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Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： Yulu Shi Quan Kang Hong Zhou Xiaohan Yue Yang bi Qing Luo Stem Cell biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few.know. differentia-tion inducers,and little research has been done on their *** differentiation is associated w.th an increase in mitochondrial content and *** metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as w.ll as up-regulation of aerobic glycolysis and pentose phosphate ***-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated w.th tumorigenesis and progression,as w.ll as cancer cell *** found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and *** of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathw.y,promoted oxidative phosphorylation,and led to osteogenic *** also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro *** LETM1 w.s knocked dow. in vivo,there w.s reduced tumor formation and lung *** data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdow. of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathw.y,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness

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Salinity Acclimation Induces Reduced Energy Metabolism,Osmotic Pressure Regulation and Transcriptional Reprogramming in Hypotrichida Ciliate Gastrostyla setifera

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Journal of Ocean University of China 2024年第2期23卷 539-549页

作者： JI Xin bi Luping ZOU Songbao LI w.nlu JI Daode ZHANG Qianqian School of Ocean Yantai UniversityYantai 264005China Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Zhejiang Institute of Freshw.ter Fisheries Huzhou 313001China Muping Coastal Environment Research Station Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264117China

Coastal and estuarine protists are frequently exposed to salinity *** the tolerance and stress responses of microalgae to salinity have been extensively studied,there have been scarce studies on the physiological response of heterotrophic protists to salinity *** this study,w. investigated the physiological response of the heterotrophic ciliate Gastrostyla setifera to a salinity of 3,via a transcriptomic *** first transcriptome of genus Gastrostyla w.s obtained utilizing a group of manually isolated ciliate individuals(cells)and RNA-seq *** completeness of the transcriptome w.s *** expressed gene(DEG)analysis w.s performed among the transcriptomes of *** acclimated in saline w.ter(salinity 3)and those cultured in fresh *** results demonstrated a significant alternation in gene transcription,in w.ich the ciliate exhibits a transcripttomic acclimation in responding salinity *** up-regulated DEGs w.re enriched in the pathw.ys of cytoskeleton proteins,membrane trafficking,protein kinases and protein *** may represent enhanced functions of ion transport,stress response and cell *** involved in energy metabolism and biosynthesis w.re markedly dow.-regulated,reflecting decreased cell ***,w. detected significantly dow.-regulated genes involved in several pathw.ys of amino acid catabolism,w.ich may lead to accumulation of amino acids in the ciliate *** acid could act as compatible solutes in the cytoplasm to maintain the osmotic balance in saline ***,this w.rk is an initial exploration to the molecular basis of the heterotrophic protist responding to salinity *** result sheds light on the mechanisms of enhancement of cell protection,reduction of cell activity,and osmotic pressure regulation in ciliates acclimated to salinity.

关键词： salinity stress heterotrophic protist ciliate Gastrostyla setifera transcriptome differentially expressed gene

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Machine learning for membrane design and discovery

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Green Energy & Environment 2024年第1期9卷 54-70页

作者： Haoyu Yin Muzi Xu Zhiyao Luo Xiaotian bi Jiali Li Sui Zhang Xiaonan w.ng Department of Chemical Engineering Tsinghua University100084BeijingChina School of Materials Science&Engineering Tsinghua University100084BeijingChina Department of Chemical and biomolecular Engineering National University of SingaporeSingapore117576Singapore

Membrane technologies are becoming increasingly versatile and helpful today for sustainable *** Learning(ML),an essential branch of artiﬁcial intelligence(AI),has substantially impacted the research and development norm of new.materials for energy and *** review.provides an overview.and perspectives on ML methodologies and their applications in membrane design and dis-covery.A brief overview.of membrane technologies isﬁrst provided w.th the current bottlenecks and potential *** an appli-cations-based perspective of AI-aided membrane design and discovery,w. further show.how.ML strategies are applied to the membrane discovery cycle(including membrane material design,membrane application,membrane process design,and know.edge extraction),in various membrane systems,ranging from gas,liquid,and fuel cell separation ***,the best practices of integrating ML methods and speciﬁc application targets in membrane design and discovery are presented w.th an ideal paradigm *** challenges to be addressed and prospects of AI applications in membrane discovery are also highlighted in the end.

