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克林霉素磷酸酯软膏剂的高效液相色谱法测定与制剂稳定性

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上海医科大学学报 1997年第4期24卷 289-291页

作者：段更利戴小平郭仲秋程务本上海医科大学药物分析教研室 200032 上海新亚药业公司药物研究所 200041 上海职工医学院 200237

建立1％克林霉素磷酸酯软膏剂高效液相色谱测定法，研究该制剂的稳定性，为进一步开发此药奠定基础。HPLC仪，ShimadzuLC－9A；色谱柱为150mm×6mmID（ODS，5μm）；流动相为乙睛-磷酸盐缓冲液（27：73）；检测波长210nm。结果：工作曲... 详细信息

建立1％克林霉素磷酸酯软膏剂高效液相色谱测定法，研究该制剂的稳定性，为进一步开发此药奠定基础。HPLC仪，ShimadzuLC－9A；色谱柱为150mm×6mmID（ODS，5μm）；流动相为乙睛-磷酸盐缓冲液（27：73）；检测波长210nm。结果：工作曲线方程Y=-57.18＋1364．48X，r=0.9997（n＝6）；回收率100.4％；天内天间的相对标准差分别为1.24％、1.80％。在40℃加速试验3个月，3个批号标示量含量分别为101.7％、105.2％及106.0％。强光照射10d，3个批号的标示量含量分别为101.7％、104．1％及105.3％。结论：建立的HPLC法具有简便、快速、准确度高及重现性好等优点；该软膏剂对强光照射不敏感，室温保存稳定，值得开发。

关键词：克林霉素磷酸酯软膏剂高效液相色谱稳定性

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结核杆菌对异烟肼的耐药性,对过氧化氢的敏感度以及对触酶活动间的关系

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中华结核和呼吸杂志 1957年第3期05卷 256-256页

作者： r. Knox: Abst. of World med. 王凤连(译)

Follicular contact dermatitis revisited: A review emphasizing neomycin-associated follicular contact dermatitis

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World Journal of Clinical Cases 2014年第12期2卷 815-821页

作者： Philip r Cohen Division of Dermatology University of California San Diego San Diego CA 92131-3643 United States

Follicular contact dermatitis clinically presents as individual papules that include a central hair follicle. Pathologic features involve the follicle and the surrounding dermis: spongiosis and vesicle formation of the follicular epithelium associated with perifollicular and perivascular lymphocytic inflammation. Using the Pub med database, an extensive literature search was performed on follicular contact dermatitis and neomycin. relevant papers were reviewed and the clinical and pathologic features, the associated chemicals(including a more detailed description of neomycin), the hypothesized pathogenesis, and the management of follicular contact dermatitis were described. Several agentseither as allergens or irritants-have been reported to elicit follicular contact dermatitis. Several hypotheses have been suggested for the selective involvement of the follicles in follicular contact dermatitis: patient allergenicity, characteristics of the agent, vehicle containing the agent, application of the agent, and external factors. The differential diagnosis of follicular contact dermatitis includes not only recurrent infundibulofolliculitis, but also drug eruption, mite infestation, viral infection, and dermatoses that affect hair follicles. The primary therapeutic intervention for follicular contact dermatitis is withdrawal of the causative agent; treatment with a topical corticosteroid preparation may also promote resolution of the dermatitis. In conclusion, follicular contact dermatitis may be secondary to allergens or irritants; topical antibiotics, including neomycin, may cause this condition. Several factors may account for the selective involvement of the hair follicle in this condition. Treatment of the dermatitis requires withdrawal of the associated topical agent; in addition, topical corticosteroids may be helpful to promote resolution of lesions.

关键词： Allergic Contact Dermatitis Follicular Irritant Neomycin Papular

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玉米种植方式研究

作物学报 1963年第4期 399-409页

作者：范福仁莫惠栋秦泰辰胡雪华吴一民苏北农学院

在11个玉米种植方式试验中,研究了同等密度下,每穴株数不同、行距不同、营养面积的形状不同的效应。发现各种种植方式的产量和性状虽有一定差异,但一般多不够显著。

关键词：玉米种植窄行籽粒产量每穴株数宽窄行种植方形穴播行距六角形

Aging and the primary cosmetic nasal surgery

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Advances in Aging research 2014年第1期3卷 25-26页

