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Asian Pacific Journal of Tropical medicine 2021年第2期14卷 64-72页

作者： muhammad Zubair Shabbir Ruth Helmus Nissly Abdul Ahad masood Rabbani Levina Lim Shubhada K.Chothe murugan Subbiah Aswathy Sebastian Istvan Albert Aziz Ul-Rahman bhushan m jayarao Suresh V.Kuchipudi University of Veterinary and Animal Sciences LahorePakistan Animal Diagnostic Laboratory Department of Veterinary and Biomedical Sciencesthe Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Chattogram Veterinary and Animal Sciences University ChattogramBangladesh Bioinformatics Consulting Center the Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Veterinary and Animal Sciences Muhammad Nawaz Shareef University of AgricultureMultanPakistan

Objective:To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1(AOAV-1)isolates from poultry workers with respiratory ***:Using Illumina mi Seq,whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates.A phylogenetic and comparative analysis of all coding genes was done using bioinformatics ***:Phylogenetic analysis and genetic distance estimation suggested a close relationship among human-and avian-originated velogenic strains of genotypeⅩⅢ,sub-genotypeⅩⅢ.*** substitutions in the significant structural and biological motifs were exclusively identified in the human-originated ***:To our knowledge,this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory *** findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.

关键词： Avian orthoavulavirus 1 Human originated strain Zoonotic potential Evolution GenotypeⅩⅢ Poultry workers

Histochemical pattern of gastrocnemius muscle in fluoride toxicity syndrome

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Asian Pacific Journal of Tropical medicine 2010年第2期3卷 136-140页

作者： Shashi A bhushan B Bhardwaj m Department of Zoology Punjabi University

Objective:To evaluate the effect of sodium fluoride(NaF) on cytochemical distribution of proteins,DNA,and RNA in the gastrocnemius muscle of rat in experimental ***: Young Sprague Dawley albino rats were administered with NaF at 30,45,and 75 mg/kg bw/ day subcutaneously for 15 and 30 days,*** control animals were given the vehicle(1cc deionized double distilled water/kg bw/day).Results:In the first phase of 15 days experimentation,the gastrocnemius muscle of rats intoxicated with NaF at 30,45,and 75 mg /kg bw/ day showed decline in proteins including a amino acids as compared to control. In the second phase of 30 days experimentation,the muscle fibers of rat showed elevation in sarcolemmal and sarcoplasmic proteins in 30 mg NaF dose group,and angulated fibers exhibited increase in sarcolemmal proteins in 45 mg NaF *** marginal regions of angular and rim fibers showed deeply stained rings of sarcoplasmic proteins whereas the split fibers were faindy stained in rats treated with NaF at 75 mg/kg bw/day for 30 *** rats treated with NaF at 30 mg/kg bw/day for 15 days,the hypertrophied peripheral muscle fibers contained more DNA,however the atrophied fibers had more *** 45 mg NaF group,RNA was located in sarcolemmal regions,while DNA content decreased as compared to *** 75 mg NaF group,the muscle fibers had dark and light staining regions of DNA and *** the 30 days of experimentation,the DNA level decreased whereas RNA content increased in the gastrocnemius muscle fibers of the rat treated with NaF at 30 mg/kg bw/*** treatment group with NaF at 45 mg/kg bw/day,the RNA content slighdy declined in comparison to control,in all treatments for 15 days as well as in treatment group with NaF at 30 mg/kg bw/day for 30 days whereas the amount of DNA slightly increased as compared to treatment group with NaF at 75 mg/kg bw/day for 15 *** highest dose group revealed elevated amount of RNA whereas DNA content remained stable.C

关键词： Albino rats DNA Gastrocnemius muscle Proteins RNA Sodium fluoride

Recent Advancements in the Development of Self Healing Concrete-A Systematic Review

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Journal of Wuhan University of Technology(materials Science) 2024年第6期39卷 1449-1460页

