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Handheld high-throughput plasmonic biosensor using computational on-chip imaging

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Light(Science & Applications) 2014年第1期3卷 388-397页

作者： Arif E Cetin Ahmet F Coskun betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Departments of Electrical Engineering and Bioengineering University of CaliforniaLos Angeles(UCLA)Los AngelesCA 90095USA Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCA 91125USA Pontificia Universidad Catolica del Peru Departamento de Ciencias-QuimicaAvenida Universitaria 1801Lima 32Peru Bioengineering Department Ecole Polytechnique Federale de Lausanne(EPFL)Lausanne CH-1015Switzerland California NanoSystems Institute University of California Los AngelesLos Angeles(UCLA)Los AngelesCA90095USA

We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited *** lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the *** a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 *** large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule *** this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings.

关键词： computational imaging high-throughput biodetection lens-free imaging on-chip sensing plasmonics point of care diagnostics telemedicine

MAD FOR BEEF Houj China's Growing Appetite for Meat Affects Us All

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城市漫步（上海版、英文） 2017年第2期 42-51页

作者： betty Richardson 不详

The human connection with beef is one that has served our kind *** to primatologists,the fundamental separator between humans and our closest genetic neighbors,the great apes,is that millions of years ago we began to ... 详细信息

关键词： equally neighbor fundamental

Anti-inflammatory properties of oolong tea(Camellia sinensis)ethanol extract and epigallocatechin gallate in LPS-induced RAW 264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 1005-1009页

作者： Arina Novilla Dedi Somantri Djamhuri betty Nurhayati Dwi Davidson Rihibiha Ervi Afifah Wahyu Widowati School of Health Sciences Jenderal Achmad Yani Cimahi Jl.Terusan Jenderal SudirmanCimahi 40533West JavaIndonesia Department of Health Analyst Health Sciences Polytechnic BandungJl.Prof.Eyckman No.24Bandung 40161West JavaIndonesia Biomolecular and Biomedical Research Center Aretha Medika UtamaJl.Babakan Jeruk 2 No.9Bandung 40163West JavaIndonesia Medical Research Center Faculty of MedicineMaranatha Christian UniversityJl.Prof drg.Suria Sumantri No.65Bandung 40164West JavaIndonesia

Objective: To evaluate the anti-inflammatory activity of oolong tea ethanol extract(OTEE) and epigallocatechin gallate(EGCG) on lipopolysaccharide-induced murine macrophage cell line(RAW 264.7).Methods: A cytotoxic assay using MTS tetrazolium was conducted to find a nontoxic level of OTEE and EGCG toward RAW 264.7 cells. Interleukins(IL-6, IL-1 b), tumor necrosis factor-a(TNF-a), and cyclooxigenase-2(COX-2) levels were measured by ELISA, and nitric oxide(NO) levels measured by a nitrate/nitrite colorimetric assay to determine the inhibition activity of OTEE and ***: Lipopolysaccharide induction increases NO, COX-2, IL-6, IL-1 b, and TNF-a levels compared with the untreated cell(negative control). The positive control,lipopolysaccharide-induced RAW 264.7 without treatments showed the highest level of all pro-inflammatory cytokines and modulators tested in this study. The positive control was used as standard to obtain OTEE and EGCG inhibition activity toward NO, COX-2,IL-6, IL-1 b, and TNF-a. OTEE had a higher inhibition activity toward NO, COX-2, IL-6,and IL-1 b than EGCG; the reverse was seen for TNF-a. However, both OTEE and EGCG suppressed production of NO, COX-2, IL-6, IL-1 b, and ***: OTEE and EGCG have the potential for use as anti-inflammatory drugs,which is shown by their ability to reduce the production of NO, COX-2, IL-6, IL-1 b, and TNF-a in active macrophages.

