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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 59-64页

作者： Bibek Poudel Binod Kumar Yadav Arun Kumar bharat jha Kanak Bahadur Raut Department of Biochemistry Manipal College of Medical Sciences(MCOMS)Manipal Teaching Hospital(MTH) Research Institute of Clinical Medicine Chonbuk National University Medical School and Hospital Department of Biochemistry Institute of MedicineTribhuvan University Teaching Hospital(Institute of MedicineTUTH) Department of Internal.Medicine Institute of MedicineTribhuvan University Teaching Hospital(Institute of MedicineTUTH)

Objective:To develop the missing link between hyperuricemia and ***:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine *** was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National *** 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the *** potential confounding factors of hyperuricemia and hypertension in both cases and controls were *** acid levels in all participants were ***:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were *** mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.

关键词： Newly diagnosed hypertension Serum uric acid Hyperuricemia Joint National Committee

Effect of in ovo feeding of xylobiose and xylotriose on plasma immunoglobulin, cecal metabolites production, microbial ecology, and metabolic pathways in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1578-1589页

作者： Razib Das Pravin Mishra Birendra Mishra Rajesh jha Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background Dietary supplementation of xylooligosac charides(XOS) has been found to influence gut health by manipulating cecal microbiota and producing microbe-origin *** no study investigated and compared the effect of in ovo feeding of xylobiose(XOS2) and xy lotriose(XOS3) in *** study investigated the effect of in ovo feeding of these XOS compounds on post-hatch gut health parameters in chickens.A total of 144 fertilized chicken eggs were divided into three groups:a) non-injected control(CON),b) XOS2,and c) *** the 17^(th) embryonic day,the eggs of the XOS2 and XOS3 groups were injected with 3 mg of XOS2 and XOS3 diluted in 0.5 mL of 0.85% normal saline through the amniotic *** hatching,the chicks were raised for 21 *** was collected on d 14 to measure plasma *** digests were collected for measuring short-chain fatty acids(SCFA) on d 14 and 21,and for microbial ecology and microbial metabolic pathway analyses on d 7 and *** The results were considered significantly different at P<*** quantified plasma IgA and IgG on d 14chickens,revealing no differences among the *** chromatography results showed no significant differences in the concentrations of cecal SCFAs on d 14 but significant differences on d ***;the SCFA concentrations were lower in the XOS3 than in the CON group on d *** cecal metagenomics data showed that the abundance of the family Clostridiaceae significantly decreased on d 7,and the abundance of the family Oscillospiraceae increased on d 21 in the XOS2 compared to the *** was a reduction in the relative abundance of genus Clostridium sense stricto 1 in the XOS2 compared to the CON on d 7 and the genus Ruminococcus,torques in both XOS2 and XOS3 groups compared to the CON on d *** XOS2 and XOS3 groups reduced the genes for chondroitin sulfate degradation Ⅰ and L-histidine degradation Ⅰpathways,which contribute to improved gut health,respectivelyc in the micr

关键词： Broiler In ovo Metagenomics Prebiotic Xylooligosaccharides

Massless Dirac perturbations of black holes in f(Q)gravity:quasinormal modes and a weak deflection angle

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Communications in Theoretical Physics 2024年第9期76卷 73-82页

作者： Ahmad Al-Badawi Sohan Kumar jha Department of Physics Al-Hussein Bin Talal UniversityPO Box 2071111Ma'anJordan Department of Physics Chandernagore CollegeChandernagoreHooghlyWest BengalIndia

This article considers a static and spherical black hole(BH)in f(Q)gravity.f(Q)gravity is the extension of symmetric teleparallel general relativity,where both curvature and torsion are vanishing and gravity is described by *** this study,we investigate the possible implications of quasinormal mode(QNM)modified Hawking spectra and deflection angles generated by the *** Wentzel–Kramers–Brillouin method is used to solve the equations of motion for massless Dirac perturbation fields and explore the impact of the nonmetricity parameter(Q_(0)).Based on the QNM computation,we can ensure that the BH is stable against massless Dirac perturbations and as Q_(0)increases the oscillatory frequency of the mode *** then discuss the weak deflection angle in the weak field limit *** compute the deflection angle up to the fourth order of approximation and show how the nonmetricity parameter affects *** find that the Q_(0)parameter reduces the deflection angle.

关键词： black holes in f(Q)gravity massless Dirac perturbations quasinormal modes deflection angle

Effects of Enteromorpha prolifera polysaccharides on growth performance,intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

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Journal of Animal Science and Biotechnology 2024年第1期15卷 344-361页

