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Journal of Energy and Power Engineering 2013年第7期7卷 1293-1298页

作者： beytullah erdogan beytullah Erdo~anl, Adnan Topuzl, Sidika Ece Altini~ik2 and Habip Angac2 Sidika Ece Altinisik Habip Angac Department of Mechanical Engineering Bulent Ecevit University Zonguldak 67680 Turkey Mechanical Engineer and Bachelor's Student Bfilent Ecevit University Zonguldak 67680 Turkey

In this study, weather condition data such as the monthly average temperature, relative moisture, wind speed, pressure and the calculated wind power values of Zonguldak, Sinop, Duzce, Bartin, Kastamonu, Bolu and Karabuk cities located in western Black Sea region were examined for 10 year period (2001-2011). In the modeling of the weather conditions, linear regression analysis was used and the effect of temperature, relative moisture and pressure on wind speed was researched by non-linear regression method. Besides, in this study, the effect of roughness coefficient in cities of western Black Sea region was also taken into consideration and the wind power potentials in 10 m, 25 m and 50 m altitude were researched in detail with the help of WASP (Wind Atlas Analysis and Application) program. In the light of the values obtained by developed models and weather condition data, it was observed that some cities in the western Black Sea region have wind power potential with their effects on environment and energy.

关键词：线性回归方法黑海地区风力发电天气状况西部城市建模线性回归分析

Design of Buoys for Mounting Wind Turbines at Exposed Sites

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Journal of Ocean University of China 2018年第2期17卷 257-266页

作者： erdogan beytullah CELIKKOL Barbaros SWIFT Robinson Department of Mechanical Engineering Bülent Ecevit UniversityZonguldak 67200Turkey Department of Mechanical Engineering University of New HampshireDurhamNH 03824USA

In this study, two designs for a buoy capable of supporting a 10 kW wind turbine and its tower were developed to operate at the University of New Hampshire's Center of Ocean Renewable Energy testing site located off the Isles of Shoals, New Hampshire. The buoys are to be moored by a catenary chain system. To evaluate wave response, two Froude-scaled models were constructed, tested, and compared at the Ocean Engineering wave tank at the University of New Hampshire. These buoys have been implemented and compared with wave tank measurements of the spar displacement at a reference elevation 2.44 m above the mean water level.

关键词： wind energy ocean wave buoy

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

Raloxifene-loaded and aptamer-bonded exosomes induce autophagic and apoptotic death in HeLa cells by enhancing the lysosomotropic effect

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BIOCELL 2023年第5期47卷 1051-1063页

作者： OMER erdogan GULEN MELIKE DEMIRBOLAT OZGE CEVIK Department of Medical Biochemistry School of MedicineAydin Adnan Menderes UniversityAydin09010Turkey Department of Pharmaceutical Technology Faculty of PharmacyAcibadem Mehmet Ali Aydinlar UniversityIstanbul34758Turkey

Background:Raloxifene,a selective estrogen receptor modulator,is also known to be a lysosomotropic agent.The bioavailability of raloxifene is around 2%due to extensive hepatic transport.Exosomes are nanosized vesicles that are naturally released from cells.Method:In this study,exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability,and an aptamer was attached to the exosome membrane for targeting only HeLa cells.Characterization of exosomes isolated from HeLa cells was performed by transmission electron microscopy,zeta sizer,and western blotting.In addition,the cytotoxic,apoptotic,autophagic,and lysosomotropic effects of the prepared Exo-Apt-Ral formulation on HeLa cervical cancer cells were investigated.Results:According to zeta analysis,the sizes of the empty exosome and Exo-Apt-Ral formulation were measured as 66±12 and 120±21 nm,respectively.There was a rise in the lysosomal permeability of HeLa cells after the Exo-Apt-Ral application.In addition,both apoptotic and autophagic death mechanisms were triggered in HeLa cells after the Exo-Apt-Ral application.Conclusion:This study showed that raloxifene functionalized by loading into aptamer-bound exosomes can be a new targeted drug carrier system for cervical cancer.

关键词： Aptamer Autophagy Cervical cancer Exosomes Raloxifene

Role of Infographics in Healthcare

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Chinese Medical Journal 2018年第20期131卷 2514-2517页

作者： Melisa Balkac erdogan Ergun Faculty of Fine Arts and Design Near East University Nicosia North Cyprus

＂You have read a newspaper or blog, flipped through a magazine, or used social media recently; you have likely come across infographics- those self-contained pictorials that tell you about the gist of the story or co...

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A methodology for lining design of circular mine shafts in different rock masses

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International Journal of Mining Science and Technology 2016年第5期26卷 761-768页

作者： Ozturk Hasan Guler erdogan Mining Engineering Department Middle East Technical University

In this study, the finite element numerical modelling of 2D shaft sections in a Hoek–Brown medium are carried out in a non-hydrostatic stress state in an attempt to predict pressures developing around mine shafts. An iterative process of applying support pressure until observing no failure zone around the shaft is used to simulate the required lining support pressure for different shaft models. Later, regression analysis is carried out to find a generic shaft pressure equation representing the rock mass and the stress state. Finally, the developed pressure equation which shows a good agreement with a case study is used in elastic ‘‘thick-walled cylinder" equation to calculate the lining thickness required to prevent the development of a failure zone around the shaft. At the end of the study, a user-friendly object-oriented computer program ‘‘Shaft 2D" is developed to simplify the rigorous shaft lining thickness calculation process.