关键词： Inflammation Camellia sinensis EGCG Macrophages

Analysis of the Supply Chain in Industrial Companies in Guayaquil,Ecuador-A Secondary Publication

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Proceedings of Business and Economic Studies 2024年第1期7卷 242-255页

作者： Génesis Belén Linzán Soledispa betty Janeth Soledispa Canarte Víctor Alfonso ChávezSoledispa Oscar Rolando Fiallos González Universidad Politécnica Salesiana GuayaquilEcuador Universidad Estatal del Sur de Manabí ManabíEcuador Universidad Católica de Santiago de Guayaquil GuayaquilEcuador

This research clearly outlines the supply chain in a process of evolution and digital transformation,where the collaboration of its members is concentrated,having technological tools to help chain *** analyze the advantages that this transformation produces in the supply chain,as well as its different processes,this study has a systemic perspective that involves precise elements for organizational development,such as the different phases of each process,operations,logistics,and *** must be borne in mind that any strategy in industrial companies grants the automation of procedures in the supply chain and determines a product in any phase of production,making the organization more sensitive to any variation in *** methodology included a bibliographic and non-experimental review that allows a descriptive and analytical study,which details the various characteristics of the fact that is being investigated,collecting information through interviews with different people who are involved with industrial *** the results obtained,it was identified that digital transformation helps reduce costs and generates greater *** conclusion,it was obtained that the digital supply chain helps in each of the phases of the processes,these are supervised by devices that help to have fast and effective information.

关键词： Digital transformation Supply chain Industries 4.0 Sustainability

Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C

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World Journal of Gastroenterology 2020年第2期26卷 109-133页

作者： Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M rosenberg UCL Institute for Liver and Digestive Health Division of MedicineUniversity College LondonRoyal Free CampusHampsteadLondon NW32PF United Kingdom Department of Gastroenterology Whipps Cross University HospitalBarts Health NHS TrustLeytonstoneLondon E111NRUnited Kingdom

At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and *** to the liver,the largest solid organ in the body,leads to a cascade of inflammatory *** inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver *** fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated *** the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is ***,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical *** to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C *** facilitate this,a review of the pathogenesis of both conditions is also ***,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy.

关键词： Liver inflammation Fibrosis Cirrhosis Non-alcoholic fatty liver disease Chronic hepatitis C Chronic liver disease Anti-fibrotic Biomarker

SHANGHAI'S BEST DIM SUM Is time for brunch:Hong Kong style

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城市漫步（上海版、英文） 2015年第4期 68-71页

作者： betty RICHARDSON 不详

Dim sum,or dianxin(点心)in Mandarin denotes bite-sized breakfast or lunch food served in steamer baskets or on small plates,con-sisting of various steamed,fried or baked delicacies such as dumplings,buns,roasted meats and *** sum goes hand in hand with tea drinking:the term yum cha(饮茶)yinchal is synonymous with the taking of tea and a long,drawn-out lunch with friends or *** many,dim sum is a classic cuisine-most reputable establishments take an ifit ain't broke don't fix it approach to menus-and rightly so.

关键词： sized BEST plates

TERRACE TIME Our extensive guide to living life al fresco this summer

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城市漫步（上海版、英文） 2015年第5期 68-71页

作者： betty RICHARDSON 不详

Casual Ginger by the Park A favorite of weekend brunch seekers,Ginger by the Park has a beautifully serene terrace overlooking a quaint *** eclectic menu of Southeast Asian dishes and Western classics awaits.

关键词： favorite looking beautiful

SHANGHAPS BEST JAPANESE RESTAURANTS:VOL 2 Our guide to Shanghai’s hidden Japanese yakiniku, teppanyaki and more

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城市漫步（上海版、英文） 2015年第8期 68-71页

作者： betty RICHARDSON 不详

In last month’s issue of That’s Shanghai we brought you our top four omakase sushi restaurants;but the city’s best Japanese restaurants aren’t limited to sushi!In this article,we share our five favorite yakiniku,teppanyaki,soba and yakitori restaurants,many of which are hidden in plain sight throughout *** from the outside,some of these spots only feature Chinese or Japanese characters for their names and menus,making it a little intimidating for the ***,for those willing to take the plunge and try something new,you’ll surely be rewarded with authentic Japanese food that will make you feel as if you’ve taken a trip to the Land of the Rising Sun itself.

关键词： restaurant favorite Japanese

WHERE TO FIND STELLA ARTOIS:Four Top Drawer Xintiandi Spots

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城市漫步（上海版、英文） 2016年第10期 82-83页

作者： betty RICHARDSON 不详

*** Puro A longtime staple of Xintiandi,Estado Puro is a Spanish bar and restaurant by acclaimed patron chef Paco *** for serving molecular renditions of popular Spanish dishes in addition to traditional tapas,this re... 详细信息

关键词： restaurant perfect FIND