作者： A Ravi Theja m Srinivasula Reddy Bharat bhushan Jindal C Sashidhar Assistant Professor in SVR Engineering College NandyalAndhra PradeshIndia Associate Professor of Civil Engineering G Pulla Reddy Engineering CollegeKurnoolAPIndia Assistant Professor in School of Civil Engineering Shri Mata Vaishno Devi UniversityJammu and KashmirIndia Professor of Civil Engineering JNTU College of EngineeringJNTUAAnanthapuramuAndhra PradeshIndia

mechanical as well as durability properties are pivotal for any type of concrete which gets adversely affected due to cracks that may form due to loading beyond its *** has the intrinsic property to heal itself to some extent but not fully as the passive form of autogenous healing plays an inferior role for a complete repair of a cementitious *** self-healing capabilities can be enhanced by adding chemical admixtures,polymers,and bacteria strains induced calcium carbonate precipitation,*** this paper,the advancements in the development and performance of self-healing concrete using chemical admixtures,polymers,and bacteria strains are *** systematic review includes the available experimental tests and methodologies investigating self-healing efficiency over the last ***,this review focussed on self-healing materials,the ideology,and opinions of those in the construction field on the direction of self-healing concrete for future *** is yet not possible to predict the most appropriate technique,however,a generalized opinion about the effectiveness of the different approaches has been illustrated.

关键词： self-healing cracks bio-based healing chemical additives-based healing

And-hyperglycemic activity of leaves extract of Hyptis suavcolens *** in streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical medicine 2011年第9期4卷 689-693页

作者： Shanti bhushan mishra Amita Verma Alok mukerjee Vijayakumar m United Institute of Pharmacy UCERAllahabadIndia Faculty of Health Medical SciencesIndigenous & Alernative Systems of MedicineShiatsAllahabadIndia United Institute of Pharmacy UCER.AllahabadIndia Ethnopharmacology Division.National Botanical Research Institute LucknowIndia

Objective:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin ***:Hyptis suaveolens extract(HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes,once daily for 21 ***:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic *** of triglyceride,total cholesterol,low density *** low density lipoprotein were decreased while administering HSE at different doses,compared with their control values in diabetic ***:Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme.

关键词： Hyptis suaveolens Antidiabetic Ethanolic extract Glibenclamide Streptozotocin

Analytical approach to entropy generation and heat transfer in CNT-nanofluid dynamics through a ciliated porous medium

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Journal of Hydrodynamics 2018年第2期30卷 296-306页

作者： Noreen Sher Akbar m.Shoaib Dharmendra Tripathi Shashi bhushan O.Anwar Bég DBS&H CEME National University of Sciences and Technology School of Natural Sciences National University of Sciences and Technology Department of mechanical Engineering Manipal University medical Energy and Propulsion Engineering Sciences Department of Aeronautical and Mechanical Engineering University of Salford

The transportation of biological and industrial nanofluids by natural propulsion like cilia movement and self-generated contraction-relaxation of flexible walls has significant applications in numerous emerging technologies. Inspired by multi-disciplinary progress and innovation in this direction, a thermo-fluid mechanical model is proposed to study the entropy generation and convective heat transfer of nanofluids fabricated by the dispersion of single-wall carbon nanotubes（SWCNT） nanoparticles in water as the base fluid. The regime studied comprises heat transfer and steady, viscous, incompressible flow, induced by metachronal wave propulsion due to beating cilia, through a cylindrical tube containing a sparse（i.e., high permeability） homogenous porous medium. The flow is of the creeping type and is restricted under the low Reynolds number and long wavelength approximations. Slip effects at the wall are incorporated and the generalized Darcy drag-force model is utilized to mimic porous media effects. Cilia boundary conditions for velocity components are employed to determine analytical solutions to the resulting non-dimensionalized boundary value problem. The influence of pertinent physical parameters on temperature, axial velocity, pressure rise and pressure gradient, entropy generation function, Bejan number and stream-line distributions are computed numerically. A comparative study between SWCNT-nanofluids and pure water is also computed. The computations demonstrate that axial flow is accelerated with increasing slip parameter and Darcy number and is greater for SWCNT-nanofluids than for pure water. Furthermore the size of the bolus for SWCNT-nanofluids is larger than that of the pure water. The study is applicable in designing and fabricating nanoscale and microfluidics devices, artificial cilia and biomimetic micro-pumps.

