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永远知道发生了什么事——在小型生产企业和车间灵活而简单地控制任务流程

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现代制造 2004年第7期 52-52,54页

作者： bettina Keil

尽管技术在发展,但对当今处于瞬息万变条件下的企业来说,小型生产企业的任务控制和大型生产企业的车间控制仍然是最大的挑战,因为这是在提高供货可靠性和提高产品质量的条件下不断地降低成本的关键。

关键词：小型生产企业任务流程任务控制供应链车间控制系统

Description of a Putative Oligosaccharyl:S-Layer Protein Transferase from the Tyrosine O-Glycosylation System of Paenibacillus alveiCCM 2051T

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Advances in Microbiology 2012年第4期2卷 537-546页

作者： Robin Ristl bettina Janesch Julia Anzengruber Agnes Forsthuber Johanna Blaha Paul Messner Christina Schaffer Department of NanoBiotechnology NanoGlycobiology Unit Universitat fur Bodenkultur Wien Wien Austria Department of NanoBiotechnology NanoGlycobiology Unit Universitat für Bodenkultur Wien Wien Austria

Surface (S)-layer proteins are model systems for studying protein glycosylation in bacteria and simultaneously hold promises for the design of novel, glyco-functionalized modules for nanobiotechnology due to their 2D self-assembly capability. Understanding the mechanism governing S-layer glycan biosynthesis in the Gram-positive bacterium Paenibacillus alvei CCM 2051T is necessary for the tailored glyco-functionalization of its S-layer. Here, the putative oligosaccharyl:S-layer protein transferase WsfB from the P. alvei S-layer glycosylation gene locus is characterized. The enzyme is proposed to catalyze the final step of the glycosylation pathway, transferring the elongated S-layer glycan onto distinct tyrosine O-glycosylation sites. Genetic knock-out of WsfB is shown to abolish glycosylation of the S-layer protein SpaA but not that of other glycoproteins present in P. alvei CCM 2051T, confining its role to the S-layer glycosylation pathway. A transmembrane topology model of the 781-amino acid WsfB protein is inferred from activity measurements of green fluorescent protein and phosphatase A fused to defined truncations of WsfB. This model shows an overall number of 13 membrane spanning helices with the Wzy_C domain characteristic of O-oligosaccharyl:protein transferases (O-OTases) located in a central extra-cytoplasmic loop, which both compares well to the topology of OTases from Gram-negative bacteria. Mutations in the Wzy C motif resulted in loss of WsfB function evidenced in reconstitution experiments in P. alvei ΔWsfB cells. Attempts to use WsfB for transferring heterologous oligosaccharides to its native S-layer target protein in Escherichia coli CWG702 and Salmonella enterica SL3749, which should provide lipid-linked oligosaccharide substrates mimicking to some extent those of the natural host, were not successful, possibly due to the stringent function of WsfB. Concluding, WsfB has all features of a bacterial O-OTase, making it the most probable candidate for

关键词： Bacterial Glycosylation S-Layer Oligosaccharyl Transferase Tyrosine-O-Glycosylation Trans-Membrane Topology

Procalcitonin as a marker of infection in febrile neutropenia:A systematic review

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Modern Chemotherapy 2013年第1期2卷 8-14页

作者： Anders K.Boysen bettina R.Jensen Laurids Φ.Poulsen Paw Jensen Soren Ladefoged Department of Oncology Aarhus University HospitalAarhusDenmark Department of Oncology Aalborg University HospitalAalborgDenmark Department of Hematology Aalborg University HospitalAalborgDenmark Department of Clinical Biochemistry Aarhus University HospitalAarhusDenmark

