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Efficacy and Safety of PDM011011 Capsules as Compared to Metformin in Subjects with Type-2 Diabetes Mellitus: An Open-Label, Randomized, Active-Controlled, Multicentric, Phase III Study

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Journal of Diabetes Mellitus 2016年第1期6卷 38-48页

作者： Ashish C. Suthar Vikas G. Pai Yogesh Kadam Aniruddha Tongaonkar Shailaja kale Atul b. Deshpande Sharat Kolke Snehal Tanna Shrikant V. Deshpande Purvi Chawla Debjit biswas Somesh Sharma Piramal Enterprises Limited Mumbai India Pai Clinic and Diagnostic Center Pune India Poona Diabetes Centre Pune India Tongaonkar Hospital Pune India Orange Diabetes Clinical Research Unit Pune India Ethika Clinical Research Centre Prakruti Hospital Thane India Kolkes Clinic Mumbai India Clinic De Care Thane India Ashirwad Hospital and Medical Research Centre Thane India

Context: bitter melon (Momoradica charantia) is one of the well-known plants used for lowering blood glucose since antiquity. Aims: To compare the efficacy and safety of PDM011011 capsule (1200 mg/day) with Metformin (1000 mg/day) in a 15 weeks study using mean change in fasting plasma glucose (FPG) and Hb1Ac% in subjects with type 2 diabetes mellitus (T2DM). Settings and Design: This is an open-label, randomized, active-controlled, multicentric, phase III study. Methods and Material: A total of 123 eligible patients were randomized in 2:1 ratio in PDM011011 and Metformin arm. Total 83 subjects received PDM011011 capsule (1200 mg/day) and 40 subjects received Metformin (1000 mg/day) in their respective arms for 15 weeks. Subjects were analyzed for FPG and Hb1Ac% at baseline and during treatment visits (Visit 3 to Visit 7). Safety assessments were carried out. Results: In this study, the significant reduction in mean FPG level was observed after treatment with PDM011011 capsule and Metformin in T2DM patients. The mean change from baseline to week 15 in FPG was 14.52 mg/dL (95% CI: 6.36, 22.67) in the PDM011011-treated subjects and 28.34 mg/dL (95% CI: 21.35, 35.32) in the Metformin-treated subjects. At week 15, the mean change from baseline in HbA1c levels was 0.27% (95% CI: 0.06, 0.47) in the PDM011011 arm and 0.62% (95% CI: 0.40, 0.83) in the Metformin arm. Conclusion: PDM011011 capsule (1200 mg/day) exhibited the modest efficacy and safety as compared to Metformin (1000 mg/day) in type 2 diabetes patients.

关键词： Momoradica charantia Glycebal Diabetes mellitus Anti-Diabetic

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b-1b型轰炸机基地

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机场工程 1991年第1期 69-71页

作者： kale.,MJ 王金秀

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Effect of Oxalate Precursor Formation Temperature on Magnetic Properties of Nicuzn Ferrites

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Materials Sciences and Applications 2011年第8期

作者： Neelam S. Shinde Sujata S. Khot bhimrao P. Ladgaonkar bharat b. kale Sanjay Apte Prasad M. Tamhankar Shrikant C. Watawe

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Impacts of Date Palm Seeds （Phoenix dactyliferous L.） on Growth Indices and Nutrient Utilization of Common Carp Cyprinus carpio L,

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Journal of Agricultural Science and Technology(b) 2017年第4期7卷 280-284页

作者： Vian Mohammed Ahmed Nasreen Mohialddin Abdulrahman Sarwar Abubaker HamaAmeen bakhan Rafiq Hassan Abu baker Kamil Abbas baxan Akram Hussen Idres Shexa Hamad Sana Abdulla Karem kale Mamand Aziz Department of Animal Sciences College of Agricultural Sciences University of Sulaimani Sulaimaniya lraq

This study was carried out to study the effect of adding different levels of date palm seed （Phoentix dactyliJProus） powder in the diet of common carp （Cyprinus carpio） at fish laboratory of Animal Production Department, College of Agricultural Sciences, Sulaimani University, Sulaimani, Iraq. The actual experimental feeding trials were conducted for 70 d and the adaptation period for 21 d. A total of 81 common carp fingerlings weighted 62 ± 2 g were divided into three experimental groups. The control treatment T1 was with 0 g date palm seed, T2 with 2.5 g date palm seed per kg diet and T3 with 5 g date palm seed per kg diet. Each treatment was in three replicates in which three common carp fingerlings were stocked in each aquarium which fed the experimental diets twice daily. The results indicated that weight gain （WG） and specific growth rate （SGR） in the third treatment （T3） group were significantly higher than those of fish fed control diets. T2 consumed more diet than other treatments with 306.940 g with higher feed conversion ratio （FCR）; T3 was higher significantly in food efficiency. No significant （P 〈 0.05） differences obtained from consumed protein while the protein efficiency ratio was significantly higher in T3 with 319.323. Control was higher significantly in flesh weight without viscera with the third treatment; in flesh weight without head and viscera each the control and the second treatment was significantly higher than the third treatment. As a conclusion, the date palm seeds powder have a positive effect on growth performance of common carp.

