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Recurrent abscess after primary successful endo-sponge treatment of anastomotic leakage following rectal surgery

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World Journal of Gastroenterology 2010年第36期16卷 4570-4574页

作者： Stefan Riss Anton Stift Caroline Kienbacher bernhard Dauser Ingrid Haunold Stefan Kriwanek Wolfgang Radlsboek Michael Bergmann Division of General Surgery Department of SurgeryMedical University of ViennaA-1090 ViennaAustria Department of Surgery Floridsdorf HospitalA-1210 ViennaAustria Department of Surgery Barmherzige Brüder WienA-1020 ViennaAustria Department of Surgery Barmherzige Schwestern WienA-1060 ViennaAustria Department of Surgery Rudolfstiftung HospitalA-1030 ViennaAustria Department of Surgery G-ttlicher Heiland WienA-1170 ViennaAustria

AIM:To assess long-term efficacy of initially successful endo-sponge assisted ***:Between 2006 and 2009,consecutive patients who had undergone primary successful endo-sponge treatment of anastomotic leakage following rectal cancer surgery were enrolled in the *** were recruited from 6 surgical departments in *** and oncologic outcomes were assessed through routine endoscopic and radiologic follow-up ***:Twenty patients(7 female,13 male)were *** indications for endosponge treatment were anastomotic leakage(n=17)and insufficiency of a rectal stump after Hartmann's procedure(n=3).All patients were primarily operated for rectal *** overall mortality rate was 25%.The median followup duration was 17 mo(range 1.5-29.8 mo).Five patients(25%)developed a recurrent *** time between last day of endosponge therapy and occurrence of recurrent abscess was 255 d(range 21-733 d).One of these patients was treated by computed tomography-guided drainage and in 3 patients Hartmann's procedure had to be *** patients(10%)developed a local tumor recurrence and subsequently ***:Despite successful primary outcome,patients who receive endo-sponge therapy should be closely monitored in the first 2 years,since recurrence might occur.

关键词： Rectal surgery Anastomotic leakage Endo-sponge Endo-vacuum treatment

Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells

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Cellular & Molecular Immunology 2018年第4期15卷 388-398页

作者： Zhongming Tan Qianghui Liu Runqiu Jiang Long Lv Siamak S Shoto Isabelle Maillet Valerie Quesniaux Junwei Tang Wenjie Zhang Beicheng Sun bernhard Ryffel Key Laboratory of Living Donor Liver Transplantation Department of Liver SurgeryNational Health and Family Planning CommissionThe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Molecular Immunology and Embryology UMR 7355CNRSUniversity of OrleansOrléansFrance IIDMM University of Cape TownCape TownSouth Africa Department of General Surgery People’s Hospital of GaochunNanjingJiangsuP.R.China

Liver fibrosis is a consequence of chronic liver disease,causing morbidity and ***-33(IL-33)is a critical mediator of inflammation,which may be involved in the development of liver ***,we investigated the role of IL-33 in human patients and experimental bile-duct ligation(BDL)-induced fibrosis in *** report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver *** injury,inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor,and the activation of hepatic stellate cells(HSCs)was decreased in ST2-deficient *** IL-33 activated HSCs isolated from C57BL/6 mice,leading to the expression of IL-6,TGF-β,α-SMA and collagen,which was abrogated in the absence of ST2 or by pharmacological inhibition of MAPK ***,administration of recombinant IL-33 significantly increased hepatic inflammation in sham-operated BL6 mice but did not enhance BDL-induced hepatic inflammation and *** conclusion,BDL-induced liver inflammation and fibrosis are dependent on ST2 signaling in HSCs,and therefore,the IL-33/ST2 pathway may be a potential therapeutic target in human patients with chronic hepatitis and liver fibrosis.

关键词： hepatic stellate cells IL-33 liver fibrosis ST2

Interspecific and intraspecific variation in specific root length drives aboveground biodiversity effects in young experimental forest stands

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Journal of Plant Ecology 2017年第1期10卷 158-169页

作者： Wensheng Bu bernhard Schmid Xiaojuan Liu Ying Li Werner Härdtle Goddert von Oheimb Yu Liang Zhenkai Sun Yuanyuan Huang Helge bruelheide Keping Ma State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China College of Forestry Jiangxi Agricultural UniversityNanchang 330045China Department of Evolutionary Biology and Environmental Studies University of ZürichWinterthurerstr.190Zürich 8057Switzerland Institute of Ecology Leuphana University LüneburgScharnhorststr.1Lüneburg 21335Germany Institute of General Ecology and Environmental Protection Technische Universität DresdenPienner Str.7Tharandt 01737Germany Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-WittenbergAm Kirchtor 1Halle 06120Germany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig DeutscherPlatz 5eLeipzig 04103Germany

