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自由生活橙腹田鼠的社会组织和婚配制度(英文)

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动物学报 2005年第2期51卷 178-186页

作者： Lowell L.GETZ betty mcguire C.Sue CARTER Department of Animal Biology University of Illinois505S.GoodwinAve.UrbanaIL61801USADepartment of Biological SciencesSmith CollegeNorthamptonMA01063USADepartment of PsychiatryUniversity of Illinoisat Chicago1601W.TaylorSt.ChicagoIL60612USA

在美国伊利诺伊州中东部地区对橙腹田鼠(Microtus ochrogaster) 进行的广泛研究基础上, 我们对该鼠的社会组织和婚配制度进行了总结。橙腹田鼠的基本社会组织由最初的雌雄配偶或者单一的雌鼠(常为一对配偶的幸存者) 与留居的后代和非亲... 详细信息

在美国伊利诺伊州中东部地区对橙腹田鼠(Microtus ochrogaster) 进行的广泛研究基础上, 我们对该鼠的社会组织和婚配制度进行了总结。橙腹田鼠的基本社会组织由最初的雌雄配偶或者单一的雌鼠(常为一对配偶的幸存者) 与留居的后代和非亲缘成体的同居群组成。留居的后代占了原始繁殖单位之外的70%。另外, 直到至少两个留居后代达到成年后, 多数(80%) 的非亲缘个体才加入家族群。因此, 同居群的形成是以高水平的留居为基础的。雌雄配偶表现出与行为单配制有关的特征, 包括共享一个巢穴和家域, 雄性保卫配偶, 以及双亲行为(修饰, 拥抱和衔回幼鼠)。同居群的成员也保卫领域。

关键词：橙腹田鼠社会组织婚配制度同居群单配制

鼠类种群动态:食物资源影响力的实验评估(英文)

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兽类学报 2006年第2期26卷 114-122页

作者： Lowell L. Getz Arpat Ozgul Madan K. Oli Joyce E. Hofmann betty mcguire Department of Animal Biology University of Illinois 2113 Lynwood Drive Champaign IL 61821 USA Department of Wildlife Ecology and Conservation University of Florida 110 Newins-Ziegler Hall Gainesville FL 32611 USA Illinois Natural History Survey 607 E. Peabody Drive Champaign IL 81820 USA Department of Ecology and Evolutionary Biology Cornell UniversityCorson Hall Ithaca NY 14853 USA

本研究在美国伊利诺斯州中东部测定了中等食物质量(莓系属的牧草)和低食物质量(高杆草牧场)栖息地内橙腹田鼠(Microtusochrogaster)和草原田鼠(***)种群对附加食物的响应。在中等食物质量栖息地内投放附加食物,橙腹田鼠种群的波动幅度... 详细信息

本研究在美国伊利诺斯州中东部测定了中等食物质量(莓系属的牧草)和低食物质量(高杆草牧场)栖息地内橙腹田鼠(Microtusochrogaster)和草原田鼠(***)种群对附加食物的响应。在中等食物质量栖息地内投放附加食物,橙腹田鼠种群的波动幅度高于对照样地,但同类型食物质量栖息地内,种群平均密度和波动模式无显著的差异。仅在低等食物质量的高杆草栖息地内,投放附加食物可导致草原田鼠的种群密度高于对照样地。附加食物不直接影响两种栖息地内橙腹田鼠的成活率或成熟率,在中等食物质量栖息地中投放附加食物,繁殖活跃的成熟雌性个体比例及雄性成体的体重高于对照。附加食物不影响莓系属牧草内草原田鼠,也不能影响该动物在高杆草环境中的存活率。然而,投放附加食物,可缩短低等食物质量栖息地内草原田鼠的成熟期,提高繁殖活跃雌性的比例和迁入个体比例,增加并引起雄性个体体重增加。据此,本研究证明食物资源在橙腹田鼠和草原田鼠种群动态中只起极小的作用。

关键词：数量统汁食物资源橙腹田鼠草原田鼠附加食物

橙腹田鼠中延缓性密度依赖效应和种群波动(英文)

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动物学报 2004年第1期50卷 1-8页

作者： Lowell L.GETZ Laura E.SIMMS Joyce E.HOFMANN betty mcguire Department of Animal Biology University of Illinois 505 S.Goodwin Ave Urb anaDepartment of PhysicsAugsburg College2211 Riverside Ave MinneapolisIllinois Natural History Survey 607 E. Peabody Dr. ChampaignDepartment of Biological Sciences Smith College Northampton IL61801USAMN 55406USAIL81820USAMA01063 USA.

