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Gut microbiome in acute pancreatitis:A review based on current literature

World Journal of Gastroenterology 2021年第30期27卷 5019-5036页

作者： bharati kadamb patel kadamb H patel Madhav Bhatia Shridhar Ganpati Iyer Krishnakumar Madhavan Shabbir M Moochhala Department of Surgery National University of SingaporeSingapore 119228Singapore School of Applied Sciences Temasek PolytechnicSingapore 529757Singapore Department of Pathology University of OtagoChristchurch 8140New Zealand Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore National University Hospital National University of SingaporeSingapore 119228Singapore Department of Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

The gut microbiome is a complex microbial community,recognized for its potential role in physiology,health,and *** available evidence supports the role of gut dysbiosis in pancreatic disorders,including acute pancreatitis(AP).In AP,the presence of gut barrier damage resulting in increased mucosal permeability may lead to translocation of intestinal bacteria,necrosis of pancreatic and peripancreatic tissue,and infection,often accompanied by multiple organ dysfunction *** gut microbial homeostasis may reduce the systemic effects of AP.A growing body of evidence suggests the possible involvement of the gut microbiome in various pancreatic diseases,including *** review discusses the possible role of the gut microbiome in *** highlights AP treatment and supplementation with prebiotics,synbiotics,and probiotics to maintain gastrointestinal microbial balance and effectively reduce hospitalization,morbidity and mortality in an early *** also addresses novel therapeutic areas in the gut microbiome,personalized treatment,and provides a roadmap of human microbial contributions to AP that have potential clinical benefit.

关键词： Acute pancreatitis Gut microbiota Biomarkers Diagnostics Dysbiosis

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Prevalence of pulmonary hypertension among children with Down syndrome:A systematic review and meta-analysis

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World Journal of Clinical Pediatrics 2021年第6期10卷 177-191页

作者： Amar Taksande Divya Pujari patel Zeeshan Jameel bharati Taksande Revat Meshram Department of Pediatrics Jawaharlal Nehru Medical CollegeWardha 442004MaharashtraIndia Department of Medicine Mahatma Gandhi Institute of Medical SciencesWardha 442102MaharashtraIndia

BACKGROUND Pulmonary hypertension(PH)has serious short-and long-term *** is gaining increasing importance in high risk groups such as Down syndrome(DS)as it influences their overall survival and ***,there is a dire need to collate the prevalence rates of PH in order to undertake definitive measures for early diagnosis and *** To determine the prevalence of PH in children with *** The authors individually conducted a search of electronic databases manually(Cochrane library,PubMed,EMBASE,Scopus,Web of Science).Data extraction and quality control were independently performed by two reviewers and a third reviewer resolved any conflicts of *** words used in the literature search were“pulmonary hypertension”and“pulmonary arterial hypertension”;“Down syndrome”and“trisomy 21”and“prevalence”.The data were analyzed by Comprehensive Meta-Analysis Software Version *** of bias assessment and STROBE checklist were used for quality *** Of 1578 articles identified,17 were selected for final *** pooled prevalence of PH in these studies was 25.5%.Subgroup analysis was carried out for age,gender,region,year of publication,risk of bias and etiology of *** This review highlights the increasing prevalence of PH in children with *** is crucial for pediatricians to be aware of this morbid disease and channel their efforts towards earlier diagnosis and successful ***-based studies with a larger sample size of children with DS should be carried out to better characterize the epidemiology and underlying etiology of PH in DS.

关键词： Down syndrome Pulmonary hypertension Prevalence Trisomy 21 Persistent pulmonary hypertension Congenital heart disease

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Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 104-115页

作者： Mayank patel Rajashree Hirlekar Department of Pharmaceutics Bharati Vidyapeeth’s College of PharmacySector-8C.B.D.BelapurNavi Mumbai 400614MaharashtraIndia Department of Pharmaceutical Sciences and Technology Institute of Chemical TechnologyN.P.MargMatungaMumbai 400019India Department of Pharmaceutics VES College of PharmacyHashu Advani Memorial ComplexBehind Collector ColonyChembur(E)Mumbai 400074India

The purpose of the present study was to investigate the interaction of Cinnarizine(CIN)with Hydroxypropyl-β-Cyclodextrin(HPβCD)in the presence of Hydroxy Acids(HA).Various binary and ternary systems of CIN with HPβCD and HA were prepared by kneading and coevaporation *** the ternary systems,HA were tried in three different *** interaction in solution phase was studied in detail by the phase solubility method,and the solid phase interactions were characterized by Fourier Transform Infrared(FTIR)spectroscopy,Differential Scanning Calorimetry(DSC),X-Ray Diffractometry(XRD),Scanning Electron Microscopy(SEM)and Proton Nuclear Magnetic Resonance(^1H-NMR).Phase solubility revealed the positive effect of HA on the complexation of CIN with HPβ*** phase characterization confirmed the formation of inclusion complex in the ternary *** and dissolution studies illustrated that out of three different concentrations tried,HA were most effective at the 1 M concentration *** systems were very effective in improving the solubility as well as dissolution profile of CIN than the CIN–HPβCD binary ***,^1H-NMR and Molecular docking studies gave some insight at molecular level that actually which part of CIN was interacting with the HPβ*** docking and free energy calculation even enlighten the role of tartaric acid in increasing solubility of CIN in the ternary system.

关键词： Cinnarizine Hydroxypropyl-β-cyclodextrin Hydroxy acid Ternary system

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Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna patel Vivek Hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

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