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Neuroprotective effects of Fructus Chebulae extracts on experimental models of cerebral ischemia

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中医杂志：英文版 2014年第1期34卷 69-75页

作者： bhakta prasad gaire Hocheol Kim Department of Herbal Pharmacology College of Korean MedicineKyung Hee University

OBJECTIVE:To investigate the neuroprotective effects of Fructus Chebulae extract using both in vivo and invitromodels of cerebral ischemia.METHODS:As an in vitro model,oxygen glucose deprivation followed by reoxygenation(OGD-R)and hydrogen peroxide(H2O2)induced cellular damage in rat pheochromocytoma(PC12)cells was used to investigate the neuroprotective effects of extract of Fructus Chebulae.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to calculate cell survival.For in vivo,occlusion of left middle cerebral artery on rats was carried out as a focal cerebral ischemic model.RESULTS:Fructus Chebulae extract increases the PC12 cell survival against OGD-R and H2O2by 68%and 91.4%respectively.Fructus Chebulae also de-creases the cerebral infarct volume by 39%and extent of hemisphere swelling from 17%in control group to 10%in FructusChebulaetreated group.CONCLUSION:Fructus Chebulae,as a traditional medicine,can rescue the neuronal cell death against ischemia related damage.The possible mechanism for the neuroprotection might be the inhibition of oxidative damages occurring after acute phase of cerebral ischemia.

关键词：局灶性脑缺血神经保护作用实验模型提取物诃子细胞存活率细胞损伤神经细胞死亡

A review on the pharmacological and toxicological aspects of Datura stramonium L.

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Journal of Integrative Medicine 2013年第2期11卷 73-79页

作者： bhakta prasad gaire Lalita Subedi Department of Herbal Pharmacology College of Oriental Medicine Kyung Hee University Department of Pharmaceutical Sciences School of Health and Allied Sciences Pokhara University

Datura stramonium L., a wild-growing plant of the Solanaceae family, is widely distributed and easily accessible. It contains a variety of toxic tropane alkaloids such as atropine, hyoscamine, and scopolamine. In Eastern medicine, especially in Ayurvedic medicine, D. stramonium has been used for curing various human ailments, including ulcers, wounds, inflammation, rheumatism and gout, sciatica, bruises and swellings, fever, asthma and bronchitis, and toothache. A few previous studies have reported on the pharmacological effects of D. stramonium; however, complete information regarding the pharmacology, toxicity, ethnobotany and phytochemistry remains unclear. Ethnomedicinally, the frequent recreational abuse of D. stramonium has resulted in toxic syndromes. D. stramonium, in the form of paste or solution to relieve the local pain, may not have a deleterious effect; however, oral and systemic administration may lead to severe anticholinergic symptoms. For this reason, it is very important for individuals, mainly young people, to be aware of the toxic nature and potential risks associated with the use of this plant. This comprehensive review of D. stramonium includes information on botany, phytochemistry, pharmacology, toxicology and ethnomedicinal uses.

关键词： Datura stramonium pharmacologic actions medicine, traditional phytotherapy drug toxicity review

Scutellaria baicalensis in Stroke Management:Nature's Blessing in Traditional Eastern Medicine

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Chinese Journal of Integrative Medicine 2014年第9期20卷 712-720页

作者： bhakta prasad gaire Sang-Kwan Moon Hocheol Kim Department of Herbal Pharmacology College of Korean MedicineKyung Hee UniversitySeoul 130-701Korea Department of Carcliology and Neurology Hospital of Oriental MedicineKyung Hee UniversitySeoulKorea

Scutellaria baicalensis Georgi is the most widely used medicinal plant in traditional Eastem medicine, especially in Chinese medicine. The major phytochemicals isolated from S. baicalensis are flavonoids, glycosides and their glucoronides such as baicalin, baicalein, wogonin etc. More than 30 different kinds of flavonoids are isolated from this plant. S. baicalensis and its flavonoids are reported to have several pharmacological activities, which includes anti-allergic, antioxidant, anti apoptic, anti-inflammatory effects and many more. Recently, S. baicalensis and its isolated flavonoids have been studied for their neuroprotective effects, through a variety of in vitro and in vivo models of neurodegenerative diseases, plausibly suggesting that S. baicalensis has salutary effect as a nature＇s blessing for neuroprotection. In this review, we are focousing on the neuroprotective effects of S. baicalensis and its flavonoids in ischemia or stroke-induced neuronal cell death. We aimed at compiling all the information regarding the neuroprotective effect of S. baicalensis in various experimental models of cerebral ischemia or stroke.

关键词： Scutellaria baicalensis flavonoids neuroprotection ischemia stroke

Promising Pharmaceuticals:edited by Purusotam Basnet

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Journal of Integrative Medicine 2014年第3期12卷 191-194页

作者： Ramakanta Lamichhane bhakta prasad gaire Department of Oriental Pharmacy College of PharmacyWonkwang University Department of Pharmacology College of Pharmacy and Gachon Institute of Pharmaceutical Sciences Gachon University

The better understanding of human biology and disease pathology has been a comer stone of the rapid advancements in the field of pharmaceutical science, including drug discovery, manufacturing and treatment procedures. Building on these important achievements, Purusotam Basnet, the editor of, and a contributing author to the book entitled Promising Pharmaceuticals （its information is shown in Table 1; cover paper is shown in Figure 1）,

关键词： GMP Promising Pharmaceuticals

Effect of glycine addition on the in-vitro corrosion behavior of AZ31 magnesium alloy in Hank’s solution

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Journal of Materials Science & Technology 2021年第22期81卷 97-107页

作者： Durga bhakta Pokharel Liping Wu Junhua Dong Amar prasad Yadav Dhruba Babu Subedi Madhusudan Dhakal Lin Zha Xin Mu Aniefiok Joseph Umoh Wei Ke Shenyang National Laboratory for Materials Science(SYNL) Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Engineering University of Science and Technology of ChinaHefei230026China Environmental Corrosion Center Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Central Department of Chemistry Tribhuvan UniversityKirtipurNepal

This study reports on the effect of the addition of Glycine to Hank’s solution on the in-vitro corrosion behavior of AZ31 magnesium(Mg)alloy at 37℃and a pH of 7.4 studied by using potentiodynamic polarization(PDP),hydrogen collecting techniques and electrochemical impedance spectroscopy(EIS)in combination with surface characterization techniques such as optical microscopy(OM),scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy analysis(XPS).The results reveal that adsorption of glycine initially subdues the dissolution of AZ31 Mg alloy while in long run it enhances the dissolution of the alloy due to the commencement of the chelation effect of glycine with Ca^(2+) released from hydroxyapatite.The chelation of glycine with Ca^(2+) induces the formation of cracks in the surface film which further promotes the dissolution of AZ31 Mg alloy thereby forming a porous corrosion products layer on the surface of the alloy.As a result,both the continuous dissolution of AZ31 magnesium alloy and the hydrogen evolution rate(HER)are enhanced with increasing the immersion time in Hank’s solution.

关键词： AZ31 Mg alloy Glycine Hank’s solution EIS Chelating effect

Effect of glycine addition on the in-vitro corrosion behavior of AZ31 magnesium alloy in Hank's solution

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Effect of glycine addition on the in-vitro corrosion behavio...