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外周动脉疾病对结局的影响:对8项大样本随机经皮冠状动脉介入试验中死亡率的汇总分析

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 43-44页

作者： Saw J. bhatt d.l. Moliterno d.J. 郭俊 department of Cardiovascular Medicine the Cleveland Clinic FoundationClevelandOHUnited States Dr.

目的:本研究旨在确定外周动脉疾病(PAd)患者在经皮冠状动脉介入(PCI)治疗后的临床结局。背景:相当多接受PCI的冠状动脉疾病患者同时患有PAd,其预后可能更差。

关键词：外周动脉疾病试验结果多变量分析 PACT EPIC TARGET

Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana Contreras Juan d.Navarro-lópez lydia Jiménez-díaz Neurophysiology&Behavior lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

动脉粥样硬化血栓形成门诊患者心血管危险因素的国际患病率、认识和治疗

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 2-3页

作者： bhatt d.l. Gabriel Steg P. Magnus Ohman E. 王鹏 Cleveland Clinic Foundation 9500 Euclid Ave Cleveland OH 44195 United States.Dr

Context:Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. Objective: To determine whether atherosclerosis risk factor prevalence and treatment would demonstrate comparable patterns in many countries around the world. design, Setting, and Participants: The Reduction of Atherothrombosis for Continued Health (REACH) Registry collected data on atherosclerosis risk factors and treatment. A total of 67 888 patients aged 45 years or older from 5473 physician practices in 44 countries had either established arterial disease (coronary artery disease [CAd], n = 40 258; cerebrovascular disease, n = 18843; peripheral arterial disease, n = 8273) or 3 or more risk factors for atherothrombosis (n = 12 389) between 2003 and 2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, medication use, and degree of risk factor control. Results: Atherothrombotic patients throughout the world had similar risk factor profiles: a high proportion with hypertension (81.8% ), hypercholesterolemia (72.4% ), and diabetes (44.3% ). The prevalence of overweight (39.8% ), obesity (26.6% ), and morbid obesity (3.6% ) were similar in most geographic locales, but was highest in North America (overweight: 37.1% , obese: 36.5% , and morbidly obese: 5.8% ; P lly undertreated with statins (69.4% overall; range: 56.4% for cerebrovascular disease to 76.2% for CAd), antiplatelet agents (78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAd), and other evidence-based risk reduction therapies. Current tobacco use in patients with established vascular disease was substantial (14.4% ). Undertreated hypertension (50.0% with elevated blood pressure at baseline), undiagnosed hyperglycemia (4.9% ), and impaired fasting glucose (36

关键词：动脉粥样硬化血栓形成患者心血管危险因素患病率

与经皮冠状动脉介入术使用紫杉醇洗脱支架相关的支架血栓形成风险:荟萃分析

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世界核心医学期刊文摘(心脏病学分册) 2005年第9期 61-62页

作者： Bavry A.A. Kumbhani d.J. Helton T.J. bhatt d.l. 吴波 dr.Interventional Cardiol. C. Cleveland Clinic Foundation Dept. of Cardiovascular Medicine 9500 Euclid Avenue Cleveland OH 44195 United States

OBJECTIVES: This study investigated the risk of stent thrombosis associated with the use of paclitaxel-eluting stents(PES) compared to bare-metal stents(BMS). BACKGROUNd: Clinical experience with coronary drug-eluting stents(dES) is relatively limited. There is concern that dES used for percutaneous coronary intervention may result in subsequent thrombosis. METHOdS: We conducted a meta-analysis on eight trials(total of 13 study arms) in 3,817 patients with coronary artery disease who were randomized to either PES or BMS. RESUlTS: As compared with BMS, PES do not increase the hazard for thrombosis up to 12 months(risk ratio[RR]=1.06, 95%confidence interval[CI] 0.55 to 2.04, p=0.86]). There was no evidence of heterogeneity among the studies(chi-square value for Q-statistic=5.90[10 degrees of freedom], p=0.82). Similar results were obtained when the analysis was restricted to trials with a polymeric stent platform(Treatment of de novo coronary disease using a single pAclitaXel elUting Stent[TAXUS] -I, -II, -IV, and -VI)(RR=1.01, 95%CI 0.40 to 2.53, p=0.99), trials with longer lesions(TAXUS-IV and -VI)(RR=0.62, 95%CI 0.2 to 1.91, p=0.41), and trials that used a higher dose of paclitaxel(ASian Paclitaxel-Eluting Stent Clinical trial[ASPECT], European evalUaTion of paclitaxel Eluting Stents[ElUTES], and d.l.VER-I)(RR=1.87, 95%CI 0.52 to 6.81, p=0.34). CONClUSIONS: Current evidence suggests that standard dose PES do not increase the hazard of stent thrombosis compared to BMS.

