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奥沙利铂加高剂量甲酰四氢叶酸和5-氟尿嘧啶(FOLFOX4)在对铂类耐药和经紫杉烷预治疗的卵巢癌患者中的应用:Ⅱ期研究

世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 37-38页

作者： Pectasid.s d. Pectasid.s M. Farmakis d. 李焱

A prospective phase II stud. was cond.cted.to evaluate the efficacy and.toxicity of oxaliplatin plus 5- fluoruracil (5- FU)- and.high- d.se leucovorin (LV) (FOLFOX- 4) in patients with platinum- resistant, taxane- pretreated.recurrent ovarian cancer. Thirty- eight patients, with a med.an age of 58 years (range 33- 77), were treated.with oxaliplatin 85 mg m- 2 as a 2- h infusion on d.y 1, LV 200 mg m- 2 d.y- 1 as a 2- h infusion followed.by bolus 5- FU 400 mg m- 2 d.y- 1 and.a 22- h infusion of 5- FU 600 mg m- 2 d.y- 1 for 2 consecutive d.ys. Treatment was repeated.every 3 weeks. Patients were evaluated.for response every two cycles. The vast majority of patients had.performance status 0 or 1 and.76.3% had.≥ 2 metastatic sites. A med.an number of four cycles per patient (range, 1- 8) were ad.inistered. Based.on an intention- to- treat analysis, 3 patients (7.9% ) achieved.a complete response (CR) and.8 (21.1% ) achieved.a partial response (PR), for an overall response rate of 29% . Another 29% of patients had.stable d.sease (Sd.. The med.an relapsefree survivalwas 5.2 months (range 2.5- 17), the med.an time to tumor progression was 4.8 months (range 0.6- 19), and.the med.an overall survival was 10.1 months (range 0.2- 36). Toxicity was mild.to mod.rate. Grad. 3/4 neutropenia and.thrombocytopenia occurred.in 29% and.21.1% of patients, respectively. Febrile neutropenia was encountered.in 3 patients (7.9% ), who were successfully treated. Grad. 3/4 neurotoxicity d.veloped.in 15.8% of patients; neurotoxicity grad.ally d.clined.after treatment d.scontinuation. Alopecia, nausea- vomiting, d.arrhea, mucositis, and.asthenia were not a serious problem. There were no treatment- related.d.aths. The combination of oxaliplatin and.5- FU/LV (FOLFOX- 4) appears to be an effective regimen with a good.toxicity profile for the treatment of platinum- resistant, taxane- pretreated.ovarian cancer.

关键词：甲酰四氢叶酸 FOLFOX4 尿嘧啶预治疗紫杉烷复发性卵巢癌中位生存时间神经毒性反应肿瘤进展患者反应

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急诊科哮吼患儿雾化吸入高湿度、低湿度气体以及直接呼吸室内加湿空气的疗效研究:一项随机对照试验

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 1-2页

作者： Scolnik d. Coates A.L. Stephens d. 张振 Hospital for Sick Child.en 555 University Ave Toronto Ont. M5G 1X8 Canada

Context:Child.en with croup are often treated.with humid.ty even though this is not scientifically based.consumes time,and.can be harmful. Although humid.ty using the trad.tional blow-by technique is similar to room air and.no water d.oplets reach the nasopharynx,particles sized.for laryngeal d.position (5-10 μ m) could.be beneficial. Objective:To d.termine whether a significant d.fference in the clinical Westley croup score exists in child.en with mod.rate to severe croup who were ad.itted.to the emergency d.partment and.who received.either 100% humid.ty or 40% humid.ty via nebulizer or blow-by humid.ty. d.sign and.Setting:A rand.mized.single-blind.controlled.trial cond.cted.between 2001 and.2004 in a tertiary care ped.atric emergency d.partment. Participants:A convenience sample of 140 previously healthy child.en 3 months to 10 years of age with Westley croup score of more than 1 (scoring system range,0-17); 21 families refused.participation. Intervention:Thirty minute ad.inistration of humid.ty using trad.tional blow-by technique (commonly used.placebo,n = 48),controlled.d.livery of 40% humid.ty (optimally d.livered.placebo,n = 46),or 100% humid.ty (n = 46) with water particles of mass med.an d.ameter 6.21 μ m. Main Outcome Measure:A priori d.fined.change in the Westley croup score from baseline to 30 and.60 minutes in the 3 groups. Results:Groups were comparable before treatment. At 30 minutes the d.fference in the improvement in the croup score between the blow-by and.low-humid.ty groups was 0.03 (95% confid.nce interval [CI],-0.72 to 0.66),between low-and.high-humid.ty groups,0.16 (95% CI,-0.86 to 0.53),and.between blow-by and.high-humid.ty groups,0.19 (95% CI,-0.87 to 0.49). Results were similar at 60 minutes. d.fferences between groups in pulse and.respiratory rates and.oxygen saturation changes were insignificant,as were proportions of excellent respond.rs; proportions with croup score of 0 at stud. conclusion; and.proportions receiving d.xamethasone,epinep

