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Angiotensin-converting enzyme 2 as a potential therapeutic target for COVID-19:A review

Journal of Pharmaceutical Analysis 2022年第2期12卷 215-220页

作者： bhagat singh Dheer singh Vinod Verma Ramakant Yadav Raj Kumar Department of Medical Laboratory Technology Faculty of Paramedical SciencesUttar Pradesh University of Medical SciencesEtawah206130India Department of Anaesthesiology and Critical Care Uttar Pradesh University of Medical SciencesEtawah206130India Stem Cell Research Centre Department of HematologySanjay Gandhi Post Graduate Institute of Medical SciencesLucknow226014India Department of Neurology Uttar Pradesh University of Medical SciencesEtawah206130India Department of Neurosurgery Uttar Pradesh University of Medical SciencesEtawah206130India

As of August 16,2021,there have been 207,173,086 confirmed cases and 4,361,996 deaths due to the coronavirus disease(COVID-19),and the pandemic remains a global *** date,no effective and approved drugs are available for the treatment of ***-converting enzyme 2(ACE2)plays a crucial role in the invasion into host cells by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of ***,ACE2 density is influenced by medical conditions,such as hypertension,or by drugs,including angiotensin-converting enzyme inhibitors(ACEIs)and angiotensin receptor blockers(ARBs),which can change the fate of SARS-CoV-2 ***2 is a target for these drugs and can be manipulated to limit the viral entry and replication within the *** strategies aimed at blocking ACE2 with small molecules,peptides,and antibodies,or by neutralizing the virus through its competitive binding with human recombinant soluble ACE2(hrsACE2)are currently under *** this article,we review the current state of knowledge that emphasizes the need to find effective therapeutic agents against COVID-19 by exploiting ACE2 as a potential *** increased soluble ACE2 levels and the application of hrsACE2 in patients with COVID-19 can be implemented to control the *** has not yet been established whether hypertension and other comorbidities,independent of age,have a direct role in ***,the use of renin-angiotensin system inhibitors,ACEIs and ARBs,should not be discontinued during COVID-19 treatment.

关键词： COVID-19 ACE2 receptors hrsACE2 ACE inhibitors RAS AT1R blocker

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Geometric grid network and third-order compact scheme for solving nonlinear variable coefficients 3D elliptic PDEs

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第6期9卷 72-99页

作者： Navnit Jha Venu Gopal bhagat singh Department of Mathematics South Asian University ChanakyapuriNew Delhi 110070India The School of Mathematical Sciences University of Science and Technology of China Hefei Anhui 230026P.R.China

By using nonuniform(geometric)grid network,a new high-order finite-difference compact scheme has been obtained for the numerical solution of three-space dimensions partial differential equations of elliptic *** cell discretization to the elliptic equation makes it easier to compute and exhibit stability of the numerical *** monotone and irreducible property of the Jacobian matrix to the system of difference equations analyses the converging behavior of the numerical solution *** an experiment,applications of the compact scheme to Schr¨odinger equations,sine-Gordon equations,elliptic Allen–Cahn equation and Poisson’s equation have been presented with root mean squared errors of exact and approximate solution *** results corroborate the reliability and efficiency of the scheme.

关键词： Finite-difference method nonuniform grid compact operator monotone matrix sine-Gordon equation elliptic Allen-Cahn equation.

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基于社区的气候变化适应方法与高海拔Garhwal喜马拉雅山脉Bhagirathi地区的生计安全

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Journal of Resources and Ecology 2024年第1期15卷 197-203页

作者： Shoryabh SRIVASTAVA Bindhy Wasini PANDEY Virender singh NEGI 德里大学经济学院地理系印度德里110007 德里大学莎希德·巴加特·辛格学院地理系(E) 印度德里110017

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的... 详细信息

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的韧性。本文旨在研究HA-BV地区的CB-CCA和生计保障计划,关注应对气候变化所面临挑战的策略。研究认为优先考虑适应该地区崎岖的地形和恶劣的天气条件的可持续生计选择至关重要。例如,与山谷独特的土壤和气候动态相适应,推广温室种植和农林复合种植等替代农业,可能会带来较好的结果;此外,鼓励养蜂、手工艺和生态旅游等替代生计途径不仅可以创收,还能保护该地区的自然环境。为了鼓励当地居民实施这些环境友好的生计措施,政府和利益相关者需要进行战略性投资,基础设施的完善(包括道路建设和电力供应)可为经济增长创造良好的条件。研究结果可为喜马拉雅山地区的可持续发展做出贡献,为类似情境下未来构建气候韧性和保障生计的努力提供参考。

关键词： Bhagirathi谷基于社区的方法气候变化适应生计保障 Garhwal喜马拉雅山

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Decadal trends in precipitable water vapor over the Indus River Basin using ERA5 reanalysis data

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Journal of Mountain Science 2023年第10期20卷 2928-2945页