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动脉粥样硬化血栓形成门诊患者的1年心血管事件发生率

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 8-9页

作者： Steg G. bhatt d.l. Wilson P.W.F. 杜媛 dr. Hpital Bichat-Claude Bernard 46 rue Henri Huchard 75018 Paris France

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd)、脑血管疾病(CVd)及外周血管疾病(PAd)患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾... 详细信息

背景:目前关于社区中动脉粥样硬化血栓形成稳定患者的心血管事件发生率的资料较少。尚未在单个国际性队列中评估确诊冠心病(CAd)、脑血管疾病(CVd)及外周血管疾病(PAd)患者或有上述疾病患病风险者的事件发生率差别。目的:在确诊动脉疾病或有多项动脉粥样硬化血栓形成危险因素的门诊患者中,确定当代国际性的1年心血管事件发生率。

关键词：心血管事件血栓形成外周血管疾病动脉疾病患病风险中评估脑卒中发生率医疗诊所前瞻性队列研

氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： bhatt d.l. Fox K.A.A. Hacke W. E.J. Topol 罗亮 department of Genetics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKGROUNd: dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events. METHOdS: We randomly assigned 15,603 patients with either clinically evident cardiovascular disease or multiple risk factors to receive clopidogrel(75 mg per day) plus low-dose aspirin(75 to 162 mg per day) or placebo plus low-dose aspirin and followed them for a median of 28 months. The primary efficacy end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes. RESUlTS: The rate of the primary efficacy end point was 6.8 percent with clopidogrel plus aspirin and 7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confidence interval, 0.83 to 1.05; P=0.22). The respective rate of the principal secondary efficacy end point, which included hospitalizations for ischemic events, was 16.7 percent and 17.9 percent(relative risk, 0.92; 95 percent confidence interval, 0.86 to 0.995; P=0.04), and the rate of severe bleeding was 1.7 percent and 1.3 percent(relative risk, 1.25; 95 percent confidence interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end point among patients with multiple risk factors was 6.6 percent with clopidogrel and 5.5 percent with placebo(relative risk, 1.2; 95 percent confidence interval, 0.91 to 1.59; P=0.20) and the rate of death from cardiovascular causes also was higher with clopidogrel(3.9 percent vs. 2.2 percent, P=0.01). In the subgroup with clinically evident atherothrombosis, the rate was 6.9 percent with clopidogrel and 7.9 percent with placebo(relative risk, 0.88; 95 percent confidence interval, 0.77 to 0.998; P=0.046). CONClUSIONS: In this trial, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors. Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

Competitive interactions and coexistence of sympatric flagship carnivores in Asia

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Integrative Zoology 2024年第2期19卷 183-199页

作者： Zhilin lI Jiayu lU Xiaoyi SHI li’an dUO James l.d.SMITH Tianming WANG Tianjin Key laboratory of Conservation and Utilization of Animal diversity College of Life SciencesTianjin Normal UniversityTianjinChina department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Ministry of Education Key laboratory for Biodiversity Science and Engineering College of Life SciencesBeijing Normal UniversityBeijingChina National Forestry and Grassland Administration Key laboratory for Conservation Ecology of Northeast Tiger and.l.opard BeijingChina

