检索结果-南通市图书馆

Elderly donor graft for liver transplantation:Never too late

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2017年第6期7卷 324-328页

作者： Harleen Chela Mohamad H Yousef Abdelmajeed A Albarrak bhupinder s romana Dania N Hudhud Veysel Tahan Department of Internal Medicine University of Missouri Division of Gastroenterology and Hepatology Missouri University

The definitive treatment for end stage liver disease remains a liver transplant and hence livers are needed for these patients along with cases of acute fulminant liver *** livers are a scarce and highly valuable commodity in the current *** extending the pool of donors to include the elderly livers,it allows for increased availability of donors and reduces the mortality that is associated with the waiting list *** is an increasing prevalence of end stage liver disease due to conditions like chronic hepatitis B and C,non-alcoholic steatohepatitis,alcoholic liver *** studies show non-inferior outcomes when elderly livers are used as a vigorous selection process is *** process takes into account the characteristics of the donor,graft and recipient allowing for appropriate donor-recipient *** meet the increasing demands of livers,elderly donors should be utilized for liver *** aim of this review article is to describe the aging process of the liver and the outcomes associated with use of elderly livers for transplantation.

关键词： Liver transplantation Donor age Elderly Age Outcome success

strength and deformation characteristics of steel fibrous concrete beams

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-science A(Applied Physics & Engineering) 2007年第2期8卷 257-263页

作者： sINGH bhupinder sINGH s.P. KAUsHIK s.K Department of Civil Engineering Indian Institute of Technology Roorkee 247 667 India Department of Civil Engineering National Institute of Technology Jalandhar 144 011 India

The results of an analytical investigation of the flexural behaviour of steel Fibre Reinforced Concrete （sFRC） beams are presented. The complete response of the sFRC beams under displacement controlled static loading was obtained using nonlinear Finite Element （FE） techniques implemented with the help of ATENA 2D soRware. Issues relating to the behaviour of sFRC which have a direct bearing on the FE modelling are discussed with relevance to the software employed for the nonlinear analysis. Constitutive models amenable to numerical analysis for steel fibrous concrete are presented. The structural response throughout the loading regime was captured in terms of the load-deflection behaviour, which in addition to the post-peak response characterized the failure mode of the test beams. The crack patterns at crack initiation and at the end of the tests were also recorded. Experimental results from the specimens of two other investigators were used as control values for this investigation. The response of the specimens of this investigation was evaluated in terms of initial tangent stiffness, peak loads and toughness. Good match was obtained between the results from this investigation and corresponding experimentally obtained values, wherever available. The influence of the fibre content is reflected in the observed trends in peak loads, deflection at peak loads and toughness, which are in broad agreement with known behavioral patterns of sFRC.

关键词： Analysis Deformation strength steel Fibre Reinforced Concrete (sFRC) Toughness

Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Methodology 2025年第2期15卷 137-144页

作者： Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra bhupinder s Kalra Vandana Roy Department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India Department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia Department of Central Animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND Epilepsy impacts millions of people,with many not responding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of rosuvastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electroshock seizure(MEs)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MEs model,rosuvastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or ***,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/*** Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关键词： Antiepileptic Anticonvulsant statins Rosuvastatin Maximal electroshock seizure Pentylenetetrazol

Improved simultaneous quantitation of candesartan and hydrochlorthiazide in human plasma by UPLC–Ms/Ms and its application in bioequivalence studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2014年第2期4卷 144-152页

作者： bhupinder singh Rama s.Lokhandae Ashish Dwivedi sandeep sharma Naveen Dubey Jubiliant Clinsys Limited NoidaNew DelhiIndia Jaipur National University JaipurIndia

A validated ultra-performance liquid chromatography mass spectrometric method （UPLC-Ms/Ms） was used for the simultaneous quantitation of candesartan （CN） and hydrochlorothiazide （HCT） in human plasma. The analysis was performed on UPLC-Ms/Ms system using turbo ion spray interface. Negative ions were measured in multiple reaction monitoring （MRM） mode. The analytes were extracted using a liquid-liquid extraction （LLE） method by using 0.1 mL of plasma volume. The lower limit of quantitation for CN and HCT was 1.00 ng/mL whereas the upper limit of quantitation was 499.15 ng/mL and 601.61 ng/mL for CN and HCT respectively. CN d4 and HCT-13Cd2 were used as the internal standards for CN and HCT respectively. The chromatography was achieved within 2.0 min run time using a C18 Pheno-menex, Gemini NX （100 mm ~ 4.6 mm, 5 mm） column with organic mixture：buffer solution （80：20, v/v） at a flow rate of 0.800 mL/min. The method has been successfully applied to establish the bioequivalence of candesartan cilexetil （CNC） and HCT immediate release tablets with reference product in human subjects.

