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Potential of triptolide in reproductive management of the house rat,Rattus rattus

Integrative Zoology 2013年第3期8卷 260-276页

作者： Neena SINGLA Gaganpreet kaur bhupinder kaur babbar bhupinder Singh SANDHU Department of Zoology Punjab Agricultural UniversityLudhianaIndia Department of Veterinary Pathology Guru Angad Dev Veterinary and Animal Science UniversityLudhianaIndia

Mature and healthy male house rats,Rattus rattus(n=160)were fed on bait(cracked wheat:powdered sugar,98:2)containing different concentrations of triptolide(0.1,0.05,0.025 and 0%)for 7 and 14 days in no-choice and bi-choice feeding tests in the *** objective of the study was to record the antifertility affects of triptolide after 30 and 60 days of termination of *** revealed no significant effect of triptolide treatment on weights of testis,epididymis,seminal vesicles and prostate gland of ***,sperm motility,live sperm count,sperm density and sperm morphology in the cauda epididymal fluid were found to differ significantly(P≤0.05)between untreated and treated groups of *** major effect of triptolide on sperm morphology was in the form of sperm head tail separation,which was up to 56.0%in rats treated for 14 days in no-choice and autopsied after 30 days.A significant effect(P≤0.05)of triptolide treatment was observed on the histomorphology of the testis,which included a dose-dependent decrease in diameter of seminiferous tubules,thickness of germinal epithelium and numbers of various spermatogenic *** associations in the seminiferous epithelial cycle were poorly developed in rats ingesting medium(4.7-5.1 mg/100 g bw)and high doses(6.9-7.2 mg/100 g bw)of triptolide than rats ingesting low doses(1.8-2.3 mg/100 g bw)and untreated *** cell stages affected had not recovered fully within the 60 day period following triptolide *** present study suggests the potential of triptolide in reproductive management of Rattus rattus.

关键词： Rattus rattus reproductive organs seminiferous tubules sperm parameters triptolide

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Infections in Alcoholic Hepatitis

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 718-725页

作者： bhupinder kaur Russell Rosenblatt Vinay Sundaram Internal Medicine Department Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNYUSA Department of Gastroenterology and Hepatology and Comprehen-sive Transplant Center Cedars-Sinai Medical CenterLos AngelesCAUSA

Severe alcoholic hepatitis (sAH) is defined by a modified discriminant function ≥32 or model for end-stage liver disease (MELD) >20. Patients with sAH are in an immu-nocompromised state attributed to cirrhosis-related immu-noparesis and corticosteroid use. Individuals with sAH often develop severe infections that adversely impact short-term prognosis. Currently, the corticosteroid prednisolone is the only treatment with proven efficacy in sAH;however, the combination of corticosteroid treatment and altered host defense in sAH has been thought to increase the risk of acquiring of bacterial, opportunistic fungal, and viral infec-tions. Newer studies have shown that corticosteroids do not increase occurrence of infections in those with sAH;unfor-tunately, the lack of response to corticosteroids may instead predispose to infection development. Prompt and appropri-ate antibiotic treatment is therefore essential to improving patient outcomes. This review highlights common infections and risk factors in patients with sAH. Additionally, current diagnostic, therapeutic, and prophylactic strategies in these patients are discussed.

关键词： Alcoholic hepatitis Infections Corticosteroids STOPAH Antibiotic treatment Aspergillosis Immunodeficiency Alcoholic liver disease

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Irritable bowel syndrome in children: Pathogenesis, diagnosis and evidence-based treatment

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World Journal of Gastroenterology 2014年第20期20卷 6013-6023页

作者： bhupinder kaur Shu Siba Prosad Paul Department of Pediatric Gastroenterology Bristol Royal Hospital for Children Bristol BS2 8BJ United Kingdom

Irritable bowel syndrome (IBS) is the commonest cause of recurrent abdominal pain (RAP) in children in both more developed and developing parts of the world. It is defined by the Rome III criteria for functional gastrointestinal disorders. It is characterized by abdominal pain that is improved by defecation and whose onset is associated with a change in stool form and or frequency and is not explained by structural or biochemical abnormalities. It is estimated that 10%-15% of older children and adolescents suffer from IBS. IBS can be considered to be a brain-gut disorder possibly due to complex interaction between environmental and hereditary factors. The diagnosis of IBS is made based on the Rome III criteria together with ruling out organic causes of RAP in children such as inflammatory bowel disease and celiac disease. Once the diagnosis of IBS is made, it is important to explain to the parents (and children) that there is no serious underlying disease. This reassurance may be effective treatment in a large number of cases. Lifestyle modifications, stress management, dietary interventions and probiotics may be beneficial in some cases. Although there is limited evidence for efficacy of pharmacological therapies such as antispasmodics and antidiarrheals; these have a role in severe cases. Biopsychosocial therapies have shown encouraging results in initial trials but are beset by limited availability. Further research is necessary to understand the pathophysiology and provide specific focused therapies.

关键词： Recurrent abdominal pain Irritable bowel syndrome Brain-gut disorder Lifestyle modifications Biopsychosocial therapies Children Rome III criteria

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Compatibility studies of the Thiocolchicoside with Eudragit RLPO,Eudragit E100 and Eudragit L100 using thermal and non-thermal methods

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Drug Combination Therapy 2022年第1期4卷 1-9页

作者： Nishant Thakur bhupinder kaur Manish Goswami Chandan Sharma University Institute of Pharma Sciences Chandigarh UniversityGharuanMohaliPunjab140413India Saraswati College of Pharmacy GharuanMohaliPunjab140413India

Aim:Thiocolchicoside is a sulfur derivative of the colchicine widely used as the skeletal muscle relaxant in variety of muscle related *** of the Thiocolchicoside is screened with the Eudragit RLPO,Eudragit L-100 and Eudragit E-100 for checking its suitability for formulating as transdermal drug delivery ***:The binary mixtures of the drug and polymers were placed in the Petri plates and the temperature and humidity were adjusted at 40℃±2℃ and 75%relative *** drug and polymer mixture were examined on the FTIR and DSC for detection of any possible physical and chemical ***:Eudragit E100 and L100showed no significant interaction with the Thiocolchicoside and that was justified with differential scanning calorimetryand Fourier transform ***,Eudragit RLPO showed a slight interaction with the drug during the compatibility studies.

关键词： Thiocolchicoside Relative humidity Eudragit Compatibility Fourier transform infrared Differential scanning calorimetry

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