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Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals

Acta Pharmacologica Sinica 2007年第9期28卷 1274-1304页

作者： Lynne M HOWELLS Elena P MOISEEVA Christopher PNEAL bethany eforeman Catherine KANDREADI Yi-yang SUN E Ann HUDSON Margaret M MANSON Cancer Biomarkers and Prevention Group University of LeicesterLeicester LE1 7RHUK

There is growing interest in the ability of phytochemicals to prevent chronicdiseases,such as cancer and heart ***,some of these agents havepoor bioavailability and many of the in-depth studies into their mechanisms ofaction have been carried out in vitro using doses which are unachievable *** order to optimize the design of chemopreventive treatment,it is impor-tant to determine which of the many reported mechanisms of action are *** this review we consider the physiologically achievable doses for afew of the best studied agents (indole-3-carbinol,diindolylmethane,curcumin,epigallocatechin-3-gallate and resveratrol) and summarize the data derived fromstudies using these low concentrations in cell *** then cite examples of invitro effects which have been observed in ***,the ability of agentcombinations to act synergistically or antagonistically is *** con-clude that each of the compounds shows an encouraging range of activities invitro at concentrations which are likely to be physiologically *** arealso many examples of in vivo studies which validate in vitro *** consideration is that combinations of agents can result in significantactivity at concentrations where any single agent is ***,for each of thecompounds reviewed here,in vitro studies have provided useful insights intotheir mechanisms of action in ***,data are lacking on the full rangeof activities at low doses in vitro and the benefits or otherwise of combinations invivo.

关键词： bioavailability cancer chemoprevention curcumin diet diindolylmethane epigallo catechin-3-gallate indole-3-carbinolresveratrol

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