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In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

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Bioactive materials 2021年第10期6卷 3383-3395页

作者： Iulian V.Antoniac Aurora Antoniac Eugeniu Vasile Camelia Tecu marco Fosca Viktoriya G.Yankova Julietta V.rau University Politehnica of Bucharest 313 Splaiul Independentei StreetDistrict 6060042BucharestRomania Academy of Romanian Scientists 54 Splaiul Independentei StreetDistrict 5050094BucharestRomania Istituto di Struttura della materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere10000133RomeItaly Sechenov First moscow State medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8Build.2Moscow119991Russia

New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous *** inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-mg(10%)were *** lyophilization was used for composites *** insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron microscopy coupled with Energy Dispersive X-Ray and Transmission Electron microscopy coupled with Energy Dispersive *** HAp nanocrystallite clusters and mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen *** samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 *** release of mg from collagen(10%)-HAp(80%)-mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without *** developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.

关键词： Composite Collagen Hydroxyapatite magnesium Scaffold Hard tissue regeneration Scaffold degradation

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轿车变速器的表面致密化粉末冶金齿轮的使用性能

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粉末冶金技术 2012年第4期30卷 313-315页

作者： Cünter rau Lorenz S Sigl Gerold mrk Frank Wattenberg 韩凤麟 PmG Füssen GmbH GETRAG Innovation Center Werkzeugmaschinenlabor

选择性表面致密化是改进粉末冶金钢的一种方法,高负载齿轮经过这种加工工艺处理,就能达到使用要求。本文介绍了粉末冶金螺旋齿轮的制造工艺与性能,用三轴总成成对试验台架、承载能力试验台架及噪声试验台架测定了齿轮的使用性能,并把试... 详细信息

选择性表面致密化是改进粉末冶金钢的一种方法,高负载齿轮经过这种加工工艺处理,就能达到使用要求。本文介绍了粉末冶金螺旋齿轮的制造工艺与性能,用三轴总成成对试验台架、承载能力试验台架及噪声试验台架测定了齿轮的使用性能,并把试验结果和具有同样几何形状与表面质量的锻钢齿轮的数据进行了比较。结果表明,粉末冶金齿轮的承载能力与噪声级可和锻钢齿轮相媲美。

关键词：粉末冶金齿轮选择性表面致密化

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高使用性能粉末冶金零件的表面致密化

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粉末冶金技术 2012年第2期30卷 144-150页

作者： Lorenz S Sigl Günter rau Christian Dennert PmG Ftissen GmbH Füssen 87629德国

为保证机构的可靠性,历史上一直在用锻钢合金批量生产高转矩变速器零件,诸如变速器齿轮、高性能链轮、单向离合器座圈及滚珠轴承座圈。虽然用粉末冶金工艺生产的零件成本低廉,但常规粉末冶金钢的静态、疲劳及耐磨性能的局限性,使粉末冶... 详细信息

为保证机构的可靠性,历史上一直在用锻钢合金批量生产高转矩变速器零件,诸如变速器齿轮、高性能链轮、单向离合器座圈及滚珠轴承座圈。虽然用粉末冶金工艺生产的零件成本低廉,但常规粉末冶金钢的静态、疲劳及耐磨性能的局限性,使粉末冶金零件不能应用于上述领域。为解决这些缺欠,近年来,一直在研发用选择性表面致密化(SSD)改进粉末冶金钢性能的各种生产工艺。特别是,PmG集团开发出了一种拥有专利权的表面致密化工艺——DensiForm。利用这种工艺可使零件表面关键部分形成深度达1mm的完全致密化表面层,而零件心部仍然是多孔性的。这种结合与粉末冶金材料合金化的灵活性,使生产的烧结钢零件的使用性能可与在高应力下使用的锻钢性能相比拟。本文将介绍2个例子,即变速器中应用的表面致密化螺旋齿轮和直齿链条的驱动链轮。本文说明了螺旋齿轮和驱动链轮的生产工艺与显微组织,介绍了轿车变速器用螺旋齿轮的性能(其中包括在三轴总成的成对试验台架上得到的滚动接触疲劳的数据)和表面致密化链轮的材料性能与使用性能。

关键词：选择性表面致密化粉末冶金螺旋齿轮链轮

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轿车变速器的粉末冶金齿轮

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粉末冶金技术 2012年第5期30卷 388-395页

作者： Günter rau Lorenz S.Sigl 韩凤麟 Sinterstahl Füssen GmbH D-87629 Füssen Germany

粉末冶金齿轮由于材料中残留有孔隙,和用切削加工铸锻材料制造的零件相比,强度与耐磨性较差,不适用于重负载应用。通过横向辗压,利用选择性表面致密化,可显著改进粉末冶金齿轮的强度与耐磨性。这篇论文阐述了用压制、烧结、选择性表面... 详细信息

