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Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis

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International Journal of Oral Science 2016年第3期8卷 138-144页

作者： Jane Park bhumika shokeen Susan K Haake Renate Lux School of Dentistry University of California at Los Angeles Los Angeles USA

Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral biofilm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATCC 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine, galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, RadD, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and RadD, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-specific binding profile of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity.

关键词： adhesin bio?lm coaggregation Fusobacterium nucleatum Porphyromonas gingivalis

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Study of ZnO nanoparticle-supported clay minerals for electrochemical sensors,photocatalysis,and antioxidant applications

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ChemPhysMater 2024年第1期3卷 83-93页

作者： Mylarappa M N.Raghavendra N.R.bhumika C.H.Chaithra B.N.Nagalaxmi K.N.Shravana Kumara Department of Chemistry Sri Jagadguru Renukacharya College of ScienceArts&CommerceBengaluru 560009India Department of Chemistry East West Institute of TechnologyBengaluru 560091India Department of Chemistry Maharani Lakshmi Ammanni College for WomenBengaluru 560012India

In view of the current study’s demonstration of the synthesis of clay-doped ZnO composites,we present a low-cost method for producing clay-metal oxide(clay/ZnO).Utilizing the solution combustion technique,a composite of clay/ZnO was produced utilizing citric acid as both a fuel and a complexing *** hexagonal unit cell structure of the created clay/ZnO may be seen using XRD *** ZnO-infused clay was visible in FE-SEM micrographs as homogenous,sphere-shaped *** possible involvement of clay/ZnO photocatalytic activity in the UV-induced photodegradation of malachite green dye was *** 90%degradation rate shows the composite’s outstanding photocatalytic degradation *** resulting substance was electrochemically analyzed using a constructed electrode in 0.1 M KOH *** increased its sensor capabilities,which now include chemical and biomolecule sensors,and it excelled in cyclic voltammetry-based redox potential *** efficiently evaluate chemically synthesized NPs for electrochemical,sensing,and photocatalytic applications,this study intends to create a solution combustion procedure for the synthesis of clay/ZnO nanocomposite using urea as fuel.

关键词： Clay Clay/ZnO Photocatalytic Electrochemical sensors

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A Comprehensive Review on Preclinical Safety and Toxicity of Medicinal Plants

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 95-111页

作者： Madhav Nilakanth Mugale Kapil Dev bhumika S.More Vaishali Sunil Mishra Kaveri R.Washimkar Kishan Singh Rakesh Maurya Srikanta Kumar Rath Debprasad Chattopadhyay Naibedya Chattopadhyay Division of Toxicology and Experimental Medicine CSIR-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031India Division of Phytochemistry CSIR-Central Institute of Medicinal and Aromatic Plants(CSIR-CIMAP)Lucknow 226015India Medicinal and Process Chemistry Division CSIR-CDRI Lucknow 226031India Division of Endocrinology CSIR-CDRI Lucknow 226031India Division of Ethnomedicine ICMR-National Institute of Traditional MedicineNehru NagarBelagavi 590010and ICMR-Virus UnitKolkata 700010India Department of Health Research NSHM Knowledge CampusKolkata 700051India

Background:Globally,80%people use plant-derived products for treating or preventing *** prevalent perception about medicinal plants is that they are safe and devoid of adverse ***,approximately 1,50,000 plants contain toxic ***:The present review focuses on medicinal plant extracts/fractions toxicity assessments made in preclin-ical models by oral ***:Detail studies were searched from databases including PubMed and Google Scholar.A manual reference screening of the selected studies was done to identify relevant articles,with no language restriction being imposed at the time of ***:The studies included were performed in rodents,and the test substances were administered *** search revealed 33 widely used plants or products with significant toxicity,and phytochemicals from these plants have been *** a systematic review,we identified a plethora of medicinal plant extracts reporting safety and toxicity ***:In the future,preclinical toxicokinetic studies of herbs and the determination of their no-observed-adverse-effect levels are required for a complete safety ***,the interaction of herbs with com-monly used/over-the-counter drugs in terms of the latter’s metabolic profile should be undertaken.

关键词： Extract Herbal medicine Toxicity Rodent Secondary metabolite

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Titanium nanoparticles attenuates arsenic toxicity by up-regulating expressions of defensive genes in Vigna radiata L

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Journal of Environmental Sciences 2020年第6期32卷 18-27页

作者： Priya Katiyar bhumika Yadu Jyoti Korram Manmohan L.Satnami Meetul Kumar S.Keshavkant School of Studies in Biotechnology Pt.Ravishankar Shukla UniversityRaipur 492010India School of Studies in Chemistry Pt.Ravishankar Shukla UniversityRaipur 492010India Directorate of International Cooperation Defence Research and Development OrganizationNew Delhi 110001India