关键词： metachronal wave single-wall carbon nanotubes (SWCNT) entropy generation porous medium cilia motion heat transfer Bejan number

Overview of perspectives on cancer,newer therapies,and future directions

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Oncology and Translational medicine 2024年第3期10卷 105-109页

作者： Rajeev m.Joshi bhushan Telang Gagan Soni Asma Khalife Department of General Surgery T.N.Medical College&B.Y.L.Nair Charitable HospitalMumbaiIndia Department of Surgical Oncology Government Cancer Hospital AurangabadMaharashtraIndia Department of Surgical Disciplines All India Institute of Medical ScienceNew DelhiIndia

Theword“cancer”is associated with terrifying situations,and there is often an aggressive intent to *** about survival and fear of disfigurement cause major turmoil in the minds of patients and *** with multimodal care is the key to achieving satisfactory *** imaging modalities have aided in early detection and derivation of optimal treatment *** radical excision of tumors with neoadjuvant or concurrent chemotherapy/radiotherapy has long been the best management option,we have moved froma radical to a conservative *** advanced disease,the plan should be to provide supportive care and improve quality of *** and counseling play important *** support for correcting cancer cachexia is equally important during tumor *** therapies such as targeted therapy,stem cell therapy,and chemodynamic therapy are all focused on ensuring safe and efficient outcomes;however,the war against cancer continues to oscillate between hope and despair.

关键词： Cancer modern medicine Preventive oncology Psychology Nutrition

Integrated physiological and molecular approaches to improvement of abiotic stress tolerance in two pulse crops of the semi-arid tropics

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The Crop Journal 2018年第2期6卷 99-114页

作者： arbind k.choudhary rafat sultana m.isabel vales kul bhushan saxena ravi ranjan kumar pasala ratnakumar ICAR Research Complex for Eastern Region Patna 800 014India Bihar Agricultural University SabourBhagalpur 813 210India Texas A&m University College StationTX 77845USA International Crops Research Institute for the Semi-Arid Tropics Patancheru 502 324India National Institute of Abiotic Stress management Baramati 413 115India

Chickpea(Cicer arietinum L.) and pigeonpea [Cajanus cajan L.(millsp.)] play an important role in mitigating protein malnutrition for millions of poor vegetarians living in regions of the semi-arid tropics. Abiotic stresses such as excess and limited soil moisture(water-logging and drought), heat and chilling(high and low temperature stresses), soil salinity, and acidity are major yield constraints, as these two crops are grown mostly under rainfed conditions in risk-prone marginal and degraded lands with few or no inputs. Losses due to such stresses vary from 30% to 100% depending on their severity. The literature abounds in basic information concerning screening techniques, physiological mechanisms, and genetics of traits associated with resistance/tolerance to abiotic stresses in these two crops. However, the final outcome in terms of resistant/tolerant varieties has been far from satisfactory. This situation calls for improving selection efficiency through precise phenotyping and genotyping under high-throughput controlled conditions using modern tools of genomics. In this review, we suggest that an integrated approach combining advances from genetics, physiology, and biotechnology needs to be used for higher precision and efficiency of breeding programs aimed at improving abiotic stress tolerance in both chickpea and pigeonpea.

关键词： Abiotic stresses Chickpea Genomics Genotyping Integrated approach Pigeonpea

Assessment of tree diversity and above-ground biomass in coffee agroforest dominated tropical landscape of India's Central Western Ghats

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Journal of Forestry Research 2020年第3期31卷 1005-1015页

作者： Guddappa m.Devagiri Anil Kumar Khaple Hosuru B.Anithraj Cheppudira G.Kushalappa Amaresh Kumar Krishnappa Shashi bhushan mishra College of Forestry University of Agricultural and Horticultural SciencesShivamoggaPonnampetKodaguKaranataka 571216India

The purpose of this study was to quantify the changes in tree diversity and above-ground biomass associated with six land-use types in Kodagu district of India's Western Ghats. We collected data on species richness,composition and above-ground biomass(AGB) of trees,shrubs and herbs from 96 sample plots of 0.1 ha. Totals of83 species from 26 families were recorded across the landuses. Tree species richness, diversity and composition were significantly higher in evergreen forest(EGF) than in other land-uses. Similarly, stem density and basal area were greater in EGF compared to other land-uses. Detrended correspondence analysis(DCA) yielded three distinct groups along the land-use intensities and rainfall gradient on the first and second axes, respectively. The first DCA axis accounted for 45% and second axis for 35% of the total variation in species composition. Together the first two axes accounted for over 2/3 of the variation in species composition across land-use types. Across the land-uses,AGB ranged from 58.6 mg ha-1 in rubber plantation to327.3 mg ha-1 in evergreen forest. Our results showed that species diversity and AGB were negatively impacted bythe land-use changes. We found that coffee agroforests resembled natural forest and mixed species plantation in terms of tree diversity and biomass production, suggesting that traditional coffee farms can help to protect tree species, sustain smallholder production and offer opportunities for conservation of biodiversity and climate change mitigation.

