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Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation

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Neural Regeneration Research 2020年第10期15卷 1799-1806页

作者： bernhard A.Sabel Ying Gao Andrea Antal Institute of Medical Psychology Medical FacultyOtto-von-Guericke University of MagdeburgMagdeburgGermany Center for Behavioral and Brain Sciences(CBBS) MagdeburgGermany Sabel Vision Restoration Center MagdeburgGermany Department of Clinical Neurophysiology University Medical Center GottingenGottingenGermany

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is ***,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of *** refers to the ability of the brain to change its own functional architecture by modulating synaptic *** is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing *** ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current *** with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the *** and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their *** future of low vision is optimistic because vision loss is indeed,partially reversible.

关键词： alternating current stimulation glaucoma low vision optic nerve rehabilitation recovery stress vision vision restoration therapy visual field

Multimodal nonlinear imaging of atherosclerotic plaques differentiation of triglyceride and cholesterol deposits

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 114-123页

作者： Christian Matthäus Riccardo Cicchi Tobias meyer Annika Lattermann Michael Schmitt Bernd F.M.Romeike Christoph Krafft Benjamin Dietzek bernhard R.Brehm Francesco S.Pavone Jürgen Popp Leibniz Institute of Photonic Technology(IPHT-Jena)Albert Einstein Straβe 9 0T145 JerlaGermany Institute of Physical Chemistry and Abbe Center of PhotonicsFriedrich Schiller University Jena Helmholtzweg 407743 JenaGermany National Institute of Optics National Research Council(INO-CNR)Largo E.Fermi 6-50125FlorenceItaly European Laboratory for Non-Linear Spectroscopy(LENS)University of Florence Via Nello Carrara 1-50019 Sesto Fiorentino(Firenze)Italy Clinic for Internal Medicine Jena University Hospital Friedrich-Schiller-UniversityErlanger Allee 10107747 JenaGermany Institute of Pathology Department of Neuropathology Jena University Hospital-Friedrich-Schiller-University Erlanger Allee 1010140 JenaGermany Catholic Clinic-Koblenz Intermal Medicine&Cardiology Rudolf Virchow Str.956073 KoblenzGermany

Cardiovascular diseases in general and atherothrombosis as the most common of its individualdisease entities is the leading cause of death in the developed ***,visualizationand characterization of inner arterial plaque composition is of vital diagnostic interest,especilly for the early recognition of vulnerable *** clinical techniques provide valuablemorphological information but cannot deliver information about the chemicai composition ofindividual ***,spectroscopic imaging techniques have recently drawn consider-able *** on the spectroscopic properties of the individual plaque components,as forinstance diferent types of lipids,the composition of atherosclerotic plaques can be analyzedqualitatively as well as ***,we compare the feasibility of multimodal nonlinearimaging combining,two-photon fluorescence(TPF),coherent anti-Stokes Raman scatering(CARS)and second-hamonic generation(SHG)microscopy to contrast composition and mor-phology of lipid deposits against the surrounding matrix of connective tissue with diffractionlimited spatial *** this contribution,the spatial distribution of major constituents of the arterial wall and atherosclerotic plaques like elastin,collagen,triglycerides and cholesterol can be simultaneously visualized by a combination of nonlinear imaging methods,providing a powerful label-free complement to standard histopathological methods with great potential forin vivo application.

关键词： Nonlinear microscopy Raman spectroscopy atherosclerosis.

Biologging is suspect to cause corneal opacity in two populations of wild living Northern Bald Ibises (Geronticus eremita)

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Avian Research 2020年第4期11卷 412-420页

作者： Johannes Fritz Barbara Eberhard Corinna Esterer bernhard Goenner Daniela Trobe Markus Unsoeld bernhard Voelkl Helena Wehner Alexandra Scope Waldrappteam LIFE Northern Bald Ibis6162 MuttersAustria Department of Behavioural and Cognitive Biology University of ViennaViennaAustria Veterinary University Vienna ViennaAustria University of Bern Vetsuisse FacultyBernSwitzerland Bavarian State Collection of Zoology MunichGermany

Background:In this paper,we present evidence that biologging is strongly correlated with eye irritation,with sometimes severely impairing effects.A migratory population of the Northern Bald Ibis(Geronticus eremita,NBI)is reintroduced in Europe,in course of a LIFE+*** 2014,all individuals have been equipped with *** monitoring allows the implementation of focussed measures against major mortality ***:Initially all birds carried battery-powered devices,fixed on the lower back of the *** 2016 an increasing amount of birds has been equipped with solar-powered devices,fixed on the upper back,the more sunexposed *** 2016,we observed opacity in the cornea of one eye(unilateral corneal opacity;UCO)during a regular health monitoring for the first ***:By 2018,a total of 25 birds were affected by UCO,with varying intensity up to *** examination of the birds revealed no clear cause for the ***,only birds carrying a device on the upper back were affected(2017 up to 70%of this group).In contrast,none of the birds carrying devices on the lower back ever showed UCO *** unexpected relationship between tagging and UCO was discovered in *** we took countermeasures by removing the device or repositioning it on the lower back,we observed an immediate reduction of the incidence rate without any new cases reported since January *** roost with their head on the back,one eye closely placed to the device if it was positioned on the upper ***,we conclude that the most parsimonious explanation for the symptomatology is either a repetitive slight temperature rise in the corneal tissue due to electromagnetic radiation by the GSM module of the device or a repetitive slight mechanical irritation of the corneal *** evidence is missing so ***,cases of UCO were found in another NBI ***:Our observations indicate that further research in the fast-

