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Characterization of Changes and Driver Microbes in Gut Microbiota During Healthy Aging Using A Captive Monkey Model

Genomics, Proteomics & bioinformatics 2022年第2期20卷 350-365页

作者： Zhi-Yuan Wei Jun-Hua Rao Ming-Tian Tang Guo-An Zhao Qi-Chun li li-Ming Wu Shao-Qiang liu bi-hai li Bai-Quan Xiao Xing-Yin liu Jian-Huan Chen Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou 510260China Laboratory of Genomic and Precision Medicine Wuxi School of MedicineJiangnan UniversityWuxi 214122China Joint Primate Research Center for Chronic Diseases Jiangnan University and Institute of ZoologyGuangdong Academy of SciencesWuxi School of MedicineJiangnan UniversityWuxi 214122China Department of Pathogen-Microbiology Division Nanjing Medical UniversityNanjing 211166China

Recent population studies have significantly advanced our understanding of how age shapes the gut ***,the actual role of age could be inevitably confounded due to the complex and variable environmental factors in human populations.A well-controlled environment is thus necessary to reduce undesirable confounding effects,and recapitulate age-dependent changes in the gut microbiota of healthy *** we performed 16S rRNA gene sequencing,characterized the age-associated gut microbial profiles from infant to elderly crab-eating macaques reared in captivity,and systemically revealed the lifelong dynamic changes of the primate gut *** the most significant age-associated taxa were mainly found as commensals such as Faecalibacterium,the abundance of a group of suspicious pathogens such as Helicobacter was exclusively increased in infants,underlining their potential role in host ***,topology analysis indicated that the network connectivity of gut microbiota was even more agedependent than taxonomic diversity,and its tremendous decline with age could probably be linked to healthy ***,we identified key driver microbes responsible for such age-dependent network changes,which were further linked to altered metabolic functions of lipids,carbohydrates,and amino acids,as well as phenotypes in the microbial *** current study thus demonstrates the lifelong age-dependent changes and their driver microbes in the primate gut microbiota,and provides new insights into their roles in the development and healthy aging of their hosts.

关键词： Age-dependent change Non-human primate Healthy gut microbiota Network connectivity Driver microbe

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Hot versus cold subduction initiation

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National Science Review 2024年第2期11卷 101-102页

作者： Zhong-hai li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c... 详细信息

关键词： DRIVEN CRUST

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Design optimization of a hexapod vibration isolation system for electro-optical payload

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Chinese Journal of Aeronautics 2024年第2期37卷 330-342页

作者： Jing li Weipeng li Xiaoyan ZHANG hai HUANG School of Astronautics Beihang UniversityBeijing 100191China

The electro-optical payloads on mobile platforms generally suffer undesirable vibrations generated by maneuvers and *** vibrations are in six degrees of freedom and cause line-of-sight jitters,resulting in image blurring and loss of tracking *** this paper,a Hexapod Vibration Isolation System(HVIS)is proposed and optimized to solve this *** optimization aims to centralize and minimize the natural frequencies of HVIS,for expanding the vibration isolation bandwidth and improving the vibration isolation in the higher frequency *** that the design space for HVIS is limited and interfered with the frames of the mobile platform,a non-collision algorithm is proposed and applied in the optimization to obtain the feasible optimal *** optimization result shows that the natural frequency bandwidth has been reduced by 42.9%,and the maximum natural frequency is reduced by 30.2%.The prototypes of initial and optimal designs are manufactured and *** simulated and experimental results demonstrate the validity of the optimization,and the optimal design provides a maximum of 15 dB more isolation in rotation direction than the initial design.

关键词： Electro-optical payload Vibrations Isolation system Hexapod Optimization Non-collision design

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Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

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World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： Wei-Ming Xu hai-Fu Zhang Yong-Hang Feng Shuo-Jun li bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle *** studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty *** To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this *** Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant *** After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric ***,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,Pbipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,Pbipolar disorder(OR:55.08,95%CI:3.59-845.51,Pliver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psy

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

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Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

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World Journal of Clinical Cases 2024年第11期12卷 1918-1928页

作者： hai-Fu Zhang Ze-Xuan Su Yong-Hang Feng Shuo-Jun li bi-Yun Xie Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is *** to its relatively insidious etiology,it is easy to be ignored in the early *** China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating *** To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were *** changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two *** Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with *** receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,P<0.01).After 3 d of treatment,the patients in the CQCQD group had more bowel movements than the control group(2.51±0.25 times vs 1.00±0.17 times,P=0.01).The gastrointestinal function of most patients returned to normal,and the acute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,P<0.01).CONCLUSION In patients with HTG-AP,CQCQD can significantly reduce the TG level,shorten the recovery time of defecation,significantly improve the gastrointestinal function.

