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Comparative study of CEA and CA19-9 in esophageal,gastric and colon cancers individually and in combination(ROC curve analysis)

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Cancer Biology & Medicine 2013年第3期10卷 148-157页

作者： bhawna bagaria Sadhna Sood Rameshwaram Sharma Soniya Lalwani Department of Biochemistry S.M.S.Medical College & Hospital Department of Radiotherapy and Oncology S.M.S.Medical College & Hospital Advanced Bioinformatics Centre Birla Institute of Scientific Research

Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods： The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic （ROC） curves were plotted. Results： Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined： in esophageal cancer, sensitivity=28%, negative predictive value （NPV）=61.72%, and AUC=0.742 （SE=0.05）, with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 （SE=0.0S）, with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 （SE=0.04）, with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated： in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 （SE=0.05）, with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 （SE=0.05）, with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 （SE=0.05）, with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined： in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 （95% CI： 0.0159-0.322）; gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 （9$% CI： -0.0866-0.198）; and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 （9S% CI： 0.137-0.415）. Conclusion： CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.

关键词： Carcinoembryonic antigen carbohydrate antigen 19-9, human Receiver operating characteristic curve sensitivity andspecificity

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Operator Equations Inducing Some Generalizations of Slant Hankel Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2017-2036页

作者： Gopal DATT bhawna Bansal GUPTA Department of Mathematics PGDAV CollegeUniversity of DelhiNew Delhi-110065India Department of Mathematics Miranda HouseUniversity of DelhiDelhi-110007India

An extension of slant Hankel operator,namely,the kth-orderλ-slant Hankel operator on the Lebesgue space L^(2)(T^(n)),where T is the unit circle and n≥1,a natural number,is described in terms of the solution of a system of operator equations,which is subsequently expressed in terms of the product of a slant Hankel operator and a unitary *** study is further lifted in Calkin algebra in terms of essentially kth-orderλ-slant Hankel operators on L^(2)(T^(n)).

关键词： Hankel operator Lebesgue space of n-dimensional torus kth-order slant Hankel operator essentially kth-orderλ-slant Hankel operator

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Multimodality Medical Image Fusion Based on Pixel Significance with Edge-Preserving Processing for Clinical Applications

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Computers, Materials & Continua 2024年第3期78卷 4317-4342页

作者： bhawna Goyal Ayush Dogra Dawa Chyophel Lepcha Rajesh Singh Hemant Sharma Ahmed Alkhayyat Manob Jyoti Saikia Department of ECE and UCRD Chandigarh UniversityMohaliPunjab140413India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjab140401India Department of ECE Uttaranchal Institute of TechnologyUttaranchal UniversityDehradun248007India IES College of Technology IES UniversityBhopal462044India College of Technical Engineering The Islamic UniversityNajaf54001Iraq Department of Electrical Engineering University of North FloridaJacksonvilleFL32224USA

Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical *** fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many ***,recent image fusion techniques have encountered several challenges,including fusion artifacts,algorithm complexity,and high computing *** solve these problems,this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion ***,the method employs a cross-bilateral filter(CBF)that utilizes one image to determine the kernel and the other for filtering,and vice versa,by considering both geometric closeness and the gray-level similarities of neighboring pixels of the images without smoothing *** outputs of CBF are then subtracted from the original images to obtain detailed *** further proposes to use edge-preserving processing that combines linear lowpass filtering with a non-linear technique that enables the selection of relevant regions in detailed images while maintaining structural *** regions are selected using morphologically processed linear filter residuals to identify the significant regions with high-amplitude edges and adequate *** outputs of low-pass filtering are fused with meaningfully restored regions to reconstruct the original shape of the *** addition,weight computations are performed using these reconstructed images,and these weights are then fused with the original input images to produce a final fusion result by estimating the strength of horizontal and vertical *** standard quality evaluation metrics with complementary properties are used for comparison with existing,well-known algorithms objectively to validate the fusion *** results from th

关键词： Image fusion fractal data analysis biomedical diseases research multiresolution analysis numerical analysis

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Biodiesel from Palm Vegetable Oil

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Natural Resources 2024年第2期15卷 51-60页

作者： bhawna Yadav Lamba Sapna Jain Shreya Jha Applied Science Cluster School of Engineering UPES Dehradun India Winchester High School Massachusetts USA