作者： Wenchao Liu Huimei Liu Yaoyao Wang Zhongxiang Zhao Balamuralikrishnan Balasubramanian Rajesh jha Department of Animal Science College of Coastal Agricultural SciencesGuangdong Ocean UniversityZhanjiangGuangdong 524088People’s Republic of China Department of Food Science and Biotechnology College of Life ScienceSejong UniversitySeoul 05006South Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background Global warming leading to heat stress(HS)is becoming a major challenge for broiler *** study aimed to explore the protective effects of seaweed(Enteromorpha prolifera)polysaccharides(EPS)on the intestinal barrier function,microbial ecology,and performance of broilers under HS.A total of 144 yellow-feathered broilers(male,56 days old)with 682.59±7.38 g were randomly assigned to 3 groups:1)TN(thermal neutral zone,23.6±1.8℃),2)HS(heat stress,33.2±1.5℃ for 10 h/d),and 3)HSE(HS+0.1%EPS).Each group contained 6 replicates with 8 broilers per *** study was conducted for 4 weeks;feed intake and body weights were measured at the end of weeks 2 and *** the end of the feeding trial,small intestine samples were collected for histomorphology,antioxidant,secretory immunoglobulin A(s Ig A)content,apoptosis,gene and protein expression analysis;cecal contents were also collected for microbiota analysis based on 16S r DNA *** Dietary EPS promoted the average daily gain(ADG)of broilers during 3–4 weeks of HS(P<0.05).At the end of HS on broilers,the activity of total superoxide dismutase(T-SOD),glutathione S-transferase(GST),and the content of s Ig A in jejunum were improved by EPS supplementation(P<0.05).Besides,dietary EPS reduced the epithelial cell apoptosis of jejunum and ileum in heat-stressed broilers(P<0.05).Addition of EPS in HS group broilers'diet upregulated the relative m RNA expression of Occludin,ZO-1,γ-GCLc and IL-10 of the jejunum(P<0.05),whereas downregulated the relative m RNA expression of NF-κB p65,TNF-αand IL-1βof the jejunum(P<0.05).Dietary EPS increased the protein expression of Occludin and ZO-1,whereas it reduced the protein expression of NF-κB p65 and MLCK(P<0.01)and tended to decrease the protein expression of TNF-α(P=0.094)in heat-stressed ***,the proportions of Bacteroides and Oscillospira among the three groups were positively associated with jejunal apoptosis and pro-inflammatory cytokine ex

关键词： Broilers Cecal microbiota Heat stress Intestinal barrier function Seaweed polysaccharides

Pre‑hatch thermal manipulation of embryos and post‑hatch baicalein supplementation mitigated heat stress in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1071-1085页

作者： Sadid Al Amaz Ajay Chaudhary Prem Lal Mahato Rajesh jha Birendra Mishra Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawai’i at ManoaAgSci 2161955 East‑West RdHonoluluHI 96822USA

Background High environmental temperatures induce heat stress in broiler chickens,affecting their health and pro-duction *** dietary,managerial,and genetics strategies have been tested with some success in mitigating heat stress(HS)in *** novel HS mitigation strategies for sustaining broiler production is critically *** study investigated the effects of pre-hatch thermal manipulation(TM)and post-hatch baica-lein supplementation on growth performance and health parameters in heat-stressed *** Six hundred fertile Cobb 500 eggs were incubated for 21 *** candling on embryonic day(ED)10,238 eggs were thermally manipulated at 38.5℃ with 55%relative humidity(RH)from ED 12 to 18,then transferred to the hatcher(ED 19 to 21,standard temperature)and 236 eggs were incubated at a controlled temperature(37.5℃)till *** hatch,180-day-old chicks from both groups were raised in 36 pens(n=10 birds/pen,6 replicates per treatment).The treatments were:1)Control,2)TM,3)control heat stress(CHS),4)thermal manipulation heat stress(TMHS),5)control heat stress supplement(CHSS),and 6)thermal manipulation heat stress supplement(TMHSS).All birds were raised under the standard environment for 21 d,followed by chronic heat stress from d 22 to 35(32–33℃ for 8 h)in the CHS,TMHS,CHSS,and TMHSS groups.A thermoneutral(22–24℃)environment was maintained in the Control and TM *** was constant(50%±5%)throughout the *** the data were analyzed using one-way ANOVA in R and GraphPad software at P<0.05 and are presented as mean±*** stress significantly decreased(P<0.05)the final body weight and ADG in CHS and TMHS groups compared to the other *** TM significantly increased(P<0.05)the expression of heat shock protein-related genes(HSP70,HSP90,and HSPH1)and antioxidant-related genes(GPX1 and TXN).TMHS birds showed a significant increment(P<0.05)in total cecal volatile fatty acid(VFA)concentration compared to the CHS bird

关键词： Baicalein Growth performance Gut microbiota Heat stress Thermal manipulation

Proposed numerical and machine learning models for fiber-reinforced polymer concrete-steel hollow and solid elliptical columns

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1169-1194页

作者： Tang QIONG Ishan jha Alireza BAHRAMI Haytham F.ISLEEM Rakesh KUMAR Pijush SAMUI School of Applied Technologies Qujing Normal UniversityQujing 655011China Department of Civil Engineering Indian Institute of Technology-BHUVaranasi 221005India Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of GävleGävle 80176Sweden Department of Civil Engineering National Institute of Technology-PatnaPatna 800005India

This study employs a hybrid approach,integrating finite element method(FEM)simulations with machine learning(ML)techniques to investigate the structural performance of double-skin tubular columns(DSTCs)reinforced with glass fiber-reinforced polymer(GFRP).The investigation involves a comprehensive examination of critical parameters,including aspect ratio,concrete strength,number of GFRP confinement layers,and dimensions of steel tubes used in DSTCs,through comparative analyses and parametric *** ensure the credibility of the findings,the results are rigorously validated against experimental data,establishing the precision and trustworthiness of the *** present research work examines the use of the columns with elliptical cross-sections and contributes valuable insights into the application of FEM and ML in the design and evaluation of structural systems within the field of structural engineering.

