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Microstructure and mechanical properties of friction-stir welded St52 steel joints

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International Journal of Minerals,Metallurgy and Materials 2018年第12期25卷 1457-1464页

作者： Tevfik kucukomeroglu Semih M.Aktarer Guven Ipekoglu gurel Cam Department of Mechanical Engineering Karadeniz Technical UniversityTrabzon 61080Turkey Department of Automotive Technology Recep Tayyip Erdogan UniversityRize 53100Turkey Department of Mechanical Engineering Iskenderun Technical UniversityHatay 31200Turkey

The aim of this work is to investigate the mechanical properties and microstructures of friction-stir welded(FSWed) St52 structural steel joints. In this study, St52 steel plates with a thickness of 4 mm were butt-welded by friction-stir welding(FSW) using a tungsten carbide tool having a conical pin. The microstructure of the welded zone consists of equiaxed fine ferrite, grain boundary ferrite, Widmanstatten ferrite, and aggregates of ferrite + cementite. The microhardness measurements showed that the hardness of the welded zone was significantly higher than that of the base metal. The FSWed St52 joint exhibited a significant strength overmatching in the weld region and a strength performance similar to or slightly higher than that of the base plate.

关键词： friction-stir welding St52 steel microstructure mechanical properties

Evolution of continent ileostomy

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World Journal of Gastroenterology 2012年第27期18卷 3479-3482页

作者： gurel Nessar James S Wu Department of Gastrointestinal Surgery Yuksek Ihtisas HospitalAnkara 06100Turkey Department of Colorectal Surgery Digestive Disease InstituteClevelandOH 44195United States

Continent ileostomy can be defined as a surgical procedure that facilitates planned intermittent evacuation of a bowel reservoir through an *** was devised by Nils Kock in ***,continent ileostomy (or Kock pouch) became a viable alternative in the management of patients who had traditionally required an end *** pouch appeared to provide substantial physical and psychosocial benefits over a conventional *** procedure became popular until ileal pouch anal anastomosis (IPAA) was introduced in *** its benefits,continent ileostomy had many short term complications including intubation problems,ileus,anastomotic leaks,peritonitis and valve *** mortalities have also been reported in the *** of these problems have been eliminated with increasing experience;however,valverelated problems remain as an "Achilles' heel" of the *** modifications have been introduced to prevent this *** patients have had their pouch removed because of complications mainly related to valve *** revision rates can be high,most of the patients who retain their reservoirs are satisfied with regard to their health status and quality of ***,this procedure is still appropriate for selected patients for whom pouch surgery is not possible or for patients who have failed *** the patient and their physician must be highly motivated to accept the risk of failure and the subsequent need for revisional operations.

关键词： Continent ileostomy Kock pouch Ileal res-ervoir Surgical technique

CRISPR-Cas nucleases and base editors for plant genome editing

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aBIOTECH 2020年第1期1卷 74-87页

作者： Filiz gurel Yingxiao Zhang Simon Sretenovic Yiping Qi Department of Molecular Biology and Genetics Faculty of ScienceIstanbul UniversityVezneciler34134 IstanbulTurkey Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA Institute for Bioscience and Biotechnology Research University of MarylandRockvilleMD 20850USA

Clustered regularly interspaced short palindromic repeats(CRISPR)—CRISPR-associated protein(Cas)and base editors are fundamental tools in plant genome ***9 from Streptococcus pyogenes(SpCas9),recognizing an NGG protospacer adjacent motif(PAM),is a widely used nuclease for genome editing in living ***12a nucleases,targeting T-rich PAMs,have also been recently demonstrated in several plant ***,multiple Cas9 and Cas12a engineered variants and orthologs,with different PAM recognition sites,editing efficiencies and fidelity,have been explored in *** RNA-guided sequence-specific nucleases(SSN)generate double-stranded breaks(DSBs)in DNA,which trigger non-homologous end-joining(NHEJ)repair or homology-directed repair(HDR),resulting in insertion and deletion(indel)mutations or precise gene replacement,***,genome editing can be achieved by base editors without introducing *** far,several base editors have been applied in plants to introduce C-to-T or A-to-G transitions,but they are still undergoing improvement in editing window size,targeting scope,off-target effects in DNA and RNA,product purity and overall ***,we summarize recent progress on the application of Cas nucleases,engineered Cas variants and base editors in plants.

关键词： CRISPR SpCas9 Cas12a Cas12b PAM Cytidine/adenine base editors

Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment

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World Journal of Gastroenterology 2008年第18期14卷 2912-2914页

作者： Ismail Sari Merih Birlik Can Gonen Servet Akar Duygu gurel Fatos Onen Nurullah Akkoc Division of Rheumatology Department of Internal Medicine Dokuz Eylul University School of Medicine Izmir 35340 Turkey Division of Gastroenterology Department of Internal Medicine Dokuz Eylul University School of Medicine Izmir 35340 Turkey Department of Pathology Dokuz Eylul University School of Medicine Izmir 35340 Turkey

Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral *** infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents.

关键词： Tumor necrosis factor alpha inhibitors Adverse effects Virus diseases

Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2007年第6期13卷 837-844页

作者： Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim gurel Macit Gulten Selim Giray Nak Uludag University Medical School Department of Internal Medicine Bursa Turkey Uludag University Medical School Department of Gastroenterology Bursa Turkey Uludag University Medical School Department of Biochemistry Bursa Turkey Uludag University Medical School Department of Statistics Bursa Turkey Uludag University Medical School Department of Pathology Bursa Turkey

AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology.

