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英国医学杂志中文版 2004年第3期7卷 191-191页

作者： Cesar G Victora Fernando C Barros Rosangela C lima bernardo l horta Jonathan Wells 顾佳

目的：评价母乳喂养时间与青少年肥胖的关系。

关键词：母乳喂养喂养时间 18岁男性巴西肥胖体重身高

Behavior of diatomaceous soil in lacustrine deposits of Bogota, Colombia

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 367-379页

作者： bernardo Caicedo Cristhian Mendoza Fernando lópez Arcesio lizcano Department of Civil and Environmental Engineering Universidad de Los AndesBogotáColombia Department of Civil Engineering Universidad Nacional de Colombia Sede ManizalesManizalesColombia Ecole Centrale Paris Laboratoire MSSMat-UMR CNRS 8579ParisFrance SRK Consulting VancouverCanada

This work presents a study on the behaviors of diatomaceous soils. Although studies are rarely reported on these soils, they have been identified in Mexico City, the Sea of Japan, the northeast coast of Australia,the equatorial Pacific, and the lacustrine deposit of Bogota(Colombia), among other locations. Features of this kind of soil include high friction angle, high initial void ratio, high compressibility index, high liquid limit, and low density. Some of these features are counterintuitive from a classical soil mechanics viewpoint. To understand the geotechnical properties of the diatomaceous soil, a comprehensive experimental plan consisting of more than 2400 tests was performed, including physical tests such as grain size distribution, Atterberg limits, density of solid particles, and organic matter content; and mechanical tests such as oedometric compression tests, unconfined compression tests, and triaxial *** tests were complemented with scanning electron microscope(SEM) observations to evaluate the microstructure of the soil. The test results show that there is an increase in liquid limit with increasing diatomaceous content, and the friction angle also increases with increasing diatomaceous content. In addition, several practical correlations were proposed for this soil type for shear strength mobilization and intrinsic compression line. Finally, useful correlations were presented, such as the relationship between the state consistency and the undrained shear strength, the friction angle and the liquid limit, the void ratio at 100 kPa and the liquid limit, the plasticity index and the diatomaceous content, among others.

关键词： Diatomaceous soil Soft soils Compressibility Friction angle Natural soil

Hadron resonances as rovibrational states

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Chinese Physics C 2021年第8期45卷 99-104页

作者： Douglas l.bernardo Cristiano C.Bastos Antonio C.Pavao Departamento de Quimica Fundamental Universidade Federal de PernambucoRecife50740-540Brazil Departamento de Quimica Universidade Federal Rural de PernambucoRecife52171-900Brazil

A rovibrational model,including anharmonic,centrifugal,and Coriolis corrections,is used to calculate π,K,N,and ∑ orbital and radial *** four orbital excitations of the n meson correspond to the/?(1235),ti2(1670),63(2030),and π4(2250)*** first four radial excitations correspond to the π(1300),π(1800),π(2070),and 7t(2360)*** orbital excitations of the K meson are interpreted as the K_(1)(1270),K_(2)(1770),K_(3)(2320),and K_(4)(2500)resonances;its radial excitations correspond to the K(1460)and K(1830)*** N orbital excitations are identified with the N(1520),N(1680),N(2190),N(2220),and N(2600)*** first four radial excitations of the N family correspond to the N(1440),N(1880),N(2100),and N(2300)*** orbital excitations of the ∑ baryon are associated with the ∑(1670),∑(1915),∑(2100),and ∑(2250)resonances,whereas its radial excitations are identified with the ∑(1660),∑(1770),and ∑(1880)*** proposed rovibrational model calculations show a good agreement with the corresponding experimental values and allow for the prediction of hadron resonances,thereby proving to be useful for the interpretation of excited hadron spectra.