Arsenic(As)-toxicity is recognized as one of the major environmental problems,affecting productivity of crops worldwide,thereby threatening sustainable agriculture and food *** in nanotechnology and its impacts have brought up concerns about the application of engineered nanoparticles(NPs)in various sectors of the economy,including the field of *** various NPs,there has been a rising amount of interest regarding the effects of titanium NPs(TiNPs)on plants growth and development,and their fate of abiotic stress ***,the present study was aimed to assess the ameliorative potentialities of chemically and biologically/green synthesized TiNPs to alleviate As-induced toxic responses in Vigna radiata *** results revealed that exposure to As hindered the growth indices(radicle length and biomass)and membrane integrity,while were improved with the application of chemical and green synthesized *** addition,treatment of As provoked the accretion of reactive oxygen species(superoxide and hydrogen peroxide)and malondialdehyde(a lipid per oxidized product),but were diminished by the supplementation of chemical and green manufactured *** experimental data also signified that exogenous application of chemical and green synthesized TiNPs conferred tolerance to As-induced oxidative injuries via perking-up the expressions of antioxidant genes and enzyme systems viz;superoxide dismutase and ***,the present study inferred that chemically and green synthesized TiNPs,particularly green manufactured,effectively mitigated the adverse impacts of As by augmenting antioxidant machinery,thereby proving its potentiality in the alleviation of As-toxicity,at least in Vignaradiata L.

关键词： Antioxidants Arsenic Gene expression Titanium nanoparticles(TiNPs) Reactive oxygen species(ROS) Vigna radiata L

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Asia Pacific survey of physicians on asthma and allergic rhinitis (ASPAIR): data from China

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Chinese Medical Journal 2019年第11期132卷 1264-1271页

作者： David Hinds bhumika Aggarwal Xin Du Aruni Mulgirigama Sumitra Shantakumar Real World Evidence & Epidemiology GSK Collegeville PA 19426-0989 USA Respiratory Global Classic & Established Products GSK 139234 Singapore Respiratory Therapeutic area GSK Shanghai 201203 China Respiratory Franchise GSK Brentford Middlesex TW8 9GS UK Real World Evidence and Epidemiology GSK 139234 Singapore

Background:In China, the prevalence of allergic rhinitis (AR) and asthma has increased in the past decade. As these two diseases frequently coexist, the Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis (ASPAIR) study aimed to assess physicians5 beliefs and treatment patterns of coexistent asthma-AR across six Asian countries. This analysis presents the results from China. Methods: The 200 hospital-based general physicians and pediatricians were interviewed from five cities in China. Physicians were questioned in-person about their knowledge, beliefs and management practices for patients with coexistent asthma-AR. Results: Approximately 70% of the physicians interviewed routinely evaluated their patients with asthma or AR for signs of coexistent disease. While the majority of physicians (>90% of physicians) recognized the increased burden of coexistent asthma-AR vs. one condition alone and that coexistent disease requires additional treatment, most physicians (96%) also believed that patients with coexistent asthma-AR were well managed if either condition alone improved. Similarly, although 71% of physicians selected a combination of intranasal and inhaled corticosteroids as their preferred treatment for coexistent asthma-AR, in line with treatment guidelines, two fifths of physicians indicated that treatment for coexistent disease requires too much medication and that their patients prefer oral medications and a third of physicians believed that corticosteroids should be delayed in children. Conclusions: This survey demonstrates that physicians interviewed in China have a broad understanding of coexistent asthma-AR and its impact on patients. A holistic approach to patient management with informed decisions regarding patients' overall treatment will benefit patients who suffer from coexistent disease.

关键词： Asthma Allergic rhinitis Coexistent asthma-allergic rhinitis China Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis ASPAIR

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药剂车

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世界建筑导报 2021年第5期36卷 48-48页

作者： Emilie Taylor Welty Nick Jenisch Elizabeth Bateman Jeremy Baudy Anna Deeg Claire Divito Rebecca Dunn Adrian Evans Danelle Martin Danielle Scheeringa bhumika Shirole Zach Speroni James Rennert Dana Ridenour 不详

设计如何开启对话,并作为宣传和教育的工具?药剂车,许多移动的装有药剂的车,试图让我们想象没有监狱的景象。美国有220万犯人,约9万人无限期单独监禁。疏离、人性丧失、绝望、迷失方向、偏执、自杀意念,单独监禁带来的无法弥补,近乎毁... 详细信息

设计如何开启对话,并作为宣传和教育的工具?药剂车,许多移动的装有药剂的车,试图让我们想象没有监狱的景象。美国有220万犯人,约9万人无限期单独监禁。疏离、人性丧失、绝望、迷失方向、偏执、自杀意念,单独监禁带来的无法弥补,近乎毁灭的影响远不止这些。囚犯药剂车从受大规模监禁荼毒最深的社区采取植物,转化为药。药剂师根据交谈或书信为全美国单独监禁犯人提供天然药物、茶、酊剂、蒸汽和药膏。

关键词：单独监禁自杀意念天然药物监狱药剂师犯人

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