检验了延迟的密度依赖对橙腹田鼠 (Microtusochrogaster)一个波动种群的生存和生殖的影响 ,研究持续了 63个月 ,取样间隔为 3 5天。在研究期间 ,该种群的密度经历了 4次波动 ,每次波动的高峰都在 11月至次年 1月 ,种群数量在冬季下降... 详细信息

检验了延迟的密度依赖对橙腹田鼠 (Microtusochrogaster)一个波动种群的生存和生殖的影响 ,研究持续了 63个月 ,取样间隔为 3 5天。在研究期间 ,该种群的密度经历了 4次波动 ,每次波动的高峰都在 11月至次年 1月 ,种群数量在冬季下降。生存和生殖都有负面的密度依赖效应 ,最大效应具有 2个月的时滞。种群存活率增长对种群密度最大的正面效应具有 2个月的时滞 ,而对与增加生殖则有 3个月的时滞。内部因素和冬季都可能推延对生殖的密度依赖效应 ,但是本文未能检验这些内部因素的影响。季节性影响看来与对生存的延缓性密度依赖效应无关。负面的延缓性密度依赖效应对生存和生殖的净作用可能在于减少。

关键词：橙腹田鼠密度依赖效应种群波动种群存活率

种间竞争对同域分布田鼠种群动态的影响(英文)

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动物学报 2007年第5期53卷 800-811页

作者： Lowell L.GETZ Arpat OZGUL Madan K.OLI Joyce E.HOFMANN betty mcguire Department of Animal Biology University of Illinois Department of Wildlife Ecology and Conservation University of Florida Illinois Natural History Survey Department of Ecology and Evolutionary Biology Cornell University

我们对美国伊利诺斯州中东部的蓝草和高草牧场共生的橙腹田鼠(Microtus ochrogaster)和草原田鼠(Microtus pennsylvanicus)开放种群进行了去除实验,以测定潜在的种间竞争。在蓝草草原,橙腹田鼠和草原田鼠的种群密度不因另一种的存在而... 详细信息

我们对美国伊利诺斯州中东部的蓝草和高草牧场共生的橙腹田鼠(Microtus ochrogaster)和草原田鼠(Microtus pennsylvanicus)开放种群进行了去除实验,以测定潜在的种间竞争。在蓝草草原,橙腹田鼠和草原田鼠的种群密度不因另一种的存在而受抑制;同时,另一种存在的情况下,相互间对月存活率、青年鼠位置的持久性生殖或迁入鼠数量没有负面影响,尽管在高草草原,草原田鼠似乎对橙腹田鼠的种群密度有强烈影响,并限制了迁入鼠的数量,但是雌橙腹田鼠的存活率、青年鼠的持久性和生殖活动的比例不因草原田鼠的存在而受影响。总之,在此研究地点,种间竞争没有对橙腹田鼠和草原田鼠共存种群的动态起到驱动作用。

关键词：田鼠橙腹田鼠草原田鼠种群统计种间竞争

Application of single-cell omics in inflammatory bowel disease

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World Journal of Gastroenterology 2023年第28期29卷 4397-4404页

作者： Hengqi betty Zheng Department of Pediatrics Seattle Children’s HospitalUniversity of WashingtonSeattleWA 98105United States

Over the past decade,the advent of single cell RNA-sequencing has revolutionized the approach in cellular transcriptomics *** current technology offers an unbiased platform to understand how genotype correlates to ***-cell omics applications in gastrointestinal(GI)research namely inflammatory bowel disease(IBD)has become popular in the last few years with multiple publications as single-cell omics techniques can be applied directly to the target organ,the GI tract at the tissue *** examination of mucosal tissue and peripheral blood in IBD,the recent boom in single cell research has identified a myriad of key immune players from enterocytes to tissue resident memory T cells,and explored functional heterogeneity within cellular subsets previously *** we begin to unravel the complex mucosal immune system in states of health and disease like IBD,the power of exploration through single-cell omics can change our approach to translational *** novel techniques evolve through multiplexing single-cell omics and spatial transcriptomics come to the forefront,we can begin to fully comprehend the disease IBD and better design targets of *** addition,hopefully these techniques can ultimately begin to identify biomarkers of therapeutic response and answer clinically relevant questions in how to tailor individual therapy to patients through personalized medicine.

关键词： Single-cell omics Inflammatory bowel disease Crohn’s disease Ulcerative colitis Single cell RNA-sequencing Precision medicine

China Responds to the Conference Goals

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China Population Today 1995年第2期12卷 6-7页

作者： betty Rosenberg

ＣｈｉｎａＲｅｓｐｏｎｄｓｔｏｔｈｅＣｏｎｆｅｒｅｎｃｅＧｏａｌｓ￥ＢｅｔｔｙＲｏｓｅｎｂｅｒｇＴｏｄａｙｔｈｅＥａｒｔｈｉｓｈｏｍｅｔｏｍｏｒｅｔｈａｎ５．６ｂｉｌｌｉｏｎｐｅｏｐｌｅ．Ｎｏｗｔｈｅｎｕｍｂｅｒｉｓ... 详细信息

ＣｈｉｎａＲｅｓｐｏｎｄｓｔｏｔｈｅＣｏｎｆｅｒｅｎｃｅＧｏａｌｓ￥ＢｅｔｔｙＲｏｓｅｎｂｅｒｇＴｏｄａｙｔｈｅＥａｒｔｈｉｓｈｏｍｅｔｏｍｏｒｅｔｈａｎ５．６ｂｉｌｌｉｏｎｐｅｏｐｌｅ．Ｎｏｗｔｈｅｎｕｍｂｅｒｉｓｉｎｃｒｅａｓｉｎｇａｎｎｕａｌｌ...

