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Application of chitosan-based nanoparticles in skin wound healing

Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 299-332页

作者： Hooi Leong Loo bey hing goh Learn-Han Lee Lay Hong Chuah School of Pharmacy Monash University MalaysiaSelangor 47500Malaysia Biofunctional Molecule Exploratory Research Group School of PharmacyMonash University MalaysiaSelangor 47500Malaysia College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Novel Bacteria and Drug Discovery(NBDD)Research Group Microbiome and Bioresource Research StrengthJeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaSelangor 47500Malaysia

The rising prevalence of impaired wound healing and the consequential healthcare burdens have gained increased attention over recent *** has prompted research into the development of novel wound dressings with augmented wound healing ***(NP)-based delivery systems have become attractive candidates in constructing such wound dressings due to their various favourable *** non-toxicity,biocompatibility and bioactivity of chitosan(CS)-based NPs make them ideal candidates for wound *** review focusses on the application of CS-based NP systems for use in wound *** overview of the wound healing process was presented,followed by discussion on the properties and suitability of CS and its NPs in wound *** wound healing mechanisms exerted by CS-based NPs were then critically analysed and discussed in sections,namely haemostasis,infection prevention,inflammatory response,oxidative stress,angiogenesis,collagen deposition,and wound closure *** results of the studieswere thoroughly reviewed,and contradicting findings were identified and *** on the literature,the gap in research and future prospects in this research area were identified and *** evidence shows that CS-based NPs possess superior wound healing effects either used on their own,or as drug delivery vehicles to encapsulate wound healing *** is concluded that great opportunities and potentials exist surrounding the use of CSNPs in wound healing.

关键词： Biopolymer Chitosan nanoparticle Nanotechnology Wound dressing Wound healing

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Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： Swee Li Ng Tsuey Ning Soon Wei Hsum Yap Kai Bin Liew Ya Chee Lim Long Chiau Ming Yin-Quan Tang bey hing goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia School of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical Sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 SARS-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

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