Aim: Management of febrile neutropenia is challenged by lacking microbiological and clinical documentation of infection. Procalcitonin is emerging as a new promising biomarker of infection. We aimed to undertake a systematic review evaluating the diagnostic accuracy of procalcitonin as a marker of infection in febrile neutropenia. Methods: We performed a systematic re- view of the literature using the databases MEDLINE, EMBASE and Cochrane Library including a search of the grey literature (e.g. unpublished data, web sides of relevant societies). The methodological quality was assessed using predefined criteria. The relevant data were extracted and analyzed by two authors. Results: The literature search yielded a total of 193 studies of which nine were eligible for inclusion. There was a great variation in the quality of the methodological design. A notable heterogeneity exists regarding the studied populations and the definition of the reference standards. Among the nine included studies the sensitivity ranged from 42% to 72% and the specificity ranged from 64% - 89% at a cut off value ranging from 0.5 - 0.8 ng/ml. The studied endpoint was either microbiologically or clinically documented infection. Four studies found procalcitonin superior to Creactive protein in discriminating infection from the various other causes of fever. Conclusion: Procalcitonin appears to be a promising biomarker and might add new diagnostic information in the management of febrile neutropenia.

关键词： Procalcitonin Febrile Neutropenia

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生态现代化理论:回顾和展望

理论学刊 2011年第7期 59-62页

作者：金书秦 Arthur P.J.Mol bettina Bluemling 农业部农村经济研究中心北京100810 瓦赫宁根大学环境政策系

生态现代化已经成为环境治理研究的主流理论,横跨经济学、社会学和管理学等多个学科,受到越来越多的关注。生态现代化的核心目标就是实现经济发展与环境退化的脱钩,它的六大假设已经或正在不同地区、不同层次被检验。生态现代化最为基... 详细信息

生态现代化已经成为环境治理研究的主流理论,横跨经济学、社会学和管理学等多个学科,受到越来越多的关注。生态现代化的核心目标就是实现经济发展与环境退化的脱钩,它的六大假设已经或正在不同地区、不同层次被检验。生态现代化最为基本的要求就是解放生态,包括两大机制:通过技术创新实现经济生态化、通过制度创新实现生态经济化。生态现代化与可持续发展的不同主要体现在对代际公平的偏好程度,以及在对未来发展的乐观或悲观态度上。生态现代化理论对于指导中国社会发展的转型具有重大意义,展望其研究命题主要包括:国家生态现代化战略、环境治理模式改革、提升企业国际竞争力等。

关键词：生态现代化转型中国可持续发展

根据不同种类的消费需求零售商打造护发素概念

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中国化妆品 2014年第7期 36-37页

作者： bettina Jackwerth 艾琳巴斯夫欧洲公司个人护理部门德国蒙海姆不详

巴斯夫公司现巳开发出的针对护发素的产品概念，在有形条件下，用来满足在情感和功能方面有特定需求的人群，这种方法是一个客户调研验证类型系统中使用的。

关键词：护发素消费需求零售商种类巴斯夫公司产品概念类型系统

Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors

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Journal of Molecular Cell Biology 2020年第3期12卷 202-215页

作者： Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste bettina Couderc Institut Claudius Regaud-IUCT Oncopole Universite de ToulouseToulouseFrance INSERM UMR 1037 Cancer Research Center of Toulouse(CRCT)ToulouseFrance UMR 152 Pharma Dev Universite de ToulouseIRDUPSToulouseFrance UMR CNRS 5089 Institut de Pharmacologie et de Biologie Structurale(IPBS)ToulouseFrance

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and *** this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs *** tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor ***,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor *** CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral *** ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of *** high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance.

关键词： chemoresistance macrophages mesenchymal stromal cells ovarian adenocarcinoma chemokines

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澳大利亚本土花卉走向世界市场并非易事

中国花卉园艺 2022年第10期 72-74页

作者： bettina GOLLNOW 华新(译) 不详

澳大利亚独特的本土花卉,有望成为世界切花和观赏植物市场全新的且令人兴奋的产品,但将这些花卉资源成功转化为商业贸易并非易事. 近几十年来,澳大利亚已启动了不少私人企业或政府资助的育种项目,但成功盈利的却很少.澳大利亚很多植物... 详细信息

澳大利亚独特的本土花卉,有望成为世界切花和观赏植物市场全新的且令人兴奋的产品,但将这些花卉资源成功转化为商业贸易并非易事. 近几十年来,澳大利亚已启动了不少私人企业或政府资助的育种项目,但成功盈利的却很少.澳大利亚很多植物都是木本灌木或乔木,需要数年时间才能开花,因此要成功培育一个商业新品种,可能需要20多年时间.很多植物很难繁殖,育种人对它们的繁殖原理知之甚少,又不能将其成功地与近缘物种杂交,这使得育种更加困难.