关键词： Blindness Electromagnetic radiation Endangered bird species Eye opacity GPS-devices Mechanical irritation Reintroduction Solar-powered

Effect of excitation wavelength(blue vs near UV)and dopant concentrations on afterglow and fast decay of persistent phosphor SrAl_(2)O_(4):Eu^(2+),Dy^(3+)

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Journal of Rare Earths 2022年第7期40卷 1022-1028页

作者： bernhard Walfort Nando Gartmann Jafar Afshani Arnulf Rosspeintner Hans Hagemann LumiNova AG SwitzerlandSpeicherstrasse 60aCH-9053TeufenSwitzerland Dépt.de Chimie Physique Universitéde Genève30Quai E.AnsermetCH 1211Geneva 4Switzerland

The persistent phosphor SrAl_(2)O_(4):Eu^(2+),Dy^(3+)is the subject of numerous *** often neglected aspect is that in this phosphor,as well as in Sr_(4)Al_(14)O_(25):Eu^(2+),Dy^(3+),there are two different Sr^(2)+sites which can be occupied by the dopant Eu^(2+)ions,We first introduce a general scheme of possible energy transfers in these persistent phosphor materials including explicitly both europium ions,This scheme is used as a generic starting point to study experimentally specific *** illustrate this application with the study of the effect of excitation wavelength(444 and 382 nm)on the afterglow of differently doped SrAl_(2)O_(4):Eu^(2+),Dy^(3+)samples,as well as on the emission decay *** the same excitation intensity under 444 nm excitation,the resulting afterglow intensity is stronger than under near UV *** 382 nm,Eu^(2+)ions on both Sr^(2)+s ites in SrAl_(2)O_(4)are excited,but at room temperature the blue emission is quenched,leading to a loss of *** observed effects can further be associated with the ratio of Eu^(2+)ions and trap states which are modulated by the concentrations of Eu^(2+)and Dy^(3+)in SrAl_(2)O_(4),as well as by temperature,Increasing the nominal Dy^(3+)content from 0.1 mol%to 0.5 mol%with respect to Sr results in the doubling of the integrated afterglow intensity and confirms thus that Dy^(3+)ions are indeed involved in the trapping process,The concentration of trap states is much lower than the concentration of Eu^(2+)ions,as even with low excitation densities,a plateau of integrated afterglow intensity(corresponding to the total number of accessible traps)is *** postulate that an important fraction of excited Eu^(2+)ions can potentially transfer their energy to trap *** that all traps are filled or in a dynamical filling-depletion process under illumination(with thermal and/or optical depletion processes),for the remaining Eu^(2+)a"normal"steady-state emission is observed

关键词： Persistent phosphor Strontium aluminate Europium Forster energy transfer Rare earths

On the calibration of rotational augmentation models for wind turbine load estimation by means of CFD simulations

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Acta Mechanica Sinica 2020年第2期36卷 306-319页

作者： Belen Soledad Burgos Tafur Elia Daniele bernhard Stoevesandt Philipp Thomas Fraunhofer IWES Am Seedeich 4527572 BremerhavenGermany Flensburg University of Applied Sciences Wind Energy Technology InstituteNordstraße224943 FlensburgGermany

In this work the improved version of an engineering model which accounts for rotational augmentation effects by means of computational fluid dynamics(CFD)calibration is explored and *** on an analysis of the NREL Phase VI wind turbine,the novel modeling is presented,which uses as base line the formulation proposed by Chaviaropoulos and *** model is calibrated based on CFD simulations using *** corresponding correction of the two dimensional polars is straightforward implemented within MoWiT,an in-house software for load *** novel formulation results in improved lift and drag coefficients prediction in all considered cases,reducing the deviation with respect to the rotating CFD cases down to few *** optimal configuration including the correction for tip effects of Shen shows better agreements at the very tip of the *** the range of applicability for large wind turbine rotor blades based on a virtual 10MW rotor model is discussed.

关键词： calculation. rotational correction

Optimal measurement locations for diagnosis of aortic abnormalities in a lumped-parameter model of the systemic circulation using sensitivity analysis

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International Journal of Biomathematics 2017年第8期10卷 217-240页

作者： R. Gul S. bernhard Department of MathematicsCOMSATS Institute of Information Technology Abbottabad Pakistan Department of Electrical Engineering and Information Technology Pforzheim University of Applied Sciences Germany

The basic theme of this work is to identify the optimal measurement locations for pres- sure and flow in the systemic circulation to detect aortic stenoses and aneurysms in early stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator （MACSim）, is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria subclavia and arteria axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.

关键词： Lumped parameter model systemic circulation stenoses aneurysms globalsensitivity analysis.

