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Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani betsy Joseph Mary Thomas Vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

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Design of a Novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rodríguez-León betsy D.M.Chaparro-Rico Daniele Cafolla Francesco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

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Diabetes during COVID-19 Pneumonia in a 16-Year-Old Girl: A Case Report in Cameroon

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Open Journal of Pediatrics 2024年第4期14卷 712-718页

作者： Ritha Mbono Betoko Charlotte Eposse Suzanne Sap betsy Bate Gaelle Ntsoli Hassanatou Iyawa Calixte Ida Penda Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Laquintinie Douala Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaound Cameroon

Background: Diabetes is a known risk factor for susceptibility and severity of COVID-19 infection. It may also be a complication of COVID-19. Many hypotheses have been proposed to explain this condition. It may be due to the effect of SARS-CoV-2 on β cells or drug-related side effects. In children, there is a paucity of data on the burden of this complication. Objective: We aimed to report a case of secondary diabetes during COVID-19 in a pediatric unit. Case Presentation: A 16-year-old girl presented with severe respiratory distress. She was treated for COVID-19 infection with antibiotics and corticosteroids. On day 6 of treatment, she developed polyuria and polydipsia. A random blood glucose test showed hyperglycaemia. The diagnosis of secondary diabetes was maintained. Conclusion: Covid-19 infection can be complicated by diabetes in children. It is essential to monitor blood glucose levels regularly.

关键词： Covid-19 Diabetes Adolescents

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生成式AI可以提供理财建议吗?

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商学院 2024年第5期 14-14页

作者： betsy Vereckey 麻省理工学院斯隆管理学院

许多人在寻求定制化的投资建议时,都会与职业财务顾问联系,生成式人工智能有可能颠覆这种态势。在金融行业,从预算应用程序到客户服务聊天机器人都离不开人工智能的支持。那么大语言模型(如GPT-4)能否像理财顾问那样提供个性化的理财建... 详细信息

许多人在寻求定制化的投资建议时,都会与职业财务顾问联系,生成式人工智能有可能颠覆这种态势。在金融行业,从预算应用程序到客户服务聊天机器人都离不开人工智能的支持。那么大语言模型(如GPT-4)能否像理财顾问那样提供个性化的理财建议呢?

关键词：定制化人工智能金融行业聊天机器人应用程序语言模型客户服务财务顾问

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婴幼儿视力发育的前瞻性队列研究

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中华眼科杂志 2023年第8期59卷 627-635页

作者：曹奕雯李晓清边旸贾淑娟李明 betsy Lozoff 北京大学第一医院小儿眼科北京大学儿童视觉中心北京100034 北京大学第一医院儿科北京100034 河北省三河市妇幼保健院三河065200 美国密歇根大学安娜堡分校儿科学系美国密歇根大学安娜堡分校环境健康科学系美国安娜堡48109

目的分析婴幼儿早期视力成长发育的趋势和特点。方法前瞻性队列研究。连续纳入2008年至2013年于河北省三河市妇幼保健院出生的足月儿,在生后42 d、9月龄、18月龄3个时间点使用Teller Acuity CardⅡ(TACⅡ)条栅视力卡进行选择性观看视力... 详细信息

目的分析婴幼儿早期视力成长发育的趋势和特点。方法前瞻性队列研究。连续纳入2008年至2013年于河北省三河市妇幼保健院出生的足月儿,在生后42 d、9月龄、18月龄3个时间点使用Teller Acuity CardⅡ(TACⅡ)条栅视力卡进行选择性观看视力检查,得到其条栅视力;3岁时采用Lea Symbols图形视力表进行视力检查并将结果转换为条栅视力。受试儿童在42 d、9月龄、18月龄3个时间点均检查双眼视力,对9和18月龄儿童增加单眼视力检查,3岁儿童检查单眼视力。记录不同时间点各项视力及各时间段内视力变化值,分析受试儿童的视力发育情况,并与以往文献结果进行比较。结果共纳入1496名儿童,其中男性773名(51.67%),女性723名(48.33%)。受试儿童在42 d、9月龄和18月龄时双眼视力分别为0.9(0.6,1.1)、6.4(6.4,9.6)和9.6(9.6,9.6)周/度(cpd),差异有统计学意义(P0.05)。9月龄时视力≥6.5 cpd者占68.7%(633/921),18月龄时则为92.7%(342/369)。9至18月龄期间单眼视力增长了(0.26±0.46)倍,18月龄至3岁期间则增长了(1.36±0.52)倍。9月龄时,1279名完成了双眼视力检查的儿童中有72.01%(921名)完成了单眼视力检查,18月龄这一比例降至35.83%(369/1030)。儿童视力随年龄提高(P<0.001)。本研究各年龄儿童的视力均高于文献中广州儿童的视力(P<0.001)。结论3岁以内的健康婴幼儿的视力水平随年龄提高,9月龄之前视力发育迅速,之后变得平缓,至18月龄又开始持续快速增长。

关键词：视敏度视力测定法视力试验婴儿队列研究

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Post-fire regeneration dynamics in whitebark pine(Pinus albicaulis) forests in Wind River and Absaroka Mountains,Wyoming, USA