关键词： Machine learning Membranes AI for Membrane Data-driven Design

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Mediated electron transfer process in α-MnO_(2)catalyzed Fenton-like reaction for oxytetracycline degradation

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Chinese Chemical Letters 2024年第8期35卷 367-372页

作者： Yiqian Jiang Zihan Yang Xiuru bi Nan Yao Peiqing Zhao Xu Meng State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

In Fenton-like oxidation,the catalyst directly influences the reaction mechanism for the degradation of pollutants from ***,a α-MnO_(2)catalyst(OAm-1)w.s synthesized via a self-assembly method w.th the assistance of a ***-1 possessed a large specific surface area of_(2)21 m2/g,abundant mesoporous structures and a large proportion of Mn(III).Further characterization exhibited that OAm-1 had abundant oxygen vacancies and excellent reducibility and *** adsorption and catalytic ability of OAm-1 w.re studied in the degradation of oxytetracycline(OTC)via the activation of hydrogen peroxide(H_(2)O_(2)).Through the radical quenching experiments,electron resonance spectroscopy(EPR),X-ray photoelectron spectroscopy(XPS)and Fourier-transform infrared spectroscopy(FT-IR)analysis,Mn(III)of OAm-1 w.s proved to be the active sites for the chemisorption of *** electrochemical ex-periments and analysis have show. that a process of electron transfer mediated by OAm-1 occurred be-tw.en the pollutant and H_(2)O_(2)during a Fenton-like *** w.rk experimentally verifies the elec-tron transfer process dominated nonradical mechanism overα-MnO_(2),w.ich is helpful for understanding the catalytic mechanism of the Fenton-like oxidation.

关键词： Mediated electron transfer Hydrogen peroxide Oxidative degradation Manganese oxide Fenton oxidation

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Hybrid ion/electron interfacial regulation stabilizes the cobalt/oxygen redox of ultrahigh-voltage lithium cobalt oxide for fast-charging cyclability

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Science Bulletin 2024年第13期69卷 2071-2079页

作者： Zhihong bi Anping Zhang Gongrui w.ng Cong Dong Pratteek Das Xiaoyu Shi Zhong-Shuai w. State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory of Clean Energy Chinese Academy of SciencesDalian 116023China

High-voltage and fast-charging LiCoO_(2)(LCO)is key to high-energy/pow.r-density Li-ion ***,unstable surface structure and unfavorable electronic/ionic conductivity severely hinder its high-voltage fast-charging ***,w. construct a Li/Na-B-Mg-Si-O-F-rich mixed ion/electron interface netw.rk on the 4.65 V LCO electrode to enhance its rate capability and long-term cycling ***,the resulting artificial hybrid conductive netw.rk enhances the reversible conversion of Co^(3+)/^(4+)/O_(2)/nredox by the interfacial ion–electron cooperation and suppresses interface side reactions,inducing an ultrathin yet compact cathode electrolyte ***,the derived near-surface Na+/Mg2+/Si^(4+)-pillared local intercalation structure greatly promotes the Li^(+)diffusion around the 4.55 V phase transition and stabilizes the cathode ***,excellent 3 C(1 C=274 mA g1)fast charging performance is demonstrated w.th 73.8%capacity retention over 1000 *** findings shed new.insights to the fundamental mechanism of interfacial ion/electron synergy in stabilizing and enhancing fast-charging cathode materials.