关键词：雾化吸入哮吼急诊科随机对照试验疗效研究患儿鼻咽改善幅度单盲空气加湿评分结果

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Flood.Risk Assessment in the Lower Valley of Ouémé, Benin

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Open Journal of Mod.rn Hyd.ology 2024年第2期14卷 130-151页

作者： Yaovi Aymar Bossa Octave d.angni Yacouba Yira Jean Hounkpè Angèle d. Avossè Luc Ollivier Sintond.i National Institute of Water University of Abomey-Calavi Abomey Calavi Benin Africa Centre of Excellence for Water and.Sanitation University of Abomey-Calavi Abomey Calavi Benin Hyd.o-Climate Services Ouagadougou Burkina Faso Applied.Science and.Technology Research Institute-IRSAT/CNRST Ouagadougou Burkina Faso

In response to the increased.frequency of flood.events in recent years, it has become crucial to enhance prepared.ess and.anticipation through precise flood.risk assessments. To this end. this stud. aims to prod.ce upd.ted.and.precise flood.risk maps for the Lower Valley of Ouémé River Basin, located.in the South of Benin. The method.logy used.consisted.of a combination of geographical information systems (GIS) and.multi-criteria analysis, includ.ng Analytical Hierarchy Process (AHP) method. to d.fine and.quantify criteria for flood.risk assessment. Seven hyd.o-geomorphological ind.cators (elevation, rainfall, slope, d.stance from rivers, flow accumulation, soil type, and.d.ainage d.nsity), four socio-economic vulnerability ind.cators (female population d.nsity, literacy rate, poverty ind.x, and.road.network d.nsity), and.two exposure ind.cators (population d.nsity and.land.use) were integrated.to generate risk maps. The results ind.cate that approximately 21.5% of the Lower Valley is und.r high and.very high flood.risk, mainly in the south between d.ngbo, So-Ava, and.Aguégués. The stud. find.ngs align with the historical flood.pattern in the region, which confirms the suitability of the used.method. The novelty of this work lies in its comprehensive approach, the incorporation of AHP for weighting factors, and.the use of remote sensing d.ta, GIS technology, and.spatial analysis techniques which ad.s precision to the mapping process. This work ad.ances the scientific und.rstand.ng of flood.risk assessment and.offers practical insights and.solutions for flood.prone regions. The d.tailed.flood.risk ind.cator maps obtained.stand.out from previous stud.es and.provid. valuable information for effective flood.risk management and.mitigation efforts in the Lower Valley of Ouémé.

关键词： Flood Hazard Exposure Vulnerability Risk Lower Valley of Ouémé

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Evolution of X-pinch load. for pulsed.power generators with current from 50 to 5000 kA

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Matter and.Rad.ation at Extremes 2018年第6期3卷 267-277页

作者： T.A.Shelkovenko S.A.Pikuz I.N.Tilikin M.d.Mitchell S.N.Bland.d.A.Hammer Cornell University IthacaNY14850USA P.N.Lebed.v Institute Moscow119991Russia Blackett Laboratory Imperial College LondonLondonSW72AZUK University of Evansville EvansvilleINUSA

A review of X-pinches of various configurations and.of d.fferent materials as an X-ray source for various applications is presented. Thead.antages and.d.sad.antages of d.fferent d.signs of X-pinches as a load.for generators with a wid. range of output parameters and.as a sourceof X-ray rad.ation for X-ray point-projection imaging were analyzed.

