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动脉粥样硬化血栓形成门诊患者心血管危险因素的国际患病率、认识和治疗

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 2-3页

作者： bhatt d.l. Gabriel Steg P. Magnus Ohman E. 王鹏 Cleveland Clinic Foundation 9500 Euclid Ave Cleveland OH 44195 United States.Dr

Context:Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. Objective: To determine whether atherosclerosis risk factor prevalence and treatment would demonstrate comparable patterns in many countries around the world. design, Setting, and Participants: The Reduction of Atherothrombosis for Continued Health (REACH) Registry collected data on atherosclerosis risk factors and treatment. A total of 67 888 patients aged 45 years or older from 5473 physician practices in 44 countries had either established arterial disease (coronary artery disease [CAd], n = 40 258; cerebrovascular disease, n = 18843; peripheral arterial disease, n = 8273) or 3 or more risk factors for atherothrombosis (n = 12 389) between 2003 and 2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, medication use, and degree of risk factor control. Results: Atherothrombotic patients throughout the world had similar risk factor profiles: a high proportion with hypertension (81.8% ), hypercholesterolemia (72.4% ), and diabetes (44.3% ). The prevalence of overweight (39.8% ), obesity (26.6% ), and morbid obesity (3.6% ) were similar in most geographic locales, but was highest in North America (overweight: 37.1% , obese: 36.5% , and morbidly obese: 5.8% ; P lly undertreated with statins (69.4% overall; range: 56.4% for cerebrovascular disease to 76.2% for CAd), antiplatelet agents (78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAd), and other evidence-based risk reduction therapies. Current tobacco use in patients with established vascular disease was substantial (14.4% ). Undertreated hypertension (50.0% with elevated blood pressure at baseline), undiagnosed hyperglycemia (4.9% ), and impaired fasting glucose (36

关键词：动脉粥样硬化血栓形成患者心血管危险因素患病率

与经皮冠状动脉介入术使用紫杉醇洗脱支架相关的支架血栓形成风险:荟萃分析

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世界核心医学期刊文摘(心脏病学分册) 2005年第9期 61-62页

作者： Bavry A.A. Kumbhani d.J. Helton T.J. bhatt d.l. 吴波 dr.Interventional Cardiol. C. Cleveland Clinic Foundation Dept. of Cardiovascular Medicine 9500 Euclid Avenue Cleveland OH 44195 United States

OBJECTIVES: This study investigated the risk of stent thrombosis associated with the use of paclitaxel-eluting stents(PES) compared to bare-metal stents(BMS). BACKGROUNd: Clinical experience with coronary drug-eluting stents(dES) is relatively limited. There is concern that dES used for percutaneous coronary intervention may result in subsequent thrombosis. METHOdS: We conducted a meta-analysis on eight trials(total of 13 study arms) in 3,817 patients with coronary artery disease who were randomized to either PES or BMS. RESUlTS: As compared with BMS, PES do not increase the hazard for thrombosis up to 12 months(risk ratio[RR]=1.06, 95%confidence interval[CI] 0.55 to 2.04, p=0.86]). There was no evidence of heterogeneity among the studies(chi-square value for Q-statistic=5.90[10 degrees of freedom], p=0.82). Similar results were obtained when the analysis was restricted to trials with a polymeric stent platform(Treatment of de novo coronary disease using a single pAclitaXel elUting Stent[TAXUS] -I, -II, -IV, and -VI)(RR=1.01, 95%CI 0.40 to 2.53, p=0.99), trials with longer lesions(TAXUS-IV and -VI)(RR=0.62, 95%CI 0.2 to 1.91, p=0.41), and trials that used a higher dose of paclitaxel(ASian Paclitaxel-Eluting Stent Clinical trial[ASPECT], European evalUaTion of paclitaxel Eluting Stents[ElUTES], and d.l.VER-I)(RR=1.87, 95%CI 0.52 to 6.81, p=0.34). CONClUSIONS: Current evidence suggests that standard dose PES do not increase the hazard of stent thrombosis compared to BMS.

