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Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

World Journal of Gastroenterology 2011年第43期17卷 4772-4778页

作者： Michal Ganz Timea Csak bharath nath Gyongyi Szabo Department of Medicine University of Massachusetts Medical School

AIM:To examine the activation of the Nalp3 inflammasome and its downstream targets following lipopolysaccharide(LPS) -induced stimulation in the liver. METHODS:Six-to-eight-week-old C57BL/6 chow fed mice were injected intraperitoneally with 0.5μg/g bodyweight LPS and sacrificed 2,4,6,18 or 24 h later. LPS-induced liver damage was confirmed by a biochemical assay to detect alanine aminotransferase(ALT) *** determine if LPS stimulation in the liver led to activation of the inflammasome,real-time quantitative polymerase chain reaction was used to evaluate the mRNA expression of components of the Nalp3 ***-linked immunosorbent assays were used to determine the protein expression levels of several downstream targets of the Nalp3 inflammasome,including caspase-1 and two cytokine targets of caspase-1,interleukin(IL) -1βand IL-18. RESULTS:We found that LPS injection resulted in liver damage as indicated by elevated ALT *** was associated with a significant increase in both mRNA and protein levels of the proinflammatory cy-tokine tumor necrosis factor(TNF) -αin the liver,as well as increased levels of TNFs in *** showed that LPS stimulation led to upregulation of mRNA levels in the liver for all the receptor components of the inflammasome,including Nalp3,Nalp1,pannexin-1 and the adaptor molecule apoptosis-associated specklike,caspase recruitment domain-domain containing *** also found increased levels of mRNA and protein for caspase-1,a downstream target of the *** addition,LPS challenge led to increased levels of both mRNA and protein in the liver for two cytokine targets of caspase-1,IL-1βand IL-18. Interestingly,substantial baseline expression of pre-IL1βand pre-IL-18 was found in the *** and caspase-1 activation was indicated by the significant increase in the active forms of IL-1βand IL-18 after LPS stimulation. CONCLUSION:Our results show that the Nalp3 inflammasome is upregulated and activated in the

关键词： Endotoxin Nod-like receptor Interleukin1β Interleukin-18 Caspase-1

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Malignant pleural mesothelioma:The disdained member of thoracic oncology!

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World Journal of Experimental Medicine 2024年第3期14卷 1-10页

作者： Divya Khosla Pawan Kumar Singh bharath A Chhabria Vaishali Kataria Navneet Singh Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pulmonary and Critical Care Medicine Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohtak 124001India Department of Pulmonary and Critical Care Medicine Ramaiah Memorial HospitalBengaluru 560054India Department of Pulmonary Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos *** ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to *** has an extended latency period usually progressing over decades and presents with nonspecific *** has a median survival ranging between 10-22 *** diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive *** genetic alterations have prognostic significance as *** current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being *** combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid ***,the latter continues to be a robust treatment option for patients with the epithelioid *** is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic *** review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and *** also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically mean

关键词： Chemotherapy Diagnosis Immunotherapy Malignant pleural mesothelioma Radiotherapy

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Assessing the Viability of Gandhar Field in India’s Cambay Basin for CO_(2) Storage

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哈尔滨工程大学学报（英文版） 2024年第3期23卷 529-543页

作者： Vikram Vishal Somali Roy Yashvardhan Verma bharath Shekar Department of Earth Sciences Indian Institute of Technology BombayMumbai 400076India National Centre of Excellence in Carbon Capture and Utilization Indian Institute of Technology BombayMumbai 400076India

Our research is centered on the Gandhar oil field, which was discovered in 1983, where daily oil production has declined significantly over the years. The primary objective was to evaluate the feasibility of carbon dioxide(CO_(2)) storage through its injection into the siliciclastic reservoirs of Ankleshwar Formation. We aimed to obtain high-resolution acoustic impedance data to estimate porosity employing model-based poststack seismic inversion. We conducted an analysis of the density and effective porosity in the target zone through geostatistical techniques and probabilistic neural networks. Simultaneously, the work also involved geomechanical analysis through the computation of pore pressure and fracture gradient using well-log data, geological information, and drilling events in the Gandhar field. Our investigation unveiled spatial variations in effective porosity within the Hazad Member of the Ankleshwar Formation, with an effective porosity exceeding 25% observed in several areas, which indicates the presence of well-connected pore spaces conducive to efficient CO_(2) migration. Geomechanical analysis showed that the vertical stress(Sv) ranged from 55 MPa to 57 MPa in Telwa and from 63.7 MPa to 67.7 MPa in Hazad Member. The pore pressure profile displayed variations along the stratigraphic sequence, with the shale zone, particularly in the Kanwa Formation, attaining the maximum pressure gradient(approximately 36 MPa). However, consistently low pore pressure values(30-34 MPa) considerably below the fracture gradient curves were observed in Hazad Member due to depletion. The results from our analysis provide valuable insights into shaping future field development strategies and exploration of the feasibility of CO_(2) sequestration in Gandhar Field.