Energy obtained from a variety of non-renewable sources is considered unsustainable. Various fossil fuels, such as petroleum, coal, and natural gas, are among these sources. The combustion of fossil fuels resulted in the generation of greenhouse gases, which increased the amount of carbon dioxide in the atmosphere. Global warming and ozone layer degradation are the negative consequences. In a country like India, where consumable oils are still imported, it is sense to look at the possibility of using such unpalatable oils in CI engines that aren’t often utilized as cooking oil. Palm oil is a vegetable oil obtained from the monocarp of the oil palm’s crop. The main goal is to provide a low-cost, high-performance alternative to diesel. The possibility of palm oil as a realistic, modest, and effective hotspot for the generation of biodiesel is investigated in this research. The article is focused on the comparison of palm oil and diesel in terms of characteristics.

关键词： Biodiesel Transesterification Palm Oil Heterogeneous Catalyst Methyl Esters Sustainable Fuel Energy

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Quantile-Based Shannon Entropy for Record Statistics

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Communications in Mathematics and Statistics 2023年第2期11卷 283-306页

作者： Vikas Kumar bhawna Dangi Department of Applied Sciences University Institute of Engineering and TechnologyM.D.UniversityRohtak 124001India

The quantile-based entropy measures possess some unique properties than their distribution function *** present communication deals with the study of the quantile-based Shannon entropy for record *** this regard a generalized model is considered for which cumulative distribution function or probability density function does not exist and various examples are provided for illustration *** we consider the dynamic versions of the proposed entropy measure for record statistics and also give a characterization result for *** the end,we study F^(α)-family of distributions for the proposed entropy measure.

关键词： Shannon entropy Record value Quantile function Quantile entropy F^(α)-family

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Asymptotic and Partial Asymptotic Hankel Operators on H^2(D^n)

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Acta Mathematica Sinica,English Series 2019年第11期35卷 1729-1740页

作者： Anuradha GUPTA bhawna GUPTA Department of Mathematics Delhi College of Arts and CommerceNetaji NagarUniversity of DelhiDelhiIndia Department of Mathematics University of DelhiDelhiIndia

In this paper,we generalize the concept of asymptotic Hankel operators on H2(D)to the Hardy space H2(Dn)(over polydisk)in terms of asymptotic Hankel and partial asymptotic Hankel operators and investigate some properties in case of its weak and strong ***,we introduce ith-partial Hankel operators on H2(Dn)and obtain a characterization of its compactness for n>*** main results include the containment of Toeplitz algebra in the collection of all strong partial asymptotic Hankel operators on H2(Dn).It is also shown that a Toeplitz operator with symbolφis asymptotic Hankel if and only if φ is holomorphic function in L∞(Tn).

关键词： Hankel operator Asymptotic Hankel operator partial asymptotic Hankel operator i(th)-partial Hankel operator i(th)-partial big Hankel operator

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Recapitulation Web 3.0:Architecture,Features and Technologies,Opportunities and Challenges

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Intelligent Automation & Soft Computing 2023年第8期37卷 1609-1620页

作者： Amtul Waheed bhawna Dhupia Sultan Mesfer Aldossary Department of Computer Sciences College of Arts and SciencesPrince Sattam bin Abdulaziz UniversityWadi Al Dawasir11990Saudi Arabia

Tim Berners-Lee developed the internet at CERN in early 1990 with fundamental technologies such as HTML,URL,and HTTP which became the foundation of the *** contemporary web we use today has been much advanced over a period of time ever since the innovation of the World Wide Web was *** static web was the first version of the web,which was the read-only *** development in web technology is web 3.0 which is a distributed and decentralized web with emerging *** article emphasizes the comparison of important details with the evolution of the *** paper also demonstrates the transactional architecture of DApps in networks and decentralized state ***,connectivity,the semantic web,augmented reality and artificial intelligence are the signifi-cant features of web 3.0 *** features are tremendously used in decision-making on critical issues,which are discussed elaborately in the *** paper provides various technologies to implement web 3.0 *** evolution of web 3.0 brings forth opportunities and *** opportunities are the ownership of the data and a personalized web browsing *** main concerns are security and scalability requirements for blockchain *** article also laid out the challenges that can be considered for further research.