关键词： Western Ghats Coffee agroforest Land-use changes Diversity Above-ground biomass Carbon

Content analysis of state hazard mitigation plans and their ability to address pandemics

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Emergency management Science and Technology 2022年第1期2卷 101-111页

作者： bhushan Pawar michelle meyer Qingsheng Wang mary Kay O’Connor Process Safety Center Artie McFerrin Department of Chemical EngineeringTexas A&M UniversityCollege StationTX 77843-3122USA Hazard Reduction and Recovery Center Department of Landscape Architecture and Urban PlanningTexas A&M UniversityCollege StationTX 77843-3137USA

Hazard mitigation plans address hazards such as earthquakes,hurricanes,landslides,tornados,flooding more explicitly than pandemics or other public health *** paper analyzes and identifies pandemic-related mitigation strategies in state-level hazard mitigation plans across the United *** study identifies common and uncommon strategies that could be included in plan updates such as:use of personal protective equipment(PPE),self-isolation/quarantine,hygiene,restricted gatherings,vaccination,vulnerability assessment,economic consequences analysis,acknowledging the need to address pandemics,and referring Centers for Disease Control and Prevention(CDC)*** 54 statelevel plans are compared based on their inclusion of the nine *** show that vaccination,self-isolation/quarantine,and vulnerability assessment are the strategies most listed in *** concerns made evident by the 2020 coronavirus pandemic,such as contact tracing,environmental impact,and public services,were limited across the *** was concluded that long-term mitigation strategies for reducing the risk and speed of spread such as identifying strategic locations for testing,vaccination,and quarantine should be devised and *** should be included as a distinct class of hazards while formulating state hazard mitigation *** for addressing the impact of long working hours on the mental health of healthcare workers should be *** and psychological impact of unavailability of essential public services,such as transport and groceries,should be investigated and strategies should be formulated in the mitigation plans accordingly.

关键词： hazard state analysis

Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets

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Asian Journal of Pharmaceutical Sciences 2015年第3期10卷 239-246页

作者： Pankaj Kumar Ashok Laxmanrao Ganure Bharat bhushan Subudhi Shubhanjali Shukla Pooja Upadhyay School of Pharmaceutical Sciences Siksha O Anusandhan UniversityKhandagiri SquareBhubaneswarOrissa 751030India Sahyadri College of Pharmacy SangolaSolapurM.S.413307India Department of Pharmaceutics Indian Institute of Technology(Banaras Hindu University)Varanasi 221005India Department of Advanced Pharmaceutical Science Manipal UniversityKarnataka 576104India

The present work deals with the development of controlled release tablets of salbutamol sulphate(SS)using graft copolymers of methyl methacrylate(St-g-PmmA and Ast-g-PmmA)on starch and acetylated *** were evaluated for physical characteristics like hardness,friability,drug release,drug content and weight variations,which fulfilled all the official requirements of tablet dosage *** release rates from formulated matrix tablets were studied at SGF(pH 1.2)followed by SIF(pH 6.8).Drug release from the graft copolymer based tablets was found to be sustained upto the 14 h with>75%drug *** in-vitro release study showed that the graft copolymer based matrix formulations(F3&F4)exhibited highest correlation value(r2)for higuchi kinetic model and Korsmeyer's model with n values between 0.61 and 0.67 proved that release mechanisms were governed by both diffusion and erosion *** was no significant difference in the pharmacokinetic parameters(tmax,Cmax,AUC,Ke,and t1/2)of the graft copolymers matrices and HPmC K100m matrix tablets,indicating their comparable sustained release *** potential of graft copolymers to sustain the drug release is well supported by in-vivo pharmacokinetic studies and their adequate physicochemical properties make them promising excipients for controlled drug delivery system.

关键词： Salbutamol sulphate methyl methacrylate Graft copolymers Acetylated starch Korsmeyer's model In vitro and in vivo