关键词： excited hadron spectrum orbital and radial resonances rovibrational states

Guava extract (Psidium guajava) alters the labelling of blood constituents with technetium-99m

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 429-435页

作者： ABREU P.R.C. AlMEIDA M.C. bernardo R.M. bernardo l.C. BRITO l.C. GARCIA E.A.C. FONSECA A.S. bernardo-FIlHO M. Department of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil Department of Physiology Biological Sciences and Health Center Federal University of Sergipe So Cristóvo Sergipe 49100000 Brazil Department of Pharmacology and Psychobiology Institute of Biology Roberto Alcantara Gomes University of Estate of Rio de Janeiro Rio de Janeiro 20551030 Brazil

Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory dis-turbances and is used as anti-inflammatory medicine. In nuclear medicine, blood constituents (BC) are labelled with techne-tium-99m (99mTc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of BC with 99mTc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of BC with 99mTc. Blood samples of Wistar rats were incubated with different concentrations of guava extract and labelled with 99mTc after the percentage of incorporated radioactivity (%ATI) in BC was determined. The results suggest that aqueous guava extract could present antioxidant action and/or alters the membrane structures involved in ion transport into cells, thus decreasing the radiolabelling of BC with 99mTc. The data showed significant (Plteration of ATI in BC from blood incubated with guava extract.

关键词： Antioxidant Blood constituents Psidium guajava Technetium-99m

Effect of initial microstructure on austenite formation kinetics in high-strength experimental microalloyed steels

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1304-1312页

作者： Edgar lópez-Martínez Octavio Vázquez-Gómez Héctor Javier Vergara-Hernández bernardo Campillo Faculty of Chemistry Metallurgical Engineering Department Autonomous National University of Mexico National Council for Science and Technology Metallurgy Science Postgraduate Programme Morelia Institute of Technology Institute of Physical Sciences Autonomous National University of Mexico

Austenite formation kinetics in two high-strength experimental microalloyed steels with different initial microstructures comprising bainite-martensite and ferrite-martensite/austenite microconstituents was studied during continuous heating by dilatometric analysis. Austenite formation occurred in two steps：（1） carbide dissolution and precipitation and （2） transformation of residual ferrite to austenite. Dilatometric analysis was used to determine the critical temperatures of austenite formation and continuous heating transformation diagrams for heating rates ranging from 0.03°C.s^-1 to 0.67°C.s^-1. The austenite volume fraction was fitted using the Johnson-Mehl-Avrami-Kolmogorov equation to determine the kinetic parameters k and n as functions of the heating rate. Both n and k parameters increased with increasing heat- ing rate, which suggests an increase in the nucleation and growth rates of austenite. The activation energy of austenite formation was determined by the Kissinger method. Two activation energies were associated with each of the two austenite formation steps. In the first step, the austenite growth rate was controlled by carbon diffusion from carbide dissolution and precipitation; in the second step, it was controlled by the dissolution of residual ferrite to austenite.

关键词： non-isothermal kinetics microalloyed steel austenite heating dilatometry

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

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Cellular & Molecular Immunology 2021年第5期18卷 1106-1121页

作者： Damien Bertheloot Eicke latz bernardo S.Franklin Institute of Innate Immunity University Hospitals BonnUniversity of BonnBonnNRWGermany Department of Infectious Diseases and Immunology University of Massachusetts Medical SchoolWorcesterMAUSA German Center for Neurodegenerative Diseases BonnNRWGermany

Cell death is a fundamental physiological process in all living *** roles extend from embryonic development,organ maintenance,and aging to the coordination of immune responses and *** recent years,our understanding of the mechanisms orchestrating cellular death and its consequences on immunity and homeostasis has increased *** modalities of what has become known as‘programmed cell death’have been described,and some key players in these processes have been *** have learned more about the intricacies that fine tune the activity of common players and ultimately shape the different types of cell *** studies have highlighted the complex mechanisms tipping the balance between different cell ***,we summarize the latest discoveries in the three most well understood modalities of cell death,namely,apoptosis,necroptosis,and pyroptosis,highlighting common and unique pathways and their effect on the surrounding cells and the organism as a whole.