关键词： Carbon capture and storage Reservoir characterization Seismic inversion Geomechanics CO_(2)storage CO_(2)enhancing oil recovery

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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Entropy generation analysis from the time-dependent quadratic combined convective flow with multiple diffusions and nonlinear thermal radiation

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Chinese Journal of Chemical Engineering 2023年第1期53卷 46-55页

作者： P.M.Patil bharath Goudar Department of Mathematics Karnatak UniversityPavate NagarDharwad 580003India Wrangler Dr.D.C.Pavate Institute of Mathematical Sciences Karnatak UniversityDharwad 580003India

Diffusions of multiple components have numerous applications such as underground water flow, pollutant movement, stratospheric warming, and food processing. Particularly, liquid hydrogen is used in the cooling process of the aeroplane. Further, liquid nitrogen can find applications in cooling equipment or electronic devices, i.e., high temperature superconducting(HTS) cables. So, herein, we have analysed the entropy generation(EG), nonlinear thermal radiation and unsteady(time-dependent) nature of the flow on quadratic combined convective flow over a permeable slender cylinder with diffusions of liquid hydrogen and nitrogen. The governing equations for flow and heat transfer characteristics are expressed in terms of nonlinear coupled partial differential equations. The solutions of these equations are attempted numerically by employing the quasilinearization technique with the implicit finite difference approximation. It is found that EG is minimum for double diffusion(liquid hydrogen and heat diffusion)than triple diffusion(diffusion of liquid hydrogen, nitrogen and heat). The enhancing values of the radiation parameter R_(d) and temperature ratio θ_(w) augment the fluid temperature for steady and unsteady cases as well as the local Nusselt number. Because, the fluid absorbs the heat energy released due to radiation, and in turn releases the heat energy from the cylinder to the surrounding surface.

关键词： Unsteady flow Entropy Radiation Quasilinearization technique Numerical analysis Quadratic combined convection

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Design and applications of lattice plasmon resonances

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Nano Research 2018年第9期11卷 4423-4440页

作者： bharath Bangalore Rajeeva Linhan Lin Yuebing Zheng Materials Science and Engineering Program Department of Mechanical Engineering The University of Texas at Austin Austin Texas78712 USA

With their unique optical properties associated with the excitation of surface plasmons, metal nanoparticles （NPs） have been used in optical sensors and devices. The organization of these NPs into arrays can induce coupling effects to engineer new optical responses. In particular, lattice plasmon resonances （LPRs）, which arise from coherent interactions and coupling among NPs in periodic arrays, have shown great promise for realizing narrow linewidths, angle-dependent dispersions, and high wavelength tunability of optical spectra. By engineering the materials, shapes, sizes, and spatial arrangements of NPs within arrays, one can tune the LPR-based spectral responses and electromagnetic field distributions to deliver a multitude of improvements, including a high figure-of-merit, superior light-matter interaction, and multiband operation. In this review, we discuss recent progress in designing and applying new metal nanostructures for LPR-based applications. We conclude this review with our perspective on the future opportunities and challenges of LPR-based devices.

关键词： plasmonics,lattice plasmon resonance,nanoparticle array coupling,sensors

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Geospatial analysis of forest fragmentation in Uttara Kannada District, India

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Forest Ecosystems 2016年第3期3卷 206-220页

作者： Ramachandra T V bharath Setturu Subash Chandran Energy & Wetlands Research Group Center for Ecological Sciences（CES） Indian Institute of Science Centre for Sustainable Technologies (astra) Bangalore Karnataka 560 012 India Centre for infrastructure Sustainable Transportation and Urban Planning（CiSTUP） Indian Institute of Science Bangalore Karnataka 560 012 India

Background： Landscapes consist of heterogeneous interacting dynamic elements with complex ecological, economic and cultural attributes. These complex interactions help in the sustenance of natural resources through bio-geochemical and hydrological cycling. The ecosystem functions are altered with changes in the landscape structure, Fragmentation of large contiguous forests to small and isolated forest patches either by natural phenomena or anthropogenic activities leads to drastic changes in forest patch sizes, shape, connectivity and internal heterogeneity, which restrict the movement leading to inbreeding among Meta populations with extirpation of species. Methods： Landscape dynamics are assessed through land use analysis by way of remote sensing data acquired at different time periods. Forest fragmentation is assessed at the pixel level through computation of two indicators, i.e., Pf （the ratio of pixels that are forested to the total non-water pixels in the window） and P~ （the proportion of all adjacent （cardinal directions only） pixel pairs that include at least one forest pixel, for which both pixels are forested）. Results： Uttara Kannada District has the distinction of having the highest forest cover in Karnataka State, India. This region has been experiencing changes in its forest cover and consequent alterations in functional abilities of its ecosystem. Temporal land use analyses show the trend of deforestation, evident from the reduction of evergreen - semi evergreen forest cover from 57.31% （1979） to 32.08 % （2013） Forest fragmentation at the landscape level shows a decline of interior forests 64.42 % （1979） to 25.62 % （20] 3） and transition of non-forest categories such as crop land, plantations and built-up areas, amounting now to 47.29 %. PCA prioritized geophysical and socio variables responsible for changes in the landscape structure at local levels. Conclusion： Terrestrial forest ecosystems in Uttara Kannada District of Central Western Ghats have be

