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The Work of David Gottlieb:A Success Story

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Communications in Computational Physics 2011年第3期9卷 481-496页

作者： bertil Gustafsson Division of Scientific Computing Uppsala UniversityBox 337SE-75105 UppsalaSweden

This article is a brief survey of David Gottlieb’s extraordinary research *** is impossible to give a thorough presentation of all his research and the impact of his work,but we shall describe the main contributions and give examples of the results in some of his *** was for many years the dominating person in the development of spectral methods,and we devote much of the space in this article to this field.

关键词： Work David devote

DeepFilter: A Deep Learning Based Variant Filter for VarDict

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清华大学学报:自然科学版(英文版) 2023年第4期28卷 665-672页

作者： Hao Zhang Zekun Yin Yanjie Wei bertil Schmidt Weiguo Liu School of Software Shandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518057China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Institute for Computer Science Johannes Gutenberg UniversityMainz 55128Germany

With the development of sequencing technologies,somatic mutation analysis has become an important component in cancer research and *** is a commonly used somatic variant caller for this *** the heuristic-based VarDict algorithm exhibits high sensitivity and versatility,it may detect higher amounts of false positive variants than callers,limiting its clinical *** address this problem,we propose DeepFilter,a deep-learning based filter for VarDict,which can filter out the false positive variants detected by VarDict *** approach trains two models for insertion-deletion mutations(InDels)and single nucleotide variants(SNVs),*** show that DeepFilter can filter at least 98.5%of false positive variants and retain 93.5%of true positive variants for InDels and SNVs in the commonly used tumor-normal paired *** code and pre-trained models are available at https://***/LeiHaoa/DeepFilter.

关键词： variant filter deep learning somatic variant

Alterations of the Ca2＋ signaling pathway in pancreatic beta-cells isolated from db/db mice

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Protein & Cell 2014年第10期5卷 783-794页

作者： Kuo Liang Wen Du Jingze Lu Fei Li Lu Yang Yanhong Xue bertil Hille Liangyi Chen Department of General Surgery XuanWu Hospital Capital Medical University Beijing 100053 China National Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China The State Key Laboratory of Biomembrane and Membrane Biotechnology Beijing Key Laboratory of CardiometabolicMolecular Medicine Institute of MolecuLar Medicine Peking University Beijing 100871 China Department of Physiology and Biophysics University of Washington School of Medicine Seattle WA 98195 USA

Upon glucose elevation, pancreatic beta-cells secrete insulin in a Ca2＋-dependent manner. In diabetic animal models, different aspects of the calcium signaling path- way in beta-cells are altered, but there is no consensus regarding their relative contributions to the development of beta-cell dysfunction. In this study, we compared the increase in cytosolic Ca2＊（[Ca2＊]~） via Ca2＋ influx, Ca2＊ mobilization from endoplasmic reticulum （ER） calcium stores, and the removal of Ca2＋ via multiple mechanisms in beta-cells from both diabetic db/db mice and non- diabetic C57BL/6J mice. We refined our previous quan- titative model to describe the slow [Ca2＋]i recovery after depolarization in beta-cells from db/db mice. According to the model, the activity levels of the two subtypes of the sarco-endoplasmic reticulum Ca2＋-ATPase （SERCA） pump, SERCA2 and SERCA3, were severely down-reg- ulated in diabetic cells to 65% and 0% of the levels in normal cells. This down-regulation may lead to a reduc- tion in the Ca2＋ concentration in the ER, a compensatory up-regulation of the plasma membrane Na＋/Ca2＋ exchanger （NCX） and a reduction in depolarizationevoked Ca2＋ influx. As a result, the patterns of glucosestimulated calcium oscillations were significantly different in db/db diabetic beta-cells compared with normal cells. Overall, quantifying the changes in the calcium signaling pathway in db/db diabetic beta-cells will aid in the development of a disease model that could provide insight into the adaptive transformations of beta-cell function during diabetes development.

关键词： diabetic beta-cells calcium signalingalterations SERCA pump db/db mice

Intermolecular bonding in C60 under pressure

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Intermolecular bonding in C60 under pressure

通过BT-5300的测量更好地控制脱墨工艺

第十三届全国物理力学学术会议

作者： bertil Sunqvist

Raman scattering has been used to determine the number of intermolecular bonds formed between fullerene molecules after treatment for one hour at high temperature and high *** a new temperature gradient technique,each...

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来源： cnki会议评论

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中国造纸 2002年第5期21卷 71-72页

作者： bertil Olsson BTG制造浆纸技术 P.O.BOX:602SE-66129SaffleSweden

对于脱墨浆而言,仅以白度作为唯一测量的参数并不能反映浆中的脱墨状况,因为白度的测量会受到其他组分的干扰,同时,白度与浆中油墨的含量并没有直接的关系.

