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Oxidative stress,the blood-brain barrier and neurodegenerative diseases:The critical beneficial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares Marta Martínez bernardo lopez-torres María-Rosa Martínez-Larran aga Xu Wang Arturo Anadon María-Aranzazu Martínez National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awareness of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,generally non-toxic nature,and ease of long-term *** review article examines the role of oxidative stress in the development of NDs,explores the‘two-sidedness’of the blood-brain barrier(BBB)as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier Neurodegenerative diseases Vitamins Carotenoids Flavonoids Polyphenols

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Some contributions to mechanical behaviors of lacustrine deposit in Bogota, Colombia

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 837-849页

作者： bernardo Caicedo Cristhian Mendoza Arcesio Lizcano Fernando lopez-Caballero Department of Civil and Environmental Engineering Universidad de Los AndesBogotaColombia Department of Civil Engineering Universidad Nacional de Colombia Sede ManizalesManizalesColombia SRK Consulting VancouverCanada Laboratoire MSS-Mat CNRS UMR8579CentraleSupelecParis-Saclay UniversityFrance

This paper presents the mechanical behaviors of the lacustrine deposit,a representative soil in Bogota,***,the physical characterization of the deposit is performed via laboratory tests (grain size distribution,scanning electron microscopy,Atterberg limits and water content).This characterization intends to explain the special characteristics of the mechanical behaviors of this ***,various triaxial tests are carried out with controlled loading path,strain rate change,relaxation,extensile stress,and cyclic *** test results reveal the shape of the yield curve for Bogotá soil (in a natural state),and also show that an increasing effect of the strain rate depends on the liquid *** effect is also preserved with extensile stresses (which are poorly studied in soil mechanics).Finally,other effects,such as the loss of structure in the reconstituted samples and the effect of shear modulus at low strains,are studied for Bogota soil.

关键词： Cyclic triaxial tests Triaxial compression test Time-dependent response Lacustrine soils Soil compressibility Yield curve

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Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： Fernanda lopez-Moncada Maria Jose torres Enrique A Castellon Hector R Contreras Department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPARCduring the early stages of tumor progression remains *** this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPARC)

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Spatiotemporal patterns of burned areas,fire drivers,and fire probability across the equatorial Andes

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Journal of Mountain Science 2021年第4期18卷 952-972页

作者： Xavier ZAPATA-RiOS Carmen lopez-FABARA Abigail NAVARRETE Sandra torres-PAGUAY Miguel FLORES Department of Civil and Environmental Engineering Escuela Politecnica NacionalLadron de Guevara E11-253P.O.Box 17-01-2759QuitoEcuador Center for Research and Water Resources Studies(CIERHI) Escuela Politecnica NacionalLadron de Guevara E11-253P.O.Box 17-01-2759QuitoEcuador Faculty of Agricultural Sciences Universidad Central del EcuadorAv.UniversitariaP.O.Box 17-03-100QuitoEcuador Modeling Optimization and Inferential Statistics Group(MODES)Department of MathematicsEscuela Politecnica NacionalLadron de Guevara Ell-253P.O.Box 17-01-2759QuitoEcuador

Field-based fire studies in the equatorial Andes indicate that fires are strongly associated with biophysical and anthropogenic ***,fire controls and fire regimes at the regional scale remain ***,this paper describes spatial and temporal burned-area patterns,identifies biophysical and anthropogenic fire drivers,and quantifies fire probability across 6°of latitude and 3°of longitude in the equatorial *** spatial and temporal burned-area analysis was carried out based on 18 years(2001-2018)of the MCD64 A1 MODIS burned-area ***,topography,vegetation,and anthropogenic variables were integrated in a logistic regression model to identify the significance of explanatory variables and determine fire occurrence probability.A total of 5779 fire events were registered during the 18 years of this study,located primarily along the western cordillera of the Andes and spreading from North to ***-eight percent of these fires took place within two fire hotspots located in the northwestern and southwestern corners of the study ***-nine percent occurred during the second part of the year,between June and *** largest density of fires was primarily located on herbaceous vegetation and *** show that mean monthly temperature,precipitation and NDVI during the prefire season,the location of land cover classes such as forest and agriculture,distance to roads and urban areas,slope,and aspect were the most important determinants of spatial and temporal fire *** logistic regression model achieved a good accuracy in predicting fire probability(80%).Probability was higher in the southwestern and northern corners of the study area,and lower towards the north in the western and eastern piedmonts of the *** analysis contributes to the understanding of fires in mountains within the *** results here presented have the potential to contribute to fire management and control in the regi

