data.

关键词： index terms—named-data networking flow transmission

FINE:Future Internet iNnovation Environment

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China Communications 2015年第1期12卷 146-147页

作者： bi jun Institute for Network Sciences and Cyberspace Tsinghua University Department of Computer Science Tsinghua University Tsinghua National Laboratory for Information Science and Technology(TNList)

This article introduces FINE(Future Internet iNnovation Environment) project,which is supported by National High-tech R&D Program( "863" Program) of China.

关键词：互联网环境创新