粉末冶金齿轮由于材料中残留有孔隙,和用切削加工铸锻材料制造的零件相比,强度与耐磨性较差,不适用于重负载应用。通过横向辗压,利用选择性表面致密化,可显著改进粉末冶金齿轮的强度与耐磨性。这篇论文阐述了用压制、烧结、选择性表面致密化、表面硬化及根据要求的品质水平可能还有最后珩磨,制造轿车变速器的粉末冶金螺旋齿轮。研究了各种参数,诸如材料组成、横向辗压与热处理的工艺参数对致密化与硬度深度、孔隙形态、显微组织、齿轮齿廓、DIN品质以及表面粗糙度的影响。初步研究是在3轴的总成成对试验台架上进行的,其表明粉末冶金齿轮具有高负载承载能力。

关键词：粉末冶金螺旋齿轮横向辗压选择性表面致密化

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multi-level governance through adaptive co-management:conflict resolution in a Brazilian state park

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Ecological Processes 2014年第1期3卷 201-213页

作者： Barbara Schroter Karla Sessin-Dilascio Claas meyer bettina matzdorf Claudia Sattler Angela meyer Gregor Giersch Camila Jerico-Daminello Lukas Wortmann Leibniz Centre for Agricultural Landscape Research(ZALF) Institute of Socio-EconomicsEberswalder Straβe 8415374 MünchebergGermany Instituto de Eletrotecnica e Energia(IEE)da Universidade de São Paulo(USP) Servico Tecnico AcademicoSecretaria de Pos GraduacaoAvenida Professor Luciano Gualberto1289Cidade Universitaria05508-010 Sao PauloSPBrazil Organisation for International Dialogue and Conflict management(IDC) Kaiserstrasse 50/6Vienna 1070Austria

Introduction:Communities situated in protected areas generate conflicts among park administrators,residents and *** they stay or should they go?This article presents a positive example of a community existing in a state *** study describes the community’s governance process as well as how the park administration and the community solve the conflicts that arise and achieve a method of co-management in a multi-level governance ***:The analysis is based on the management and Transition Framework(mTF).We used a case study approach and collected data via document study,participatory observation and qualitative ***:We find that the agreed system of community-based co-management has improved the implementation and enforcement of the state park’s rules through negotiation and communication mechanisms in the park *** relative success is due to the construction of social capital,equality and ***:For state parks in similar situations,the findings suggest that:1)a community should have at least a minimal level of self-organization;2)the empowerment of the community in the decision-making process is useful;3)the park administration should gain the trust of the residents;and 4)the effective management of ecosystem services can create a win-win situation for the community as well as the park.

关键词： management of ecosystem services Social capital Protected areas Communities Latin America

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RF magnetron-sputtered coatings deposited from biphasic calcium phosphate targets for biomedical implant applications

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Bioactive materials 2017年第3期2卷 170-176页

作者： K.A.Prosolov K.S.Popova O.A.Belyavskaya J.V.rau K.A.Gross A.Ubelis Yu.P.Sharkeev Institute of Strength Physics and materials Science of SB RAS TomskAcademicheskii pr.2/4634055Russia National Research Tomsk Polytechnic University TomskLenina pr.30634050Russia Istituto di Struttura della materia Consiglio Nazionale delle Ricerche(ISM-CNR)via del Fosso del Cavaliere 10000133RomaItaly Faculty of materials Science and Applied Chemistry Riga Technical UniversityAzenes Str.14/24RigaLV-1048Latvia University of Latvia 19Raina blvd.RigaLV-1586Latvia

Bioactive calcium phosphate coatings were deposited by radio-frequency magnetron sputtering from biphasic targets of hydroxyapatite and tricalcium phosphate,sintered at different mass%*** to Raman scattering and X-ray diffraction data,the deposited hydroxyapatite coatings have a disordered ***-temperature treatment of the coatings in air leads to a transformation of the quasi-amorphous structure into a crystalline one.A correlation has been observed between the increase in the Ca content in the coatings and a subsequent decrease in Ca in the biphasic targets after a series of deposition *** was proposed that the addition of tricalcium phosphate to the targets would led to a finer coating's surface topography with the average size of 78 nm for the structural elements.