Aims Although the net biodiversity effect(ne)can be statistically partitioned into complementarity and selection effects(CE and SE),there are different underlying mechanisms that can cause a certain *** objective was to assess the role of resource partitioning and species interactions as two important mechanisms that can bring about CEs by interspecific and intraspecific trait *** We measured tree height of 2493 living individuals in 57 plots and specific root length(SRL)on first-order roots of 368 of these individuals across different species richness levels(1,2,4,8 species)in a large-scale forest biodiversity and ecosystem functioning experiment in subtropical China(BEF-China)established in *** describe the effects of resource partitioning between species by a fixed component of interspecific functional diversity(RaoQ)and further effects of species interactions by variable components of interspecific and intraspecific functional diversity(community weighted trait similarity and trait dissimilarity,CWS and CWD).Finally,we examined the relationships between biodiversity effects on stand-level tree height and functional diversity(RaoQ,CWS and CWD)in SRL using linear regression and assessed the relative importance of these three components of functional diversity in explaining the diversity *** Findings Our results show that species richness significantly affected SRL in five and tree height in ten out of 16 species.A positive ne was generally brought about by a positive CE on stand-level tree height and related to high values of RaoQ and CWS in SRL.A positive CE was related to high values of all three components of root functional diversity(RaoQ,CWS and CWD).Our study suggests that both resource partitioning and species interactions are the underlying mechanisms of biodiversity effects on stand-level tree growth in subtropical forest.

关键词： aboveground complementarity effects belowground resource partitioning biodiversity and ecosystem functioning species interactions tree height

The development and function of follicular helper T cells in immune responses

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Cellular & Molecular Immunology 2012年第5期9卷 375-379页

作者： Maogen Chen Zhiyong Guo Weiqiang Ju bernhard Ryffel Xiaoshun He Song Guo Zheng Organ Transplant Center 1st Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Division of Rheumatology and Immunology Department of MedicineUniversity of2Division of Rheumatology and ImmunologyDepartment of MedicineUniversity of Southern CaliforniaKeck School of MedicineLos AngelesCAUSA UMR6218 Molecular ImmunologyUniversity of Orleans and CNRS3b rue de la FerollerieOrleansFrance

Follicular helper T cells （Tfh） have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

关键词： autoimmune diseases follicular helper T cells systemic lupus erythematousus

Impact of tree diversity and environmental conditions on the survival of shrub species in a forest biodiversity experiment in subtropical China

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Journal of Plant Ecology 2017年第1期10卷 179-189页

作者： Bo Yang Ying Li Bingyang Ding Sabine Both Alexandra Erfmeier Werner Härdtle Keping Ma bernhard Schmid Thomas Scholten Gunnar Seidler Goddert von Oheimb Xuefei Yang Helge bruelheide Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-WittenbergAm Kirchtor 106120 HalleGermany Key Laboratory of Speciality Plant Resources of Jiangxi Province Jingdezhen University838 Cidu AvenueJingdezhenJiangxi 333000China Faculty of Sustainability Institute of EcologyLeuphana University LüneburgScharnhorststr 121335 LüneburgGermany College of Life and Environmental Sciences Wenzhou UniversityWenzhouZhejiang 325035China Institute of Biological and Environmental Sciences University of Aberdeen23 St Machar DriveAberdeen AB243UUUK Institute for Ecosystem Research GeobotanyKiel UniversityOlshausenstr 7524118 KielGermany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences20 NanxincunXiangshanBeijing 100093China Institute of Evolutionary Biology and Environmental Studies University of ZürichWinterthurerstr 1908057 ZürichSwitzerland Department of Geosciences Chair of Soil Science and GeomorphologyEberhard Karls University TübingenRümelinstraße19-23D-72070 TübingenGermany Technische Universität Dresden Institute of General Ecology and Environmental ProtectionPienner Straße 701737 TharandtGermany Key Laboratory of Biodiversity and Biogeography Kunming Institute of BotanyCAS KunmingKunming 650201China