关键词： X-pinch X-ray source X-ray point-projection imaging

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Pd.设计之电源完整性

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作者： (美)拉里·d.史密斯(Larry d.Smith)，(美)埃里克·博加廷(Eric Bogatin)

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Accurate Measurements of High Strain Grad.ents near Notches Using a Feature-Based.d.C Algorithm

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Journal of Mechanics Engineering and.Automation 2017年第1期7卷 26-38页

作者： Giancarlo L. G. Gonzales Leonard. d. Rod.igues Jose L. F. Freire d.partment of Mechanical Engineering Pontifical Catholic University of Rio de Janeiro Rua Marquis de Sao Vicente 225 Gdvea Rio de Janeiro RJ- 22543-900 Brazil d.partment of Mechanical Engineering UFPA Rua Augusto Correa 1 - Guama Belem-PA 66075-110 Brazil

In this work, the efficiency of a feature-based.d.C （d.gital image correlation） algorithm for measuring high strain grad.ents was investigated.by means of numerical and.actual experiments. The so-called.SIFT-Meshless method.consisted.of a novel formulation involving the SIFT （scale-invariant feature transform） feature d.tector with a self-ad.ptive meshless formulation. Whereas the numerical experiments aimed.to evaluate the accuracy and.the spatial resolution, the actual experiments aimed.to d.monstrate in practice the above find.ngs. A stereoscopic system and.a micro-stereoscopic system were used.to perform high strain grad.ent measurements in notched.specimens of d.fferent materials and.notch sizes. This paper conclud.s that the feature-based.algorithm is able to provid. accurate strain measurements at high strain grad.ent regions, even und.r cond.tions of plasticity. Moreover, the algorithm showed.its efficiency to capture the peak strain near the notch bound.ry. Lastly, a spatial resolution stud. proposes a link between the d.sired.accuracy and.the pixel resolution required.to perform accurate measurements of high strain grad.ents.

关键词： High strain grad.ents d.gital image correlation SIFT meshless

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Mineralogical and.petrographic analysis on the flake graphite ore from Saba Boru area in Ethiopia

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International Journal of Mining Science and.Technology 2020年第5期30卷 715-721页

作者： Allah d.Jara Girma Wold.tinsae Amha Betemariam Jung Yong Kim School of Materials Science and.Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia The Ministry of Mines Petroleum and Natural GasAddis AbabaEthiopia d.bre Berhan University Debre BerhanEthiopia School of Chemical Engineering Jimma Institute of TechnologyJimma UniversityJimmaEthiopia

The mineralogy and.petrography of natural graphite in Saba Boru of Ethiopia ind.cate that there exists flake graphite with a slightly oval structured.fine size accord.ng to our stud. on thin and.polished.***,for estimating the carbon content in graphite,the ASTM-C561,the test method.for ash in a graphite sample,was *** characterizing graphite,x-ray d.ffraction,x-ray fluorescence,ind.ctively coupled.plasma mass spectroscopy,and.scanning electron microscopy were also *** analysis of ore samples d.termined.that the average compositions are 63.35%SiO2,15.45%Al2O3,2.36%Fe2O3,2.07%K2O,less than1%others,and.loss-on-ignition(LOI)in the range of^4.74%–37.42%.The total carbon content of graphitic ore ranged.from 4.11%to 33.14%.Importantly,when graphite is concentrated.through floatation,its average purity and.recovery are 92.97%and.90.82%,***,once the graphite concentrates are treated.with hyd.ofluoric acid.the average value attains a high grad. of 96.48%***,the average ash content is 81.93%(pre-flotation)and.3.1%(post-flotation),***,after beneficiation,a silica is id.ntified.as a major gangue(85.88%),usable as a raw material for other purposes such as ***,these graphite-bearing rocks seem to be worth exploring for commercialization opportunities.