关键词： Asia China Delivery Of Health Care Developing Countries Eastern Asia Economic Development Economic Factors Family Planning Health International Agencies Organizations Un World Population Conferences

Targeting calcium signaling in Alzheimer’s disease: challenges and promising therapeutic avenues

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Neural Regeneration Research 2024年第3期19卷 501-502页

作者： LinLin Song YongPei Tang betty Yuen Kwan Law Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administration RegionChina

The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral *** an estimated 50 million people being affected worldwide,the incidence of AD is constantly increasing *** hallmark of AD is the accumulation of amyloid-beta protein(Aβ)in the form of amyloid plaques and hyperphosphorylated tau protein in the form of neurofibrillary ***,increasing evidence suggests that calcium ion(Ca2+)dysregulation also plays a crucial role in the pathogenesis of AD(Calvo-Rodriguez and Bacskai,2021).As a key second messenger,Ca2+regulates a wide range of cellular processes,including the release of neurotransmitters,gene expression,and cell ***^(2+)also regulates the activity of Calcium/calmodulin-dependent protein kinase II,which is critical for synaptic plasticity,learning,and memory(Kaushik et al.,2022).Alternation in the Ca^(2+)signal is an early event in the pathogenesis of AD,which can lead to synaptic dysfunction,neuronal loss,and cognitive impairment.

关键词： Alzheimer homeostasis globally

Transformations of the Pleiomorphic Plant MTOC during Sporogenesis in the Hepatic Marchantia polymorpha

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Journal of Integrative Plant Biology 2007年第8期49卷 1244-1252页

作者： Roy C.Brown betty E.Lemmon Masaki Shimamura Department of Biology University of Louisiana-LafayetteLafayetteLA 70504USA Department of Biological ScienceGraduate School of ScienceHiroshima UniversityKagami-yamaHigashi-Hiroshima 739-8526Japan

Sporogenesis in the hepatic Marchantia polymorpha L. provides an outstanding example of the pleiomorphic nature of the plant microtubule organizing center （MTOC）. Microtubules are nucleated from γ-tubuUn in MTOCs that change form during mitosis and meiosis. Following entry of cells into the reproductive pathway of sporogenesis, successive rounds of mitosis give rise to packets of 4-16 sporocytes. Mitotic spindles are organized at discrete polar organizers （POs）, a type of MTOC that is unique to this group of early divergent land plants. An abrupt and radical transformation in microtubule organization occurs when sporocytes enter meiosis： POs are lost and γ-tubulin is closely associated with surfaces of two large elongated plastids that subsequently divide into four. Migration of the four plastid MTOCs into a tetrahedral arrangement establishes the future spore domains and the division polarity of meiosis. As is typical of many bryophytes, cones of microtubules from the four plastid MTOCs initiate a quadripolar microtubule system （QMS） in meiotic prophase. At this point a transformation in the organization of the MTOCs occurs. The γ-tubulin detaches from plastids and forms a diffuse spheroidal pole in each of the spore domains. The plastids, which are no longer MTOCs, continue to divide. The diffuse MTOCs continue to nucleate cones of microtubules during transformation of the QMS to a bipolar spindle. Following meiosis I, γ-tubulin is associated with nuclear envelopes, and the spindles of meiosis II are organized from diffuse MTOCs at the tetrad poles. At simultaneous cytokinesis, radial microtubule systems are organized at nuclear envelope MTOCs in each of the tetrad members.

关键词： bryophyte γ-tubulin meiosis microtubules mitosis MTOC.

Channeling the water data deluge:a system for flexible integration and analysis of hydrologic data

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International Journal of Digital Earth 2016年第3期9卷 272-299页

作者： Michael P.mcguire Martin C.Roberge Jie Lian Department of Computer and Information Sciences Towson UniversityTowsonMDUSA Department of Geography and Environmental Planning Towson UniversityTowsonMDUSA

The hydrologic cycle and understanding the relationship between rainfall and runoff is an important component of earth system science,sustainable development,and natural disasters caused by *** this in mind,the integration of digital earth data for hydrologic sciences is an important area of ***,it takes a tremendous amount of effort to perform hydrologic analysis at a large scale because the data to support such analyses are not available on a single system in an integrated format that can be easily ***,the state-of-the-art in hydrologic data integration typically uses a rigid relational database making it difficult to redesign the data model to incorporate new data *** HydroCloud system incorporates a flexible document data model to integrate precipitation and stream flow data across spatial and temporal dimensions for large-scale hydrologic *** this paper,a document database schema is presented to store the integrated data-set along with analysis tools such as web services for data access and a web interface for exploratory data *** utility of the system is demonstrated based on a scientific workflow that uses the system for both exploratory data analysis and statistical hypothesis testing.

关键词： hydrology data integration cloud-based systems NoSQL NEXRAD precipitation stream flow