关键词： Land use dynamics Forest fraqmentation Interior forests Biodiversity Geophysical variables

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Optimal finite-dimensional spectral densities for the identification of continuous-time MIMO systems

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Control Theory and Technology 2019年第3期17卷 276-296页

作者： I.M.MITHUN Shravan MOHAN bharath BHIKKAJI Department of Electrical Engineering Indian Institute of Technology Madras Chennai 600036 India

This paper presents a method for designing in puts to identify linear con tinuous-time multiple-input multiple-output (MIMO) systems. The goal here is to design a T-optimal band-limited spectrum satisfying certain input/output power constraints. The input power spectral density matrix is parametrized as the productφu(jω)= 1/2H(jω)H^H(jω),where H(jω) is a matrix polynomial. This parametrization transforms the T-optimal cost function and the constraints into a quadratically constrained quadratic program (QCQP). The QCQP turns out to be a non-convex semidefinite program with a rank one constraint. A convex relaxation of the problem is first solved. A rank one solution is constructed from the solution to the relaxed problem. This relaxation admits no gap between its solution and the original non-convex QCQP problem. The constructed rank one solution leads to a spectrum that is optimal. The proposed input design methodology is experimentally validated on a cantilever beam bonded with piezoelectric plates for sensing and actuation. Subspace identification algorithm is used to estimate the system from the input-output data.

关键词： System identification optimal input design fisher information matrix quadratically constrained quadratic program

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Parkinson’s Disease Classification Using Random Forest Kerb Feature Selection

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Intelligent Automation & Soft Computing 2023年第5期36卷 1417-1433页

作者： E.bharath T.Rajagopalan Department of Computer Science and Engineering University College of EngineeringVillupuramKakupppam605103India Department of Science and Humanities University of College of EngineeringAriyalurKavanur621705India

Parkinson’s disease(PD)is a neurodegenerative disease cause by a deﬁciency of *** have identiﬁed the voice as the underlying symptom of *** vocal disorder studies provide adequate treatment and support for accurate PD *** learning(ML)models have recently helped to solve problems in the classiﬁcation of chronic *** work aims to analyze the effect of selecting features on ML efﬁciency on a voice-based PD detection *** includes PD classiﬁcation models of Random forest,decision Tree,neural network,logistic regression and support vector *** feature selection is made by RF mean-decrease in accuracy and mean-decrease in Gini *** forest kerb feature selection(RFKFS)selects only 17 features from 754 *** proposed technique uses validation metrics to assess the performance of ML *** results of the RF model with feature selection performed well among all other models with high accuracy score of 96.56%and a precision of 88.02%,a sensitivity of 98.26%,a speciﬁcity of 96.06%.The respective validation score has an Non polynomial vector(NPV)of 99.47%,a Geometric Mean(GM)of 97.15%,a Youden’s index(YI)of 94.32%,and a Matthews’s correlation method(MCC)90.84%.The proposed model is also more robust than other *** was also realised that using the RFKFS approach in the PD results in an effective and high-performing medical classiﬁer.

关键词： Parkinson’s disease machine learning healthcare random forest feature selection classiﬁcation

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Dynamic Active Noise Control of Broadband Noise in Fighter Aircraft Pilot Helmet

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Sound & Vibration 2022年第4期56卷 319-331页

作者： Y.K.bharath S.Veena Malnad College of Engineering Hassan573202India National Aerospace Laboratories Bengaluru560017India

This paper presents the development of a dynamic Active Noise Control(ANC)algorithm aimed towards redu-cingthe broadbandnoiseinside the helmet earcups ofaﬁghter aircraftpilot *** dynamicANC involves a Variable Step-Size Grifﬁths(VSSG)FxLMS algorithm to attenuate noise entering directly through helmet,a LMS based adaptive noise canceller to attenuate noise entering through the pilot microphone,and energy detectors for failure protection and optimized battery power *** algorithms are implemented on Texas Instruments’TMS320C6748 processor and are tested in a helmet ANC experimental setup.

关键词： Active noise control Variable Step-Size Grifﬁths algorithm FxLMS

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