Understanding the competition and coexistence of flagship carnivores is key to creating strategies for their conservation in the face of global carnivore *** studies exploring the dynamics and competition between tigers(Panthera tigris)and.l.opards(***)span decades,there is a lack of understanding regarding the factors that influence their coexistence mechanisms on a broad scale,as well as the drivers determining their exploitative and interference *** gathered a comprehensive list of research papers among which 36 papers explored the interspecific interactions between tigers and.l.opards and tested the influence of biotic and abiotic factors on the coexistence mechanisms along three dimensions using multiple response variables regression mod.l.;we also tested the influence of ecological drivers determining the exploitative or interference competition between tigers and *** and ungulate density were the most important predictors in regulating the coexistence *** and.l.opards exhibited more positive relations/higher overlaps as elevation increased in the spatial *** addition,they showed a higher dietary overlap in the prey-rich *** determined that interference competition between tigers and.l.opards was less frequently observed in habitats with dense tree cover and homogeneous vegetation ***,studies with multiple metrics would promote the detection of interference *** study provides new insight into the competitive interactions and coexistence mechanisms of tigers and.l.opards on a broad ***-makers and managers should pay more attention to the factors of elevation,prey abundance,and habitat structures for the conservation of tigers and.l.opards.

关键词： carnivores coexistence mechanisms competitive interactions exploitative competition interference competition

Two-Stream Approximation to the Radiative Transfer Equation:A New Improvement and Comparative Accuracy with Existing Methods

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Advances in Atmospheric Sciences 2024年第2期41卷 278-292页

作者： F.Momo TEMGOUA l.Akana NGUIMdO dNJOMO Environmental Energy Technologies laboratory(EETl) Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon department of Electrical and Electronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical mod.l.ng of the interaction between solar radiation and the Earth's atmosphere is formalized by the radiative transfer equation(RTE), whose resolution calls for two-stream approximations among other methods. This paper proposes a new two-stream approximation of the RTE with the development of the phase function and the intensity into a third-order series of legendre polynomials. This new approach, which adds one more term in the expression of the intensity and the phase function, allows in the conditions of a plane parallel atmosphere a new mathematical formulation of γparameters. It is then compared to the Eddington, Hemispheric Constant, Quadrature, Combined d.l.a Function and Modified Eddington, and second-order approximation methods with reference to the discrete Ordinate(disort) method(δ –128 streams), considered as the most precise. This work also determines the conversion function of the proposed New Method using the fundamental definition of two-stream approximation(F-TSA) developed in a previous work. Notably,New Method has generally better precision compared to the second-order approximation and Hemispheric Constant methods. Compared to the Quadrature and Eddington methods, New Method shows very good precision for wide domains of the zenith angle μ 0, but tends to deviate from the disort method with the zenith angle, especially for high values of optical thickness. In spite of this divergence in reflectance for high values of optical thickness, very strong correlation with the disort method(R ≈ 1) was obtained for most cases of optical thickness in this study. An analysis of the legendre polynomial series for simple functions shows that the high precision is due to the fact that the approximated functions ameliorate the accuracy when the order of approximation increases, although it has been proven that there is a limit order depending on the function from which the precision is lost. This observation indicates that increasing the order of app

关键词： Radiative Transfer Equation two-stream method legendre polynomial optical thickness moments of specific intensity conversion function transmittance reflectance

Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution

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Bio-design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana d’Amone Francesco Colella lara Pierantoni Valeria Famà Giuseppe Gigli Rui l.Reis J.Miguel Oliveira loretta l.d.l.Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly department of Mathematics and Physics“Ennio de Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell *** this study,ratiometric O_(2)-sensing membranes were prepared by electrospinning,an easy,low-cost,scalable,and robust method for fabricating ***(ε-caprolactone)and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing probe,and rhodamine B isothiocyanate,which was used as the reference *** functionalized scaffolds were morphologically characterized by scanning electron microscopy,and their physicochemical profiles were obtained by Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning microscopy,performing photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(dO)*** sensing nanofibers showed a high response to changes in dO concentrations in the physiological-pathological range from 0.5%to 20%and good stability under ratiometric *** addition,the sensing systems were highly biocompatible for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEl2,breast cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitable biological environment in *** O_(2)-sensing biomaterials can potentially measure alterations in cell metabolism caused by changes in ambient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence