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Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America

World Journal of Gastroenterology 2020年第44期26卷 6993-7004页

作者： Flora maria Lorenzo Fortes Ney Boa Sorte Victor D mariano Laila D Andrade Fernanda A Oliveira Monique CA santos Claudia Ivanilda N dos santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana Pharmaceutical Sciences Pos-graduation Program State University of BahiaSalvadorBA 40460-120Brazil Outpatient Gastroenterology Unit General Hospital Roberto SantosSalvadorBA 40286-901Brazil Life Sciences Department State University of BahiaSalvadorBA 41150-000Brazil Department of Medicine FTC UniversitySalvadorBA 41741-590Brazil Department of Sciences of Nutrition School of NutritionFederal University of BahiaSalvadorBA 41701-035Brazil

BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent *** is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal ***(TB)remains a public health problem,and it has a high incidence in several ***,knowledge of the risk of developing TB in patients with IBD is *** To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin *** A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB *** Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB *** TNFα blockers increased the relative risk of developing active TB compared to other *** four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active *** adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional *** TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most *** Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin *** risk was increased when anti-TNFα was combined with *** time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection.

关键词： Inflammatory bowel disease Therapy Tumor necrosis factor alpha Relative risk Tuberculosis Latent tuberculosis

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Assessing Naturalness Changes Resulting from a Historical Land Use in Brazil South Region: An Analysis of the 1986-2016 Period

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Journal of Environmental Protection 2019年第2期10卷 149-163页

作者： Ivan Luís Rovani José Eduardo dos santos Vanderlei Secretti Decian Elisabete maria Zanin PPG-ERN/UFSCar Universidade Federal de S&atilde o Carlos (UFSCar) S&atilde o Carlos Brazil Department of Biological Science Universidade Regional Integrada do Alto Uruguai e das Miss&otilde es (URI) Erechim Brazil

The effects of land use and cover changes and the application of the Urbanity Index were analyzed to identify critical or non-critical naturalness scenery in the Northern Region of Rio Grande do Sul (Brazil), over a period of 30 years. Between 1986 and 2016, the main significant land use change was the reduction of the agricultural anthropic and the increase of the natural vegetation land use areas. About 90% - 80% of the total study areas were characterized by anthropic pattern features, with a predominantly agricultural matrix. The conversion of agricultural anthropic into natural areas resulted in increased naturalness landscape and a gain in the stock of natural capital. The increase in the natural vegetation area, mainly to the north and east of the region, set in a steep relief, became remarkable after 1990. The Urbanity Index values evidenced a highest naturalness condition (natural vegetation areas) to the northern and eastern, while a smaller naturalness condition (agricultural and non-agricultural areas) to the southern and western and central of the Northern Region of Rio Grande do Sul. These changes are related to a non-impaired (northern and eastern) and a impaired scenery (southern, western and central portion) of the ecological sustainability of the Northern Region of Rio Grande do Sul, after a 30-year period (1986-2016). These results pointed out that land use transitions resulted in a consolidated farming scenario in which agricultural intensification coincided with the reduction of farming area and increased naturalness as a reverse trend to the agricultural frontier dynamics.

关键词： Land Use and Cover Native Vegetation Urbanity Index Environmental Management

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Wood Ash Fertilization on Structural Characteristics and Chlorophyll Index of Tropical Forage Grasses

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American Journal of Plant Sciences 2015年第9期6卷 1341-1348页

作者： Edna maria Bonfim-Silva Claudia Cardoso dos santos Tonny José Araújo da Silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

The appropriate nutrient supply via fertilization is essential for an adequate plant growth and development. The objective of this study was to evaluate the structural characteristics and chlorophyll index of Marandu and Xaraes grasses fertilized with wood ash. The experiment was conducted in a greenhouse;the experimental design was entirely randomized, with 12 treatments and six replications arranged in a 2 × 6 factorial scheme: two forage grasses (Marandu and Xaraes) and six wood ash doses (0;3;6;9;12;and 15 g·dm-3). Each plot was composed of pots with 7 dm3 soil and five plants. Soil moisture was maintained by the gravimetric method at 60% of the maximum soil water retention capacity. Three harvests of the plant aerial part were performed at 30-day intervals. The evaluated characteristics were plant height, leaf number, tiller number, and chlorophyll index. Results were submitted to the variance analysis by F test and, after verification of the significant effects on Marandu and Xaraes characteristics, were also submitted to Tukey test;the wood ash doses were evaluated according to the regression analysis at 5% probability. Wood ash doses ranging from 10.15 to 15 g·dm-3 resulted in quadratic responses of plant height, leaf number, and tiller number for both Marandu and Xaraes grasses. The highest values of chlorophyll index derived from wood ash doses of 9.44 and 10.92 g·dm-3, with increments greater than 50%, 25%, and 9% at the first, second, and third harvests, respectively. The wood ash, when used as a fertilizer, improves structural characteristics and increases chlorophyll indices of Marandu and Xaraes grasses cultivated in Cerrado Rhodic Hapludox.