作者： H. Shemshadi r. Sahaf Iranian research Center on Aging University of Social Welfare and Rehabilitation Sciences Tehran Iran Plastic and reconstructive Surgery Iranian Research Center on Aging University of Social Welfare and Rehabilitation Sciences Tehran Iran

Purpose: The main goal of this article is to review the literature of general health and nasal anatomical-physiological profile of the elderly, prior to considering them as a candidate for primary cosmetic rhinoplasty (PCr). rhinoplasty is the cosmetic nose’s surgical alteration. Materials and Methods: We extracted the information from internet search engines and the End Note software version X7. Criteria were applied to the most appropriate clinical messages related to the elderly. We focused on their general health status and their nasal anatomicalphysiological considerations prior to consider them for undergoing PCr. research links were mostly from the Pub med and the medline databases. results: the literature review showed that as people age, their health status and anatomical-physiological components of their nose alter. Their nasal anatomical supports get weaker, and their nasal internal and external physiology undergoes modifications. Functions related to the nasal supports, normal physiology of smell, airway passage, humidification mechanism and their general appearances are affected by age. Conclusion: Cosmetic surgeons must be aware of the aforementioned changes of the patients’ past and present health. Considering performing a complete systemic evaluation and the nasal anatomical-physical examination to assess the degrees of alterations, are crucial pre-operatively.

关键词： Elderly Elderly Cosmetic Surgery Elderly rhinoplasty Elderly Nasal Surgery

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治疗结核病如单凭化学疗法是不够的

中华结核和呼吸杂志 1957年第4期05卷 328-328页

作者： A. r. Allem, Arch. Int. med. 齐仁安(摘)

First principles study of structural, electronic and mechanical properties of transition metal hydrides(TMH, TM=Mo,Tc, ru)

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Transactions of Nonferrous Metals Society of China 2013年第9期23卷 2700-2707页

作者： G. SUDHA PrIYANGA A.T.ASVINI MEENAATCI r. rAJESWArA PALANICHAMY K.IYAKUTTI N.M.S.S. Vellaichamy Nadar College Department of Physics and Nanotechnology SRM University

The structural, electronic and mechanical properties of transition metal hydrides （TMH, TM=Mo, Tc, ru） are investigated by means of first principles calculation based on density fimctional theory with generalized gradient approximation. Among the five crystallographic structures that have been investigated, the cubic phase is found to be more stable than the hexagonal ones. A structural phase transition from ZB to WC in Moll, NaC1 to NiAs in TcH and NaCI to ZB to NiAs in ruH is also predicted under high pressure. The calculated elastic constants indicate that all the three hydrides are mechanically stable at ambient pressure.

关键词： ab-initio method structural phase transition electronic properties elastic property

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Astaxanthin rich Algal Meal and Vitamin C against H. pylori Infection in BALB／cA Mice

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胃肠病学 2000年第B8期5卷 86-87页

作者： WangXin r.Willen T.Wadstron Dept.ofInf.Dis.＆med.Microbiol UniversityofLund Dept.ofPathol SahlgrenskaUniversityHospitalGothenburgSweden

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

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Bone research 2018年第2期6卷 189-196页

作者： Julie E.Pickett John M.Thompson Agnieszka Sadowska Christine Tkaczyk Bret r.Sellman Andrea Minola Davide Corti Antonio Lanzavecchia Lloyd S.Miller Daniel LJ Thorek Division of Nuclear medicine and Molecular Imaging Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineGaithersburgMDUSA Department of Orthopaedic Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Infectious Disease MedImmune LLCGaithersburgMDUSA Humabs Bio med SA BellinzonaSwitzerland Institute for research in Biomedicine Universitàdella Svizzera italianaBellinzonaSwitzerland Department of Dermatology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Division of Infectious Disease Department of MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA Cancer Molecular and Functional Imaging Program Department of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21205USA

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody（mAb） probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid（LTA）. Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection（PJI）. In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography（PET） with [^（18）F]FDG and [^（18）F]Na F as well as X-ray computed tomography（CT）, before being evaluated with the zirconium-89-labeled antibody specific for LTA（[^（89）Zr]SAC55）.The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater（P 〈 0.05） uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^（89）Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI.

关键词： Zr Molecularly specific detection bacterial lipoteichoic acid diagnosis prosthetic infection bone LTA SAC PET FDG tracer

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