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Computational Water, Energy, and Environmental Engineering 2014年第1期3卷 1-7页

作者： Claudia Lange bertram kuch Joerg W. Metzger Department of Hydrobiology and Analysis of Organic Trace Compounds Institute for Sanitary Engineering Water Quality and Solid Waste Management University of Stuttgart Stuttgart Germany

In recent years, many research and development activities have focussed on endocrine disrupting compounds (EDCs) in rivers, lakes and surface waters as the potential cause of reproductive disturbances in different aquatic organisms e.g. fish and mollusk. The effluent of wastewater treatment plants was identified as main source for EDCs entering the aquatic environment. The purpose of the present study was to determine the estrogenic activity of wastewater and the elimination efficiency of various WWTPs in the different purification steps using the E-screen assay, an in-vitro test system based on the increasing proliferation of human breast cancer cells (MCF-7) in response to the presence of hormonal active substances. In contrast to expensive and time-intensive targeted instrumental single substance analysis an effect-related biological testing provides a sum parameter for the entirety of compounds contributing to the total estrogenic activity (agonists and antagonists, anti-estrogenic and also toxic compounds) in concentration units of the reference substance 17b-estradiol. The current standard purification methods of biological wastewater treatment in particular the activated sludge process significantly reduce estrogenicity (average 95%). Sorption on activated carbon and subsequent precipitation leads to a further reduction of the overall estrogenic activity up to 99%.

关键词： 17β-Estradiol E-Screen Assay Estrogens Micropollutants Water Quality

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博登湖中PCB、PBDE的研究

实验与分析 2008年第4期 48-49页

作者： Jorg A.Pfeiffer bertram kuch Harald Hetzenauer Herbert Loftier 斯图加特大学水利工程、水资源及污染物管理研究所水化学部湖泊研究所(ISF)

PCB、PBDE等有机卤化物可以通过食物链进入人体，对人体健康造成危害。斯图加特大学的研究人员研究了博登湖鱼类和贝类中PCB、PBDE的含量。

关键词： PCB 斯图加特大学有机卤化物人体健康研究人员食物链

Diagnostic delay in inflammatory bowel diseases in a German population

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World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： Elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence

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World Journal of Gastroenterology 2008年第14期14卷 2187-2193页

作者： Harald Hoensch bertram Groh Lutz Edler Wilhelm Kirch Kreiskrankenhaus Gross-Gerau Innere AbteilungWilhelm-Seipp-StrasseGross-Gerau D64521Germany Department of Clinical Pharmacology Medical FacultyTechnical University Dresden Fiedler Strasse 27 Dresden D01307 Germany German Cancer Research Center Division of BiostatisticsIm Neuenheimer Feld 280 Heidelberg D69120 Germany

AIM: To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy. METHODS: Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire. RESULTS: Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027). CONCLUSION: Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer.

关键词： Flavonoids Colorectal cancer Recurrence risk Intestinal neoplasia Colon polyps

Memory CD8+ T cell differentiation in viral infection: A cell for all seasons

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World Journal of Gastroenterology 2007年第36期13卷 4848-4857页

作者： Henry Radziewicz Luke Uebelhoer bertram Bengsch Arash Grakoui Emory Vaccine Center and Department of Microbiology and Immunology Department of Medicine Emory University School of Medicine Atlanta GA 30322 United States Department of Medicine University Hospital Freiburg Freiburg 79106 Germany

Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.

关键词： Viral infection Hepatitis C virus Memory T cell phenotype Differentiation

Systematic review of the etiology behind patellar clunk syndrome

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World Journal of Orthopedics 2020年第3期11卷 184-196页

作者： Sean bertram Sequeira James Scott Wendy Novicoff Quanjun Cui Department of Orthopedic Surgery University of Virginia School of Medicine

BACKGROUND Total knee arthroplasty is one of the most successful operations performed worldwide *** clunk syndrome(PCS)is a postoperative complication that arises due to the development of a fibrous nodule along the undersurface of the quadriceps *** current literature on PCS has not yet come to a consensus regarding its *** date,this is the first study that analyzes the existing literature on PCS in order to generate a conclusion regarding its *** is hypothesized that prosthesis design is the main component behind the development of *** To determine the etiology of PCS and its association with pre and post-operative characteristics of the prosthesis and native *** We conducted a systematic review according to the PRISMA guidelines by searching through PubMed,Cochrane,and Google Scholar from May-July 2018 for cases of PCS using search MeSH terms“patella OR patellar”AND“clunk”OR“catch”OR“crepitus”.The search included case series and clinical trials and excluded review articles,yielding 30 articles from the original search and 3 additional articles from reference *** extracted data upon the outcomes in patients afflicted with PCS to determine the etiology of *** performed additional bias assessments to validate our search algorithm and *** Prosthesis design was the metric most frequently implicated in the incidence of PCS,though several other metrics were contributory toward its *** prosthetic designs incorporate a reduced intercondylar box ratio and box width to reduce contact between the proximal patellar pole and the intercondylar box,thereby reducing incidence of *** The etiology of PCS is multifactorial,owing to the growing metrics that have associations with its *** conclusion is validated by the significance of prosthesis design as the most likely parameter involved in developing PCS since different prosthesis designs are often the result of different paramet

关键词： Patella clunk Crepitation Total knee arthroplasty Patella catch Prosthesis design Insall-Salvati ratio