关键词： Hypertriglyceridemic acute pancreatitis Chinese medicine Chaiqin Chengqi Decoction Serum lipid Triglycerides

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Feedback of Efficient Shock Acceleration on Magnetic-field Structure Inside Young Type Ia Supernova Remnants

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Research in Astronomy and Astrophysics 2024年第6期24卷 234-244页

作者： Jun-Yu Shen bi-Wen Bao li Zhang Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Key Laboratory of Statistical Modeling and Data Analysis of Yunnan Province Yunnan UniversityKunming 650091China

Using an effective adiabatic index γ_(eff) to mimic the feedback of efficient shock acceleration,we simulate the temporal evolution of a young type Ia supernova remnant (SNR) with two different background magnetic field(BMF) topologies:a uniform and a turbulent *** density distribution and magnetic-field characteristics of our benchmark SNR are studied with two-dimensional cylindrical magnetohydrodynamic *** γ_(eff)is considered,we find that:(1) the two-shock structure shrinks and the downstream magnetic-field orientation is dominated by the Rayleigh–Taylor instability structures;(2) there exists more quasi-radial magnetic fields inside the shocked region;and (3) inside the intershock region,both the quasi-radial magnetic energy density and the total magnetic energy density are enhanced:in the radial direction,with γ_(eff)=1.1,they are amplified about 10–26 times more than those with γ_(eff)=5/*** in the angular direction,the total magnetic energy densities could be amplified about 350 times more than those with γ_(eff)=5/3,and there are more grid cells within the intershock region where the magnetic energy density is amplified by a factor greater than 100.

关键词： methods:numerical ISM:magnetic fields ISM:supernova remnants magnetohydrodynamics(MHD)

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Fatigue-resistant Hydrogels

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Chemical Research in Chinese Universities 2024年第1期40卷 64-77页

作者： li Luofei LEI hai CAO Yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China Department of Physics Zhejiang UniversityHangzhou 310027P.R.China

Hydrogels have been extensively studied for applications in various fields, such as tissue engineering and soft robotics, as determined by their mechanical properties. The mechanical design of hydrogels typically focuses on the modulus, toughness, and deformability. These characteristics play important roles and make great achievements for hydrogel use. In recent years, a growing body of research has concentrated on the fatigue property of hydrogels, which determines their resistance to crack propagation in the networks during cyclic mechanical loads for applications. However, knowledge of hydrogel fatigue behavior remains notably deficient. Here, we present a brief overview of the fatigue behavior of hydrogels, encompassing the general experimental methods to measure the fatigue property and fundamental theoretical calculation models. Then, we highlight multiple strategies to enhance the fatigue resistance of hydrogels. Finally, we present our perspectives on fatigue-resistant hydrogels, outstanding challenges and potential directions for future research.

关键词： Hydrogel Fatigue-resistant Fracture

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Sparse Adversarial Learning for FDIA Attack Sample Generation in Distributed Smart

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2095-2115页

作者： Fengyong li Weicheng Shen Zhongqin bi Xiangjing Su College of Computer Science and Technology Shanghai University of Electric PowerShanghai201306China College of Electrical Engineering Shanghai University of Electric PowerShanghai201306China

False data injection attack(FDIA)is an attack that affects the stability of grid cyber-physical system(GCPS)by evading the detecting mechanism of bad *** FDIA detection methods usually employ complex neural networkmodels to detect FDIA ***,they overlook the fact that FDIA attack samples at public-private network edges are extremely sparse,making it difficult for neural network models to obtain sufficient samples to construct a robust detection *** address this problem,this paper designs an efficient sample generative adversarial model of FDIA attack in public-private network edge,which can effectively bypass the detectionmodel to threaten the power grid system.A generative adversarial network(GAN)framework is first constructed by combining residual networks(ResNet)with fully connected networks(FCN).Then,a sparse adversarial learning model is built by integrating the time-aligned data and normal data,which is used to learn the distribution characteristics between normal data and attack data through iterative ***,we introduce a Gaussian hybrid distributionmatrix by aggregating the network structure of attack data characteristics and normal data characteristics,which can connect and calculate FDIA data with normal ***,efficient FDIA attack samples can be sequentially generated through interactive adversarial *** simulation experiments are conducted with IEEE 14-bus and IEEE 118-bus system data,and the results demonstrate that the generated attack samples of the proposed model can present superior performance compared to state-of-the-art models in terms of attack strength,robustness,and covert capability.

关键词： Distributed smart grid FDIA adversarial learning power public-private network edge

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A Rendezvous Mission to the Second Earth Trojan Asteroid 2020 XL_5 with Low-Thrust Multi-Gravity Assist Techniques

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Research in Astronomy and Astrophysics 2024年第1期24卷 245-264页

作者： Shi-hai Yang Bo Xu Xin li School of Aeronautics and Astronautics Sun Yat-sen UniversityShenzhen 518107China

As the second of Earth's Trojan asteroids, 2020 XL_(5) is worthy of rendezvous and even sample return missions in many aspects. In this paper, a rendezvous mission to Earth's second Trojan asteroid 2020 XL_(5) is ***, due to its high inclination and large eccentricity, direct impulsive transfer requires large amounts of fuel consumption. To address this challenge, we explore the benefits of electric propulsion and multi-gravity assist techniques for interplanetary missions. These two techniques are integrated in this mission design. The design of a low-thrust gravity-assist(LTGA) trajectory in multi-body dynamics is thoroughly investigated,which is a complex process. A comprehensive framework including three steps is presented here for optimization of LTGA trajectories in multi-body dynamics. The rendezvous mission to 2020 XL_(5) is designed with this three-step approach. The most effective transfer sequence among the outcomes involves Earth–Venus–Earth–Venus-2020 XL_(5). Numerical results indicate that the combination of electric propulsion and multi-gravity assists can greatly reduce the fuel consumption, with fuel consumption of 9.03%, making it a highly favorable choice for this rendezvous mission.

关键词： minor planets asteroids:general celestial mechanics Planetary Systems

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue Sun Wen li hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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