关键词： Lining thickness Shaft support Shaft Non-hydrostatic stress

Boldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats:Role of oxidative stress,inflammation and caspase-3

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BIOCELL 2022年第9期46卷 2111-2122页

作者： NERGIZ HACER TURGUT HUSEYIN GUNGOR MEHMET EKICI MUMIN ALPER erdogan MEHMET ONDER KARAYIGIT HAKI KARA Department of Pharmacology Faculty of PharmacyIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pharmacology and Toxicology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of MedicineIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pathology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey

Side effects of cisplatin,especially dose-dependent nephrotoxicity,are major factors limiting its use in cancer.Boldine((S)-2,9-dihydroxy-1,10-dimethoxy-aporphine)is a natural alkaloid known for its strong antioxidant activity present in leaves/bark of boldo tree(Peumus boldus Molina),a native tree in Chile.Here,we aimed to investigate the nephroprotective effect of boldine and its underlying mechanisms on cisplatin-induced rat renal injury.Thirty Wistar albino rats divided into 5 groups(Control,Cis,Bold.40,Cis+Bold.20,Cis+Bold.40 groups)were used.Rats received boldine(20 or 40 mg/kg/day),or vehicle(saline)intraperitoneal for 14 days and a single dose cisplatin(7 mg/kg,ip)was applied on the 10th day to induce nephrotoxicity.Rats and kidney tissue were weighed to determine kidney index.Blood urea nitrojen(BUN)and creatinine levels,the amount of thiobarbituric acid reactive substances(TBARS,an index of lipid peroxidation),superoxide dismutase(SOD),glutathione peroxidase(GPx)enzyme activities and tumor necrosis factor alpha(TNF-α)levels were measured and histopathologic examination was performed.Inducible nitric oxide synthase(iNOS)and caspase-3 expressions were detected immunohistochemically.Nephrotoxicity induced by cisplatin was apparent by elevated levels of BUN,creatinine,kidney index,TBARS and TNF-α,and decreased body weight,SOD and GPx enzyme levels.Pretreatment with boldine protected the renal function at both boldine doses by fixing the renal damage markers,oxidative stress,caspase-3 and iNOS expression.Histopathological findings supported biochemical findings.Taken together these findings indicate that boldine has promising protective effect against cisplatin nephrotoxicity by improving oxidative stress,inflammation,histopathological alterations and by alleviating caspase 3 expression.

关键词： Boldine Caspase-3 Cisplatin nephrotoxicity Inflammation Oxidative stress

ON SPECTRAL PROPERTIES OF A NEW OPERATOR OVER SEQUENCE SPACES c AND c_0

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Acta Mathematica Scientia 2014年第5期34卷 1481-1494页

作者： Ezgi erdogan Vatan KARAKAYA Department of Mathematics Marmara UniversityKad?ky Department of Mathematical Engineering Y?ld?z Technical University

In this work, we classify and calculate spectra such as point spectrum, continuous spectrum and residual spectrum over sequences spaces？∞, c and c0 according to a new matrix operator W which is obtained by matrix pr... 详细信息

关键词： spectrum of an operator matrix transformation sequence space

Physical and Mechanical Properties of PP Composites based on Different Types of Lignocellulosic Fillers

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Journal of Wuhan University of Technology(Materials Science) 2018年第6期33卷 1298-1307页

作者： Selcuk erdogan Umit HUNER Trakya University Faculty of Engineering Department of Mechanical Engineering

The presents preparation and characterization of different types of lignocellulosic fillers(pine wood sawdust/walnut shell flour/black rice husk powder) reinforced polypropylene composites were presented. The effect of MAPP as coupling agent(4 wt%) on the physical and mechanical properties was also investigated. Polypropylene composites were prepared at different rates of filler/matrix(wt%) by using extrusion(for melt blending) and hot compression molding process. Maximum values of tensile and flexural strength were obtained as 26.1 and 43.4 MPa, respectively, whereas the elongation at break value was 4.11% at 10% pine wood sawdust reinforced PP. Tensile and flexural modulus of composites reached the maximum values as 3855 and 3633 MPa with the composite of 30% walnut shell flour reinforced PP. Characterization of composites was carried out by using tensile test, flexural test, FT-IR, and SEM.

关键词： natural filler water absorption FTIR polypropylene MAPP

NOTES ON THE SPECTRAL PROPERTIES OF THE WEIGHTED MEAN DIFFERENCE OPERATOR G(u,v;?) OVER THE SEQUENCE SPACE ?_1

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Acta Mathematica Scientia 2016年第2期36卷 477-486页

作者： Vatan KARAKAYA Ezgi erdogan Department of Mathematical Engineering Yzldiz Technical UniversityDavutpasaIstanbulTurkey Department of Mathematics Marmara UniversityKadikoyIstanbulTurkey

In the study by Baliarsingh and Dutta [Internat. J.Anal., Vol.2014（2014）, Article ID 786437], the authors computed the spectrum and the fine spectrum of the product operator G （u, v; A） over the sequence space e1. The product operator G （u, v; △） over l1 is defined by （G（u,v;△）x）k=^k∑i=0ukvi（xi- xi-1） with xk = 0 for all k 〈 0, where x = （xk）∈e1,and u and v axe either constant or strictly decreasing sequences of positive real numbers satisfying certain conditions. In this article we give some improvements of the computation of the spectrum of the operator G （u, v; △） on the sequence space gl.

关键词： Spectrum of an operator weighted mean difference operator sequence space