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农业,一个完整的资产类别

农经 2017年第4期 40-42页

作者： Kirk haney

农业科技如今已然成为一个完整的资产类别,2016年580笔的交易数量以及32.3亿美元的投资总额刷新了行业纪录。种子阶段融资活动数量占到总交易活动量的57%,投资金额达到2.3亿美元,相比去年同期增长了16%,比2015年增长了77%。农业科技,一... 详细信息

农业科技如今已然成为一个完整的资产类别,2016年580笔的交易数量以及32.3亿美元的投资总额刷新了行业纪录。种子阶段融资活动数量占到总交易活动量的57%,投资金额达到2.3亿美元,相比去年同期增长了16%,比2015年增长了77%。农业科技,一个完整的资产类别随着全球人口的增长,市场对优质粮食的需求也在增加。在技术和资本的驱动下,农业和食品行业正在经历着前所未有的巨变,

关键词：农业科技资产类别交易数量食品行业投资总额融资活动种子阶段投资金额

High Content Screening: Science, Techniques and Applications 1

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Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism

2008年

作者： Steven A. haney

ISBN: (数字)9780470229859

ISBN: (纸本)9780470039991

The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.

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World Journal of Stem Cells 2016年第10期8卷 306-315页

作者： Taylor C Peak Nora M haney William Wang Kenneth J DeLay Wayne J Hellstrom Department of Urology School of MedicineTulane University

The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation.

关键词： Stem cell therapy Leydig cells Primary hypogonadism Stem Leydig cells Testosterone Bone marrow-derived stem cells Adipose-derived mesenchymal stem cells

Picomolar antimalarial agent from a Chinese medicinal plant

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Science China Chemistry 2022年第1期65卷 82-86页

作者： Bin Zhou Flavia M.Zimbres Joshua H.Butler Cheng-Hui Xu Reagan S.haney Yan Wu Maria B.Cassera Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Biochemistry and Molecular Biology Center for Tropical and Emerging Global Diseases(CTEGD)University of GeorgiaAthensGeorgia 30602United States

In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1–7)with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp.brachystachys by solid data acquired by diverse methods.Among them,compound 3 with an EC50 value of 4.3 pM against the chloroquine-resistant Plasmodium falciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than artemisinin.This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.

关键词： medicinal plants dimeric sesquiterpenoids antimalarial agent structure-activity relationship

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家庭啤酒厂

科技新时代（上半月） 2007年第10期 101-102页

作者： MIKE　haney

假如有一台闪闪发光的机器，利用它你只要做很少的工作就能酿造出自己的啤酒，你会觉得怎么样？我相信绝大多数男人都很想来一台，这同样也正是本刊摄影师约翰·加内特花费数周时间制作了这样一台机器的原因。整套装备安装在两个不锈钢... 详细信息

假如有一台闪闪发光的机器，利用它你只要做很少的工作就能酿造出自己的啤酒，你会觉得怎么样？我相信绝大多数男人都很想来一台，这同样也正是本刊摄影师约翰·加内特花费数周时间制作了这样一台机器的原因。整套装备安装在两个不锈钢小车上，从煮沸提取物（经过浓缩的小麦汁或者预先发酵的啤酒原汁）开始，最后冷凝得到啤酒。

关键词：啤酒厂家庭摄影师不锈钢提取物机器酿造原汁

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六招成就最佳雇主

人力资源 2008年第14期 11-13页

作者： Bud haney Jim Sirbasku 美国Profiles International Inc

如何才能吸引和留住人才?其实这并没什么秘诀,无非是好的雇主非常清楚潜在和现有的员工最看重的是什么,并且为满足他们的需求而不断努力罢了。那么,员工最看重的是什么呢?知名的美国人才服务机构Profiles International公司曾经就员工... 详细信息

如何才能吸引和留住人才?其实这并没什么秘诀,无非是好的雇主非常清楚潜在和现有的员工最看重的是什么,并且为满足他们的需求而不断努力罢了。那么,员工最看重的是什么呢?知名的美国人才服务机构Profiles International公司曾经就员工为什么辞职进行了一次调查,发现了影响员工更换工作的五个主要原因:对公司的管理不满意或对被管理的方式不满意;成就得不到表彰;没有机会晋升;薪酬和福利不令人满意;对工作厌倦。不难发现,这一调查结果很能说明问题,如果你希