作者： Seema RANI Jyotsna singh Subhash singh Purushottam TIWARI Suraj MAL Department of Geography Institute of ScienceBanaras Hindu UniversityUttar Pradesh 221005India Department of Geography Shaheed Bhagat Singh CollegeUniversity of DelhiNew Delhi 110017India Center for the Study of Regional Development Jawaharlal Nehru UniversityNew DelhiDelhi 11oo6zIndia

Precipitable Water Vapor(PWV)constitutes a pivotal parameter within the domains of atmospheric science,and remote sensing due to its profound influence on Earth’s climate dynamics and weather *** exerts a significant impact on atmospheric stability absorption and emission of radiation,thus engendering alterations in the Earth’s radiative *** such,precise quantification of PWV holds the potential to enhance weather prognostication and fortify preparedness against severe meteorological *** study aimed to elucidate the spatial and temporal changes in seasonal and annual PWV across the Indus River Basin and its sub-basins using ERA5 reanalysis *** present study used ERA5 PWV(entire atmospheric column),air temperature at 2 m(t2m)and 500 hPa(T_500hPa),evapotranspiration,and total cloud cover data from 1960 to *** Sen slope estimator and Mann-Kendall test were used for trend *** and multiple regression methods were used to understand the association of PWV with other *** findings have unveiled the highest increase in mean PWV during the monsoon(0.40 mm/decade),followed by premonsoon(0.37 mm/decade),post-monsoon(0.27 mm/decade),and winter(0.19 mm/decade)throughout the study ***,the mean PWV exhibited the most pronounced positive trend in the sub-basin Lower Indus(LI),followed by Panjnad(P),Kabul(K),and Upper Indus(UI)across all seasons,except *** PWV has also risen in the Indus basin and its sub-basins over the last six *** exhibits a consistent upward trend up to an elevation of 3500 m within the basin which is most pronounced during the monsoon season,followed by the *** escalating PWV within the basin is reasonably ascribed to increasing air temperatures,augmented evapotranspiration,and heightened cloud *** findings hold potential utility for pertinent authorities engaged in water resource management and planning.

关键词： Himalaya Precipitable Water Vapor Indus River Basin Atmosphere Climate Change ERA5 Reanalysis data

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Analysis on multiple optical line terminal passive optical network based open access network

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Frontiers of Optoelectronics 2019年第2期12卷 208-214页

作者： Love KUMAR Amarpal singh Vishal SHARMA IK Gujral Punjab Technical University Kapurthala Punjab 144603India Beant College of Engineering and Technology Gurdaspur Punjab 143521India Shaheed bhagat singh State Technical Campus Ferozepur Punjab 152004India

Passive optical networks (PONs) offer suffi-cient bandwidth to transfer huge amount having different packet sizes and data rates being generated by fusion of various networks. Additionally, multiple optical line terminals (OLTs) PONs reduce the computational com-plexity of data processing for nonuniform traffic. However, in order to improve the bandwidth allocation efficiency of a mixture of service providers, dynamic bandwidth algo-rithm (DBA) is needed for uplink communication. In this paper, a PON based open access network (OAN) is analyzed for bi-directional communication at various data rates. Multiple wavelengths are used to modulate the data of various service providers to evade the complicated DBA for uplink data broadcasting. The performance of the network is reported in terms of bandwidth exploitation, uplink effectiveness, overhead-to-data ratio and time cycle duration. The network is analyzed at various data rates to reveal the data accommodation capacity.

关键词： passive optical network (PON) open access network (OAN) optical line terminal (OLT) hybrid network

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Community Responses to Mountain Tourism:A Case in Bhyundar Valley,Indian Himalaya

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Journal of Mountain Science 2009年第4期6卷 394-404页

作者： Ram Babu singh Suraj Mal Chandra Prakash Kala Department of Geography Delhi School of EconomicsUniversity of Delhi Department of Geography Shaheed Bhagat Singh CollegeUniversity of Delhi Ecosystem and Environment Management Division Indian Institute of Forests Management

Tourism industry has become an important part of Indian economy,and tourism development has been,however,concentrated to a few areas. Accumulation of tourism activities has reached the critical stage in most of the tourism centers,which pose serious threats to the natural environment. The Bhyundar Valley of Nanda Devi Biosphere Reserve (NDBR) in Uttarakhand State of the Indian Himalaya is a burning example of such problems. Land use/cover changes,deforestation and accumulation of garbage are some of the negative impacts of unregulated tourism in the valley. Unsustainable activities of tourists and villagers in the valley make such problems very severe. To deal with the ongoing problems and ensure community involvement in tourism management and environmental conservation,the Biosphere Reserve Authority introduced ecotourism in the form of Eco Development Committees (EDCs) in the Bhyundar Valley. Study reveals that many problems associated with tourism have been minimized to some extent with the help of EDCs but few are still prevailing in valley. However,the existing attempts to conserve the valley from the negative effects of tourism are inadequate and modifications are needed in the current initiatives.

关键词： Mountain tourism Land use change Community response Eco development committee Environmental management

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