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Assessment of correlation between serum titers of hepatitis c virus and severity of liver disease

World Journal of Gastroenterology 2004年第16期10卷 2409-2411页

作者： bhupinders.anand MariaVelez Department of Medicine V.A.Medical Center and Baylor College of MedicineHoustonTexas 77030USA

AIM:The significance of hepatitis C virus (HCV) serum titers has been examined in several clinical situations. There is much evidence that patients with a lower viral load have better response rates to anti-viral therapy compared to those with higher ***,a direct association has been observed between serum titers of HCV and transmission rates of the *** aim of the present study was to determine if there was any correlation between HCV viral load and the severity of liver disease. METHODS:Fifty patients with HCV infection were included in the *** comprised of 34 subjects with a history of alcohol use and 16 *** serum HCV RNA assay was carried out using the branched DNA (bDNA) *** regression analysis was performed between serum viral titers and liver *** addition,for the purpose of comparison,the subjects were divided into two groups:those with low viral liters (≤50 genome mEq/mL) and high titers (>50 mEq/mL). RESULTS:All subjects were men,with a mean±SD age of 47±7.8 *** mean HCV RNA level in the blood was 76.3×10~5±109.1 genome equivalents/*** was no correlation between HCV RNA levels and age of the patients (r=0.181),and the history or amount (g/d) of alcohol consumption (r=0.07).Furthermore,no correlation was observed between serum HCV RNA levels and the severity of liver disease as judged by the values of serum albumin (r=0.175),bilirubin (r=0.217),ALT (r=0.06) and AST (r=0.004) ***,no significant difference was observed between patients with low viral titers and high liters with respect to any of the parameters. CONCLUSION:Our results indicate that the severity of liver disease is independent of serum levels of hepatitis C *** findings are important since they have a direct impact on the current debate regarding the role of direct cytopathic effect of hepatitis C virus versus immune-mediated injury in the pathogenesis of HCV-related liver damage.

关键词： Adult Alanine Transaminase Alcohol Drinking Aspartate Aminotransferases Diagnosis, Differential Genome, Viral Hepacivirus purification Hepatitis C Humans Liver Diseases Liver Function Tests Middle Aged RNA, Viral Regression Analysis Severity of Illness Index Viral Load

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