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动脉粥样硬化血栓形成门诊患者的1年心血管事件发生率

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 8-9页

作者： Steg G. bhatt d.l. Wilson P.W.F. 杜媛 dr. Hpital Bichat-Claude Bernard 46 rue Henri Huchard 75018 Paris France

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd)、脑血管疾病(CVd)及外周血管疾病(PAd)患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾... 详细信息

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd)、脑血管疾病(CVd)及外周血管疾病(PAd)患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾病或有多项动脉粥样硬化血栓形成危险因素的门诊患者中,确定当代国际性的1年心血管事件发生率。

关键词：心血管事件血栓形成外周血管疾病动脉疾病患病风险中评估脑卒中发生率医疗诊所前瞻性队列研

氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： bhatt d.l. Fox K.A.A. Hacke W. E.J. Topol 罗亮 department of Genetics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKGROUNd: dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events. METHOdS: We randomly assigned 15,603 patients with either clinically evident cardiovascular disease or multiple risk factors to receive clopidogrel(75 mg per day) plus low-dose aspirin(75 to 162 mg per day) or placebo plus low-dose aspirin and followed them for a median of 28 months. The primary efficacy end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes. RESUlTS: The rate of the primary efficacy end point was 6.8 percent with clopidogrel plus aspirin and 7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confidence interval, 0.83 to 1.05; P=0.22). The respective rate of the principal secondary efficacy end point, which included hospitalizations for ischemic events, was 16.7 percent and 17.9 percent(relative risk, 0.92; 95 percent confidence interval, 0.86 to 0.995; P=0.04), and the rate of severe bleeding was 1.7 percent and 1.3 percent(relative risk, 1.25; 95 percent confidence interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end point among patients with multiple risk factors was 6.6 percent with clopidogrel and 5.5 percent with placebo(relative risk, 1.2; 95 percent confidence interval, 0.91 to 1.59; P=0.20) and the rate of death from cardiovascular causes also was higher with clopidogrel(3.9 percent vs. 2.2 percent, P=0.01). In the subgroup with clinically evident atherothrombosis, the rate was 6.9 percent with clopidogrel and 7.9 percent with placebo(relative risk, 0.88; 95 percent confidence interval, 0.77 to 0.998; P=0.046). CONClUSIONS: In this trial, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors. Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

经皮冠状动脉介入术后的临床终点定义及其与晚期死亡率的关系:一项归因风险评估

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 46-46页

作者： Chew d.P. bhatt d.l. lincoff A.M. 杜媛 Flinders Medical Centre Flinders Drive Bedford Park SA 5042 Australia Prof.

Objectives: To explore the relative and absolute risks associated with various definitions for myocardial infarction, bleeding and revascularisation within the context of percutaneous coronary intervention(PCI). Methods: The REPlACE-2(randomised evaluation of PCI linking Angiomax to reduced clinical events) database of patients undergoing PCI was used. Various definitions of myocardial infarction, bleeding and revascularisation were mod.l.ed by logistic regression assessing their relationship with 12-month mortality. Estimates from these mod.l. were used to calculate the “attributable fraction”for late mortality associated with each definition. Results: The most liberal definition of myocardial infarction was associated with an attributable risk of 13.7%(95%CI 3.4%to 23.0%). The most stringent definition was associated with an attributable risk of 4.6%(95%CI 0.6%to 8.6%). Restrictive definitions of bleeding such as TIMI(thrombolysis in myocardial infarction) major bleeding are associated with a high odds ratio of risk(6.1, 95%CI 2.1 to 17.7, p=0.001) but low attributable fraction(3.5%, 95%CI 0.9%to 6.8%). Conclusions: Stringent end point definitions may under-represent the clinical significance of adverse outcomes after PCI. Considering both the proportional and absolute risk associated with definitions may be a more useful method for evaluating clinical trial end points. This analysis supports the current definitions of ischaemic events but suggests that more liberal definitions of bleeding events may also be relevant to late mortality.