关键词： MODIS MCD64A1 Spectral vegetation indices Pre-fire season NDVI and precipitation Remote sensing

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A Data Mining Approach to Detecting Bias and Favoritism in Public Procurement

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Intelligent Automation & Soft Computing 2023年第6期36卷 3501-3516页

作者： Yeferson torres-Berru Vivian F.lopez-Batista Lorena Conde Zhingre University of Salamanca Salamanca37008Spain Instituto Tecnológico Superior Sudamericano Loja1101608Ecuador Universidad Internacional del Ecuador Loja1101608Ecuador

In a public procurement process,corruption can occur at each stage,favoring a participant with a previous agreement,which can result in over-pricing and purchases of substandard products,as well as gender *** paper’s aim is to detect biased purchases using a Spanish Language corpus,ana-lyzing text from the questions and answers registry platform by applicants in a public procurement process in ***,gender bias is detected,pro-moting both men and women to participate under the same *** order to detect gender bias and favoritism towards certain providers by contracting enti-ties,the study proposes a unique hybrid model that combines Artificial Intelli-gence algorithms and Natural Language Processing(NLP).In the experimental work,303,076 public procurement processes have been analyzed over 10 years(since 2010)with 1,009,739 questions and answers to suppliers and public insti-tutions in each *** bias and favoritism were analyzed using a Word2-vec model with word embedding,as well as sentiment analysis of the questions and answers using the VADER *** 32%of cases(96,984 answers),there was favoritism or gender bias as evidenced by responses from contracting *** proposed model provides accuracy rates of 88% for detecting favor-itism,and 90%for detecting gender *** one-third of the procure-ment processes carried out by the state have indications of corruption and *** Latin America,government corruption is one of the most significant challenges,making the resulting classifier useful for detecting bias and favoritism in public procurement processes.

关键词： Favoritism bias natural language processing Word2vec sentiment analysis word embeddings

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Green extraction of phenolic compounds from Perle Hallertau and Nuggets hop pellets

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Food Bioscience 2022年第6期50卷 474-481页

作者： Vanesa Sanz Maria Dolores torres Jose M.lopez Vilarino Herminia Dominguez Chemical Engineering Department Faculty of ScienceCampus OurenseUniversity of VigoSpain R&D Department Hijos de RiveraS.A.U.c/ José Maria Riveranº6A CoruñaSpain

Operation conditions to recover and quantify active compounds from Perle Hallertau (PH) and Nuggets (N) hops, following a sequential combination of ultrasound and microwave assisted ethanolic extraction were studied. Ultrasound treatment (55 °C, 60% ethanol, 30 minutes) allowed extracts with phenolic contents of 160.43 mg GAE/g extract and ABTS radical scavenging capacity equivalent to 400.24 mg Trolox/g extract for PH. Optimal conditions for N were found at 55 °C, using 60% ethanol for 120 minutes (98.80 mg GAE/g extract) and 55 °C, 40% ethanol for 180 min (370.00 mg Trolox/g extract). The remaining solids were further processed under ethanolic microwave extraction (130–190 °C, 5 minutes) with the optimal results obtained at 190 °C for PH (77.11 and 98.67 mg GAE/g extract) and N (226.96 and 368.72 mg Trolox/g extract). Results obtained provided hops pellets as a rich source of active compounds that could be suitable for food and no food industry applications.

关键词： Humulus lupulus Cascade extraction Environmentally friendly technologies Ultrasound Microwave Antioxidants

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Immunologic, metabolic and genetic factors in hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3443-3456页

作者： Nora A Fierro Karina Gonzalez-Aldaco Rafael torres-Valadez Erika Martinez-lopez Sonia Roman Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara"Fray Antonio Alcalde" and Health Sciences CenterUniversity of GuadalajaraGuadalajara 44280JaliscoMexico

The mechanisms that regulate disease progression during hepatitis C virus(HCV)infection and the response to treatment are not clearly *** studies have demonstrated that a strong host immune response against HCV favors HCV *** addition,genetic factors and metabolic machinery,particularly cholesterol modulation,are involved in HCV *** is likely that the interplay between all of these factors contributes to the outcome of HCV *** recent years,the world has experienced its largest epidemic of *** and the United States are the leading sufferers from this epidemic at the global *** is associated with the development ofnumerous pathologies including hypercholesterolemia which is one of the eight most important risk factors for mortality in *** may be related to the course of HCV infection in this ***,we focus on the urgent need to study the progression of HCV infection in relation to ethnic *** are discussed that hold promise in identifying immune,metabolic and genetic factors that,in conjunction,could be therapeutic targets or predictors of the progression of HCV infection.