关键词：最佳雇主员工流失率员工离职

Not yet IDEAL?-evidence and learning curves of minimally invasive pancreaticoduodenectomy

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 812-814页

作者： Felix Nickel Caelán Max haney Beat-Peter Müller-Stich Thilo Hackert Department of General Visceraland Transplantation SurgeryHeidelberg UniversityHospital HeidelbergHeidelbergGermany

In response to“What’s the next step in evaluating laparoscopic pancreaticoduodenectomy?”(http://***/article/view/29682/25710)by Fernando Burdío,Luís Grand and Ignasi Poves.First and foremost,we would like to express our sincere condolences on the passing of Professor Ignasi Poves.We were deeply saddened to hear of this and wish his family,friends and colleagues strength in these difficult times of grieving.

关键词： IDEAL learning Grand

Estimating Potential Nitrogen Mineralisation Using the Solvita Soil Respiration System

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Open Journal of Soil Science 2015年第12期5卷 319-323页

作者： Richard L. haney Elizabeth B. haney Grassland Soil and Water Research Laboratory Agricultural Research Service United States Department of Agriculture (USDA-ARS) Temple TX USA Texas AgriLife Research & Extension Center Texas A & M University Temple TX USA

Nitrogen (N) mineralisation contributes considerably to crop growth in fertilized and unfertilized fields. It is useful to be able to assess potential N mineralisation to increase fertilizer application efficiency, prevent excessive N runoff, and improve environmental system models. The microbes present in soil mineralize N based on many factors, including soil temperature and moisture, tillage, and levels of organic C and N. The measurement of soil’s ability to mineralize N is considered a good indicator of soil quality. Many methods have been developed to estimate N mineralisation in the laboratory and field. The 7-day anaerobic N mineralisation method developed in the 1960’s is considered reliable and is often used to compare new N-mineralisation testing methods. This study examines the use of soil CO2 evolution as determined using the Solvita Soil Respiration System (Solvita) for estimating N mineralisation by comparing it directly to the anaerobic N mineralisation test. Measured CO2 using Solvita was strongly correlated with anaerobic N mineralisation (r2 = 0.82). Results indicate that the Solvita Soil Respiration System can be used to rapidly assess soil respiration and relative N mineralisation potential in any given soil and is considerably faster and easier to perform in a laboratory setting than the anaerobic N mineralisation test.

关键词： Anaerobic N Nitrogen Mineralisation Soil Respiration

Evaluation of Size Structure in Freshwater Cyanobacterial Populations: Methods to Quantify Risk Associated with Changes in Biomass and Microcystin Concentrations

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Journal of Water Resource and Protection 2019年第6期11卷 810-829页

作者： Nancy J. Leland James F. haney Kristin Conte Karen Malkus-Benjamin Bryan Horsely Lim-Tex North Andover MA USA Department of Zoology University of New Hampshire Durham NH USA Manchester Water Works Manchester NH USA Town of Barnstable Barnstable MA USA Association to Preserve Cape Cod Dennis MA USA

Cyanobacterial populations in surface waters, including drinking water supplies and recreational waters, represent an ever present challenge for resource managers. As communities continuously respond to external and internal processes, dynamic profiles of composition, dominance, growth and toxigenicity emerge. In this study measures of size structure and biomass, quantified using light microscopy and fluorometry, were used to estimate microcystin concentrations through linear regression analysis. Toxigenic profiles using cyanobacterial biomass were developed for lakes dominated by Microcystis spp. and Dolichospermum spp., influenced by both genus-specific pigment concentrations as well as microcystin concentrations. Community composition (Log %MIC) and biomass were used to describe microcystin concentrations in mixed assemblages, where composition was the first input variable. The accessory photopigment phycocyanin was used to describe the linear relationship between the daily growth and net microcystin production rates in the bloom-forming Microcystis spp. samples, suggesting that this size-fractionated sample may provide indications of potential toxigenicity in the whole lake water sample. Future investigations using fluorometric evaluation of cyanobacterial populations could provide additional applications and metrics for use by resource managers to quantify risk association with elevated cyanotoxin concentrations.

关键词： Microcystis Dolichospermum Phycocyanin Microcystins Growth Rates