关键词： Alternative Fertilizer Brachiaria brizantha Marandu Xaraes

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Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart

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Asian Pacific Journal of Tropical Biomedicine 2019年第5期9卷 222-226页

作者： Jacqueline Cosmo ANDrade Ana Raquel Pereira da Silva Ant?nia Thassya Lucas dos santos maria Audilene Freitas Yedda maria Lobo Soares de Matos maria Flaviana Bezerra Morais Braga Camila Fonseca Bezerra maria Isabeli Pereira Gon?alo maria Celeste Vega Gomez Míriam Rolóm Cathia Coronel Paulo Riceli Vasconcelos Ribeiro Edy Sousa de Brito Henrique Douglas Melo Coutinho Microbiology and Molecular Biology Laboratory Biological Chemistry Department Regional University of Cariri-URCA Bioassays Laboratory-LABIO Federal University of Cariri-UFCA Brejo Santo University campus (CE) Center for the Development of Scientific Research Moisés Bertoni Foundation/Díaz Gill Laboratories Natural Products Chemistry Multiuser Laboratory LMQPN Embrapa Tropical Agroindustry

Objective: To compare the in vitro antiparasitic activity of aqueous extracts from Ziziphus joazeiro leaves and stem bark against Trypanosoma cruzi, Leishmania braziliensis, and Leishmania infantum, as well as to evaluate its cytotoxicity in mammalian cells, in addition to identifying the chemical composition of the extracts. Methods: Ziziphus joazeiro leaf and stem bark aqueous extracts were prepared by cold extraction maceration and subjected to ultra-efficient liquid chromatography coupled to a quadrupole/time of flight system. The susceptibility assays used Trypanosoma cruzi CLB5 strains and promastigote forms of Leishmania braziliensis and Leishmania infantum for antiparasitic activity of the extracts. Moreover, mammalian fibroblasts NCTC clone 929 were used for cytotoxicity analysis. Results: Terpenoid compounds, flavonoids and phenolic acid were identified in extracts. The stem bark aqueous extracts presented more significant results in terms of antiparasitic activity compared with the leaf aqueous extracts, especially against Leishmania braziliensis and Leishmania infantum promastigote forms with an IC50 < 500 μg/mL. The cytotoxicity evaluation showed moderate toxicity of the stem bark aqueous extracts, which is relevant information for the rational use of this plant part since it is widely used by the population. Conclusions: These preliminary results may contribute to the formulation of new therapeutic agents against this group of neglected diseases, so further investigations are required to delineate the mechanisms of action mainly of the aqueous extract of stem bark of Ziziphus joazeiro.

关键词： Antiepimastigote Antipromastigote UPLC-MS-ESI-QTOF

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Optimization of Biosurfactant Production from Glycerol by Pseudomonas Aeruginosa EQ 109 Using Factorial Design 2^3

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Journal of Chemistry and Chemical Engineering 2010年第10期4卷 1-12页

作者： Francisca Pessoa De Franca Flavia Padilha Bastos dos santos Lea maria de Almeida Lopes School of Chemistry Federal University of Rio de Janeiro CT BI. E Fundao Island 21949-909 Rio de Janeiro RJ Brazil Institute of Maeromolecules Professora Eloisa Mano /Lapin Federal University of Rio de Janeiro CT Bl. J Fundao Island 21941-598. Rio de Janeiro. RJ. Brazil