关键词：造纸制浆有效残留油墨浓度 BT-5300 测量脱墨工艺

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新一代保护与当地控制

电网技术 1995年第2期19卷 47-53页

作者： bertil Lundqvist , ABB Relays Sweden

微处理器技术为开发新型电力系统控制和保护装置提供了可能。在以第一代微处理器为基础的继电及控制设备中，基于微处理器的独立装置成组地取代了老式的静止型或电磁型装置。利用可按照不同要求进行配置的硬件和软件模块，第二代设备的... 详细信息

微处理器技术为开发新型电力系统控制和保护装置提供了可能。在以第一代微处理器为基础的继电及控制设备中，基于微处理器的独立装置成组地取代了老式的静止型或电磁型装置。利用可按照不同要求进行配置的硬件和软件模块，第二代设备的模块化程度更高。为了真正运用微处理器技术，必须采用与现代软件和硬件技术相结合的设计方法，以前的装置的面向／模块化方式已为平台方式所取代，运用面向对象的设计思想，已开发出具有用于保护、当地控制、通信及操作界面（ＭＭＩ）的硬件和软件的基本系统。与远动的配合也必须予以考虑。灵活的软件与硬件为增强装置的功能提供了可能。可以对终端进行预编程和预安装，也可以方便地在现场对其进行重新编程。利用这种新型的平台，应用工程师可以灵活地按用户要求设计出与特定要求相匹配的保护、监视和控制系统。

关键词：电力系统继电保护微处理器

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焊接与连接技术的未来

焊接 2006年第2期 6-12页

作者： bertil Pekkari 朴东光国际焊接学会(IIW) 中国机械工程学会焊接学会

自从100年以前药皮焊条问世以来,人们还发明了几种其它焊接防法,如埋弧焊、TIG焊、MIG/MAG焊、等离子弧切割及药芯焊丝电弧焊.接下来我们还能期待什么?机械连接技术或结构粘接对这些传统的焊接技术会构成威胁吗?

关键词：机械连接技术焊接方法 MIG/MAG焊药芯焊丝电弧焊等离子弧切割药皮焊条 TIG焊焊接技术结构粘接埋弧焊

Study of the Effect of Different Solids Load on the Optimum pH during Enzymatic Hydrolysis of Steam Exploded Corn Stover

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Journal of Chemistry and Chemical Engineering 2011年第10期5卷 880-889页

作者： Rodolfo A. Romero bertil Stromberg Anita Locke Biochemical Technology Andritz Inc. Glens Falls NY USA

The understanding of enzymatic saccharification of pretreated lignocellulosic material is of great importance. There are several important commercially available enzymes in the market that are used for this purpose. The conditions of pH and temperature performance of any particular enzyme are very well defined and it is clearly indicated by its manufacturer and it depends on the type of enzyme or enzymes in the complex pool. It is well know that commercial cellulases work best at pH around 4.8-5.0 and as a consequence this is widely used in the industry and the literature. In this study it was found that optimum pH of cellulases is different than that recommended by its manufacturer at higher solids load saccharification. The optimum pH changes depending on the consistency or solids loads of the matrix where the enzyme is acting upon. Steam exploded corn stover was tested with cellulases and xylanases at different pH, consistencies and ionic strength. Results showed that the optimum pH at lower consistency （1% w/w） is the same as the one recommended by the manufacturer and in the literature; however at higher consistency the value obtained was higher （pH 5.5 to pH 6.5） instead ofpH 4.8. The difference could represent up to 30-50% higher yields and hence of great importance for the economics of second generation fuel production. An explanation of this behavior could be associated with the Donnan effect theory. This effect indicates that the presence of charged groups in the fiber matrix creates a pH gradient within the slurry. If the charged groups are negatively charged this would create a local or internal pH lower than the surrounding liquid pH. This could explain why by reducing the concentration of H^＋ higher enzymatic conversion yields were observed.

关键词： Enzyme optimum pH Donnan effect steam explosion cellulose hydrolysis corn stover biofuel

Development of protective antibodies to Streptococcus pneumoniae in healthy children

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Open Journal of Pediatrics 2012年第1期2卷 42-46页

作者： David Bjornheden bertil Kaijser Bill Hesselmar Institute for Clinical Science Department of PaediatricsThe Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden Department of Clinical Bacteriology The Sahlgrenska AcademyUniversity of GothenburgGothenburgSweden

Aim: To study how immunity to Streptococcus pneumoniae normally develops in healthy children. Methods: Ninety two healthy children at 3 - 5, 7 - 9 and 13 - 15 years of age were recruited. No one of the children had previously been given pneumococcal vaccine. Serum was analysed for pooled antigens of the 23 most common pneumococcal polysaccharides with ELISA technique, and results are given in opitical density (OD). A three-level semi-quantitative system was used to assess degree of immunity to Streptococcus pneumoniae . Cut-off levels were OD ≤ 0.7 and OD ≥ 1.3, separating low, intermediate and high degree of immunity. Results: Median values for OD differed significantly between the groups, with OD 0.91, 1.18 and 1.10 respectively (p = 0.004). Levels were lower in the youngest age group, but from age 7-9 years, levels were similar trough out childhood. Twenty six percent of the children in the youngest age-group had a low degree of protection (OD ≤ 0.7) to Streptococcus pneumoniae . Such low levels were uncommon from 7 - 9 years of age, found in only 13% of the children. Conclusion: Protective antibodies to Streptococcus pneumoniae develops mainly during the preschool period. Thereafter, levels are stable throughout childhood up to the age of 15 years.

关键词： Antibody Formation Child Streptococcus Pneumoniae