关键词： Weight gain specific growth rate relative growth rate feed conversion ratio food efficiency protein efficiency ratio date palm seeds common carp.

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基于J2EE/CORbA的MODIS 1b数据发布平台的设计

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计算机与数字工程 2005年第11期33卷 112-114页

作者：贾卡乐曾致远张莉华中科技大学水电与数字化工程学院武汉430074

提出了将J2EE和CORbA的集成应用于基于HDF4格式的遥感数据发布系统的思想,介绍了HDF4文件格式,阐述了该应用的必要性;分析了该模型的体系结构以及客户端、应用服务器端、CORbA组件和数据库的设计过程;最后展望了该模型的应用前景。

关键词： J2EE CADRbA HDF4 MODIS

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Discontinuous Galerkin Methods on Unstructured Spacetime Grids:Recent Progress

Discontinuous Galerkin Methods on Unstructured Spacetime Gri...

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： Robert b. Haber Department of Theoretical & Applied Mechanics University of Illinois at Urbana-Champaign 104 S. Wright St. IL 61801 USA

This paper reviews recent progress relating to spacetime discontinuous Galerkin (SDG) finite element methods and applications implemented on unstructured spacetime grids. Our focus is on methods for hyperbolic problems for which it is possible to construct causal spacetime meshes that support patch-by-patch solution procedures with O(N) computational complexity. We begin with a review of spacetime discontinuous Galerkin finite element formulations, emphasizing recent work on shock capturing strategies and the use of Godunov fluxes. We describe new spacetime meshing procedures that 1) generate causal meshes for nonlinear conservation laws, 2) focus h-adaptive refinement on the spacetime trajectories of shocks and other critical solution features, and 3) execute in parallel with run-time load balancing to compensate for adaptive refinement and basis enrichment. We also describe special per-pixel rendering and visualization technologies for visualization of high-order data sets defined on unstructured spacetime grids. We survey current applications of SDG methods, including cohesive interface models for fracture and dewetting of microstructural inclusions, the Euler equations for incompressible gas dynamics, and Hamilton-Jacobi equations for modeling interface dynamics in the evolution of material microstructures. Finally, we discuss new applications of SDG concepts to coupled continuum and atomistic models. The author wishes to express his gratitude to coworkers who made substantial contributions to the work reported here: R. Abedi, J. Erickson, Y. Fan, M. Garland, D. Guoy, M. Hawker, M. Hills, K. Jegdic, R. Jerrard, D. Johnson, S. kale, b. Kraczek, J. Palaniappan, b. Petracovici, J. Sullivan, S, Thite, C. Xia, and Y. Zhou. This work was partially supported by the Center for Process Simulation & Design under US NSF grant DMR-0121695 and by the Center for Simulation of Advanced Rockets under US DOE grant LLNL b341494.

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Nutritional Yield of African Indigenous Vegetables in Water-Deficient and Water-Sufficient Conditions

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Food and Nutrition Sciences 2014年第9期5卷 812-822页

作者： Jen Wen Luoh Caroline b. begg Rachael C. Symonds Dolores Ledesma Ray-Yu Yang biostatistics AVRDC-The World Vegetable Center Tainan Taiwan biotechnology and Molecular breeding AVRDC-The World Vegetable Center Tainan Taiwan Department of Plant Science McGill University Ste-Anne-de-Bellevue Canada Nutrition AVRDC-The World Vegetable Center Tainan Taiwan

Water scarcity in certain regions of sub-Saharan Africa impacts agricultural production while prolonging dry seasons, and contributing to food insecurity and malnutrition. The objectives of the study were to evaluate the nutritional yield (edible yield × nutritional content) of indigenous leafy vegetables commonly consumed in Africa under water-stressed conditions. Two species of amaranth, two species of African nightshade, and two varieties of Ethiopian kale were examined under environment-controlled water-sufficient and water-deficient conditions. Fresh and dry stem and leaf weights significantly decreased in the three crop groups under the water-deficient treatment. Nutritional values for carotenoids, tocopherols, calcium and zinc showed significant differences at the content level among treatments. Among the 6 crops evaluated, the amaranth species named Amaranthus hypochondriacus and the African nightshade species named Solanum scabrum had the lowest nutrient losses in drought conditions.

关键词： les Abiotic Stress Drought Tolerant Micronutrients Antioxidant Activity

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