关键词： Candesartan cilexetil Hydrochlorothiazide UPLC Ms/Ms Bioequivalence Candcsartan cilexetil-hydrochlorothiazide(ATACAND HCT)

Impact of all oral anti-hepatitis C virus therapy:A metaanalysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第5期7卷 806-813页

作者： siddharth Bansal Ashwani K singal Brendan M Mc Guire bhupinder s Anand Department of Internal Medicine University of Alabama Birmingham Department of Gastroenterology and Hepatology University of Alabama Birmingham Department of Gastroenterology and Hepatology Michael E.DeB akey VA Medical Center and Baylor College of Medicine

AIM:To investigate the efficacy,safety,and cost of treatment of direct acting antivirals(DAAs) with and without peg interferon alfa2a(P),and/or ribavirin(R) in treating hepatitis C virus(HCV) genotype 1 ***:MEDLINE was searched for randomized controlled trials(RCT) using DAAs for HCV *** 1 trials and studies with investigational drugs on genotype 2 or 3,and on human immunodeficiency virus patients were *** were pooled for sustained virologic response(sVR),serious adverse effects,and drug discontinuation rate on various treatment arms in trials:P + R;1st generation DAA(telaprevir or boceprevir) + P + R;2nd generation DAA(sofosbuvir or simeprevir) + P + R;2nd generation DAA + R;two 2nd generation DAA + R;and two 2nd gen *** were analyzed separately for each arm for treatment naive and non-responders(NR) to previous *** cost of treatment with each regimen for achieving one sVR was also ***:Twenty three RCTs(n = 9354,62% male,11% cirrhosis) were *** oral(P free) regimens with combination of 2 DAA achieved sVR above 95%.The cost of treatment to achieve an sVR with DAA based regimens was lower for NR compared to P+R ***,the cost per sVR remained higher for treatment naive ***:second generation and emerging DAAs are promising agents in HCV treatment,with a very high level of safety and *** important drawback is their high ***,the present meta-analysis shows that the cost per sVR for non responders(but not for naive patients) was lower compared to P + *** finding together with the superior safety profile and better compliance makes these drugs highly *** is possible that further reduction in treatment duration may make them even more cost effective.

关键词： Hepatitis C Meta-analysis Direct actingantivirals Oral agents Newer agents Hepatitis C virus

Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2014年第5期4卷 316-324页

作者： Ashish Dwivedi bhupinder singh sandeep sharma R.s.Lokhandae Naveen Dubey Bioanalytical Department Jubilant Life SciencesC-46Sector 62Noida 201307India Jaipur National University JaipurIndia

A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquid-liquid extraction step. The precursor to product ion transitions of m/z 705.3/392.3, m/z 721.2/408.3 and m/z 708.2/435.4 were used to detect and quantify itraconazole, hydroxy itraconazole and itraconazole-d3 respectively. The lower limit of quantitation was found to be 0.500 ng/mL for itraconazole and 1.00 ng/mL for hydroxy itraconazole. The mean recoveries for itraconazole and hydroxy itraconazole were found to be 100.045% and 100.021%, respectively. This developed method with a chromatographic run time of 2.0 min was successfully applied to a bioequivalence study of 100 mg itraconazole capsule.

关键词： Itraconazole,Hydroxy itraconazole,Ultra-performance liquidchromatography, Human plasma simultaneous analysis

Tubulovillous adenoma of anal canal: A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第11期12卷 1780-1781页

作者： bhupinder s Anand Gordana Verstovsek George Cole Departments of Medicine Pathology and surgery Michael E.DeBakey Veterans Administration Medical Center and Baylor College of MedicineHoustonTexasUnited States

Tumors arising from the anal canal are usually of epithelial origin and are mostly squamous cell carcinoma or basal cell carcinoma. We present a case of benign anal adenomas arising from the anus, an extremely rare diagnosis. A 78-year-old white man presented with rectal bleeding of several months duration. Examination revealed a 4 cm friable mass attached to the anus by a stalk. At surgery, the mass was grasped with a Babcock forceps and was resected using electrocautery. Microscopic examination revealed a tubulovillus adenoma with no areas of high grade dysplasia or malignant transformation. The squamocolumnar junction was visible at the edges of the lesion confirming the anal origin of the tumor. We believe the tubulovillus adenoma arose from either an anal gland or its duct that opens into the anus. Although seen rarely, it is important to recognize and treat these tumors at an early stage because of their potential to transform into adenocarcinoma.