关键词： Apoptosis Necroptosis Pyroptosis Inflammation Survival

Photometric and Spectroscopic Study of Ten low Mass Ratio Contact Binary Systems:Orbital Stability,O'Connell Effect and Infrared Calcium line Filling

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Research in Astronomy and Astrophysics 2024年第8期24卷 212-222页

作者： Surjit S.Wadhwa Adam Popowicz Raúl Michel Petar Kostić Oliver Vince Nick F.H.Tothill Ain Y.De horta Miroslav D.Filipović School of Science Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Department of Electronics Electrical Engineering and MicroelectronicsSilesian University of TechnologyAkademicka 1644120 GliwicePoland Instituto de Astronomía UNAM.A.P.87722800 EnsenadaBCMéxico Astronomical Observatory Volgina 711060 BelgradeSerbia

low mass ratio contact binary systems are more likely to have unstable orbits and potentially *** addition,such systems exhibit characteristics such as starspots and high energy emissions(UV)suggestive of chromospheric and magnetic *** curve modeling of ten contact binary systems is *** were found to be of extreme low mass ratio ranging from 0.122 to 0.24 and three were found to be potentially unstable and possible merger *** of the infrared calcium absorption lines is a marker of increased chromospheric *** use the available large Sky Area Multi-Object Fiber Spectroscopic Telescope spectra along with matched standard spectra(broadened for rotation)to measure the excess filling of the central core depression flux of the two main infrared calcium absorption linesλ8542 andλ*** find that all reported contact binaries have excess filling of the core flux in the infrared calcium *** of the systems reported were also observed by the Galaxy Evolution Explorer mission and we find that all three have features of excess ultraviolet emissions further adding evidence for increased chromospheric activity in low mass ratio contact *** of both orbital stability and absorption line filling is dependent on the determination of geometric and absolute parameters from light curve *** an insignificant number of contact binary light curves exhibit the O’Connell effect,usually attributed to *** discuss the inclusion of starspots in light curve solutions and how they influence the geometric and absolute parameters.

关键词： (stars)binaries eclipsing-techniques photometric-stars chromospheres

HDl signaling and protection against coronary artery atherosclerosis in mice

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The Journal of Biomedical Research 2016年第2期30卷 94-100页

作者： bernardo l Trigatti Mark Fuller Department of Biochemistry and Biomedical Sciences McMaster University and Thrombosis and Atherosclerosis Research InstituteMcMaster University and Hamilton Health Sciences

Atherosclerosis is a leading underlying factor in cardiovascular disease and stroke,important causes of morbidity and mortality across the *** epidemiological studies demonstrate that high levels of high density lipoprotein（HDl） are associated with reduced risk of atherosclerosis and preclinical,animal model studies demonstrate that this association is *** the molecular mechanisms underlying the protective effects of HDl will allow more strategic approaches to development of HDl based *** evidence suggests that an important aspect of the ability of HDl to protect against atherosclerosis is its ability to trigger signaling responses in a variety of target cells including endothelial cells and macrophages in the vessel *** signaling responses require the HDl receptor,scavenger receptor class B type 1（SR-B1）,an adaptor protein（PDZK1） that binds to the cytosolic C terminus of SR-B1,Akt1 activation and（at least in endothelial cells） activation of endothelial NO synthase（eNOS）.Mouse models of atherosclerosis,exemplified by apolipoprotein E or low density lipoprotein receptor gene inactivated mice（apoE or lDlR KO） develop atherosclerosis in their aortas but appear generally resistant to coronary artery *** the other hand,inactivation of each of the components of HDl signaling（above）in either apoE or lDlR KO mice renders them susceptible to extensive coronary artery atherosclerosis suggesting that HDl signaling may play an important role in protection against coronary artery disease.

关键词： coronary artery disease high density lipoprotein myocardial infarction scavenger receptor class B type 1

Screen-printed graphite electrode on polyvinyl chloride and parchment strips integrated with genetic programming for in situ nitrate sensing of aquaponic pond water

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Information Processing in Agriculture 2024年第2期11卷 187-201页

作者： Ronnie ConcepcionⅡ bernardo Duarte Maria Gemel Palconit Jonah Jahara BaunArgel Bandala Ryan Rhay Vicerra Elmer Dadios Department of Manufacturing Engineering and Management De La Salle UniversityManila 1004 Philippines MARE-Marine and Environmental Sciences Centre.&ARNET-Aquatic Research Infrastructure Network Associated laboratory Faculdade de Ciencias da Universidade de LisboaCampo Grande1749-016 LisboaPortugal Departamento de Biologia Vegetal da Faculdade de Ciencias da Universidade de lisboa Campo Grande 1749-016 LisboaPortugal Department of Electronics and Computer Engineering De La Salle UniversityManila 1004 Philppines