关键词： High-voltage Fast-charging LiCoO_(2) Interfacial ion-electron cooperation Local intercalation

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The pseudospectrum and spectrum(in)stability of quantum corrected Schw.rzschild black hole

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 55-75页

作者： Li-Ming Cao Jia-Ning Chen Liang-bi w. Libo Xie Yu-Sen Zhou School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Peng Huanw. Center for Fundamental Theory Hefei 230026China Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

In this study,w. investigate the pseudospectrum and spectrum(in)stability of quantum corrected Schw.rzschild black ***,w. use the hyperboloidal framew.rk to cast the quasinormal mode(QNM)problem into an eigenvalue problem associated w.th a non-selfadjoint operator,and then the spectrum and pseudospectrum are ***,the invariant subspace method is exploited to improve the computational efficiency for *** investigation into the spectrum(in)stability entails tw. main *** the one hand,w. calculate the spectra of the quantum corrected black hole,then by the means of the migration ratio,the impact of the quantum correction effect on the Schw.rzschild black hole has been *** results indicate that the so-called“migration ratio instability”w.ll occur for small black holes w.th small angular momentum number *** the eikonal limit,the migration ratios remain the same for each *** the other hand,w. study the spectrum(in)stability of the quantum corrected black hole by directly adding some particular perturbations into the effective potential,w.ere perturbations are located at the event horizon and null infinity,*** are tw. interesting observations under the same perturbation energy ***,perturbations at infinity are more capable of generating spectrum instability than those at the event ***,w. find that the peak distribution can lead to the instability of QNM spectrum more efficiently than the average distribution.

关键词： quasinormal modes pseudospectrum hyperboloidal coordinate

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Computational Experiments for Complex Social Systems:Integrated Design of Experiment System

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1175-1189页

作者： Xiao Xue Xiangning Yu Deyu Zhou Xiao w.ng Chongke bi Shufang w.ng Fei-Yue w.ng College of Intelligence and Computing Tianjin UniversityTianjin 300350China School of Softw.re Shandong UniversityJinan 250101China School of Artificial Intelligence Anhui UniversityHefei 230601China School of Geographic and Environmental Sciences Tianjin Normal UniversityTianjin 300387China Institute of Automation Chinese Academy of Sciences Beijing 100190China

Pow.red by advanced information industry and intelligent technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).And human factors have become crucial in the operations of complex social *** mechanical analysis and social simulations alone are pow.rless for analyzing complex social *** this backdrop,computational experiments have emerged as a new.method for quantitative analysis of complex social systems by combining social simulation(e.g.,ABM),complexity science,and domain ***,in the process of applying computational experiments,the construction of experiment system not only considers a large number of artificial society models,but also involves a large amount of data and *** a result,how.to integrate various data,model and know.edge to achieve a running experiment system has become a key *** paper proposes an integrated design framew.rk of computational experiment system,w.ich is composed of four parts:generation of digital subject,generation of digital object,design of operation engine,and construction of experiment ***,this paper outlines a typical case study of coal mine emergency management to verify the validity of the proposed framew.rk.

关键词： artificial system operations

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Spark Plasma Sintering of Boron Carbide Using Ti_(3)SiC_(2) as a Sintering Additive

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Journal of w.han University of Technology(Materials Science) 2024年第3期39卷 645-650页

作者： Hülya biçer Mustafa Tuncer Hasan Göçmez Iurii Bogomol Valerii Kolesnichenko Andrey Ragulya Kutahya Dumlupinar University School of EngineeringDepartment of Metallurgical and Materials EngineeringKütahya 43100Tur-key Boron Based Advanced Ceramics Application and Research Center Kütahya Dumlupınar UniversityKütahya 43100Turkey Advanced Technologies Center(İLTEM) Kütahya Dumlupınar UniversityKütahya 43000Turkey Department of High-Temperature Ma-terials and Pow.er Metallurgy National Technical University of Ukraine“Igor Sikorsky Kyiv Polytechnic Institute”Kyiv 03056Ukraine Frantsevich Institute for Problems of Materials Science National Academy of Sciences of UkraineKyiv 03056Ukraine

Boron carbide has unique properties for w.de application possibilities;how.ver,poor sinterability limits its *** approach to overcome this limitation is the addition of secondary phases into boron *** carbide based composite ceramics are produced by the direct addition of secondary phases into the structure or via reactive sintering using a sintering *** present study investigated the effect of Ti_(3)SiC_(2) addition to boron carbide by reactive spark plasma sintering in the range of 1700-1900℃.Ti_(3)SiC_(2) phase decomposed at high temperatures and reacted w.th B4C to form secondary phases of TiB2 and *** results demonstrated that the increase of Ti_(3)SiC_(2) addition(up to 15 vol%)effectively promoted the densification of B4C and yielded higher ***,as the amount of Ti_(3)SiC_(2) increased further,the formation of microstructural inhomogeneity and agglomeration of secondary phases caused a decrease in hardness.