关键词： RF-magnetron sputtering Biphasic hydroxyapatite-tricalcium phosphate targets Thin hydroxyapatite coatings Plasma coatings Biocompatibility

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Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

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Journal of molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour melissa Prat Benolt Thibault Renaud mével Léa Lemaitre Helene Leray marie-Veronique Joubert Kimberley Coulson muriel Golzio Lise Lefevre Eliane mery Alejandra martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste bettina Couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERm UmR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UmR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UmR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-mSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(mSCs)can acquire a CA-mSCs *** tumor cells trigger the transformation of mSCs to CA-mSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-mSCs promote the differentiation of monocytes towards m2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-mSC-activated macrophages lose their m2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

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Structural modification of titanium surface by octacalcium phosphate via Pulsed Laser Deposition and chemical treatment

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Bioactive materials 2017年第2期2卷 101-107页

作者： I.V.Smirnov J.V.rau m.Fosca A.De Bonis A.Latini R.Teghil V.I.Kalita A.Yu.Fedotov S.V.Gudkov A.E.Baranchikov V.S.Komlev A.Abaikov institute of metallurgy and materials science russian academy of sciencesleninsky prospect 49119334 moscowrussia istituto di struttura della materia consiglio nazionale delle ricerchevia del fosso del cavaliere 10000133 romeitaly dipartimento di scienze universita della basilicataviale dell'ateneo lucano1085100 potenzaitaly universita di roma“la sapienza” dipartimento di chimicapiazzale aldo moro500185 romeitaly lobachevsky state university gagarin av5.23603950 nizhny novgorodrussia prokhorov institute of general physics russian academy of sciencesvavilova street38119991 moscowrussia institute of theoretical and experimental biophysics russian academy of sciencesinstitutskaya street3pushchino142290 moscow regionrussia kurnakov institute of general and inorganic chemistry of the russian academy of sciences leninsky prospect 31119991 moscowrussia

In the present study, the Pulsed Laser Deposition (PLD) technique was applied to coat titanium for orthopaedicand dental implant applications. Calcium carbonate (CC) was used as starting coating *** deposited CC films were transformed into octacalcium phosphate (OCP) by chemical treatments. Theresults of X-ray diffraction (XRD), Raman, Fourier Transform Infrared Spectroscopy (FTIR) and scanningelectron microscopy (SEm) studies revealed that the final OCP thin films are formed on the titaniumsurface. Human myofibroblasts from peripheral vessels and the primary bone marrow mesenchymalstromal cells (BmmSs) were cultured on the investigated materials. It was shown that all the investigatedsamples had no short-term toxic effects on cells. The rate of division of myofibroblast cells growing onthe surface and saturated BmmSs concentration for the OCP coating were about two times faster than ofcells growing on the CC films.

关键词： Titanium implants Coating Pulsed Laser Deposition Calcium carbonate Octacalcium phosphate

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同步器系统的粉末冶金零件

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粉末冶金技术 2013年第2期31卷 149-155页

作者： Lorenz S Sigl Günter rau 韩凤麟(译) PmG Fussen GmbH Hiebelerstraβe 4 Fussen D - 87629德国不详

近年来,手动变速器的同步器系统中的关键零件,诸如同步器齿毂与同步器锁环,都在用粉末冶金工艺大量生产。本文首先介绍近年来生产先进同步器齿毂用的高强度粉末冶金钢;然后对碳纤维、烧结摩擦层及mo丝喷涂衬面3种同步器锁环用摩擦衬面... 详细信息

近年来,手动变速器的同步器系统中的关键零件,诸如同步器齿毂与同步器锁环,都在用粉末冶金工艺大量生产。本文首先介绍近年来生产先进同步器齿毂用的高强度粉末冶金钢;然后对碳纤维、烧结摩擦层及mo丝喷涂衬面3种同步器锁环用摩擦衬面进行了比较,根据压力与滑动速度讨论了其摩擦性能与寿命长短;最后,特别强调了粉末冶金的新发展,诸如滑动齿套与负载齿轮,给出并讨论了滑动齿套的应用试验结果,阐述了表面致密化螺旋齿轮的使用性能,给出了运转-时间试验的结果,并和常规的锻钢齿轮进行了比较。

关键词：粉末冶金手动变速器同步器齿毂同步器锁环滑动齿套表面致密化齿轮

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Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi marco Fosca Enrico Sassoni Gianluca Vadalà martina Cappelletti Francesco Valle Nicola Baldini Julietta V.rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“m.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of metallurgy and materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First moscow State medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADmSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

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