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Higher Child-Reported Internalizing and Parent-Reported Externalizing Behaviors were Associated with Decreased Quality of Life among Pediatric Cardiac Patients Independent of Diagnosis:A Cross-Sectional Mixed-Methods Assessment

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Congenital Heart Disease 2021年第3期16卷 255-267页

作者： jacqueline S.Lee Angelica Blais julia jackson bhavika j.patel Lillian Lai Gary Goldfield Renee Sananes Patricia E.Longmuir Children’s Hospital of Eastern Ontario Research Institute OttawaCanada Faculty of Health Science University of OttawaOttawaCanada Faculty of Medicine University of OttawaOttawaCanada Children’s Hospital of Eastern Ontario OttawaCanada The Hospital for Sick Children TorontoCanada

Background:Pediatric cardiology patients often experience decreased quality of life(QoL)and higher rates of mental illness,particularly with severe disease,but the relationship between them and comparisons across diagnostic groups are *** mixed-methods cross-sectional study assessed the association between QoL anxiety and behavior problems among children with structural heart disease,arrhythmia,or other cardiac ***:Children(6–14 years,n=76,50%female)and their parents completed measures of QoL(PedsQL),behavior(BASC-2,subset of 19 children)and anxiety(MASC-2,children 8+years).Pearson correlations/regression models examined associations between QoL,behavior and anxiety,controlling for age,sex,diagnosis and condition *** t-tests compared results to published normative ***-structured interviews(15 children,13 parents)examined self-and parent-reported perceptions of the patient’s emotional ***:Child reported social QoL(95%CI difference:−11.0,−2.1),emotional well-being(95%CI difference:−12.5,−3.8)and adjustment skills(95%CI difference:−13.9,−3.0)were significantly below published norms(p<0.05).Neither age,sex,nor diagnosis were significantly related to questionnaire *** to children with mild conditions,child and parent-reported QoL was significantly lower in children with complex conditions(np2≥0.14,p<0.05).Lower QoL was strongly associated with more internalizing problems based on both child(r=−0.78,p<0.001)and parent(r=−0.67,p<0.001)*** responses suggested emotional distress was attributed to“normal”child problems rather than the child’s cardiac ***:Children with complex cardiac conditions,regardless of diagnosis,had diminished *** the PedsQL in clinical settings may help identify pediatric cardiology patients experiencing emotional distress(i.e.,anxiety and depression).

关键词： Anxiety emotional well-being internalizing behaviors congenital heart defects arrhythmia cardiomyopathy

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Chitosan DNA nanoparticles for oral gene delivery

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World journal of Medical Genetics 2016年第3期6卷 22-33页

作者： bhavika j patel Nithin K Vignesh Gonzalo Hortelano Department of Health Sciences McMaster University Department of Biology School of Science and Technology Nazarbayev University School of Biomedical Engineering McMas-ter University Department of Pathology and Molecular Medicine McMaster University

Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21st century, the simple concept of gene therapy - the introduction of a functional copy of desired genes in affected individuals - is proving to be more challenging than expected. Oral gene delivery has shown intriguing results and warrants further exploration. In particular, oral administration of chitosan DNA nano-particles, one the most commonly used formulations of therapeutic DNA, has repeatedly demonstrated successful in vitro and in vivo gene transfection. While oral gene therapy has shown immense promise as treatment options in a variety of diseases, there are still signifcant barriers to overcome before it can be considered for clinical applications. In this review we provide an over-view of the physiologic challenges facing the use of chitosan DNA nanoparticles for oral gene delivery at both the extracellular and intracellular level. From administration at the oral cavity, chitosan nanoparticles must traverse the gastrointestinal tract and protect its DNA contents from signifcant jumps in pH levels, various intestinal digestive enzymes, thick mucus layers with high turnover, and a proteinaceous glycocalyx meshwork. Once these extracellular barriers are overcome, chitosan DNA nanoparticles must enter intestinal cells, escape endolysosomes, and disassociate from genetic material at the appropriate time allowing transport of genetic material into the nucleus to deliver a therapeutic ef-fect. The properties of chitosan nanoparticles and modified nanoparticles are discussed in this review. An understanding of the barriers to oral gene delivery and how to overcome them would be invaluable for future gene therapy development.

