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CT-guided high-dose-rate brachytherapy in the interdisciplinary treatment of patients with liver metastases of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 530-538页

作者： Gero Wieners Alexander Christian Schippers Federico Collettini Dirk Schnapauff bernd hamm Peter Wust Hanno Riess Bernhard Gebauer Department of Diagnostic and Interventional Radiology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Radiation Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum

BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter percutaneously into the targeted lesion. The aim of this study was to assess local tumor control, safety and efficacy of CT-HDRBT in the treatment of liver metastases of pancreatic cancer. METHODS： Twenty consecutive patients with 49 unresectable liver metastases of pancreatic cancer were included in this retrospective trial and treated with CT-HDRBT, applied as a single fraction high-dose irradiation（15-20 Gy） using a 192 Irsource. Primary endpoint was local tumor control and secondary endpoints were complications, progression-free survival and overall ***： The mean tumor diameter was 29 mm（range 10-73）. The mean irradiation time was 20 minutes（range 7-42）. The mean coverage of the clinical target volume was 98%（range 88%-100%）. The mean D100 was 18.1 Gy and the median D100 was 19.78 Gy. Three major complications occurred with post-interventional abscesses, three of which were seen in 15 patients with biliodigestive anastomosis（20%）and overall 15%. The mean follow-up time was 13.7 months（range 1.4-55.0）. The median progression-free survival was 4.9 months（range 1.4-42.9, mean 9.4）. Local recurrence occurred in 5（10%） of 49 metastases treated. The median overall survival after CT-HDRBT was 8.6 months（range 1.5-55.3）. Eleven patients received chemotherapy after ablation with a median progression-free survival of 4.9 months（mean 12.9）. Nine patients did not receive chemotherapy after intervention with a median progression-free survival of 3.2 months（mean 5.0）. The rate of local tumor control was 91% in both groups after 12 ***： CT-HDRBT was safe and effective for the treatment of liver metastases of pancreatic cancer.

关键词： brachytherapy pancreatic cancer liver metastases CT intervention

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论文化帝国主义

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作者： (德)伯尔尼德·哈姆(bernd hamm) (加)拉塞尔·斯曼戴奇(Russell Smandych)

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Biologically Inspired Girder Structure for the Synchrotron Radiation Facility PETRA IV

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Journal of Bionic Engineering 2023年第5期20卷 1996-2017页

作者： Simone Andresen Norbert Meyners Daniel Thoden Markus Körfer Christian hamm Bionic Lightweight Design&Functional Morphology Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI)Am Handelshafen 1227570BremerhavenGermany Deutsches Elektronen-Synchrotron(DESY) Notkestraße 8522607HamburgGermany

Lightweight structures are widely used across different industry ***,they get easily excited by external influences,such as *** high vibration amplitudes can be avoided by shifting the structural eigenfrequencies,which can be achieved adapting the structural design considering optimisation procedures and structures primarily inspired by *** procedures has been applied to the development process of a girder structure installed in a synchrotron radiation facility to support heavy magnets and other *** objective was to design a 2.9 m long girder structure with high eigenfrequencies,a high stiffness and a low *** on a topology optimisation result,a parametric beam–shell model including biologically inspired structures(e.g.,Voronoi combs,ribs,and soft and organic-looking transitions)was built *** subsequent cross-sectional optimisation using evolutionary strategic optimisation revealed an optimum girder structure,which was successfully manufactured using the casting *** measurements validated the numerical *** changes in the specifications can be implemented in the bio-inspired development process to obtain adapted girder structures.