Neoadjuvant stereotactic radiosurgery for intracerebral metastases of solid tumors(NepoMUC):a phase I dose escalation trial

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Cancer Communications 2019年第1期39卷 623-631页

作者： Christian D.Diehl Ehab Shiban Christoph Straube Jens Gempt Jan J.Wilkens Markus Oechsner Carmen Kessel Claus Zimmer Benedict Wiestler bernhard.meyer Stephanie E.Combs Department of Radiation Oncology Klinikum rechts der Isar HospitalTechnical University of MunichIsmaninger Straße 2281675 MunichGermany Department of Radiation Sciences Institute of Innovative Radiotherapy85764 NeuherbergGermany Department of Neurosurgery Klinikum rechts der Isar HospitalTechnical University of Munich81675 MunichGermany Department of Diagnostic and Interventional Neuroradiology Klinikum rechts der Isar HospitalTechnical University of Munich81675 MunichGermany

Background:More than 25%of patients with solid cancers develop intracerebral *** of surgery,radia-tion therapy(RT)is a mainstay in the treatment of intracerebral *** fractionated stereotactic RT(FSRT)to the resection cavity of intracerebral metastases is a treatment of choice to reduce the risk of local ***,FSRT has to be delayed until a sufficient wound healing is attained;hence systemic therapy might be *** stereotactic radiosurgery(SRS)might offer advantages over adjuvant FSRT in terms of better target delineation and an earlier start of systemic ***,we conducted a study to find the maximum tolerated dose(MTD)of neoadjuvant SRS for intracerebral ***:This is a single-center,phase I dose escalation study on neoadjuvant SRS for intracerebral metastases that will be conducted at the Klinikum rechts der Isar Hospital,Technical University of *** rule-based traditional 3+3 design for this trial with 3 dose levels and 4 different cohorts depending on lesion size will be *** primary endpoint is the MTD for which no dose-limiting toxicities(DLT)*** adverse events of each participant will be evaluated according to the Common Terminology Criteria for Adverse Events(CTCAE)version 5.0 continuously during the study until the first follow-up visit(4-6 weeks after surgery).Secondary endpoints include local control rate,survival,immunological tumor characteristics,quality of life(QoL),CTCAE grade of late clinical,neurological,and neurocognitive *** addition to the intracerebral metastasis which is treated with neoadjuvant SRS and resection up to four additional intracerebral metastases can be treated with definitive *** on the occurrence of DLT up to 72 patients will be *** recruitment phase will last for 24 ***:Neoadjuvant SRS for intracerebral metastases offers potential advantages over postoperative SRS to the resection

关键词： Cancer Intracerebral metastasis Stereotactic radiosurgery Fractionated stereotactic radiation therapy Microsurgical resection Neoadjuvant radiation therapy Maximum tolerated dose Protocol

Towards SDN Based Queuing Delay Estimation

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China Communications 2016年第3期13卷 27-36页

作者： MA Haiyan YAN Jinyao Panagiotis Georgopoulos bernhard Plattner Faculty of Science and Technology Communication University of China Computer Engineering and Networks Laboratory Swiss Federal Institute of Technology Zurich (ETH Zurich)

As one of Qo S(Quality of Service) metrics, delay is critical important to delay sensitive applications, such as interactive video, network game and online surgery. In this paper, we exploit SDN(Software Defined Networking) advantages to solve delay Qo S problem. Our work mainly focuses on SDN based queuing delay estimation with real traffic and end-to-end delay control. First, we propose a queuing estimation model and extended it for end-to-end delay of the whole path. It is proved to be feasible and accurate with experimental results in SDN environment. Second, in order to demonstrate the use of our proposed model, we also implement an end-to-end delay control application in SDN. It fulfills specific delay Qo S requirements by dynamically switching flows to a suitable queue based on estimation results and delay requirements.

关键词： autonomic Qo S dynamic model delay performance SDN

Pervasive geo-security - a lightweight triple-A approach to securing distributed geo-service infrastructures

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International Journal of Digital Earth 2014年第5期7卷 373-390页

作者： Bernd Resch bernhard Schulz Manfred Mittlboeck Thomas Heistracher Research Studio iSPACE Research Studios AustriaSalzburgAustria SENSEable City Laboratory Massachusetts Institute of TechnologyBostonMAUSA Department of Information Technology and Systems Management University of Applied SciencesSalzburgAustria

Security has recently become a major concern in distributed geo-infrastructures for spatial data ***,a lightweight approach for securing distributed low-power environments such as geo-sensor networks is *** first part of this article presents a survey of current security mechanisms for authentication and *** on this survey,a lightweight and scalable token-based security infrastructure was developed,which is tailored for use in distributed geo-web service *** developed security framework comprises dedicated components for authentication,rule-based authorisation and optimised storage and administration of access *** validation purposes,a prototypical implementation of the approach has been created.

关键词： pervasive security distributed geo-service infrastructures triple-A geo-authorisation standardised sensor networks service protection Geographic Information Systems(GIS) geoinformatics spatial data infrastructure Digital Earth Digital Earth Architecture