关键词： Gene therapy Oral gene delivery Chitosan nanoparticles Glycocalyx pH Enzymes Endolysosomal escape Intracellular transport Nuclear transport Mucus

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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim Adel Burgos Vishwa patel Brian Zanotti Michael V.Volin M.Asif Amin Myles j.Lewis Costantino Pitzalis Shiva Arami joseph A.Karam Nadera j.Sweiss Shiva Shahrara jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： johan Gustafsson Fariba Roshanzamir Anders Hagnestål Sagar M.patel Oseeyi I.Daudu Donald F.Becker jonathan L.Robinson jens Nielsen Department of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

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Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R patel Omar Saeed Sandhya Murthy Yogita Rochlani Daniel B Sims Sasha Vukelic Stephen j Forest jamil F Borgi Daniel j Goldstein Ulrich P jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

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INTRODUCTION TO INCONEL ALLOY 740: AN ALLOY DESIGNED FOR SUPERHEATER TUBING IN COAL-FIRED ULTRA SUPERCRITICAL BOILERS

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Acta Metallurgica Sinica(English Letters) 2005年第4期18卷 479-488页

作者： S.j. patel Special Metals Corporation Huntington WV 25705 USA

Chinese utilities as well as those worldwide are facing increased demand for additional electricity, reduced plant emissions and greater efficiency. To meet this challenge will require increasing boiler temperature, pressure and coal ash corrosion resistance of the materials of boiler construction of future coal-fired boilers. A new nickel-based tube alloy, INCONEL^R alloy 740, is described aiming at meeting this challenge. Emphasis will be on describing the alloy＇ s mechanical properties, coal-ash and steam corrosion resistance. Microstructural stability as a function of temperature and time is addressed as well as some of the early methodology em- ployed to arrive at the current chemical composition.

关键词： ultrasupercritical boiler tubing INCONEL coal-fired

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Characterization of colloidal arsenic at two abandoned gold mine sites in Nova Scotia, Canada, using asymmetric flow-field flow fractionation-inductively coupled plasma mass spectrometry

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journal of Environmental Sciences 2016年第11期28卷 189-196页

作者： Kathryn j Tindale Pritesh j patel Dirk Wallschlager Environmental and Life Sciences Graduate Program School of the Environment Department of Chemistry and Water Quality Centre Trent University Peterborough ON K9L 0G2 Canada Ore Pros Inc Beamsville ON LOR 1B2 Canada

Asymmetric flow-field flow fractionation-inductively-coupled plasma-mass spectrometry was used to determine whether colloidal arsenic（As） exists in soil pore water and soil extract samples at two arsenic-contaminated abandoned gold mines（Montague and Goldenville, Nova Scotia）. Colloidal arsenic was found in 12 out of the 80 collected samples（= 15%）, and was primarily associated with iron（Fe） in the encountered colloids. The molar Fe/As ratios indicate that the colloids in some samples appeared to be discrete iron–arsenic minerals, whereas in other samples, they were more consistent with As-rich iron（oxy）hydroxides. Up to three discrete size fractions of colloidal As were encountered in the samples, with mean colloid diameters between 6 and 14 nm. The pore water samples only contained one size fraction of As-bearing colloids（around 6 nm diameter）, while larger As-bearing colloids were only encountered in soil extracts.

关键词： Arsenic Colloids Gold mine tailings ICP-MS Nova Scotia Nanoparticles

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Urban Growth Monitoring using Remote Sensing and Geo-Informatics: Case Study of Gandhinagar, Gujarat State (India)

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International journal of Geosciences 2017年第4期8卷 563-576页

作者： bhavika Badlani Ajay N. patel Krunal patel Manik H. Kalubarme Institute of Technology Nirma University Ahmedabad India Department of Science & Technology Bhaskaracharya Institute for Space Applications and Geo-Informatics (BISAG) Government of Gujarat Gandhinagar India

