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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun bi Youxiang Chew Shang sui Chaolin Tan Zhenglin Du Jinlong su Fern Lan Ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑xia su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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中药活性成分筛选方法研究进展

海峡药学 2018年第11期30卷 43-46页

作者：毕素侠王莹李大鹏戚进余伯阳中国药科大学中药学院南京211198

中药活性成分的筛选对于中药的发展至关重要。目前,已有许多方法技术用于中药活性成分的筛选。本文就近年来国内外对中药活性成分筛选方法的研究进展进行综述,分别介绍了基于活性成分分离鉴定、血清药物化学和血清药理学、代谢组学、分... 详细信息

中药活性成分的筛选对于中药的发展至关重要。目前,已有许多方法技术用于中药活性成分的筛选。本文就近年来国内外对中药活性成分筛选方法的研究进展进行综述,分别介绍了基于活性成分分离鉴定、血清药物化学和血清药理学、代谢组学、分子识别技术、计算机虚拟技术的活性成分筛选方法,以期为中药现代研究提供参考。

关键词：中药活性成分筛选方法

Efficient synthesis of nigerose by a novel nigerose phosphorylase from Anaerosporobacter mobilis

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Systems Microbiology and biomanufacturing 2023年第3期3卷 498-508页

作者： Ran bi Jing Wu Lingqia su Wei xia State Key Laboratory of Food Science and Technology Jiangnan University1800 Lihu AvenueWuxi 214122China School of biotechnology and Key Laboratory of Industrial biotechnology Ministry of Education Jiangnan University1800 Lihu AvenueWuxi 214122China International Joint Laboratory on Food Safety Jiangnan University1800 Lihu AvenueWuxi 214122China

Nigerose is a kind of rare disaccharide connected by anα-1,3 glucosidic bond,which is a potential probiotic due to its antidigestive properties and beneficial *** study identified and characterized a novel GH65 glycoside phosphorylase derived from Anaerosporobacter mobilis(AmNP).This new protein could specifically catalyze the phospholysis of nigerose to generate glucose and glucose-1-phosphate in the presence of phosphate,indicating it was a typical nigerose *** to the previously reported nigerose phosphorylases,AmNP exhibited lower affinity towards nigerose in phosphorolysis reaction and higher affinity towards glucose in reverse phosphorolysis reaction,which indicated that AmNP might be superior in the synthetic capability of *** AmNP was employed to synergize with maltose phosphorylase from Lactobacillus brevis(LbMP)to catalyze the synthesis of nigerose using maltose as the *** optimization of reaction conditions,the highest nigerose yield reached 132.0 g/L with a 66.3%conversion rate,which was higher than ever reported cases using the same reaction pathway to our *** findings on AmNP in this work were expected to provide a new candidate for large-scale enzymatic synthesis of nigerose and have important theoretical significance for studying nigerose phosphorylase.

关键词： Nigerose Nigerose phosphorylase Coupling reaction Enzymatic synthesis

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-xia Liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** suMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (bitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Identification of differential brain regions in MCI progression via clustering-evolutionary weighted SVM ensemble algorithm

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Frontiers of Computer Science 2021年第6期15卷 165-173页

作者： xia-an bi Yiming XIE Hao WU Luyun XU Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha 410081China College of Information Science and Engineering Hunan Normal UniversityChangsha 410081China Business School of Hunan Normal University Changsha 410081China

Mild cognitive impairment(MCI)as the potential sign of serious cognitive decline could be divided into two stages,i.e.,late MCI(LMCI)and early MCI(EMCI).Although the different cognitive states in the MCI progression have been clinically defined,effective and accurate identification of differences in neuroimaging data between these stages still needs to be further *** this paper,a new method of clustering-evolutionary weighted support vector machine ensemble(CEWSVME)is presented to investigate the alterations from cognitively normal(CN)to EMCI to *** CEWSVME mainly includes two *** first step is to build multiple SVM classifiers by randomly selecting samples and *** second step is to introduce the idea of clustering evolution to eliminate inefficient and highly similar SVMs,thereby improving the final classification ***,we extracted the optimal features to detect the differential brain regions in MCI progression,and confirmed that these differential brain regions changed dynamically with the development of *** exactly,this study found that some brain regions only have durative effects on MCI progression,such as parahippocampal gyrus,posterior cingulate gyrus and amygdala,while the superior temporal gyrus and the middle temporal gyrus have periodic effects on the *** work contributes to understanding the pathogenesis of MCI and provide the guidance for its timely diagnosis.

关键词： machine learning MCI progression optimal feature extraction differential brain regions functional magnetic resonance imaging

Government subsidy’s Effect on the Channel Strategies of Energy-Saving supply Chain

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Journal of Systems Science and Systems Engineering 2023年第6期32卷 729-770页

作者： Zijian bi xiaohui Yu Qiang Zhang Zihan su State Grid Jibei Electric Power Co. LtdTangshan063000China Institute for Carbon Peak and Neutrality&Logistics School Beijing101149China School of Management&Economics Beijing Institute of TechnologyBeijing100081China

As subsidy is a popular form of stimulating consumption,not only for home appliances market,the effectiveness of selling promotion subsidies need to be *** this paper,we check the role of promotion subsidies in the offline channel layout by establishing three models,i.e.,no subsidy,customer rebate and retailer *** kinds of online-to-offline strategies are considered,which are retailer’s opening separate and sharing offline *** is gotten that:both customer rebate and retailer subsidy increase the possibility of opening offline channels by sharing offline store strategy,but customer rebate takes high price than no subsidy while retailer subsidy is on the *** the growing subsidy,both customer rebate and retailer subsidy could make offline channels opened by separate or sharing offline store strategy,but the customer rebate brings more *** customer rebate and retailer subsidy require less social welfare to open offline channel,but the customer rebate brings more consumer surplus of opening offline channels than retailer subsidy for a given market ***,government should give the subsidy to customer,not to retailer,even if it brings the increasing of product’price.

关键词： biform game online-to-offline strategies social welfare service

Community attitudes toward ecotourism development and environmental conservation in nature reserve:a case of Fujian Wuyishan National Nature Reserve,China

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Journal of Mountain Science 2017年第7期14卷 1405-1418页

作者： CHEN bi-xia QIU Zhen-mian Faculty of Agriculture University of the RyukyusNishihara Town School of Economics Fujian Normal University Kanazawa University

Using social exchange theory, this study investigated residents＇ attitudes toward the preliminary stage of tourism development in nature reserves in Wuyishan National Nature Reserve of China, and the socio-economic and negative effects of residents＇ attitude toward the tourist industry. Results of the questionnaire survey indicated that local people perceived they could benefit from the economic activities related to tourism, and were supportive of the conservation of natural resources and local culture, sustainable community development, and community participation in ecotourism planning and management. This study also revealed that the variables of age, gender, education level, household income, family size, non-farm work arrangements, and the distance to tourism attractions, have significant association with respondents＇ attitudes toward ecotourism development, or negative impacts of the tourist industry. Respondents who are male, or have a higher household income, are more supportive of tourism development inside the reserve. Younger and more highly educated community members are more likely to support learning more about natural and cultural resources and landscapes. Respondents who have a hieher household income, or live far fromthe village center, are more concerned about the negative environmental impacts of tourism development.

关键词： Economic benefits Environmentalconservation Nature reserve Residents' attitude Tourism development Wuyishan National NatureReserve