Effect of introducing an online system on the follow-up of elbow arthroplasty

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World Journal of Orthopedics 2016年第12期7卷 826-831页

作者： Jetske Viveen Ante Prkic bertram The Koen LM Koenraadt Denise Eygendaal Upper Limb Unit Department of Orthopaedic SurgeryAmphia Hospital Foundation for Orthopedic Research Care & EducationAmphia Hospital Department of Orthopaedic Surgery University of Amsterdam

AIM To evaluate the effect of introducing a structured online follow-up system on the response *** Since June 2015 we have set up an electronic followup system for prosthesis in orthopedic patients. This system allows prospective data gathering using both online and paper questionnaires. In the past all patients received questionnaires on paper. This study includes only patients who received elbow arthroplasty. Response rates before and after introduction of the online database were compared. After the implementation,completeness of the questionnaires was compared between paper and digital versions. For both comparisons Fisher's Exact tests were *** A total of 233 patients were included in the study. With the introduction of this online follow-up system,the overall response rate increased from 49.8% to 91.6%(P 0.05).Paper questionnaires had a completeness of 54.4%,which was lower compared to the online questionnaires where we reached full completeness(P < 0.01). Furthermore,non-responders proved to be younger with a mean age of 52 years compared to a mean age 62 years of responders(P < 0.05).CONCLUSION The use of a structured online follow-up system increased the response rate. Moreover,online questionnaires are more complete than paper questionnaires.

关键词： Patient reported outcome measures Elbow Follow-up Arthroplasty Online Database

Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferonβ 1a

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World Journal of Gastroenterology 2007年第26期13卷 3638-3640页

作者： Eckart Schott Friedemann Paul Jens T Wuerfel Frauke Zipp Birgit Rudolph bertram Wiedenmann Daniel C Baumgart Department of Medicine Division of Gastroenterology and HepatologyCharité Medical SchoolHumboldt-University of BerlinGermany Cecilie-Vogt-Clinic for Molecular Neurology Charité Medical SchoolHumboldt-University of BerlinGermany Department of Pathology Charité Medical SchoolHumboldt-University of BerlinGermany

To alert clinicians to a potential novel adverse drug effect of interferonβ la, we herein report a patient with relapsing-remitting multiple sclerosis who developed ulcerative colitis following treatment with interferonβ la. Ulcerative colitis persisted despite discontinuation of interferonβ la treatment and switching the patient to glatiramer acetate. Tacrolimus （FK506）, 6-mercaptopurine, and prednisolone were required to induce remission. Both ulcerative colitis and multiple sclerosis were eventually well controlled using this regimen. Our report underscores that caution should be exercised when prescribing immunostimulatory agents in patients with inflammatory bowel disease （IBD） and challenges current efforts to stimulate innate immunity as a novel therapeutic concept for IBD.

关键词： Ulcerative colitis Interferonβ la Tacrolimus Innate immunity Multiple sclerosis Adverse drug effects

时间相关单光子计数记录快速荧光寿命图像(英文)

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深圳大学学报（理工版） 2008年第3期25卷 238-243页

作者： bertram SU Vicky KATSOULIDOU Wolfgang BECKER Becker&Hickl公司 Nahmitzer Damm 30德国柏林D-12277

基于时间相关单光子计数(TCSPC)的荧光寿命成像(FLIM)的获取时间取决于成像的图像尺寸、样品寿命的精度及样品计数率.对于高密度荧光团样品,如染色组织或植物细胞,当前可用的样品计数率与TCSPC荧光寿命成像技术最高的计数率接近.该文描... 详细信息

基于时间相关单光子计数(TCSPC)的荧光寿命成像(FLIM)的获取时间取决于成像的图像尺寸、样品寿命的精度及样品计数率.对于高密度荧光团样品,如染色组织或植物细胞,当前可用的样品计数率与TCSPC荧光寿命成像技术最高的计数率接近.该文描述了在高计数率下TCSPC性能,并估计计数损失及堆积效应.结果表明,整个体系的寿命误差比预料的要小.因此, TCSPC FLIM可在获取时间低于1s的情况下记录寿命图像.为增加FLIM时间序列记录,利用存储交换技术,在采集下一个光子期间读取正在记录的数据,使用两个平行TCSPC模块,可以每秒两幅图像记录荧光寿命时间序列.该技术可应用于活体植物组织叶绿素的瞬态测量.

关键词：荧光寿命成像技术时间相关单光子计数叶绿素瞬态测量

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信息技术在海事行业的发展趋势

船舶工程 2009年第3期31卷 82-84页

作者： Volker bertram 德国劳氏工程服务部

2009年5月10日-12日，第八届“计算机和信息技术在海事行业中的应用（COMPIT）”国际会议在匈牙利首都布达佩斯举行。自2000年举办首届会议以来，COMPIT已成为海事行业信息技术领域的重要会议，汇聚了众多软件开发商和用户。会议内容涵... 详细信息

2009年5月10日-12日，第八届“计算机和信息技术在海事行业中的应用（COMPIT）”国际会议在匈牙利首都布达佩斯举行。自2000年举办首届会议以来，COMPIT已成为海事行业信息技术领域的重要会议，汇聚了众多软件开发商和用户。会议内容涵盖了船舶的生命周期，以及海上设施与设备，从设计到营运。此外，它还是征集和筹备国际研发项目的交流平台。

关键词：信息技术发展趋势行业海事国际会议软件开发商布达佩斯生命周期