关键词： Tubulovillous adenoma Anal canal

Bibliometric analysis of biochar research in 2021:a critical review for development,hotspots and trend directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biochar 2023年第1期5卷 102-122页

作者： Ping Wu bhupinder Pal singh Hailong Wang Zhifen Jia Yujun Wang Wenfu Chen Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China school of Environmental and Rural science University of New EnglandArmidaleNSW 2351Australia school of Environmental and Chemical Engineering Foshan UniversityFoshan 528000GuangdongChina University of Chinese Academy of sciences Beijing 100049China Key Laboratory of soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008JiangsuChina Biochar Engineering and Technology Research Center of Liaoning Province Rice Research InstituteAgronomy CollegeShenyang Agricultural UniversityShenyang 110866LiaoningChina Institute of Eco-Environmental and soil sciences Guangdong Academy of SciencesGuangzhou 510650China

As a bioproduct from the thermal decomposition of biomass,biochar has various applications in diversified *** this study,a bibliometric analysis was conducted to visualize the current research status and trends of biochar research.A total of 5535 documents were collected from the Web of science Core Collection and subjected to visualization analysis for the biochar field’s development in 2021 with Citespace *** visual analysis results demonstrate that the number of publications expanded dramatically in 2021,and the growth trend would *** and UsA were the most contributing countries in biochar research in terms of the number of *** on the keyword co-occurrence analyses,“Biochar for toxic metal immobilization”,“Biochar-based catalyst for biofuel production”,“Biochar for global climate change mitigation”,“Biochar for salinity and drought stress amelioration”,“Biochar amendment in composting”,and“Biochar as additives in anaerobic digestion”were the main research trends and hotspots in this field in *** indicates that the biochar research was *** the research hotspots,the employment of biochar as heterogeneous catalysts for biofuel production gained great attention in *** the contrary,bioremediation using functional bacteria immobilized on biochar and biochar-assisted advanced oxidation process were well-studied but with less frequency than other topics in ***,the future research was proposed for green and sustainable applications of *** review provides a comprehensive overview of the research frontiers,the evolution of research hotspots,and potential future research directions in the biochar field.

关键词： Bibliometric analysis Citespace Research hotspots Toxic metal immobilization sustainable application

Efficacy of journaling in the management of mental illness:a systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2022年第1期10卷 36-42页

作者： Monika sohal Pavneet singh bhupinder singh Dhillon Harbir singh Gill Northeast Addiction and Mental Health Centre for Holistic Recovery CalgaryAlbertaCanada Department of Family Medicine University of CalgaryCalgaryAlbertaCanada

Objectives Journaling is a common non-pharmacological tool in the management of mental illness,however,no clear evidence-based guideline exists informing primary care providers on its *** seek here to present this synthesis that may begin to inform future research and eventual evidence-based guideline *** Of the 3797 articles retrieved from MEDLINE,EMBAsE,PsycINFO,20 peer-reviewed randomised control trials(31 outcomes)met inclusion *** studies addressed the impact of a journaling intervention on PTsD,other anxiety disorders,depression or a combination of the *** criteria Peer reviewed,randomised control trials on the impact of journaling on mental illness were *** sources MEDLINE,EMBAsE and *** The data are highly heterogeneous(control arm=I^(2) of 71.2%,intervention arm=I^(2) of 83.8%)combined with a B-level strength of Recommendation Taxonomy *** was additionally found that there is a significant pre-post psychometric scale difference between control(−0.01,95%CI−0.03 to 0.00)and intervention arms(−0.06,95%CI−0.09 to−0.03).This 5%difference between groups indicates that a journaling intervention resulted in a greater reduction in scores on patient health ***’s d effect size analysis of studies suggests a small to moderate *** Further studies are needed to better define the *** review suggests that while there is some randomised control data to support the benefit of journaling,high degrees of heterogeneity and methodological flaws limit our ability to definitively draw conclusions about the benefit and effect size of journaling in a wide array of mental *** the low risk of adverse effects,low resource requirement and emphasis on self-efficacy,primary care providers should consider this as an adjunct therapy to complement current evidence-based management.

关键词： journal analysis illness