关键词： Biomimetics Eigenfrequency maximisation Evolutionary structural optimisation Lightweight design Topology optimisation Voronoi combs

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Transfer of Natural Micro Structures to Bionic Lightweight Design Proposals

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Journal of Bionic Engineering 2013年第4期10卷 469-478页

作者： M. Maier D. Siegel K.-D. Thoben N. Niebuhr C. hamm Alfred Wegener Institute for Polar and Marine Research Am Handelshafen 12 27570 Bremerhaven Germany Institute for Marine Resources GmbH Bussestr. 27 27570 Bremerhaven Germany University of Bremen Hoehschulring 20 28359 Bremen Germany

The abstraction of complex biological lightweight structure features into a producible technical component is a funda- mental step within the transfer of design principles from nature to technical lightweight solutions. A major obstacle for the transfer of natural lightweight structures to technical solutions is their peculiar geometry. Since natural lightweight structures possess irregularities and often have extremely complex forms due to elaborate growth processes, it is usually necessary to simplify their design principles. This step of simplification/abstraction has been used in different biomimetic methods, but so far, it has an arbitrary component, i.e. it crucially depends on the competence of the person who executes the abstraction. This paper describes a new method for abstraction and specialization of natural micro structures for technical lightweight compo- nents. The new method generates stable lightweight design principles by using topology optimization within a design space of preselected biological archetypes such as diatoms or radiolarian. The resulting solutions are adapted to the technical load cases and production processes, can be created in a large variety, and may be further optimized e.g. by using parametric optimization.

关键词： biomimetic finite elements design space design principle topology optimization parametric optimization dia- toms radiolarian

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Promoting recovery from severe mental illness: Implications from research on metacognition and metacognitive reflection and insight therapy

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World Journal of Psychiatry 2018年第1期8卷 1-11页

作者： Paul Henry Lysaker Jay A hamm Ilanit Hasson-Ohayon Michelle L Pattison Bethany L Leonhardt Department of Psychiatry Roudebush VA Med Ctr and the Indiana University School of Medicine Department of Psychiatry Indiana University School of Medicine Department of Psychiatry Eskenazi Health Midtown Community Mental Health Eskenazi Health Midtown Community Mental Health Department of Psychology Hasson-Ohayon I Bar Ilan Univ Dept Psychol Department of Psychology University of Indianapolis College of Applied Behavioral Sciences

Research indicates that individuals with schizophrenia recover. Recovery, however means different things to different individuals and regardless of what kind of experiences define recovery, the individual diagnosed with the serious mental illness must feel ownership of their recovery. This raises the issue of how mental health services should systematically promote recovery. This paper explores the practical implications for research on metacognition in schizophrenia for this issue. First, we present the integrated model of metacognition, which defines metacognition as the spectrum of activities which allow individual to have available to themselves an integrated sense of self and others as they appraise and respond to the unique challenges they face. Second, we present research suggesting that many with schizophrenia experience deficits in metacognition and that those deficits compromise individuals' abilities to manage their lives and mental health challenges. Third, we discuss a form of psychotherapy inspired by this research, Metacognitive Reflection and Insight Therapy which assists individuals to recapture the ability to form integrated ideas about themselves and others and so direct their own recovery. The need for recovery oriented interventions to focus on process and on patient's purposes, assess metacognition and consider the intersubjective contexts in which this occurres is discussed.

关键词： Schizophrenia Rehabilitation Self Psychosis Metacognition Recovery Psychotherapy Social cognition

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清华英语自然拼读乐园

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2013年

作者： (美)hamm Kabbabe

该系列教程共分3个级别，每个级别含主课本、故事书、主课本练习册、故事书练习册、多媒体光盘。主课本单元学习结束后，引导孩子阅读配套故事书，提高其单词解码能力，加强高频词认知，直至达到流利阅读。

ISBN: (纸本)9787302320777

关键词：英语课

来源：畅想之星图书光盘版（南... 评论

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对比高水平与低水平分级运动试验终点的预后价值

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国外医学（物理医学与康复学分册） 1989年第3期9卷 119-121页

作者： hamm LF 夏苓春

心肌梗塞(MI)后早期分级运动试验在病人评价中已成为普遍程序。自1977年以来,一些研究报道了在MI 后3周内进行的运动试验。MI 后立即实施运动试验被用于评价病人对各种水平体力活动的心血管反应,并依照病人心脏意外的潜在危险对病人进... 详细信息

心肌梗塞(MI)后早期分级运动试验在病人评价中已成为普遍程序。自1977年以来,一些研究报道了在MI 后3周内进行的运动试验。MI 后立即实施运动试验被用于评价病人对各种水平体力活动的心血管反应,并依照病人心脏意外的潜在危险对病人进行分类.