Nitrate is the primary water-soluble macronutrient essential for plant growth that is converted from excess fish feeds,fish effluents,and degrading biomaterials on the aquaponic pond floor,and when aquacultural malpractices occur,large amounts of it retain in the water system causing increase rate in eutrophication and toxifies fish and aquaculture *** nitrate sensor prototypes still require performing the additional steps of water sample deionization and dilution and were constructed with expensive *** response to the challenge of sensor enhancement and aquaponic water quality monitoring,this study developed sensitive,repeatable,and reproducible screen-printed graphite electrodes on polyvinyl chloride and parchment paper substrates with silver as electrode material and 60:40 graphite powder:nail polish formulated conductive ink for electrical traces,integrated with 9-gene genetic expression model as a function of peak anodic current and electrochemical test time for nitrate concentration prediction that is embedded into low-power Arduino ESP32 for in situ nitrate sensing in aquaponic pond *** SPE electrical traces were designed on the two types of *** electron microscopy with energy dispersive X-ray confirmed the electrode surface *** cyclic voltammetry using 10 to 100 mg/l KNO3 and water from three-depth regions of the actual pond established the electrochemical test time(10.5 s)and electrode potential(0.135 V)protocol necessary to produce peak current that corresponds to the strength of nitrate ions during *** findings from in situ testing revealed that the proposed sensors have strong linear predictions(R2=0.968 MSE=1.659 for nSPEv and R2=0.966 MSE=4.697 for nSPEp)in the range of 10 to 100 mg/l and best detection limit of 3.15μg/l,which are comparable to other sensors of more complex *** developed three-electrode electrochemical nitrate sensor confirms that it is reliable for bot

关键词： Aquaponic water quality Electrochemical technology Genetic programming Graphite electrode Nitrate sensor Precision agriculture Printed electronics Scanning electron microscopy Screen-printed electrode Voltammetry

Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage

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Bioactive Materials 2024年第7期37卷 253-268页

作者： Sara Freitas-Ribeiro Helena Moreira lucília P.da Silva Jennifer Noro Belem Sampaio-Marques Paula ludovico Mariana Jarnalo Ricardo horta Alexandra P.Marques Rui l.Reis Rogerio P.Pirraco B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimaraesPortugal ICVS/3B’s-PT Government Associate laboratory Braga/GuimaraesPortugal life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal Department of Plastic and Reconstructive Surgery and Burn UnityCentro Hospitalar de Sao JoaoPortoPortugal Faculty of Medicine-University of Porto Portugal

The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems *** engineering offers a potential solution to address these shortages,but several challenges remain,with prevascularization being a critical factor for in vivo survival and integration of tissue engineering ***,a different challenge hindering the clinical implementation of such products,regards their efficient preservation from the fabrication site to the *** has emerged as a potential solution for this issue due to its milder effects on biologic systems in comparison with other cold preservation *** impact on prevascularization,however,has not been well *** this work,3D prevascularized constructs were fabricated using adipose-derived stromal vascular fraction cells and preserved at 4◦C using Hypothermosol or basal culture media(α-MEM).Hypothermosol efficiently preserved the structural and cellular integrity of prevascular networks as compared to constructs before *** contrast,the use ofα-MEM led to a clear reduction in prevascular structures,with concurrent induction of high levels of apoptosis and autophagy at the cellular *** vivo evaluation using a chorioallantoic membrane model demonstrated that,in opposition toα-MEM,Hypothermosol preservation retained the angiogenic potential of constructs before preservation by recruiting a similar number of blood vessels from the host and presenting similar integration with host *** results emphasize the need of studying the impact of preservation techniques on key properties of tissue engineering constructs such as prevascularization,in order to validate and streamline their clinical application.

关键词： Tissue engineering Prevascularization Hypothermic preservation Clinical translation