关键词： Web 3.0 DApps Ethereum smart contracts blockchain

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Probiotic fermentation of polyphenols: potential sources of novel functional foods

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Food Production, Processing and Nutrition 2022年第1期4卷 259-274页

作者： Rohit Sharma bhawna Diwan Brij Pal Singh Saurabh Kulshrestha Faculty of Applied Sciences&Biotechnology Shoolini University of Biotechnology and Management SciencesSolan173229India Department of Microbiology Central University of HaryanaMahendragarhIndia

Fermented functional food products are among the major segments of food processing *** imparts several characteristic effects on foods including the enhancement of organoleptic characteristics,increased shelf-life,and production of novel health beneficial ***,in addition to macronutrients present in the food,secondary metabolites such as polyphenols are also emerging as suitable fermentable *** the traditional antimicrobial view of polyphenols,accumulating research shows that polyphenols exert differential effects on bacterial communities by suppressing the growth of pathogenic microbes while concomitantly promoting the proliferation and survival of probiotic ***,probiotic bacteria not only survive among polyphenols but also induce their fermentation which often leads to improved bioavailability of polyphenols,production of novel metabolic intermediates,increased polyphenolic content,and thus enhanced functional capacity of the fermented *** addition,selective fermentation of combinations of polyphenol-rich foods or fortification with polyphenols can result in novel functional *** present narrative review specifically explores the potential of polyphenols as fermentable substrates in functional *** discuss the emerging bidirectional relationship between polyphenols and probiotic bacteria with an aim at promoting the development of novel functional foods based on the amalgamation of probiotic bacteria and polyphenols.

关键词： Probiotics Polyphenols Fermented Foods Lactic acid bacteria Tea

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Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs

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Chinese Chemical Letters 2016年第5期27卷 707-710页

作者： Ashwani Kumar Dhingra bhawna Chopra Rameshwar Dass Sanjeev Kumar Mittal Guru Gobind Singh College of Pharmacy Yamuna Nagar 135001 Haryana India Department of Pharmacy IK Gujral Punjab Technical University Jalandhar 144001 Punjab India Department of Industrial Chemistry Guru Nanak Khalsa College Yamuna Nagar 135001 Haryana India IEC School of Pharmacy IEC University Baddi 173205 Himachal Pardesh India

In view of potent antimicrobial and anti-inflammatory activities exhibited by S-substituted imidazolones, a variety of novel imidazolone analogs 3a-I were synthesized by the condensation of different substituted oxazolones I with various aromatic amines 2. All the synthesized compounds were screened for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several analogs produced good or moderate activities particularly against the tested Gram-positive bacteria Micrococcus luteus and Gram-negative bacteria Pseudornonas aeruginosa and, Meanwhile, compounds 3b and 3c displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. Two of S-substituted imidazo/one derivatives, 3k and 3d show good anti-inflammatory activity. The structures of all the newly svnthesized compounds were elucidated using IR, 1H NMR and 13C NMR.

关键词： Oxazolones Imidazolones Antimicrobial activity Anti-inflammatory activity

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Depletion and dysfunction of Vy,2Vo2 T cells in HIV disease： mechanisms, impacts and therapeutic implications

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Cellular & Molecular Immunology 2013年第1期10卷 42-49页

作者： Haishan Li Suchita Chaudry bhawna Poonia Yiming Shao C David Pauza Institute of Human Virology and Department of Medicine University of Maryland School of Medicine Baltimore MD USA and State Key Laboratory for Infectious Disease Controland Prevention National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Infection with human immunodeficiency virus （HIV） disrupts the balance among yT cell subsets, with increasing Vo1＋ cells and substantial depletion of circulating Vo2＋ cells. Depletion is an indirect effect of HIV in CD4-negative Vo2 cells, but is specific for phosphoantigen-responsive subpopulations identified by the Vy2-Jy1.2 （also called Vy9-JyP） T cell receptor rearrangement. The extent of cell loss and recovery is related closely to clinical status, with highest levels of functional V cells present in virus controllers （undetectable viremia in the absence of antiretroviral therapy）. We review the mechanisms and clinical consequences for V cell depletion in HIV disease. We address the question of whether HIV-mediated V cell depletion, despite being an indirect effect of infection, is an important part of the immune evasion strategy for this virus. The important roles for V cells, as effectors and immune regulators, identify key mechanisms affected by HIV and show the strong relationships between V62 cell loss and immunodeficiency disease. This field is moving toward immune therapies based on targeting V cells and we now have clear goals and expectations to Ruide interventional clinical trials.

关键词： HIV disease ST cells mechanisms impacts therapeutic implications

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