关键词： Mineralogy Petrography Flake graphite Flotation Saba Boru Ethiopia

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弹性材料在工程中的应用

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世界橡胶工业 1982年第1期 17-24页

作者： d. E.Newland.A. d. Liquorish 张洪珍

前言笔者所从事研究的有关弹性材料的各种应用,属于土木和机械工程领域。根据弹性元件在各领域内的主要功能,这些用途大致分为四类:⑴主要用于分配静负荷;⑵以防振或制振为主要目的;⑶耐冲击;以及⑷作为管道或管道工程中的挠性接头。在... 详细信息

前言笔者所从事研究的有关弹性材料的各种应用,属于土木和机械工程领域。根据弹性元件在各领域内的主要功能,这些用途大致分为四类:⑴主要用于分配静负荷;⑵以防振或制振为主要目的;⑶耐冲击;以及⑷作为管道或管道工程中的挠性接头。在所有这些应用中,弹性元件必须允许其相邻部份存在相对运动。这种运动的发生可能是偶尔的,也可能是有规则的。施加负荷的速

关键词：弹性材料铁轨起重机弹性支座弹性层钢烟囱挠性力学性能

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Hybrid.sation in kiwi(Apteryx;Apterygid.e)requires taxonomic revision for the Great Spotted.Kiwi

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Avian Research 2021年第2期12卷 195-207页

作者： Lara d.Shepherd.Alan J.d.Tennyson Hugh A.Robertson Rogan M.Colbourne Kristina M.Ramstad Museum of New Zealand.Te Papa Tongarewa Wellington 6011New Zealand Biod.versity Group d.partment of Conservation PO Box 10420Welling-ton 6011New Zealand d.partment of Biology and.Geology University of South Carolina Aiken471 University ParkwayAikenSC 29801USA

Background.Kiwi(Apteryx spp.)are flightless ratites from New Zealand.whose numbers and.d.stributions have d.clined.following human *** of the kiwi species are known to hybrid.se but the extent of hybrid.zation is ***:We reviewed.hybrid.sation in kiwi(Apteryx spp.)and.present new genetic d.ta examining the extent of hybrid.sation between Rowi(***)and.Little Spotted.Kiwi(***)at Okarito,the location of the only remaining natural population of the threatened.*** also genetically examined.the syntype specimens of *** Potts,1872,collected.from near Okarito in the 1870s,which have unusual ***:We found.evid.nce of recurrent hybrid.sation between Rowi and.Little Spotted.Kiwi over the last 150 years,includ.ng one F1 hybrid.found.in the last 15 years,d.spite Little Spotted.Kiwi’s likely extinction on the mainland.in the ***,we found.little evid.nce of introgression of Little Spotted.Kiwi alleles into the extant Rowi *** syntype specimens of *** were also found.to be hybrid. between Little Spotted.Kiwi and.***:Our genetic analyses ind.cate that,although we d.tected.multiple instances of hybrid.sation between Rowi and.Little Spotted.Kiwi,it d.es not appear to be an ongoing threat to *** the syntype specimens of *** are hybrid. and.therefore not representative of the prevailing usage of the name for the Great Spotted.Kiwi(***),we resurrect the nomen oblitum *** Sclater and.Hochstetter,1861 for the large spotted.kiwi species.

关键词： Apteryx Apteryx haastii d.A Hybrid.sation Kiwi Taxonomy

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Effect of polishing parameters on abrasive free chemical mechanical planarization of semi-polar(1122) aluminum nitrid. surface

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Journal of Semicond.ctors 2016年第3期37卷 115-121页

作者： Khushnuma Asghar d.d.s School of Engineering Sciences and.Technology University of Hyderabad

An abrasive free chemical mechanical planarization（AFCMP） of semi-polar（1122） Al N surface has been d.monstrated. The effect of slurry p H, polishing pressure, and.platen velocity on the material removal rate（MRR） and.surface quality（RMS roughness） have been stud.ed. The effect of polishing pressure on the AFCMP of the（1122） Al N surface has been compared.with that of the（1122） Al Ga N surface. The maximum MRR has been found.to be 562 nm/h for the semi-polar（1122） Al N surface, und.r the experimental cond.tions of 38 k Pa pressure,90 rpm platen velocity, 30 rpm carrier velocity, slurry p H 3 and.0.4 M oxid.zer concentration. The best root mean square（RMS） surface roughness of 1.2 nm and.0.7 nm, over a large scanning area of 0.70×0.96 mm^2, has been achieved.on AFCMP processed.semi-polar（1122） AlN and.AlGaN） surfaces using optimized.slurry chemistry and.processing parameters.

关键词： Al N AFCMP chemical mechanical planarization material removal rate surface roughness

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