关键词： elliptical column fiber-reinforced polymer machine learning finite element method ABAQUS

Rice Heat Tolerance Breeding: A Comprehensive Review and Forward Gaze

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Rice science 2024年第4期31卷 375-400,I0022页

作者： Ravindran Lalithambika VISAKH Sreekumar ANAND Sukumaran Nair ARYA Behera SASMITA Uday Chand jha Rameswar Prasad SAH Radha BEENA Department of Genetics and Plant Breeding College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India Crop Improvement Division Indian Council of Agricultural Research-National Rice Research InstituteCuttackOdisha 7530006India Department of Plant Breeding and Genetics Indian Institute of Pulse ResearchKanpur 208024India Department of Plant Physiology College of AgricultureVellayaniKerala Agricultural UniversityThiruvananthapuramKerala 695522India

The yield potential of rice is seriously affected by heat stress due to climate change. Since rice is a staple food globally, it is imperative to develop heat-resistant rice varieties. Thus, a thorough understanding of the complex molecular mechanisms underlying heat tolerance and the impact of high temperatures on various critical stages of the crop is needed. Adoption of both conventional and innovative breeding strategies offers a long-term advantage over other methods, such as agronomic practices, to counter heat stress. In this review, we summarize the effects of heat stress, regulatory pathways for heat tolerance, phenotyping strategies, and various breeding methods available for developing heat-tolerant rice. We offer perspectives and knowledge to guide future research endeavors aimed at enhancing the ability of rice to withstand heat stress and ultimately benefit humanity.

关键词： genetic mechanism high-temperature stress molecular breeding genomics selection

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar jha Shreesh Ojha Dinesh Kumar Niraj Kumar jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Evaluation of temperature dependent vortex pinning properties in strongly pinned YBa_(2)Cu_(3)O_(7-δ)thin films with Y_(2)BaCuO_(5)nanoinclusions

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Superconductivity 2024年第1期9卷 95-105页

作者： Alok K.jha Kaname Matsumoto Tomoya Horide Shrikant Saini Ataru Ichinose Paolo Mele Yutaka Yoshida Satoshi Awaji Department of Materials Science and Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Department of Mechanical and Control Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Central Research Institute of Electrical Power Industry YokosukaKanagawa 240-0196Japan College of Engineering-Innovative Global Program Shibaura Institute of TechnologyMinuma-kuSaitama 337-8570Japan Department of Energy Engineering and Science Nagoya UniversityChikusa-kuNagoya 464-8603Japan Institute for Materials Research Tohoku UniversityAoba-kuSendai 980-8577Japan

The pinning of quantized magnetic vortices in superconducting YBa_(2)Cu_(3)O_(7-δ)(YBCO or Y123)thin films with Y_(2)BaCuO_(5)(Y211)nanoinclusions have been investigated over wide temperature range(4.2-77 K).The concentration of Y211 nanoinclusions has been systematically varied inside YBCO thin films prepared by laser ablation technique using surface modified target *** pinning force density values(Fp∼0.5 TNm^(−3)at 4.2 K,9 T)have been observed for the YBCO film with moderate concentration of Y211 nanoinclusions(3.6 area%on ablation target).In addition,uniform enhancement in critical current density(J_(c))was observed in the angular dependent J_(c)measurement of YBCO+Y211 nanocomposite films.Y211 nanoinclusions have been found to be very efficient in pinning the quantized vortices thereby enhancing the in‐field J_(c)values over a wide range of *** the concentration of Y211 secondary phase into Y123 film matrix results into agglomeration of Y211 phase and observed as increased Y211 nanoparticle *** larger secondary phase nanoparticles are not as efficient pinning centers at lower temperatures as they are at higher temperatures due to substantial reduction of the coherence length at lower *** of the temperature dependence of J_(c)for YBCO+Y211 nanocomposite films has been conducted and possible vortex pinning mechanism in these nanocomposite films has been discussed.

关键词： YBCO thin film Critical current Vortex pinning Nanoscale APCs

Improving Education for a More Equitable World:Social Justice Perspectives

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ECNU Review of Education 2024年第2期7卷 209-213页

作者：李军 Garima jha Western University I137 Western RoadLondonON N6G IG7Canada

To many,education remains a dream of equal opportunities for all learners,regardless of their backgrounds and *** advocated 2,500 years ago for education without discrimination(有教无类),a dream of education for *** evolving vision was renewed right after WWII by the United Nations Universal Declaration of Human Rights,stipulating that everyone has the right to *** pioneers,like minority woman leader Patsy Mink,have long envisioned equal education with persevering efforts for the United States,the realities in the country and worldwide do not reflect this dream.

关键词： dream everyone education