关键词：心肌梗塞运动疗法预后分级

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肝内囊性病变的诊断和介入治疗

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放射学实践 1993年第1期8卷 10-15页

作者： B.hamm P.Teller 王天才 Klinik fur Radiologie Abteilung fur Rontgendiagnostik Universitatsklinikum Steglitz der Freien Universitat Berlin Hindenburgdamm 30.1000 Berlin 45FRGPrlv.-Doz Dr 同济医科大学附属同济医院

采用现代断层显像方法诊断肝脏囊性病变是不成问题的。但是,对肝脏病灶的分类并依其病变不同而采用不同的治疗手段则向超声、CT和磁共振提出了一项特别的任务。本文研究的目的是从放射学观点出发,对不同囊性肝脏病进行研究,并报告介入... 详细信息

采用现代断层显像方法诊断肝脏囊性病变是不成问题的。但是,对肝脏病灶的分类并依其病变不同而采用不同的治疗手段则向超声、CT和磁共振提出了一项特别的任务。本文研究的目的是从放射学观点出发,对不同囊性肝脏病进行研究,并报告介入治疗的可能性。

关键词：肝内囊性病变 X线诊断治疗

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胜者永不放弃！

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英语画刊(高中版) 2020年第32期 14-16页

作者： Mia hamm

米娅喜欢打篮球,喜欢打棒球,但最喜欢的还是踢足球。参考译文:米娅喜欢篮球,米娅喜欢棒球,但米娅最喜欢的还是足球。她每天都和朋友们一起踢球。哒哒哒,她的脚趾可以把球控制在她想让它在的地方。接着,啪的一声!她会把球直接踢进网里。...

米娅喜欢打篮球,喜欢打棒球,但最喜欢的还是踢足球。参考译文:米娅喜欢篮球,米娅喜欢棒球,但米娅最喜欢的还是足球。她每天都和朋友们一起踢球。哒哒哒,她的脚趾可以把球控制在她想让它在的地方。接着,啪的一声!她会把球直接踢进网里。射门得分!她队里的每个人都会欢呼起来。不过有时候,结果并非如人所愿。

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西格丽德·温塞特的《伊达·伊丽莎白》——一位母亲的情节剧?(英文)

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外国文学研究 2007年第5期29卷 9-21页

作者：克里斯丁.汉姆挪威卑尔根大学斯堪的纳维亚语言文学系

本文通过文本阅读结合当时挪威对性别问题的争论的社会政治背景,探讨西格丽德.温塞特的《伊达.伊丽莎白》中的母亲身分主题。这部小说最初因其情节剧式的成分,在小说美学层面遭到许多批评。本文使用朱丽亚.克里斯蒂瓦和斯坦利.卡维尔的... 详细信息

本文通过文本阅读结合当时挪威对性别问题的争论的社会政治背景,探讨西格丽德.温塞特的《伊达.伊丽莎白》中的母亲身分主题。这部小说最初因其情节剧式的成分,在小说美学层面遭到许多批评。本文使用朱丽亚.克里斯蒂瓦和斯坦利.卡维尔的理论,分析得出温塞特是有意将这些情节成分放在一起,以表达妇女并不简单是母亲,而是如何真正成为母亲。温塞特首先摆出20世纪30年代妇女的窘境,因为她们缺乏话语表述做母亲的经历。通过运用情节剧,温塞特试图让读者体验母亲的经历,特别是让读者能分享主人公如何确立自己真正母亲地位的历程。笔者认为主人公的发展是追求女性自由的历程。

关键词：温塞特《伊达·伊丽莎白》母亲身分情节剧性别问题

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