关键词： Steatosis Steatohepatitis Cytokeratin 18 M30-antigen M65-antigen

Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients

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World Journal of Gastroenterology 2007年第45期13卷 6027-6030页

作者： Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim gurel Selim Giray Nak Macit Gulten Uludag University Medical School Department of Internal Medicine Bursa 16059 Turkey Uludag University Medical School Department of Gastroenterology Bursa 16059 Turkey Uludag University Medical School Department of Microbiology and Infectious Diseases Bursa 16059 Turkey Uludag University Medical School Departmentof Biochemistry Bursa 16059 Turkey

AIM： To investigate the diagnostic efficacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis （SBP）. METHODS： A total of 63 consecutive patients with cirrhotic ascites （38 male, 25 female） tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic fluid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm^3. RESULTS： Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specificity, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically significant effects on diagnostic accuracy. CONCLUSION： Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP.

关键词： Spontaneous bacterial peritonitis Urinaryreagent strip Leukocyte esterase Nitrite

Relation of Biochemical Parameters with Flow-mediated Dilatation in Patients with Metabolic Syndrome

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Chinese Medical Journal 2017年第13期130卷 1564-1569页

作者： Nurver Turfaner Sipahioglu Barls Ilerigelen Zeynep B. Gungor Gulsel Ayaz Hakan Ekmekci Cigdem Bayram gurel Gunay Can Huseyin Sonmez Turgut Ulutin Fikret Sipahioglu Department of Family Medicine Cerrahpasa Medical Faculty Istanbul University Istanbu134303 Turkey Department of Cardiology Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Biochemistry Cerrahpasa Medical Faculty Istanbul University Istanbu134303 Turkey Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Public Health Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey

Background： Metabolic syndrome （MetS） is one of the high cardiovascular （CV） situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the major CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS. Methods： The study was performed between December 2010 and August 2014. A total of 55 patients （ 15 females and 40 males） with MetS and 81 healthy controls （37 females and 44 males） with a body mass index 〈25 kg/m2 were enrolled in the study. Endothelial dysfunction was measured by flow-mediated dilatation （FMD）, oxidative stress parameters; high-sensitivity C-reactive protein （hs-CRP）, oxidized low-density lipoprotein （ox-LDL）, endothelial nitric oxide synthase （e-NOS）, nitric oxide, and cell adhesion markers; yon Willebrand factor, and e-selectin. Platelet aggregation （endothelial adenosine diphosphate）, total platelet count, and mean platelet volume were additionally analyzed and demographic parameters were explored. Student＇s t-test, Mann-Whitney U-test, and Chi-square test were used to analyze the results. Results： The fasting blood glucose （z = 3.52, P = 0.001 ）, hs-CRP （z - 3.23, P = 0.004）, ox-LDL （z = 2.62, P= 0,013）, and e-NOS （z = 2.22, P = 0.026） levels and cardiac risk score （z - 5.23, P 〈 0.001） were significantly higher in patients with MetS compared with the control group. Smoking was correlated with decreased FMD （χ2 = 9.26, P = 0.002） in MetS patients but not in the control group. Conclusions： Increased ox-LDL, hs-CRP, and e-NOS are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive nitrogen and oxygen species. In addition, in patients w

关键词： Endothelial Dysfunction Metabolic Syndrome Oxidative Stress Smoking

A New Hybrid System Design for Thermal Energy Storage

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Journal of Thermal Science 2020年第5期29卷 1300-1308页

作者： CEYLA Ilhan ALI Ismail Hamad Guma ERGUN Alper gurel Ali Etem ACAR Bahadir iSLAM Nurse Department of Energy Systems Engineering Faculty of TechnologyKarabtik UniversityKarabik 78050Turkey Department of Mechanical and Manufacturing Engineering Faculty of TechnologyDuzce UniversityDtizce 81620Turkey

Due to some serious environmental problems like global warming and greenhouse effect,studies on solar energy systems are being conducted all over the *** studies conducted in recent years are on hybrid designs in which solar energy systems can realize both electricity and heat production at the same *** this way,both electrical energy and heat energy can be generated from the same system In this study,the design and analysis of a concentrated solar air collector with a heat storage unit were carried *** the solar air collector,heat energy was depot in paraffin wax,and the electrical energy which was stored in the battery using the PV(photovoltaic)modules in the system enabled the operation of the system *** experiments which aimed at determining system performance were carried out in winter when the ambient temperature was *** experiments were performed with or without a heat storage unit,and a comparative analysis was *** was found that the temperature of the air released from the collector ranged from 15°C to 40°C when the exterior temperature was-5°*** average efficiency of the concentrated system without the heat storage unit was calculated as 67%.The average efficiency of the concentrated system with the heat storage unit was calculated as 96%.

关键词： heat storage phase change material concentrated solar air collector

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天然彩棉的特征属性和性能

中国纤检 2010年第11期 64-67页

作者： Tulin oktem Aynur gurel Huseyin Akdemir

彩棉纤维在生态纺织品的生产中越来越受欢迎。它们的使用避免了白色棉花的湿法处理工艺,降低了染色过程中的成本消耗。本文测试了浅棕色、深棕色和绿色天然彩棉纤维的应用测试结果,发现天然彩棉纤维具有很好的色牢度效果。

关键词：彩棉棉代替染色基因天然色素