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Journal of Forestry Research 2015年第3期26卷 719-733页

作者： Jennifer G.Klutsch betsy A.Goodrich William R.Jacobi Department of Bioagricultural Sciences and Pest Management Colorado State University Ft. CollinsCO 80523-1177 USA Department of Renewable Resources University of Alberta 442 Earth Science BuildingEdmonton AB T6G 2E3 Canada School of Forestry Northern Arizona University PO Box 15018 Flagstaff AZ 86011 USA

Whitebark pine （Pinus albicaulis） populations are in decline across the species＇ range due to historic wildfire exclusion, mountain pine beetle （Dendroctonus ponderosae, MPB） outbreaks, and an invasive fungal pathogen causing the disease white pine blister rust （Cronartium ribicola, WPBR）. Despite reliance on stand- replacing fires, information on whitebark pine regeneration occurrence is limited and the trajectory of future forests is largely unknown in some areas of the range. Regeneration densities were assessed in burned and adjacent non-burned areas at six high elevation locations in northwest Wyoming where stand-replacing fires occurred 8-32 years before thesurveys. In these locations at the eastern extent of the species range, we assessed what site factors were associ- ated with regeneration success. Whitebark pine regen- eration density was greater and seedlings were older in non-burned compared to burned areas. Within burns, north aspects had more regeneration than south aspects. Potential seed source densities and other species＇ regeneration were positively related to whitebark p^ne regeneration densities in burned areas. South facing slopes or grass covered areas may have either delayed or no regeneration of whitebark pine without the help of artificial planting.

关键词： Recruitment Age structure White pineblister rust - Mountain pine beetle Restoration

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Pandemic COVID-19:Current status and challenges of antiviral therapies

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Genes & Diseases 2020年第4期7卷 502-519页

作者： Winglam Chan betsy He Xiong Wang Ming-Liang He Department of Biomedical Sciences City University of Hong KongHong KongChina Rensselaer Polytechnic Institute TroyNYUSA CityU Shenzhen Research Institute NanshanShenzhenChina

The pandemic COVID-19,caused by a new coronavirus SARS-CoV-2 infection,has infected over 12 million individuals and caused more than 55,200 death ***,there is no specific drug to treating this *** we summarized the mechanisms of antiviral therapies and the clinic findings from different *** chemotherapies have been conducted by in multiple cohorts in different *** FDA has fast approved remdesivir for treating COVID-19,it only speeds up recovery from COVID-19 with mildly reduced *** chloroquine was suggested a potential drug against SARS-CoV-2 infection due to its in vitro antiviral effects,it is imperative high-quality data from worldwide clinical trials are necessitated for an approved *** terms of hydroxychloroquine(HCQ)therapy,although WHO has stopped all the clinic trials due to its strong side-effects in COVID patients,large scale clinical trials with a long-term outcome follow-up may warrant HCQ and azithromycin combination in combating the *** plasma(CP)therapy suggested its safety use in SARS-CoV-2 infection;but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human *** research should be conducted to define the exact mechanism of SARS-CoV-2 pathogenesis,suitable animal models or ex vivo human lung tissues aid in studying replication,transmission and spread of the novel viruses,thereby facilitating highly effective therapies.

关键词： Chloroquine Convalescent plasma therapy COVID-19 Hydroxychloroquine Ivermectin Natural killer cell therapy Remdesivir SARS-CoV-2

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An Online Emergency Currciulum for Nurses Internationally

An Online Emergency Currciulum for Nurses Internationally

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第七届亚太地区灾难医学学术交流会

作者： betsy Weiner International Nursing Coalition for Mass Casualty Education Vanderbilt UniversityU.S.A

＜正＞The Vanderbilt University School of Nursing has taken a leadership role with the establishment of the International Nursing Coalition for Mass Casualty Education （INCMCE）. This coalition consists of organizational representatives of schools, accrediting bodies, specialty organizations and governmental agencies interested in promoting mass casualty education for nurses. Several grants have been obtained to develop an online curriculum that addresses the competencies as developed by the INCMCE members for all nurses. （See *** for further information.）

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Wait——don't date Dating not necessarily good practice for marriage

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英语自学 2000年第7期 2-3页

作者： betsy Severin 宋芳

“等等一先别约会”是一位美国大学生Bet-sy Severin为一家报纸写的专栏文章。文章读来轻松诙谐,但蕴涵其中的作者对恋爱和婚姻问题的一些见解却是值得我们认真思考的。文章的语言非常口语化,这对我们学习当代美国口语定会有所帮助。

关键词： don’t date Dating not necessarily good practice for marriage

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Pumpkins Abound

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小学生时代（大嘴英语） 2021年第10期 16-19页

作者： betsy Blake Susan Miller(图) 不详

Pumpkins on the back porch,A pumpkin at the *** on the countertop,The table,and the floor.A pumpkin on the garden gate And two under the tree.A pumpkin in the window And a pumpkin on me!

关键词： pump floor Pump

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