One possible application for the excess of glycerol, which is an exceeding byproduct in biodiesel industry, was used as carbon and energy sources for bioproducts synthesis. This work aims to evaluate biosurfactant production from glycerol by Pseudomonas aeruginosa EQ 109 isolated from crude oil-contaminated soil. Factorial design 2^3 was utilized to optimize the amount of biosurfactant produced, by using pH （A）, initial biomass concentration （B）, and initial glycerol concentration （C） as independent factors. The experiments were carried out in flasks containing 100 mL of mineral medium. Biosurfactant production was monitored by increase of the emulsification of aviation kerosene （E24） and surface tension reduction （STr）. The results have shown that, at pH = 7.0, in order to increase E24, variables as B and C are the most influential, leading to a maximum value of E24 = 79%, as well as for an increase of GC （GCmax = 49%）. STR was the variable with the best correlation factor for the proposed linear model （R2=0.96） and its maximum value was 48%. Xfwas not significant to the model, although it was influenced by pH and C, with C = 40g/L （Xfmax = 4.56 g/L）.

关键词： Biodiesel biosurfactant factorial design glycerol Pseudomonas aeruginosa.

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Helicobacter pylori infection: Beyond gastric manifestations

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World Journal of Gastroenterology 2020年第28期26卷 4076-4093页

作者： maria Luisa Cordeiro santos Breno Bittencourt de Brito Filipe Antonio França da Silva mariana Miranda Sampaio Hanna santos Marques Natalia Oliveira e Silva Dulciene maria de Magalhaes Queiroz Fabricio Freire de Melo Instituto Multidisciplinar em Saude Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual da Bahia Vitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

Helicobacter pylori(***)is a bacterium that infects more than a half of world’s *** it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric *** to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological *** that context,when considered the gastrointestinal tract,*** positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and ***,lower serum levels of iron and vitamin B12 have been found in patients with *** infection,leading to the emergence of anemias in a portion of *** regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barré***,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the *** that,the ***-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected ***,the occurrence of dermatological and ophthalmic disorders have also been related to that *** this sense,this minireview aims to gather the main studies associating *** infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of *** in those diseases.

关键词： Helicobacter pylori Extragastric Neurological Cardiovascular Autoimmune Ophthalmic Diabetes Timeline Treatment

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Helicobacter pylori infection:How does age influence the inflammatory pattern?

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World Journal of Gastroenterology 2022年第4期28卷 402-411页

作者： Glauber Rocha Lima Araújo Hanna santos Marques maria Luísa Cordeiro santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa santos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

The inflammatory pattern during Helicobacter pylori(***)infection is changeable and *** childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor *** the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among ***-positive *** the last few years,the participation of the Th17 response in the gastric inflammation against *** infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the ***,this cytokine profile might play a pivotal role in the effectiveness of *** *** is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with ***,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism.

关键词： Helicobacter pylori Inflammation Treg response Th1 response Th17 response Gastric diseases

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Hydrogeochemical Research of Surface Water of the Córrego Sujo Watershed, Teresópolis, RJ, Brazil

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Agricultural Sciences 2017年第5期8卷 435-450页

作者： Paula Coelho Araujo André S. Avelar Vítor dos santos Costa maria Isabel Martinez Geoscience Department Federal University of Rio de Janeiro Rio de Janeiro Brazil

The surface water quality was investigated in the Córrego Sujo watershed, located in the municipality of Teresópolis, a mountainous region in the state of Rio de Janeiro, Brazil. The emphasis focused on inorganic parameters of water, since there are applications of pesticides in agricultural cultivations. The natural and anthropogenic contributions of the study area were monitored monthly in eight sites in the river channels of the drainage basin. The results were analyzed using an ICP-OES spectrophotometer and subsequently compared to Conama Resolution 357/05. In order to support the interpretation of the results of water quality, flow and precipitation data were measured in the watershed, along with the land use and vegetation cover map produced from a GeoEye satellite image. The study revealed that the surface waters were in high concentrations and above those recommended by Conama Resolution. It was noted also that the lithological and pedological variables influenced the results of water quality. Regarding seasonality, it has not been possible to establish a common standard to all elements in the rainy season or dry season, however, in the analysis of each parameter separately, there was evidence of a concentration distribution in temporal variation. Therefore, the results of this study indicate that it is also necessary to highlight these issues in the territorial planning of the municipality and in the management of the Committee of Rio Piabanha watershed, to avoid the increasing of uncontrolled expansion of irrigated crops and intensive use of agrochemical inputs.