Aims Although shrubs are an important component of forests,their role has not yet been considered in forest biodiversity *** the biodiversity-ecosystem functioning(BEF)experiment with subtropical tree species in south-east China(BEF-China),we factorially combined tree with shrub species-diversity ***,we tested the hypotheses that shrub survival differs between the 10 planted shrub species,with lower survival rates of late-than early-successional species and is affected by environmental conditions,such as topography and top soil characteristics,as well as by biotic factors,represented by tree,shrub and herb layer *** We analyzed the survival of 42000 shrub individuals in 105 plots varying in tree and shrub species richness of the BEF-China project four years after *** survival was analyzed with generalized linear mixed effects models at the level of individuals and with variance partitioning at the plot *** intercept and random slope models of different explanatory variables were compared with respect to the Bayesian Information Criterion(BIC).Important Findings Survival rates differed largely between the 10 shrub species,ranging from 26%to 91%for Ardisia crenata and Distylium buxifolium,*** of species identity,single abiotic factors explained up to 5%of species survival,with a negative effect of altitude and slope inclination and a positive effect of the topsoil carbon to nitrogen ratio,which pointed to drought as the major cause of shrub *** contrast,neither tree nor shrub richness affected shrub survival at this early stage of the *** the biotic predictors,only herb layer species richness and cover of the dominant fern species(Dicranopteris pedata)affected shrub ***,our models that included all variables could explain about 65%in shrub survival,with environmental variables being most influential,followed by shrub species identity,while tree speci

关键词： BEF-China biodiversity-ecosystem functioning experiment forest herb layer plant survival shrub species richness

Encyclopedia of Materials: Science and Technology (v. 10) 1st

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Improving risk stratification for 2022 European Leukemianet favorablerisk patients with acute myeloid leukemia

2001年

作者： K.H.J. Buschow Ph.D. Robert Cahn Merton C Flemings bernhard Ilschner Edward J Kramer Subhash Mahajan Patrick Veyssiere

来源：畅想之星图书光盘版（南... 评论

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The Innovation 2024年第6期5卷 89-99页

作者： Kellie J.Archer Han Fu Krzysztof Mrózek Deedra Nicolet Alice S.Mims Geoffrey L.Uy Wendy Stock John C.Byrd Wolfgang Hiddemann Klaus H.Metzeler Christian Rausch Utz Krug Cristina Sauerland Dennis Görlich Wolfgang E.Berdel bernhard J.Woermann Jan braess Karsten Spiekermann Tobias Herold Ann-Kathrin Eisfeld Division of Biostatistics College of Public HealthThe Ohio State UniversityColumbusOHUSA Google Inc.Mountain ViewCAUSA Clara D.Bloomfield Center for Leukemia Outcomes Research The Ohio State University Comprehensive Cancer CenterColumbusOHUSA Alliance Statistics and Data Management Center The Ohio State University Comprehensive Cancer CenterColumbusOHUSA Department of Medicine Division of OncologyWashington University School of MedicineSt.LouisMOUSA Department of Medicine Section of Hematology/OncologyUniversity of ChicagoChicagoILUSA Department of Internal Medicine University of CincinnatiCincinnatiOHUSA Department of Medicine III University HospitalLMU MunichMunichGermany Department of Oncology and Hematology Hospital Barmherzige Br€uderRegensburgGermany Department of Medicine 3 Klinikum LeverkusenLeverkusenGermany Institute of Biostatistics and Clinical Research University of M€unsterM€unsterGermany Department of Medicine A University Hospital M€unsterM€unsterGermany German Society of Hematology and Oncology BerlinGermany

Assignment of patients diagnosed with acute myeloid leukemia(AML)to the 2022 European Leukemianet(ELN)favorable genetic risk group has important clinical implications,as allogeneic stem cell transplantation in first complete remission(CR)is not advised due to a relatively good outcome of patients receiving chemotherapy alone and transplant-associated ***,not all favorable genetic risk patients experience long-term relapse-free survival(RFS),making recognition of patients who would most likely be cured of high importance.

关键词： patients myeloid Leukemia

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马克斯曲式理论体系中的基本概念与分类方法

美育学刊 2018年第4期9卷 72-77页

作者：闵讷王旭青浙江音乐学院作曲指挥系浙江杭州310024 杭州师范大学艺术教育研究院浙江杭州311121

19世纪中期,马克斯以其独特的理论视角,发展出一套音乐结构术语与分析符号,对19世纪音乐结构理论具有促进与完善意义。通过对马克斯提出的"动机""过程""主题""回旋曲式""奏鸣曲式"等概念的阐述,可探究马克斯曲式理论中各种音乐结构类型... 详细信息

19世纪中期,马克斯以其独特的理论视角,发展出一套音乐结构术语与分析符号,对19世纪音乐结构理论具有促进与完善意义。通过对马克斯提出的"动机""过程""主题""回旋曲式""奏鸣曲式"等概念的阐述,可探究马克斯曲式理论中各种音乐结构类型之间的关联性,进而审思马克斯结构分类方法的学理意义及其影响。

关键词：马克斯曲式理论《音乐创作与实用理论指南》回旋曲式奏鸣曲式