关键词： Hepatitis C virus Immune response Lipids Metabolism Genetics

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Dysregulation of the PD-1/PD-L1 pathway contributes to the pathogenesis of celiac disease

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Cellular & Molecular Immunology 2019年第9期16卷 777-779页

作者： Candelaria Ponce de Leon Miguel Angel lopez-Casado Pedro Lorite Teresa Palomeque Maria Isabel torres Department of Experimental Biology University of JaenJaenSpain Department of Pediatrics Gastroenterology Hospital Virgen de las NievesGranadaSpain

In this study,we focus on the alteration of the programmed cell death 1(PD-1)/PD-L1 pathway in celiac *** discuss the diverse roles of the PD-1 pathway in regulating immune responses and how this knowledge can improve celiac disease(CD)*** PD-1 and PD-L1 levels in the serum and in intestinal biopsies of CD patients may be relevant to the determination of a possible correlation between markers of the autoimmune response,inflammation,and disease activity.

关键词： celiac pathogenesis inflammation

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Tetrapartite entanglement measures of W-class in noninertial frames

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Chinese Physics B 2019年第7期28卷 122-130页

作者： Ariadna J. torres-Arenas Edgar O. lopez-Zuniga J. Antonio Saldana-Herrera Qian Dong Guo-Hua Sun Shi-Hai Dong Laboratorio de Información Cuantica CIDETEC Instituto Politecnico Nacional UPALM CDMX 07700 Mexico Facultad de Ciencias Fisico Matematicas Universidad Autónoma de Nuevo Leon San Nicolas de los Garza NL 66450 Mexico Catedratica CONACyT Centro de Investigacion en Computacion Instituto Politecnico Nacional UPALM CDMX 07738 Mexico

We present the entanglement measures of a tetrapartite W-class entangled system in a noninertial frame, where the transformation between Minkowski and Rindler coordinates is *** cases are ***, when one qubit has uniform acceleration whilst the other three remain ***, when two qubits have nonuniform accelerations and the others stay *** 1–1 tangle, 1–3 tangle, and whole entanglement measurements π4 and Π4, are studied and illustrated with graphics through their dependence on the acceleration parameter rd for the first case and rc and rd for the second *** is found that the negativities(1–1 tangle and 1–3 tangle) and π-tangle decrease when the acceleration parameter rd or in the second case rc and rd increase, remaining a nonzero entanglement in the majority of the *** means that the system will be always entangled except for special *** is shown that only the 1–1 tangle for the first case vanishes at infinite accelerations, but for the second case the 1–1 tangle disappears completely when r > *** analytical expression for the von Neumann information entropy of the system is found and we note that it increases with the acceleration parameter.

关键词： W-class tetrapartite entanglement Dirac field noninertial frames nonuniform acceleration

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Potential role of the IL-33/ST2 axis in celiac disease

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Cellular & Molecular Immunology 2017年第3期14卷 285-292页

作者： lopez-Casado MA Lorite P Palomeque T torres MI Department of Pediatrics Gastroenterology Hospital Virgen de las Nieves Granada Spain Department of Experimental Biology University of Jaen Jaen Spain

The IL-33/ST2 axis has been implicated in the pathogenesis of several tissue-specific autoimmune diseases. Celiac disease （CD） is the only autoimmune disease in which both the major genetic factors （HLA-DQ2/DQ8） and etiologic ones （dietary gluten） for susceptibility are known. We have measured serum levels and determined intestinal tissue expression of IL-33 and its receptor soluble ST2 in patients with CD to investigate their association with disease activity. Serum and tissue levels of both IL-33 and sST2 were significantly higher in patients with CD compared with those in control patients without CD. We show that toxic peptides extracted from barley and wheat gliadin significantly stimulate the production of IL-33 and ST2 in cultured peripheral blood mononuclear cell from celiac patients, strongly implicating the IL-33/ST2 axis in the pathogenesis of CD. The higher levels of IL-33 and its receptor ST2 in tissue and serum reflect an active inflammatory state and may represent a potential biomarker for disease activity. A better understanding of IL-33/ ST2 release, mode of action, and regulation will be crucial to develop therapeutics that target the IL-33/ST2 pathway to treat CD.

关键词： celiac disease gluten peptides IL-33 ST2

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