关键词：临床终点比伐卢定风险评估血运重建相对和绝对临床事件评估研究晚期死亡出血事件比值比

REACH(减少动脉粥样硬化血栓形成保持健康)注册研究:针对易发生动脉粥样硬化血栓形成事件的危险人群的一项国际性、前瞻性观察研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 9-9页

作者： Ohman E.M. bhatt d.l. Steg P.G. 杜媛 division of Cardiology Duke University Medical CenterDuke Hospital NorthDurhamNCUnited States.Dr

Background: The risk of atherothrombosis is a large health care burden worldwide. With its global prevalence, there is a need to understand all the associated risk factors, both old and new, and their interdependencies in the development of this complex disease leading to myocardial infarction, ischemic stroke, and vascular death and, thus, the major cause of mortality throughout the world. Methods: The REACH Registry sought to compile an international data set to extend our knowledge of atherothrombotic risk factors and ischemic events in the outpatient setting. The Registry will recruit approximately 68 000 outpatients in 44 countries across 6 major regions(latin America, North America, Europe, Asia, the Mid.l. East, and Australia) from >5000 physician outpatient practices. Patients aged ≥45 years with at least 3 atherothrombotic risk factors or documented cerebrovascular, coronary artery, or peripheral arterial disease will be enrolled. Medical history, risk factors, demographic information, and management will be collected at baseline, and clinical events that occur during the follow-up period of up to 2 years in duration will be recorded. Conclusion: The REACH Registry offers an opportunity to provide a better understanding of the prevalence and clinical consequences of atherothrombosis in the outpatient setting in a wide range of patients from different parts of the world.

关键词：动脉粥样硬化血栓形成注册研究前瞻性观察危险人群国际性危险因素健康

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic lydia Jiménez-díaz Juan d.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

lIGHT PORTABlE ElECTROPNEUMATIC lOUdSPEAKER

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Chinese Journal of Acoustics 1989年第4期8卷 359-365页

作者： MACdONAld d.l. Racal Acoustics ltd.U.K

This paper analyses the influence of certain parameters and factors on the characteristics of the electropneumatic loudspeaker and describes the experimental work carried out. The developed portable electropneumatic loudspeaker possesses good properties with a flat frequency response from 400 Hz to 2 kHz and a maximum sound pressrue output of 120dB at a distance 2 metre on axis from the horn mouth .The magnetic flux density at the magnetic gap is 19 ,000 gauss .The electropneumatic loudspeaker is small in size and.l.ghtweight.

关键词： lIGHT PORTABlE ElECTROPNEUMATIC lOUdSPEAKER

Structural and mass transport properties of liquid ytterbium in the temperature range 1123 K–1473 K

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Chinese Physics B 2023年第6期32卷 481-488页

作者： d d Satikunvar N K bhatt B Y Thakore department of Physics Sardar Patel UniversityVallabh VidyanagarGujarat 388120India department of Physics Maharaja Krishnakumarsinhji Bhavnagar UniversityBhavnagarGujarat 364001India

We have studied the structural and atomic transport properties of liquid f-shell Yb in the temperature range 1123 K–1473 K. Pair interactions between atoms are derived using a local pseudopotential. The potential parameters are fitted to the phonon dispersion curve at room temperature. The local pseudopotential used in the present study is computationally more efficient with only three parameters, and it is found to be transferable to the liquid phase without changing the *** the various computed properties agree with reported theoretical and experimental findings, the adopted fitting scheme is justified. As a significant outcome of the study, we find that(i) the melting in Yb is governed by the lindemann's law,(ii)the mass transport mechanism obeys the Arrhenius law,(iii) the role of the three-particle correlation function in deriving the velocity autocorrelation function is small,(iv) the mean-square atomic displacement is more sensitive to the choice of interaction potential than the other bulk properties, and(v) liquid Yb does not show liquid.l.quid phase transition within the studied temperature range. Further, due to the good description of the structural and mass transport properties, we propose that Yb remains divalent at reduced density.

关键词： transport properties pseudopotential single-particle dynamics ytterbium