关键词： reactive sintering SPS boron carbide MAX phase

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Boosting spring runoff into the sea by reservoir regulation and its potential for estuarine fishery recovery

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Science China Earth Sciences 2024年第5期67卷 1591-1603页

作者： Xiao w. Houjie w.NG Yongyong FAN Naishuang bi Chiyuan MIAO Jingping XU Zuosheng YANG College of Marine Geosciences Key Laboratory of Submarine Geosciences and Prospecting Technologyand Frontiers Science Center for Deep Ocean Multispheres and Earth SystemOcean University of ChinaQingdao 266100China Laoshan National Laboratory Qingdao 266061China Institute of the Yellow.River Estuary and Coast Science Dongying 257000China State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Department of Ocean Science&Engineering Southern University of Science and TechnologyShenzhen 518055China

w.th global surge in reservoir construction over the past decades,river systems w.rldw.de have been profoundly ***,flow.manipulation by reservoirs has altered the natural hydrological processes,resulting in extensive modifications of fluvial-marine *** the adverse ecological consequences of reservoirs has become a global concern and has garnered increasing *** Yellow.River,as one of the most extensively manipulated river systems globally,has experienced substantial changes in the amount and timing of w.ter discharge due to the presence of numerous reservoirs scattered throughout its catchment *** alterations have caused physicochemical changes in the estuary and subsequent modifications to the estuarine *** recent years,the Yellow.River Conservancy Committee initiated the release of w.ter through the Xiaolangdi Dam during the major spaw.ing period of fisheries,specifically in the spring,w.th the aim of improving the estuarine ecological *** 2011 to 2020,a total of 84.05 km^(3)of w.ter w.s discharged from the Xiaolangdi Reservoir during spring seasons,of w.ich 40%(33.16 km^(3))constituted w.ter impounded w.thin the reservoir during preceding ***,the spring w.ter discharge from the Yellow.River to the sea increased significantly from 1.50 km^(3)/yr to 3.46 km^(3)/yr in the past decade,leading to a decrease in estuarine salinity by 1.6 *** estuarine fishery resources,such as fish eggs in the Yellow.River estuary,have demonstrated evident *** reservoir regulation in the Yellow.River,w.ich has successfully enhanced spring w.ter discharge and subsequently restored estuarine fishery resources,presents an effective attempt for mitigating the adverse ecological effects associated w.th reservoirs.

关键词： Reservoir regulation w.ter release Spring runoff Estuarine ecosystem Yellow.River

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Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

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Genes & Diseases 2024年第5期11卷 198-218页

作者： Han Sun Yafang Gao Xinyu Ma Yizhou Deng Lintao bi Lisha Li Department of Hematology and Oncology China-Japan Union HospitalJilin UniversityChangchunJilin 130021China The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchunJilin 130021China

Mechanical stimulation is the key physical factor in cell *** acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specific signature alterations during the pathological *** research continues,the role of epigenetic science in mechanotransduction is attracting ***,the molecular mechanism of the synergistic effect betw.en mechanotransduction and epigenetics in physiological and pathological processes has not been *** focus on how.histone modifications,as important components of epigenetics,are coordinated w.th multiple signaling pathw.ys to control cell fate and disease ***,w. propose that histone modifications can form regulatory feedback loops w.th signaling pathw.ys,that is,histone modifications can not only serve as dow.stream regulators of signaling pathw.ys for target gene transcription but also provide feedback to regulate signaling *** and epigenetic changes could be potential markers and therapeutic targets in clinical practice.

关键词： FAK Histone modifications MAPK Mechanotransduction RhoA w.T/b-catenin YAP/TAZ

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