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Dermatologic Extrahepatic Manifestations of Hepatitis C

Journal of Clinical and Translational Hepatology 2015年第2期3卷 127-133页

作者： bhavtosh dedania George Y.Wu Department of Medicine Division of Gastroenterology-Hepatology University of Connecticut Heath Center Farmington CT USA

Hepatitis C virus (HCV) affects millions of people worldwide,and an estimated 3.2 million people in the United *** is a hepatotropic and lymphotropic virus that causes not only liver disease,but also a significant number of extrahepatic manifestations (EHMs).Up to 74% of patients affected by HCV will have HCV-related EHMs of some severity in their *** EHMs vary from simple cutaneous palpable purpura to complex lymphoproliferative disorders,including lymphomas and immune-complex deposit diseases causing local and/or systemic *** cryoglobulinemia (MC) is manifested by multiple systemic organ involvement,mainly skin,kidney,peripheral nerves,and salivary glands,and less frequently causes widespread vasculitis and malignant *** affects up to 3% of HCV-infected patients with cryoglobulinemia of clinical significance,i.e.>6%.Severe disease requires immunosuppressive or plasma exchange *** prevalence in the United States in patients with porphyria cutanea tarda (PCT) was reported to be 66%,much higher than that in general ***,all patients with PCT should be screened for *** skin rash of PCT varies from large blisters to small vesicles and/or milia on the *** manifestations due to PCT usually respond to anti-HCV treatment together with reducing skin sun exposure,avoiding triggers,having routine phlebotomy (especially for people with chronic iron overload states),and using *** planus (LP),which typically affects both the skin and oral mucosa is a chronic inflammatory disease of squamous cell origin affecting about 1% of the worldwide *** prevalence of HCV in patients with LP varies based on geographic *** review here the basic pathophysiology,clinical features,and management of dermatologic manifestations of HCV.

关键词： Dermatologic manifestations Extra-hepatic manifestations Hepatitis C virus Cryoglobulinemia Porphyria cutanea tarda Lichen planus

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