The Gandhinagar town has undergone unprecedented urban growth after assuming the status of a capital of Gujarat state, India in 1971. The Gandhinagar city lies on the western bank of river Sabarmati and city is also known as the “Tree capital of India” because of greenery with 54% green cover. The urban sprawl in Gandhinagar town was analyzed using multi-temporal Landsat TM data from 1981 to 2015. Spectral indices namely Normalized Difference Vegetation Index (NDVI), Normalized Difference Built-up Index (NDBI) and Built-up Index (BUI) were generated from the Landsat TM bands covering visible Red (R), Near Infrared (NIR) and Short Wave Infrared (SWIR) wavelength regions. Spectral variations in built-up, open spaces, urban vegetation and water areas were studied by generating two-dimensional spectral plots of NDBI and BUI. The spectral response of built up areas like Urban-dense and urban-sparse classes are quite distinct from other cover types like open spaces, urban vegetation and water. The results indicate that the normalized difference built-up index (NDBI) and Built-up Index (BUI) were very useful for mapping urban built-up areas in Gandhinagar town using Landsat Thematic Mapper (TM) data. The built-up area in Gandhinagar increased from 1100.1 ha during jan 1989 to 1907.3 ha during jan 2015 which indicates about 73 per cent increase in the built-up area during the period of 26 years. The urban vegetation which includes parks and gardens in the city has also shown increasing trend during the period of 1989 to 2015. However, the area under open spaces has decreased as the development of built-up area has increased as per development plan of the Gandhinagar town.

关键词： Landsat-TM Normalized Difference Vegetation Index (NDVI) Normalized Difference Built-up Index (NDBI) Built-up Index (BUI) Urban Sprawl monitoring

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Impact of metabolic dysfunction-associated steatotic liver disease on COVID-19 hospitalizations:A propensity-matched analysis of the United States

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World journal of Virology 2024年第1期13卷 51-60页

作者： Abdullah Sohail Hassam Ali Pratik patel Subanandhini Subramanium Dushyant Singh Dahiya Amir H Sohail Manesh Kumar Gangwani Sanjaya K Satapathy Department of Internal Medicine University of Iowa Roy J and Lucille A Carver College of MedicineIowaIA 52242United States Division of Gastroenterology and Hepatology East Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology Mather Hospital/Hofstra University Zucker School of MedicineNY11777United States Department of Internal Medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New MexicoAlbuquerqueNM 87106United States Department of Internal Medicine The University of ToledoToledoOH 43606United States Section on Gastroenterology and Hepatology North Shore University Hospital and Long Island Jewish Medical CenterManhassetNY 11030United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),formally known as nonalcoholic fatty liver disease,is the most common chronic liver disease in the United *** with MASLD have been reported to be at a higher risk of developing severe coronavirus disease 2019(COVID-19)and ***,most studies are single-center studies,and nationwide data in the AIM To study the influence of MASLD on COVID-19 hospitalizations during the initial phase of the *** We retrospectively analyzed the 2020 National Inpatient Sample(NIS)database to identify primary COVID-19 hospitalizations based on an underlying diagnosis of MASLD.A matched comparison cohort of COVID-19 hospit-alizations without MASLD was identified from NIS after 1:N propensity score matching based on gender,race,and comorbidities,including hypertension,heart failure,diabetes,and *** primary outcomes included inpatient mortality,length of stay,and hospitalization *** outcomes included the prevalence of systemic *** A total of 2210 hospitalizations with MASLD were matched to 2210 hospitalizations without MASLD,with a good comorbidity ***,there was a higher prevalence of severe disease with more intensive care unit admissions(9.5%vs 7.2%,P=0.007),mechanical ventilation(7.2%vs 5.7%,P=0.03),and septic shock(5.2%vs 2.7%,P<0.001)in the MASLD cohort than in the non-MASLD ***,there was no difference in mortality(8.6%vs 10%,P=0.49),length of stay(5 d vs 5 d,P=0.25),and hospitalization costs(42081.5$vs 38614$,P=0.15)between the MASLD and non-MASLD *** The presence of MAFLD with or without liver cirrhosis was not associated with increased mortality in COVID-19 hospitalizations;however,there was an increased incidence of severe COVID-19 *** data(2020)predates the availability of COVID-19 vaccines,and many MASLD patients have since been *** will be interesting to see if these trends are

关键词： COVID-19 Metabolic dysfunction-associated steatotic liver disease Prevalence Hospital charges Inpatient resource utilization

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ANTIMICROBIAL ACTIVITY OF COPOLYMERS OF 2,4-DICHLOROPHENYL ACRYLATE WITH STYRENE:SYNTHESIS,CHARACTERIZATION AND REACTIVITY RATIOS

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Chinese journal of Polymer Science 2009年第1期27卷 121-130页

作者： Hetal j.patel Mitesh G.patel Kirit H.patel Arabinda K.Ray Rajni M.patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar-388120GujaratIndia

Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR *** copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) *** molecular weight,as well as intrinsic viscosity,was obtained by vapor pressu...

关键词： Copolymers Reactivity ratios Vapor pressure osmometry Thermal analysis Antimicrobial screening

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