关键词： Hydrogeochemistry Natural and Anthropogenic Influences Land Use Surface Waters Rivers

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Health 2020年第10期12卷 1360-1370页

作者： Lucas Lima de Carvalho Lucas Rodrigues Claro Amanda dos santos Cabral Marcela Pereira da Silva Mello Bruna Liane Passos Lucas Marcelly Valadares Souza Simone Fonseca Lucas Alexandre Oliveira Tellles Ravini Fernandez dos santos Vieira dos santos Marcia Augusta Pereira dos santos Claudia Lima Campos Alzuguir maria Cristina Dias da Silva Antonio Eduardo Vieira dos santos maria Antonieta Rubio Tyrrell Eduardo Alexander Júlio César Fonseca Lucas Anna Nery School of Nursing Federal University of Rio de Janeiro Rio de Janeiro Brazil Celso Lisboa University Center Rio de Janeiro Brazil State Secretariat of Education of Rio de Janeiro Rio de Janeiro Brazil Department of Medicine in Primary Health Care Faculty of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal and Child Nursing Faculty of Nursing State University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal-Child Nursing Faculty of Nursing Fernandez Figueira Institute of the Oswaldo Cruz Foundation State University of Rio de Janeiro Rio de Janeiro Brazil

This documentary research aimed to describe the results of an epidemiological survey that sought to determine the prevalence of Infections Related to Health Care (IRHC) in newborns admitted to a Neonatal Intensive Care Unit (NICU) at the city of Rio de Janeiro. For methodology, the existing data in the original research database were used as the primary source. The method used was the case study in a quantitative approach. The data have been statistically arranged by odds ratio, which measured the possibility of IRHC development at the 102 newborns, by exposition at the risk factors. Results: IRHC prevalence with pneumonias, sepsis, navel’s infection and ocular infections predominance rises. Prematures are 4.10 more susceptible. Twelve hours after amniotic rupture there are 1.77 more chances of infections. Babies with more than 10 days of hospitalization are 4.70 more susceptible than those with 10 days. The registers examined were incipient at the IRHC’s characterization, beginning and duration, which make the IRHC’s diagnostic/notification difficult.

关键词： Neonatal Nursing Cross Infection Data Interpretation Statistical

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Effect of Environmental Factors on Rock-inhabiting Fungal Communities from Brazilian Soapstone Samples

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Journal of Environmental Science and Engineering(B) 2017年第2期6卷 55-71页

作者： Douglas Boniek Lorena Vivien Neves de Oliveira Noelly de Queiroz Ribeiro Christiane Abreu Oliveira Paiva Ubiraci Gomes de Paula Lana Antonio Femando batista.dos santos maria Aparecida de Resende Stoianoff Post-Graduate Program in Microbiology Institute of Biological Sciences Federal University of Minas Gerais UFMG BeloHorizonte 31270-901 Brazil Embrapa Milho Sorgo Brazilian Agricultural Research Corporation Sete Lagoas 35701-970 Brazil Faculty of Engineering and Architecture Foundation of Education and Culture of Minas Gerais Belo Horizonte 30310-190Brazil Department of Microbiology Institute of Biological Sciences Federal University of Minas Gerais UFMG Belo Horizonte31270-901 Brazil

The present study aims to evaluate the environmental effect on fungal community composition associated with biodeterioration occurring in stones （soapstone） at two distinct locations in Minas Gerais State, Brazil： Congonhas city and Sanctuary of Cara^a. Four collections of fungal communities over one year were obtained from both research sites from the soapstone block surfaces exposed for over two decades. The molecular diversity profile of the fungal community at the two localities was obtained by DGGE （Denaturing Gradient Gel Electrophoresis）, and the genomes of the most representative population were sequenced. DGGE showed the formation of two clusters with filamentous fungal communities. Sequencing of the most representative bands revealed the presence of fungi associated with the biodeterioration of soapstone. In addition, many of the identified species were associated with photobionts that could generate lichens, indicating that environmental characteristics affect the occurrence of filamentous fungi, which leads to biodeterioration of stones. Authors＇ study focused on an environmental variation of an extreme habitat for fungi associated with soapstone in the state of Minas Gerais, Brazil and identified the presence of interesting rock-inhabiting fungal communities including species related to lichens, which can accelerate the deterioration of stones by the production of organic acids.

关键词： Fungal community biodeterioration soapstone cultural heritage Minas Gerais state.

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