关键词：花卉资源观赏植物商业贸易近缘物种切花澳大利亚私人企业政府资助

Cytokinin but not gibberellin application had major impact on the phenylpropanoid pathway in grape

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Horticulture Research 2021年第1期8卷 599-613页

作者： Kamal Tyagi Itay Maoz bettina Kochanek Noa Sela Larry Lerno Susan EEbeler Amnon Lichter Department of Postharvest Science Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Department of Viticulture and Enology University of CaliforniaDavisCA 95616USA Department of Plant Pathology Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Food Safety and Measurement Facility University of CaliforniaDavisCA 95616USA

Cytokinin and gibberellic acid(GA)are growth regulators used to increase berry size in seedless grapes and it is of interest to understand their effects on the phenylpropanoid pathway and on ripening *** 3 and synthetic cytokinin forchlorfenuron(N-(2-chloro-4-pyridyl)-N′-phenylurea,CPPU)and their combination were applied to 6 mm diameter fruitlets of‘Sable Seedless’,and berries were sampled 51 and 70 days(d)following *** treatments increased berry size and delayed sugar accumulation and acid degradation with a stronger effect of ***,but not GA,reduced berry color and the levels of *** CPPU reduced the levels of anthocyanins by more than 50%,the combined treatment of GA+CPPU reduced the levels by about 25%at 51 *** treatment had minor effects on flavonols content but increased the levels of monomeric flavan-3-ols by more than *** analysis using HPLC showed that proanthocyanidin content was significantly increased by CPPU,whereas mean degree of polymerization was reduced from 26 to *** analysis by GC-MS showed changes in composition with CPPU or GA treatment with potential impact on ***-seq analysis showed that GA had a minor overall effect on the transcriptome whereas CPPU had pronounced effects on gene expression at both 51 and 70 *** the control and CPPU at similar Brix of ca.19.7°,a reduced expression of stilbene synthases(STSs)including their regulators MYB14 and MYB15,and other phenylpropanoid-related genes was observed in CPPU-treated ***,our study shows that CPPU had a major influence on the phenylpropanoid pathway and affected multiple ripening-related processes.

关键词： CPPU impact treatment

IL-8在食管癌中表达对肿瘤血管形成及患者预后的影响

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华中科技大学学报（医学版） 2005年第4期34卷 451-453,457页

作者：苏铁芬 bettina Tilton 袁永辉李娜萍 Martin Schilling 吴人亮华中科技大学同济医学院基础医学院病理系武汉430030 萨尔州大学洪堡医学院外科德国洪堡66424

目的研究白细胞介素8(IL8)在食管癌组织中的表达变化,以及此变化对肿瘤血管形成、患者预后的影响。方法利用实时逆转录聚合酶链反应(realtimeRT PCR)和免疫组织化学技术检测食管癌及正常组织中IL8mRNA和蛋白表达,并采用Ⅷ因子相关抗原(F... 详细信息

目的研究白细胞介素8(IL8)在食管癌组织中的表达变化,以及此变化对肿瘤血管形成、患者预后的影响。方法利用实时逆转录聚合酶链反应(realtimeRT PCR)和免疫组织化学技术检测食管癌及正常组织中IL8mRNA和蛋白表达,并采用Ⅷ因子相关抗原(FⅧRAg)检测微血管密度。结果食管癌组织中IL8mRNA及蛋白表达显著高于正常组织。IL8mRNA高表达与远处淋巴结转移、微血管高密度、生存时间短(<26个月)、早期复发(<16个月)有关(均P<0.05)。癌组织中微血管密度比周围正常组织高(P<0.01)。结论在食管癌中,IL8mRNA高表达的患者发生转移机率高,复发早,生存时间短;IL8可以作为一个判定食管癌预后的指标。

关键词：食管癌白细胞介素-8 微血管密度